阅读说明：本技术 一种肠通贴及其制备方法 (Intestine-dredging patch and preparation method thereof ) 是由 冯高飞 于 2021-09-24 设计创作，主要内容包括：本发明涉及医药技术领域,尤指一种肠通贴及其制备方法。本申请的肠通贴可以起到清热解毒,化瘀止痛,软坚散结的作用,同时用于治疗各种肿瘤、肿块、结节之病性属热的疼痛,尤其适用于因骨转移引起癌痛患者。而且该临床观察发现对疼痛改善情况显著,反复使用仍然可以取效,不会耐药,提高了患者生活质量,减少治疗期间抗生素等使用频次,降低住院费用,有一定的经济和社会价值,临床值得加以推广。(The invention relates to the technical field of medicines, in particular to an intestine-dredging patch and a preparation method thereof. The intestinal patch can play the roles of clearing away heat and toxic materials, removing blood stasis, relieving pain, softening hardness and dissipating stagnation, is used for treating various pains caused by heat in the disease of tumors, lumps and nodules, and is particularly suitable for patients with cancer pain caused by bone metastasis. The clinical observation shows that the pain relieving effect is remarkable, the effect can be achieved even if the traditional Chinese medicine composition is repeatedly used, the drug resistance is avoided, the life quality of patients is improved, the use frequency of antibiotics and the like in the treatment period is reduced, the hospitalization cost is reduced, and the traditional Chinese medicine composition has certain economic and social values and is worthy of popularization clinically.)

1. An intestine-dredging patch, which is characterized in that: the composite material comprises the following raw materials in parts by weight: 30-50 parts of raw rhubarb, 30-50 parts of areca peel, 30-50 parts of corydalis tuber, 30-50 parts of salvia miltiorrhiza, 15-30 parts of prepared aconite, 30-50 parts of cistanche, 15-30 parts of angelica, 15-30 parts of liquorice, 15-30 parts of red paeony root, 15-30 parts of white paeony root, 5-10 parts of centipede, 5-10 parts of asarum, 15-30 parts of mangnolia officinalis, 15-30 parts of bighead atractylodes rhizome, 10-20 parts of peach kernel, 10-20 parts of safflower, 15-30 parts of immature bitter orange, 15-30 parts of radish seed and 870 parts of gel plaster matrix 425.

2. The patch according to claim 1, wherein: the composite material comprises the following raw materials in parts by weight: 30 parts of raw rhubarb, 30 parts of areca peel, 30 parts of corydalis tuber, 30 parts of salvia miltiorrhiza, 15 parts of prepared aconite, 30 parts of cistanche, 15 parts of angelica, 15 parts of liquorice, 15 parts of red paeony root, 15 parts of white paeony root, 5 parts of centipede, 5 parts of asarum, 15 parts of magnolia officinalis, 15 parts of bighead atractylodes rhizome, 10 parts of peach kernel, 10 parts of safflower, 15 parts of immature bitter orange, 150 parts of radish seed and 425 parts of gel plaster matrix.

3. The method for preparing an intestine patch according to claim 1, wherein the method comprises the following steps: the method comprises the following steps:

step 1: preparing a fluid extract: weighing 30-50 parts of cistanche, 15-30 parts of prepared aconite, 15-30 parts of angelica, 15-30 parts of liquorice, 10-20 parts of peach kernel and 10-20 parts of safflower according to parts by weight, extracting liquid by a water extraction method, and concentrating the liquid into fluid extract;

step 2: preparing coarse powder: weighing 30-50 parts of raw rhubarb, 30-50 parts of areca peel, 30-50 parts of corydalis tuber, 30-50 parts of salvia miltiorrhiza, 15-30 parts of liquorice, 15-30 parts of red paeony root, 15-30 parts of white paeony root, 5-10 parts of centipede, 5-10 parts of asarum, 15-30 parts of mangnolia officinalis, 15-30 parts of bighead atractylodes rhizome, 15-30 parts of immature bitter orange and 15-30 parts of radish seed according to the parts by weight, and crushing the raw materials into coarse powder;

and step 3: preparing fine powder: uniformly mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, drying the mixture, and crushing the dried mixture into fine powder;

and 4, step 4: preparing a finished product: and (3) weighing 425 and 870 parts of the gel plaster matrix according to the weight part ratio, uniformly mixing the fine powder prepared in the step (3) with the gel plaster matrix, and preparing a finished product.

4. The method for preparing an intestine patch according to claim 3, wherein the method comprises the following steps: the specific steps in the step 1 are as follows: weighing 30-50 parts of cistanche, 15-30 parts of prepared aconite, 15-30 parts of angelica, 15-30 parts of liquorice, 10-20 parts of peach kernel and 10-20 parts of safflower according to the parts by weight, adding water for extraction for 2-3 times, wherein the water amount is 6-10 times of the total weight of the raw materials, the extraction time is 1-3 hours, combining the extracting solutions, filtering, and concentrating the filtrate to obtain the active ingredient, namely the fluid extract.

5. The method for preparing an intestine patch according to claim 3, wherein the method comprises the following steps: in the step 2, 30-50 parts of raw rhubarb, 30-50 parts of areca peel, 30-50 parts of corydalis tuber, 30-50 parts of salvia miltiorrhiza, 15-30 parts of liquorice, 15-30 parts of red paeony root, 15-30 parts of white paeony root, 5-10 parts of centipede, 5-10 parts of asarum, 15-30 parts of mangnolia officinalis, 15-30 parts of bighead atractylodes rhizome, 15-30 parts of immature bitter orange and 15-30 parts of radish seed are weighed according to parts by weight, and the raw materials are crushed by a crusher and sieved by a 60-80 meshes to obtain coarse powder for later use.

6. The method for preparing an intestine patch according to claim 3, wherein the method comprises the following steps: and 3, mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, drying the uniformly mixed mixture at 80-100 ℃ by using a dryer, crushing the dried mixture by using a crusher, and sieving the crushed mixture by using a sieve of 100 meshes and 150 meshes to obtain fine powder for later use.

7. The method for preparing an intestine patch according to claim 6, wherein the method comprises the following steps: mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, stirring for 10-30 minutes until the mixture is uniformly mixed, and drying the uniformly mixed mixture for 20-30 minutes at 80-100 ℃ by a dryer.

8. The method for preparing an intestine patch according to claim 3, wherein the method comprises the following steps: in the step 4, the mass ratio of the fine powder to the gel plaster matrix is 2:3, and the gel plaster matrix comprises sodium polyacrylate, dihydroxyaluminum glycinate, glycerol, azone and water, wherein the mass ratio of the sodium polyacrylate, the dihydroxyaluminum glycinate, the glycerol, the azone and the water is 288: 4: 660: 30: 2550.

Technical Field

The invention relates to the technical field of medicines, in particular to an intestine-dredging patch and a preparation method thereof.

Background

Constipation usually refers to difficult defecation, prolonged defecation period, or short defecation period, but dry stool with difficult defecation, or not hard stool with difficulty in defecation. The malignant tumor patients have weak constitution and poor digestion function, constipation and abdominal distension are common digestive tract symptoms, and the probability of constipation of the tumor patients is greatly increased by using opioid analgesics due to cancer pain. Research shows that the incidence rate of constipation of tumor patients caused by taking opioids is up to more than 80%, for the tumor patients, long-term constipation can cause various complications, such as abdominal pain, abdominal distension, appetite reduction, nausea and vomiting, dysphoria, anxiety and depression, and the like, and cancer pain can be aggravated to a certain extent, and the problems can affect the treatment effect and the life quality of the tumor patients. The traditional Chinese medicine has unique characteristics for treating constipation. For example, the internal treatment of traditional Chinese medicine is based on the theory of traditional Chinese medicine; the traditional Chinese medicine external treatment methods such as acupuncture, massage, plaster and the like can select a proper individual treatment scheme according to the state of illness of a patient. The traditional Chinese medicine ointment is convenient to use clinically, relatively small in adverse reaction, economical and effective, and can improve the life quality of tumor patients while relieving clinical symptoms, so that the traditional Chinese medicine ointment has unique characteristics in preventing and treating tumor-related constipation and is widely applied to traditional Chinese medicine clinical work.

Currently, common medicines include a plaster prescription which can be used for treating constipation and abdominal distension, and particularly, an external plaster specially aiming at constipation and abdominal distension related to malignant tumors does not exist.

Disclosure of Invention

In order to solve the problems, the invention provides an intestine-dredging patch which has the functions of promoting blood circulation to remove blood stasis, regulating qi to eliminate flatulence and relaxing bowels. Can be used for treating various malignant tumors, and treating constipation and abdominal distention related to malignant tumors, and also can be used for treating non-mechanical incompetence intestinal obstruction caused by malignant tumors.

In order to achieve the purpose, the invention adopts the technical scheme that: the intestinal tract clearing patch comprises the following raw materials in parts by weight: 30-50 parts of raw rhubarb, 30-50 parts of areca peel, 30-50 parts of corydalis tuber, 30-50 parts of salvia miltiorrhiza, 15-30 parts of prepared aconite, 30-50 parts of cistanche, 15-30 parts of angelica, 15-30 parts of liquorice, 15-30 parts of red paeony root, 15-30 parts of white paeony root, 5-10 parts of centipede, 5-10 parts of asarum, 15-30 parts of mangnolia officinalis, 15-30 parts of bighead atractylodes rhizome, 10-20 parts of peach kernel, 10-20 parts of safflower, 15-30 parts of immature bitter orange, 15-30 parts of radish seed and 870 parts of gel plaster matrix 425.

Further, the feed comprises the following raw materials in parts by weight: 30 parts of raw rhubarb, 30 parts of areca peel, 30 parts of corydalis tuber, 30 parts of salvia miltiorrhiza, 15 parts of prepared aconite, 30 parts of cistanche, 15 parts of angelica, 15 parts of liquorice, 15 parts of red paeony root, 15 parts of white paeony root, 5 parts of centipede, 5 parts of asarum, 15 parts of magnolia officinalis, 15 parts of bighead atractylodes rhizome, 10 parts of peach kernel, 10 parts of safflower, 15 parts of immature bitter orange, 150 parts of radish seed and 425 parts of gel plaster matrix.

The application also provides a preparation method of the intestinal patch, which comprises the following steps:

step 1: preparing a fluid extract: weighing 30-50 parts of cistanche, 15-30 parts of prepared aconite, 15-30 parts of angelica, 15-30 parts of liquorice, 10-20 parts of peach kernel and 10-20 parts of safflower according to parts by weight, extracting liquid by a water extraction method, and concentrating the liquid into fluid extract;

step 2: preparing coarse powder: weighing 30-50 parts of raw rhubarb, 30-50 parts of areca peel, 30-50 parts of corydalis tuber, 30-50 parts of salvia miltiorrhiza, 15-30 parts of liquorice, 15-30 parts of red paeony root, 15-30 parts of white paeony root, 5-10 parts of centipede, 5-10 parts of asarum, 15-30 parts of mangnolia officinalis, 15-30 parts of bighead atractylodes rhizome, 15-30 parts of immature bitter orange and 15-30 parts of radish seed according to the parts by weight, and crushing the raw materials into coarse powder;

and step 3: preparing fine powder: uniformly mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, drying the mixture, and crushing the dried mixture into fine powder;

and 4, step 4: preparing a finished product: and (3) weighing 425 and 870 parts of the gel plaster matrix according to the weight part ratio, uniformly mixing the fine powder prepared in the step (3) with the gel plaster matrix, and preparing a finished product.

Further, the specific steps in step 1 are as follows: weighing 30-50 parts of cistanche, 15-30 parts of prepared aconite, 15-30 parts of angelica, 15-30 parts of liquorice, 10-20 parts of peach kernel and 10-20 parts of safflower according to the parts by weight, adding water for extraction for 2-3 times, wherein the water amount is 6-10 times of the total weight of the raw materials, the extraction time is 1-3 hours, combining the extracting solutions, filtering, and concentrating the filtrate to obtain the active ingredient, namely the fluid extract.

Further, in the step 2, 30-50 parts of raw rhubarb, 30-50 parts of areca peel, 30-50 parts of corydalis tuber, 30-50 parts of salvia miltiorrhiza, 15-30 parts of liquorice, 15-30 parts of red paeony root, 15-30 parts of white paeony root, 5-10 parts of centipede, 5-10 parts of asarum, 15-30 parts of mangnolia officinalis, 15-30 parts of bighead atractylodes rhizome, 15-30 parts of immature bitter orange and 15-30 parts of radish seed are weighed according to parts by weight, and the raw materials are crushed by a crusher and pass through a 60-80-mesh sieve to obtain coarse powder for later use.

Further, mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, drying the uniformly mixed mixture at 80-100 ℃ by a dryer, and crushing the dried mixture by a crusher to obtain fine powder for later use, wherein the fine powder is obtained by sieving the crushed mixture with a sieve of 100 meshes and 150 meshes.

Further, the fluid extract prepared in the step 1 and the coarse powder prepared in the step 2 are mixed and stirred for 10-30 minutes until being uniformly mixed, and simultaneously, the uniformly mixed mixture is dried for 20-30 minutes at 80-100 ℃ by a dryer.

Further, the mass ratio of the fine powder to the gel plaster matrix is 2:3, and the gel plaster matrix comprises sodium polyacrylate, dihydroxyaluminum glycinate, glycerol, azone and water, wherein the mass ratio of the sodium polyacrylate, the dihydroxyaluminum glycinate, the glycerol, the azone and the water is 288: 4: 660: 30: 2550.

the invention has the beneficial effects that: the intestinal canal patch has the effects of promoting blood circulation to remove blood stasis, regulating qi and relieving flatulence, and clearing hollow viscera and assisting defecation, is used for treating various malignant tumors and treating related constipation and abdominal distension, and can also be used for treating non-mechanical incomplete intestinal obstruction caused by malignant tumors. Clinical application shows that the intestinal patch has obvious curative effect on treating constipation related to malignant tumor, particularly constipation caused by opioid, can improve the life quality of patients and increase the population of patients using analgesic drugs. Meanwhile, for incomplete intestinal obstruction related to malignant tumors, particularly patients with small intestinal obstruction, fasting, fluid infusion, enema and gastrointestinal decompression cannot achieve ideal curative effects, patients in later period often have no surgical treatment opportunity, and partial patients can achieve the effects of clearing bowels, relieving flatulence, promoting qi circulation and assisting defecation by using an intestinal patch for external application, so that the intestinal obstruction is relieved.

Detailed Description

The invention relates to an intestine-dredging patch which comprises the following raw materials in parts by weight: 30-50 parts of raw rhubarb, 30-50 parts of areca peel, 30-50 parts of corydalis tuber, 30-50 parts of salvia miltiorrhiza, 15-30 parts of prepared aconite, 30-50 parts of cistanche, 15-30 parts of angelica, 15-30 parts of liquorice, 15-30 parts of red paeony root, 15-30 parts of white paeony root, 5-10 parts of centipede, 5-10 parts of asarum, 15-30 parts of mangnolia officinalis, 15-30 parts of bighead atractylodes rhizome, 10-20 parts of peach kernel, 10-20 parts of safflower, 15-30 parts of immature bitter orange, 15-30 parts of radish seed and 870 parts of gel plaster matrix 425.

Further, the feed comprises the following raw materials in parts by weight: 30 parts of raw rhubarb, 30 parts of areca peel, 30 parts of corydalis tuber, 30 parts of salvia miltiorrhiza, 15 parts of prepared aconite, 30 parts of cistanche, 15 parts of angelica, 15 parts of liquorice, 15 parts of red paeony root, 15 parts of white paeony root, 5 parts of centipede, 5 parts of asarum, 15 parts of magnolia officinalis, 15 parts of bighead atractylodes rhizome, 10 parts of peach kernel, 10 parts of safflower, 15 parts of immature bitter orange, 150 parts of radish seed and 425 parts of gel plaster matrix.

Raw rhubarb has the main functions of removing food retention and relieving constipation by purgation, and is used for treating excess heat in stomach and intestine and constipation.

The areca peel, an effect on intestinal smooth muscle, the areca peel decoction can increase the tension of isolated intestinal canal of a rabbit, reduce the contraction amplitude, and the effect of the areca peel decoction can be antagonized by atropine.

The corydalis tuber, which is used as a medicine, has the functions of promoting blood circulation, removing blood stasis, promoting qi circulation and relieving pain, is mainly used for treating diseases such as pain in heart, abdomen, waist and knees, traumatic injury, pain caused by blood stasis, irregular menstruation and the like, and is a traditional analgesic.

The root of red-rooted salvia contains tanshinone, is a strong menstrual flow clearing agent, has the effects of removing blood stasis, promoting tissue regeneration, promoting blood circulation, regulating menstruation and the like, is a key gynecological medicine and is mainly used for treating metrorrhagia, irregular menstruation, blood stasis, abdominal pain, menstrual pain, amenorrhea and temple pain. Has good effect on treating coronary heart disease. In addition, the medicine also can be used for treating insomnia caused by neurasthenia, arthralgia, anemia, mastitis, lymphadenitis, arthritis, sore and furuncle pain and swelling, erysipelas, acute and chronic hepatitis, kidney menyan nephritis, traumatic injury, liver and spleen swelling caused by late schistosomiasis, and epilepsy 30286. It can be used for external application to wash paint sore.

The prepared aconite, which is a traditional Chinese medicine commonly used in clinic, has pungent and hot nature and has the efficacies of reviving yang, rescuing from collapse, tonifying fire, supporting yang, dispelling cold, relieving pain and the like.

Cistanche deserticola, kidney yang-tonifying; replenishing essence and blood; moistening intestinal tract. Deficiency of both the major and kidney yang; impotence due to deficiency of essence and blood; spermatorrhea; white turbidity; frequent micturition and dribbling; lumbago and weak feet; tinnitus and blurred vision; menstrual period of menstruation; infertility due to cold uterus; constipation due to intestinal dryness.

Angelica sinensis for enriching blood; promoting blood circulation; regulating menstruation and relieving pain; moistening dryness and smoothing intestine. The main symptoms are blood deficiency; menoxenia; amenorrhea; dysmenorrhea; the accumulation of symptoms; (ii) metrorrhagia and metrostaxis; abdominal pain due to deficiency-cold; flaccidity and paralysis; numbness of the skin; intestinal dryness and difficult defecation; severe dysentery with diarrhea; carbuncle, cellulitis, sore and ulcer; injury from falling.

Licorice root, radix Glycyrrhizae is used for stomachache, abdominal pain and acute pain of gastrocnemius, and is often combined with peony root to enhance the curative effect of treating acute pain of gastrocnemius.

Red peony root, radix Paeoniae Rubra, which is responsible for warm-toxicity and macula; hematemesis and epistaxis; the intestinal wind gives the blood; conjunctival congestion with swelling and pain; carbuncle, swelling and sore; amenorrhea; dysmenorrhea; metrorrhagia and leukorrhea and turbid urine; hypochondriac pain due to stasis; hernia accumulation; injury from falling. Can be used for treating macula due to toxic heat, hematemesis, epistaxis, conjunctival congestion, swelling and pain, liver depression, hypochondriac pain, amenorrhea, dysmenorrhea, abdominal pain, traumatic injury, carbuncle, swelling, and pyocutaneous disease.

Radix Paeoniae alba can be used for treating rheumatalgia, lumbago due to kidney deficiency, lumbar muscle strain, traumatic injury, contusion, food stagnation, abdominal distention and pain, infantile malnutrition, and snake and dog bite.

Scolopendra, chronic fever, poisonous drinking, eating snake, bug and fish poison, killing ghost, old essence, warm malaria and removing three worms. Treat heart and abdomen cold and heat accumulation, abortion, and remove aversion to blood.

Asarum herb, cough with dyspnea, headache, brain movement, spasm of joints, wind-damp arthralgia and muscle death. It can improve vision and benefit nine orifices for a long time, and can reduce weight and prolong life (Ben Jing). Warming middle-jiao and lower-jiao, breaking phlegm and promoting diuresis, relieving stagnation in chest, eliminating throat impediment, smelling smell, epilepsy, lower mammary gland stagnation, sweating, blood stagnation, calming five internal organs, invigorating liver and gallbladder, and regulating essence and qi (Bian Lu). It can be used for treating cough, skin peeling, rheumatism, pruritus, toothache, and dental pain. Containing the ingredients, the medicine can remove halitosis (carry and play the role). Moisten liver dryness, treat governor vessel disease, strengthen spine and faint (good ancient), treat tongue and mouth.

Magnolia bark, cortex Magnolia officinalis, pungent in flavor and warm in nature, has effects of activating qi-flowing, eliminating dampness, warming the middle warmer, relieving pain, lowering adverse qi, and relieving asthma. The Magnolia officinalis decoction has strong antibacterial effect on Staphylococcus, Streptococcus, Bacillus dysenteriae, Pasteurella and Vibrio cholerae, and also has certain relieving effect on rhabdomyotonia.

The white atractylodes rhizome has the effects of strengthening spleen and tonifying qi, eliminating dampness and promoting diuresis, arresting sweating and preventing miscarriage, and is used for treating spleen deficiency and poor appetite, abdominal distension and diarrhea, phlegm and fluid retention and dizzy palpitation, edema, spontaneous perspiration and threatened abortion.

Peach kernel, semen Persicae is used for amenorrhea, dysmenorrhea, abdominal mass, pulmonary abscess, intestinal abscess, traumatic injury, intestinal dryness, constipation, cough and asthma.

Safflower has the functions of promoting blood circulation, dredging channels, removing blood stasis and relieving pain, and is helpful for treating amenorrhea, dysmenorrhea, lochiorrhea, thoracic obstruction, cardialgia, stasis and abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, sore and ulcer with swelling and pain. Has effects of promoting blood circulation, removing blood stasis, eliminating dampness, and relieving swelling.

Immature bitter orange, accumulation and stagnation in the body, fullness and distending pain, constipation, diarrhea and dysentery with tenesmus, accumulation of chest, gastroptosis, uterine prolapse and rectocele.

Radish seed, semen raphani, has the effects of promoting digestion, relieving flatulence, descending qi and resolving phlegm. Can be used for treating food stagnation, abdominal distention and pain, constipation, stagnation, dysentery, phlegm stagnation, and cough and asthma. Enters spleen, stomach and lung channels, can eliminate food and swell, and has remarkable efficacy.

The application also provides a preparation method of the intestinal patch, which comprises the following steps:

step 1: preparing a fluid extract: weighing 30-50 parts of cistanche, 15-30 parts of prepared aconite, 15-30 parts of angelica, 15-30 parts of liquorice, 10-20 parts of peach kernel and 10-20 parts of safflower according to parts by weight, extracting liquid by a water extraction method, and concentrating the liquid into fluid extract;

step 2: preparing coarse powder: weighing 30-50 parts of raw rhubarb, 30-50 parts of areca peel, 30-50 parts of corydalis tuber, 30-50 parts of salvia miltiorrhiza, 15-30 parts of liquorice, 15-30 parts of red paeony root, 15-30 parts of white paeony root, 5-10 parts of centipede, 5-10 parts of asarum, 15-30 parts of mangnolia officinalis, 15-30 parts of bighead atractylodes rhizome, 15-30 parts of immature bitter orange and 15-30 parts of radish seed according to the parts by weight, and crushing the raw materials into coarse powder;

and step 3: preparing fine powder: uniformly mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, drying the mixture, and crushing the dried mixture into fine powder;

and 4, step 4: preparing a finished product: and (3) weighing 425 and 870 parts of the gel plaster matrix according to the weight part ratio, uniformly mixing the fine powder prepared in the step (3) with the gel plaster matrix, and preparing a finished product.

Further, the specific steps in step 1 are as follows: weighing 30-50 parts of cistanche, 15-30 parts of prepared aconite, 15-30 parts of angelica, 15-30 parts of liquorice, 10-20 parts of peach kernel and 10-20 parts of safflower according to the parts by weight, adding water for extraction for 2-3 times, wherein the water amount is 6-10 times of the total weight of the raw materials, the extraction time is 1-3 hours, combining the extracting solutions, filtering, and concentrating the filtrate to obtain the active ingredient, namely the fluid extract.

Further, in the step 2, 30-50 parts of raw rhubarb, 30-50 parts of areca peel, 30-50 parts of corydalis tuber, 30-50 parts of salvia miltiorrhiza, 15-30 parts of liquorice, 15-30 parts of red paeony root, 15-30 parts of white paeony root, 5-10 parts of centipede, 5-10 parts of asarum, 15-30 parts of mangnolia officinalis, 15-30 parts of bighead atractylodes rhizome, 15-30 parts of immature bitter orange and 15-30 parts of radish seed are weighed according to parts by weight, and the raw materials are crushed by a crusher and pass through a 60-80-mesh sieve to obtain coarse powder for later use.

Further, mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, drying the uniformly mixed mixture at 80-100 ℃ by a dryer, and crushing the dried mixture by a crusher to obtain fine powder for later use, wherein the fine powder is obtained by sieving the crushed mixture with a sieve of 100 meshes and 150 meshes.

Further, the fluid extract prepared in the step 1 and the coarse powder prepared in the step 2 are mixed and stirred for 10-30 minutes until being uniformly mixed, and simultaneously, the uniformly mixed mixture is dried for 20-30 minutes at 80-100 ℃ by a dryer.

Further, the mass ratio of the fine powder to the gel plaster matrix is 2:3, and the gel plaster matrix comprises sodium polyacrylate, dihydroxyaluminum glycinate, glycerol, azone and water, wherein the mass ratio of the sodium polyacrylate, the dihydroxyaluminum glycinate, the glycerol, the azone and the water is 288: 4: 660: 30: 2550.

the specific use method comprises the following steps: the Chinese medicinal plaster is applied to SHENQUE and TIANSHU acupoints 2 times daily for 4-6 hr each time. Note: the wound or skin injury part needs to be avoided when the patch is used.

The present application provides specific preferred examples:

the first embodiment is as follows:

the intestinal tract clearing patch comprises the following raw materials in parts by weight: 30 parts of raw rhubarb, 30 parts of areca peel, 30 parts of corydalis tuber, 30 parts of salvia miltiorrhiza, 15 parts of prepared aconite, 30 parts of cistanche, 15 parts of angelica, 15 parts of liquorice, 15 parts of red paeony root, 15 parts of white paeony root, 5 parts of centipede, 5 parts of asarum, 15 parts of magnolia officinalis, 15 parts of bighead atractylodes rhizome, 10 parts of peach kernel, 10 parts of safflower, 15 parts of immature bitter orange, 150 parts of radish seed and 425 parts of gel plaster matrix.

Also provides a preparation method of the intestinal patch, which comprises the following steps:

step 1: preparing a fluid extract: weighing 30 parts of cistanche, 15 parts of prepared aconite, 15 parts of angelica, 15 parts of liquorice, 10 parts of peach kernel and 10 parts of safflower according to the weight parts, adding water for extraction for 2 times, wherein the water addition amount is 6 times of the total weight of the raw materials each time, the extraction time is 1 hour each time, combining the extracting solutions, filtering, and concentrating the filtrate to obtain the active ingredient, namely the fluid extract.

Step 2: preparing coarse powder: weighing 30 parts of raw rhubarb, 30 parts of areca peel, 30 parts of corydalis tuber, 30 parts of salvia miltiorrhiza, 15 parts of liquorice, 15 parts of red paeony root, 15 parts of white paeony root, 5 parts of centipede, 5 parts of asarum, 15 parts of magnolia officinalis, 15 parts of bighead atractylodes rhizome, 15 parts of immature bitter orange and 15-30 parts of radish seed according to the parts by weight, crushing the raw materials by a crusher, and sieving the crushed raw materials by a 60-mesh sieve to obtain coarse powder for later use;

and step 3: preparing fine powder: mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, stirring for 10 minutes until the fluid extract and the coarse powder are uniformly mixed, drying the uniformly mixed mixture for 20 minutes at 80 ℃ by using a dryer, crushing the dried mixture by using a crusher, and sieving the crushed mixture by using a 100-mesh sieve to obtain fine powder for later use;

and 4, step 4: preparing a finished product: and (3) weighing 425 parts of the gel plaster matrix according to the weight part ratio, uniformly mixing the fine powder prepared in the step (3) with the gel plaster matrix, and preparing a finished product.

The second embodiment is as follows:

the intestinal tract clearing patch comprises the following raw materials in parts by weight: 50 parts of raw rhubarb, 50 parts of areca peel, 50 parts of corydalis tuber, 50 parts of salvia miltiorrhiza, 30 parts of prepared aconite root, 50 parts of cistanche, 30 parts of angelica, 30 parts of liquorice, 30 parts of red paeony root, 30 parts of white paeony root, 10 parts of centipede, 10 parts of asarum, 30 parts of magnolia officinalis, 30 parts of bighead atractylodes rhizome, 20 parts of peach kernel, 20 parts of safflower, 30 parts of immature bitter orange, 30 parts of radish seed and 870 parts of gel plaster substrate.

Also provides a preparation method of the intestinal patch, which comprises the following steps:

step 1: preparing a fluid extract: weighing 50 parts of cistanche, 30 parts of prepared aconite, 30 parts of angelica, 30 parts of liquorice, 20 parts of peach kernel and 20 parts of safflower according to the parts by weight, adding water for extraction for 3 times, wherein the water addition amount is 10 times of the total weight of the raw materials each time, the extraction time is 3 hours each time, combining the extracting solutions, filtering, and concentrating the filtrate to obtain the active ingredient, namely the fluid extract.

Step 2: preparing coarse powder: weighing 50 parts of raw rhubarb, 50 parts of areca peel, 50 parts of corydalis tuber, 50 parts of salvia miltiorrhiza, 30 parts of liquorice, 30 parts of red paeony root, 30 parts of white paeony root, 10 parts of centipede, 10 parts of asarum, 30 parts of magnolia officinalis, 30 parts of bighead atractylodes rhizome, 30 parts of immature bitter orange and 30 parts of radish seed according to the parts by weight, crushing the raw materials by a crusher, and sieving the crushed raw materials by a 80-mesh sieve to obtain coarse powder for later use;

and step 3: preparing fine powder: mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, stirring for 30 minutes until the fluid extract and the coarse powder are uniformly mixed, drying the uniformly mixed mixture for 30 minutes at 100 ℃ by using a dryer, crushing the dried mixture by using a crusher, and sieving the crushed mixture by using a 150-mesh sieve to obtain fine powder for later use;

and 4, step 4: preparing a finished product: 870 parts of the gel plaster substrate is weighed according to the weight part ratio, and the fine powder prepared in the step 3 is uniformly mixed with the gel plaster substrate to prepare a finished product.

Clinical cases

Case one: patient luodi, female, age 81, case number: 063680, farmers, chief complaints of "half a year of cervical cancer and half a month of dyschezia" of 12 months of 2020, the color ultrasound examination of vaginal bleeding suggests the actual occupation of the cervix. The subsequent pathological examination and immunohistochemistry showed that (cervical tumors) invasive cancers combined with the immunophenotype were consistent with adenosquamous carcinomas. The patient undergoes surgery and radiotherapy and chemotherapy, lower abdominal pain occurs before half a month, pain is improved after the oxycodone sustained-release tablet is orally taken, but constipation and abdominal distension symptoms occur, the effect of oral lactulose and traditional Chinese medicine decoction is poor, a small amount of defecation can be realized after the enema is used, but abdominal distension is not obvious in relief, the intestine is externally applied to the Shenque point and the Tianshu after the hospital visits, 2 times per day, 4 hours each time, the defecation can be automatically realized on the 1 st day after the medicine is taken, abdominal distension is improved, the medicine is taken out for outpatient service and is brought home for standby, and the general condition is good.

Case two: the patient was old, female, 82 years old, case No. 055160, examined 2 months in 2020 and PET-CT: the descending colon has thickened intestinal wall in the distal segment and is active in metabolism, and intestinal cancer is considered: the periintestinal mesentery and peritoneum are affected frequently, the metabolism is active, and the implantation metastasis is considered. Laparotomy exploration + partial colectomy + sigmoidectomy + distal rectal closure + colostomy + peritoneal tumor reduction performed after 2020-04-22. Postoperative nutritional support and symptomatic treatment. Postoperative pathology: colon mucous adenocarcinoma, grade III, was not treated with radiotherapy or chemotherapy after the operation. Defecation has not been achieved in nearly 3 days, and outpatient treatment is not good, and the outpatient service is admitted to the hospital by 'colon malignant tumor' for further combined treatment of Chinese and Western medicines. The abdominal orthotopic sheet examination after hospital admission prompts incomplete intestinal obstruction, the abdominal orthotopic sheet examination is subjected to symptomatic treatment such as fluid infusion, fasting, clystering, gastrointestinal decompression and the like, the abdominal orthotopic sheet obstruction is rechecked after half a month without improvement, the intestinal obstruction is externally applied to Shenque point for 2 times/day, 4 hours each time, the fistulization opening of a patient can automatically exhaust and defecate after 7 days of medication, a large amount of stubborn stool is removed by the fistulization opening of the patient when 14 days of medication are taken, gastric juice is remarkably reduced, a gastrointestinal decompression tube is removed, a liquid diet is ordered, the patient does not obviously vomit, abdominal distension does not obviously aggravate, the intermittent evacuation and defecate can be performed, and the intestinal obstruction is remarkably improved.

Case three: patient li zhi, male, 72 years old, case No. 065022, and CT of nasopharynx and nasal sinuses in 05 months of 2014: nasopharyngeal carcinoma is considered as the nasopharynx parietal and right posterior wall tumor; there is a possibility of multiple enlarged lymph nodes in the right neck. The pathology of the biopsy showed: non-keratinizing carcinoma of the nasopharynx, undifferentiated, with partial accompanying squamous epithelial differentiation. The diagnosis is as follows: non-keratinizing carcinoma of the nasopharynx cT2bN1MO, stage IIB. Nasopharynx radiotherapy was performed 10 to 11 months in 2014. After periodic review, no obvious recurrence of metastasis was observed. The swelling of the left cervical lymph node was found in 09 months in 2020 without pain. Color highlighting of neck lymph nodes: parenchymal abnormal lymph nodes in the two cervical IV area. The lower left cervical lymph node puncture biopsy is guided by ultrasonic wave, and the pathology after operation is shown as follows: cancer tissue infiltration is observed, and nasopharyngeal carcinoma metastasis is considered in combination with the medical history and immunohistochemistry. In situ hybridization shows: EBER (+). 2020-12-22 to 2021-01-15 one line for 2 cycle treatment with Pabollizumab + albumin paclitaxel + carboplatin, and for zoledronic acid for bone destruction. 2021-05-01 is administered with albumin paclitaxel + Pabolizumab for 1 cycle. Patients who complain about chemotherapy have obvious fatigue and refuse to continue chemotherapy. The patient starts to have headache 1 month before, the pain is improved after the oxycodone sustained release tablet is orally taken, the constipation symptom appears, the defecation is not performed 7 days before the admission, and the abdominal distension is obvious. Clystering is carried out after admission, and a small amount of excrement is accumulated after clystering. And (4) continuing to perform cleaning enema, externally applying Shenque to assist defecation on the intestine-dredging formula, and then discharging a large amount of excrement for 2-3 days as long as the patient externally applies the intestine-dredging formula for 1-2 times every day.

In conclusion, clinical application shows that the intestinal tract cleaning patch has obvious curative effect on treating constipation related to malignant tumor, particularly constipation caused by opioid, can improve the life quality of patients and increase the population of patients using analgesic drugs. Meanwhile, for incomplete intestinal obstruction related to malignant tumors, particularly patients with small intestinal obstruction, fasting, fluid infusion, enema and gastrointestinal decompression cannot achieve ideal curative effects, patients in later period often have no surgical treatment opportunity, and partial patients can achieve the effects of clearing bowels, relieving flatulence, promoting qi circulation and assisting defecation by using an intestinal patch for external application, so that the intestinal obstruction is relieved.

The above embodiments are merely illustrative of the preferred embodiments of the present invention, and not restrictive, and various changes and modifications to the technical solutions of the present invention may be made by those skilled in the art without departing from the spirit of the present invention, and the technical solutions of the present invention are intended to fall within the scope of the present invention defined by the appended claims.