阅读说明：本技术 一种温阳消瘤止痛贴及其制备方法 (Yang warming, tumor eliminating and pain relieving plaster and preparation method thereof ) 是由 冯高飞 于 2021-10-13 设计创作，主要内容包括：本发明涉及医药技术领域,尤指一种温阳消瘤止痛贴及其制备方法。本申请的温阳消瘤止痛贴可以起到温阳通络,活血止痛,软坚散结的作用,同时用于治疗各种肿瘤、肿块、结节之病性属寒的疼痛,尤其适用于证属寒瘀互结的癌痛患者。而且该临床观察发现对疼痛改善情况显著,反复使用仍然可以取效,不会耐药,提高了患者生活质量,减少治疗期间口服镇痛药物等使用频次,降低住院费用,有一定的经济和社会价值,临床值得加以推广。(The invention relates to the technical field of medicines, in particular to a yang-warming tumor-eliminating pain-relieving plaster and a preparation method thereof. The yang warming, tumor eliminating and pain relieving patch can play a role in warming yang and dredging collaterals, promoting blood circulation and relieving pain, and softening hardness and dissipating stagnation, is used for treating cold pain caused by disease properties of various tumors, lumps and nodules, and is particularly suitable for cancer pain patients with cold-stasis syndrome. The clinical observation shows that the pain relieving effect is remarkable, the pain relieving effect can be achieved after the pain relieving agent is repeatedly used, the drug resistance is avoided, the life quality of patients is improved, the use frequency of oral analgesic drugs and the like during treatment is reduced, the hospitalization cost is reduced, and the pain relieving agent has certain economic and social values and is worthy of popularization in clinical practice.)

1. A yang warming, tumor eliminating and pain relieving plaster is characterized in that: the composite material comprises the following raw materials in parts by weight: 10-15 parts of prepared common monkshood mother root, 10-15 parts of prepared kusnezoff monkshood root, 10-15 parts of pseudo-ginseng, 15-30 parts of frankincense, 15-30 parts of myrrh, 15-30 parts of selfheal, 15-30 parts of Chinese sage herb, 15-30 parts of barbed skullcap herb, 15-30 parts of turtle shell, 10-15 parts of borneol, 10-15 parts of cicada slough, 10-15 parts of paris rhizome, 5-10 parts of scorpion, 5-10 parts of centipede and 435 parts of gel plaster substrate 225-.

2. The yang-warming tumor-eliminating pain-relieving plaster of claim 1, which is characterized in that: the composite material comprises the following raw materials in parts by weight: 10 parts of prepared common monkshood mother root, 10 parts of prepared kusnezoff monkshood root, 10 parts of sanchi, 15 parts of frankincense, 15 parts of myrrh, 15 parts of selfheal, 15 parts of Chinese sage herb, 15 parts of barbed skullcap herb, 15 parts of turtle shell, 10 parts of borneol, 10 parts of cicada slough, 10-15 parts of Chinese paris rhizome, 5 parts of scorpion, 5 parts of centipede and 225 parts of gel plaster matrix.

3. The preparation method of the yang-warming tumor-eliminating pain-relieving plaster as claimed in claim 1, wherein: the method comprises the following steps:

step 1: preparing a fluid extract: weighing 15-30 parts of selfheal, 15-30 parts of sculellaria barbata, 10-15 parts of cicada slough, 10-15 parts of prepared radix aconiti kusnezoffii, 15-30 parts of Chinese sage herb and 10-15 parts of rhizoma paridis according to the parts by weight, extracting the liquid by a water extraction method, and concentrating the liquid into a fluid extract;

step 2: preparing coarse powder: weighing 10-15 parts of pseudo-ginseng, 15-30 parts of frankincense, 15-30 parts of myrrh, 15-30 parts of turtle shell, 10-15 parts of borneol, 5-10 parts of scorpion and 5-10 parts of centipede according to the weight part ratio, and crushing the raw materials into coarse powder;

and step 3: preparing fine powder: uniformly mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, drying the mixture, and crushing the dried mixture into fine powder;

and 4, step 4: preparing a finished product: and (3) weighing 435 parts of the gel plaster substrate 225 and 435 parts by weight, uniformly mixing the fine powder prepared in the step (3) with the gel plaster substrate, and preparing a finished product.

4. The preparation method of the yang-warming tumor-eliminating pain-relieving plaster according to claim 3, which is characterized in that: the specific steps in the step 1 are as follows: weighing 15-30 parts of selfheal, 15-30 parts of sculellaria barbata, 10-15 parts of cicada slough, 10-15 parts of prepared radix aconiti kusnezoffii, 15-30 parts of Chinese sage herb and 10-15 parts of rhizoma paridis according to parts by weight, adding water for extraction for 2-3 times, wherein the water amount added each time is 6-10 times of the total weight of the raw materials, the extraction time for each time is 1-3 hours, combining the extracting solutions, filtering, and concentrating the filtrate to obtain the active component, namely the fluid extract.

5. The preparation method of the yang-warming tumor-eliminating pain-relieving plaster according to claim 3, which is characterized in that: in the step 2, 10-15 parts of pseudo-ginseng, 15-30 parts of frankincense, 15-30 parts of myrrh, 15-30 parts of turtle shell, 10-15 parts of borneol, 5-10 parts of scorpion and 5-10 parts of centipede are weighed according to the parts by weight, and the raw materials are crushed by a crusher and sieved by a 60-80 mesh sieve to obtain coarse powder for later use.

6. The preparation method of the yang-warming tumor-eliminating pain-relieving plaster according to claim 3, which is characterized in that: and 3, mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, drying the uniformly mixed mixture at 80-100 ℃ by using a dryer, crushing the dried mixture by using a crusher, and sieving the crushed mixture by using a sieve of 100 meshes and 150 meshes to obtain fine powder for later use.

7. The preparation method of the yang-warming, tumor-eliminating and pain-relieving patch according to claim 6 is characterized in that: mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, stirring for 10-30 minutes until the mixture is uniformly mixed, and drying the uniformly mixed mixture for 20-30 minutes at 80-100 ℃ by a dryer.

8. The preparation method of the yang-warming tumor-eliminating pain-relieving plaster according to claim 3, which is characterized in that: in the step 4, the mass ratio of the fine powder to the gel plaster matrix is 2:3, and the gel plaster matrix comprises sodium polyacrylate, dihydroxyaluminum glycinate, glycerol, azone and water, wherein the mass ratio of the sodium polyacrylate, the dihydroxyaluminum glycinate, the glycerol, the azone and the water is 288: 4: 660: 30: 2550.

Technical Field

The invention relates to the technical field of medicines, in particular to a yang-warming tumor-eliminating pain-relieving plaster and a preparation method thereof.

Background

Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or a similar experience to this. Cancer pain occurs in a variety of malignancies, with about 50% of cancer patients experiencing varying degrees of cancer pain and about 75% of advanced cancer patients experiencing cancer pain. Active treatment of cancer pain is one of the 4 major points in the World Health Organization (WHO) with respect to the overall planning of cancer. Modern medicine for cancer pain usually adopts a three-step pain relieving scheme for treatment, and about 40 percent of patients still have cancer pain which cannot be effectively controlled. The long-term use of the analgesic can generate drug resistance, dependence and toxic and side effects. Clinical research shows that the traditional Chinese medicine external treatment method not only has better pain relieving effect on cancer, but also has lighter toxic and side effects and convenient and fast clinical application, and also has certain tumor control effect, so that the survival quality of patients is improved, and the survival period of the patients is prolonged. At present, the application of using Wuxiang pain-relieving ointment, Xiaopi pain-relieving ointment, Chanwu gel ointment and the like to treat cancer pain in clinic has certain curative effect, but no traditional Chinese medicine ointment prescription specially aiming at cancer pain exists at present, the curative effect is single, and the clinical effect is unstable.

Disclosure of Invention

In order to solve the problems, the invention provides a yang-warming tumor-eliminating pain-relieving plaster, which has the functions of warming yang, dredging collaterals, promoting blood circulation, relieving pain and softening hardness to dissipate stagnation, is used for treating pains caused by various tumors, lumps and nodules, and belongs to cold-stasis syndrome.

In order to achieve the purpose, the invention adopts the technical scheme that: the yang warming, tumor eliminating and pain relieving plaster comprises the following raw materials in parts by weight: 10-15 parts of prepared common monkshood mother root, 10-15 parts of prepared kusnezoff monkshood root, 10-15 parts of pseudo-ginseng, 15-30 parts of frankincense, 15-30 parts of myrrh, 15-30 parts of selfheal, 15-30 parts of Chinese sage herb, 15-30 parts of barbed skullcap herb, 15-30 parts of turtle shell, 10-15 parts of borneol, 10-15 parts of cicada slough, 10-15 parts of paris rhizome, 5-10 parts of scorpion, 5-10 parts of centipede and 435 parts of gel plaster substrate 225-.

Further, the feed comprises the following raw materials in parts by weight: 10 parts of prepared common monkshood mother root, 10 parts of prepared kusnezoff monkshood root, 10 parts of sanchi, 15 parts of frankincense, 15 parts of myrrh, 15 parts of selfheal, 15 parts of Chinese sage herb, 15 parts of barbed skullcap herb, 15 parts of turtle shell, 10 parts of borneol, 10 parts of cicada slough, 10-15 parts of Chinese paris rhizome, 5 parts of scorpion, 5 parts of centipede and 225 parts of gel plaster matrix.

The application also provides a preparation method of the yang-warming tumor-eliminating pain-relieving plaster, which comprises the following steps:

step 1: preparing a fluid extract: weighing 15-30 parts of selfheal, 15-30 parts of sculellaria barbata, 10-15 parts of cicada slough, 10-15 parts of prepared radix aconiti kusnezoffii, 15-30 parts of Chinese sage herb and 10-15 parts of rhizoma paridis according to the parts by weight, extracting the liquid by a water extraction method, and concentrating the liquid into a fluid extract;

step 2: preparing coarse powder: weighing 10-15 parts of pseudo-ginseng, 15-30 parts of frankincense, 15-30 parts of myrrh, 15-30 parts of turtle shell, 10-15 parts of borneol, 5-10 parts of scorpion and 5-10 parts of centipede according to the weight part ratio, and crushing the raw materials into coarse powder;

and step 3: preparing fine powder: uniformly mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, drying the mixture, and crushing the dried mixture into fine powder;

and 4, step 4: preparing a finished product: and (3) weighing 435 parts of the gel plaster substrate 225 and 435 parts by weight, uniformly mixing the fine powder prepared in the step (3) with the gel plaster substrate, and preparing a finished product.

Further, the specific steps in step 1 are as follows: weighing 15-30 parts of selfheal, 15-30 parts of sculellaria barbata, 10-15 parts of cicada slough, 10-15 parts of prepared radix aconiti kusnezoffii, 15-30 parts of Chinese sage herb and 10-15 parts of rhizoma paridis according to parts by weight, adding water for extraction for 2-3 times, wherein the water amount added each time is 6-10 times of the total weight of the raw materials, the extraction time for each time is 1-3 hours, combining the extracting solutions, filtering, and concentrating the filtrate to obtain the active component, namely the fluid extract.

Further, in the step 2, 10-15 parts of pseudo-ginseng, 15-30 parts of frankincense, 15-30 parts of myrrh, 15-30 parts of turtle shell, 10-15 parts of borneol, 5-10 parts of scorpion and 5-10 parts of centipede are weighed according to the weight parts, and the raw materials are crushed by a crusher and sieved by a 60-80 mesh sieve to obtain coarse powder for later use.

Further, in step 3, the fluid extract prepared in step 1 is mixed with the coarse powder prepared in step 2, then the uniformly mixed mixture is dried at 80-100 ℃ by a dryer, and then the dried mixture is crushed by a crusher and passes through a 100-mesh 150-mesh sieve to obtain fine powder for later use.

Further, the fluid extract prepared in the step 1 and the coarse powder prepared in the step 2 are mixed and stirred for 10-30 minutes until being uniformly mixed, and simultaneously, the uniformly mixed mixture is dried for 20-30 minutes at 80-100 ℃ by a dryer.

Further, in the step 4, the mass ratio of the fine powder to the gel plaster matrix is 2:3, and the gel plaster matrix comprises sodium polyacrylate, dihydroxyaluminum glycinate, glycerol, azone and water, wherein the mass ratio of the sodium polyacrylate, the dihydroxyaluminum glycinate, the glycerol, the azone and the water is 288: 4: 660: 30: 2550.

the invention has the beneficial effects that: the yang-warming tumor-eliminating pain-relieving plaster has the functions of warming yang, dredging collaterals, promoting blood circulation, relieving pain, softening hardness and dissipating stagnation. Can be used for treating pain caused by various tumors, lumps, and nodules, which are caused by cold and blood stasis. The yang warming, tumor eliminating and pain relieving plaster is an external traditional Chinese medicine plaster prescription with better analgesic effect, on one hand, the plaster can improve the pain of cancer patients, reduce the dosage of opioid analgesic drugs and increase the compliance of patients, and on the other hand, a plurality of traditional Chinese medicines with anti-tumor effect are added in the plaster, so that the plaster can play a certain role in inhibiting the tumor growth and even achieving the effect of reducing the tumor volume.

Detailed Description

The invention relates to a yang-warming tumor-eliminating pain-relieving plaster which comprises the following raw materials in parts by weight: 10-15 parts of prepared common monkshood mother root, 10-15 parts of prepared kusnezoff monkshood root, 10-15 parts of pseudo-ginseng, 15-30 parts of frankincense, 15-30 parts of myrrh, 15-30 parts of selfheal, 15-30 parts of Chinese sage herb, 15-30 parts of barbed skullcap herb, 15-30 parts of turtle shell, 10-15 parts of borneol, 10-15 parts of cicada slough, 10-15 parts of paris rhizome, 5-10 parts of scorpion, 5-10 parts of centipede and 435 parts of gel plaster substrate 225-.

Further, the feed comprises the following raw materials in parts by weight: 10 parts of prepared common monkshood mother root, 10 parts of prepared kusnezoff monkshood root, 10 parts of sanchi, 15 parts of frankincense, 15 parts of myrrh, 15 parts of selfheal, 15 parts of Chinese sage herb, 15 parts of barbed skullcap herb, 15 parts of turtle shell, 10 parts of borneol, 10 parts of cicada slough, 10-15 parts of Chinese paris rhizome, 5 parts of scorpion, 5 parts of centipede and 225 parts of gel plaster matrix.

Prepared monkshood, dispelling wind and removing dampness, warming meridians and relieving pain. Can be used for treating arthralgia due to wind-cold-dampness, breast pain, chest pain, arthralgia, psychroalgia of heart and abdomen, cold hernia pain, anesthesia and pain relieving.

The prepared kusnezoff monkshood root has the effects of dispelling wind, eliminating dampness, warming channels and relieving pain. Can be used for treating arthralgia due to wind-cold-dampness, arthralgia, psychroalgia of heart and abdomen, and hernia of cold type.

Notoginseng radix, radix Notoginseng, for stopping bleeding, dissipating blood and relieving pain, incised wound, traumatic injuries, pole sore, and persistent bleeding, is chewed or not mixed with other herbs to stop bleeding. It is also indicated for hematemesis, epistaxis, bloody dysentery, metrorrhagia, profuse menstruation, postpartum lochiorrhea, blood-moving pain, red eye, carbuncle and swelling, and snake bite.

Mo Yao is indicated for stagnant pain in chest and abdomen, dysmenorrhea, amenorrhea, mass, traumatic injury, abscess, sores and ulcers, intestinal abscess, red eyes with swelling and pain. Has the effects of promoting blood circulation, relieving pain, eliminating swelling, promoting granulation, and removing blood stasis.

Spica Prunellae, scrofula due to cold and heat, head sore of mouse, goiter, accumulation of qi, swelling and damp arthralgia of foot, and weight loss.

The Chinese sage herb has the functions of sterilizing, resisting virus, detoxicating, dispelling plague and eliminating epidemic.

The Chinese Lobelia herb, the whole herb, has the functions of clearing away heat and toxic material, promoting blood circulation to remove blood stasis, relieving swelling and pain, resisting cancer and the like. Is cold in nature and sour in taste, and the whole herb contains various vitamins, trace elements, amino acids and other components. Has the effects of cooling blood, removing toxic substances, removing blood stasis, relieving pain, relieving swelling, clearing heat and promoting diuresis.

Carapax Trionycis has effects in nourishing yin, clearing away heat, suppressing yang hyperactivity, calming endogenous wind, softening and resolving hard mass, and can be used for treating fever due to yin deficiency, fatigue, bone steaming, and epilepsy due to fright convulsion.

Borneol can dredge orifices, dispel stagnated fire, remove nebula and improve eyesight, and relieve swelling and pain. It is indicated for wind stroke, vomiting, coma due to febrile disease, epilepsy due to convulsion, phlegm-phlegm, qi block, deafness, sore throat, aphtha, otitis media, carbuncle, swelling, hemorrhoid, nebula, and enterobiasis.

Cicada slough, dispelling wind-heat, dispersing lung qi and relieving spasm. It is used to treat wind-heat common cold, cough, hoarseness, measles without adequate eruption, rubella, infantile convulsion, conjunctival congestion, nebula, furuncle, toxic swelling, and tetanus.

Rhizoma paridis has the effects of clearing heat and removing toxicity, relieving swelling and pain, cooling liver and arresting convulsion, and is commonly used for treating furuncle and carbuncle, sore throat, snake and insect bite, traumatic injury and convulsion.

Scorpion, Scorpio, enters liver meridian and moves well, it can calm down liver wind, dispel wind and unblock collaterals, and has good effects of extinguishing wind and relieving spasm, so it is the essential herb for treating spasm and convulsion. For convulsions due to convulsions and spasm, it is often combined with Wu Gong.

Scolopendra, chronic fever, poisonous drinking, eating snake, bug and fish poison, killing ghost, old essence, warm malaria and removing three worms. Treat heart and abdomen cold and heat accumulation, abortion, and remove aversion to blood.

The application also provides a preparation method of the yang-warming tumor-eliminating pain-relieving plaster, which comprises the following steps:

step 1: preparing a fluid extract: weighing 15-30 parts of selfheal, 15-30 parts of sculellaria barbata, 10-15 parts of cicada slough, 10-15 parts of prepared radix aconiti kusnezoffii, 15-30 parts of Chinese sage herb and 10-15 parts of rhizoma paridis according to the parts by weight, extracting the liquid by a water extraction method, and concentrating the liquid into a fluid extract;

step 2: preparing coarse powder: weighing 10-15 parts of pseudo-ginseng, 15-30 parts of frankincense, 15-30 parts of myrrh, 15-30 parts of turtle shell, 10-15 parts of borneol, 5-10 parts of scorpion and 5-10 parts of centipede according to the weight part ratio, and crushing the raw materials into coarse powder;

and step 3: preparing fine powder: uniformly mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, drying the mixture, and crushing the dried mixture into fine powder;

and 4, step 4: preparing a finished product: and (3) weighing 435 parts of the gel plaster substrate 225 and 435 parts by weight, uniformly mixing the fine powder prepared in the step (3) with the gel plaster substrate, and preparing a finished product.

Further, the specific steps in step 1 are as follows: weighing 15-30 parts of selfheal, 15-30 parts of sculellaria barbata, 10-15 parts of cicada slough, 10-15 parts of prepared radix aconiti kusnezoffii, 15-30 parts of Chinese sage herb and 10-15 parts of rhizoma paridis according to parts by weight, adding water for extraction for 2-3 times, wherein the water amount added each time is 6-10 times of the total weight of the raw materials, the extraction time for each time is 1-3 hours, combining the extracting solutions, filtering, and concentrating the filtrate to obtain the active component, namely the fluid extract.

Further, in the step 2, 10-15 parts of pseudo-ginseng, 15-30 parts of frankincense, 15-30 parts of myrrh, 15-30 parts of turtle shell, 10-15 parts of borneol, 5-10 parts of scorpion and 5-10 parts of centipede are weighed according to the weight parts, and the raw materials are crushed by a crusher and sieved by a 60-80 mesh sieve to obtain coarse powder for later use.

Further, step 3, mixing the fluid extract prepared in step 1 with the coarse powder prepared in step 2, drying the uniformly mixed mixture at 80-100 ℃ through a dryer, and then crushing the dried mixture through a crusher, and sieving the crushed mixture through a sieve of 100 meshes and 150 meshes to obtain fine powder for later use.

Further, the fluid extract prepared in the step 1 and the coarse powder prepared in the step 2 are mixed and stirred for 10-30 minutes until being uniformly mixed, and simultaneously, the uniformly mixed mixture is dried for 20-30 minutes at 80-100 ℃ by a dryer.

The specific use method comprises the following steps: the Chinese medicinal ointment is applied to the pain part 2 times a day for 4-6 hours each time. Note: the wound or skin injury part needs to be avoided when the patch is used.

The present application provides specific preferred examples:

the first embodiment is as follows:

the yang warming, tumor eliminating and pain relieving plaster comprises the following raw materials in parts by weight: the following raw materials in parts by weight: 10 parts of prepared common monkshood mother root, 10 parts of prepared kusnezoff monkshood root, 10 parts of sanchi, 15 parts of frankincense, 15 parts of myrrh, 15 parts of selfheal, 15 parts of Chinese sage herb, 15 parts of barbed skullcap herb, 15 parts of turtle shell, 10 parts of borneol, 10 parts of cicada slough, 10 parts of Chinese paris rhizome, 5 parts of scorpion, 5 parts of centipede and 225 parts of gel plaster substrate.

Also provides a preparation method of the yang-warming tumor-eliminating pain-relieving plaster, which comprises the following steps:

step 1: preparing a fluid extract: weighing 15 parts of selfheal, 15 parts of barbed skullcap herb, 10 parts of cicada slough, 10 parts of prepared radix aconiti kusnezoffii, 15 parts of Chinese sage herb and 10 parts of paris polyphylla according to the parts by weight, adding water for extraction for 2 times, wherein the water addition amount is 6-10 times of the total weight of the raw materials each time, the extraction time is 1 hour each time, combining the extracting solutions, filtering, and concentrating the filtrate to obtain the active component, namely the fluid extract.

Step 2: preparing coarse powder: weighing 10 parts of pseudo-ginseng, 15 parts of frankincense, 15 parts of myrrh, 15 parts of turtle shell, 10 parts of borneol, 5 parts of scorpion and 5 parts of centipede according to parts by weight, crushing the raw materials by a crusher, and sieving the crushed raw materials by a 80-mesh sieve to obtain coarse powder for later use;

and step 3: preparing fine powder: mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, stirring for 10 minutes until the fluid extract and the coarse powder are uniformly mixed, drying the uniformly mixed mixture for 20 minutes at 80 ℃ by using a dryer, crushing the dried mixture by using a crusher, and sieving the crushed mixture by using a 100-mesh sieve to obtain fine powder for later use;

and 4, step 4: preparing a finished product: and (3) weighing 225 parts of gel plaster matrix according to the weight part ratio, uniformly mixing the fine powder prepared in the step (3) with the gel plaster matrix, and preparing a finished product.

The second embodiment is as follows:

the yang warming, tumor eliminating and pain relieving plaster comprises the following raw materials in parts by weight: the following raw materials in parts by weight: 15 parts of prepared common monkshood mother root, 15 parts of prepared kusnezoff monkshood root, 15 parts of sanchi, 30 parts of frankincense, 30 parts of myrrh, 30 parts of common selfheal fruit-spike, 30 parts of Chinese sage herb, 30 parts of barbed skullcap herb, 30 parts of turtle shell, 15 parts of borneol, 15 parts of cicada slough, 15 parts of paris rhizome, 10 parts of scorpion, 10 parts of centipede and 435 parts of gel plaster substrate.

Also provides a preparation method of the yang-warming tumor-eliminating pain-relieving plaster, which comprises the following steps:

step 1: preparing a fluid extract: weighing 30 parts of selfheal, 30 parts of sculellaria barbata, 15 parts of cicada slough, 15 parts of prepared radix aconiti kusnezoffii, 130 parts of Chinese sage herb and 15 parts of rhizoma paridis according to the parts by weight, adding water for extraction for 3 times, wherein the water addition amount is 10 times of the total weight of the raw materials, the extraction time is 3 hours each time, combining the extracting solutions, filtering, and concentrating the filtrate to obtain the active ingredient, namely the fluid extract.

Step 2: preparing coarse powder: weighing 15 parts of pseudo-ginseng, 30 parts of frankincense, 15-30 parts of myrrh, 30 parts of turtle shell, 15 parts of borneol, 10 parts of scorpion and 10 parts of centipede according to the weight parts, crushing the raw materials by a crusher, and sieving the crushed raw materials by a 80-mesh sieve to obtain coarse powder for later use;

and step 3: preparing fine powder: mixing the fluid extract prepared in the step 1 with the coarse powder prepared in the step 2, stirring for 10 minutes until the fluid extract and the coarse powder are uniformly mixed, drying the uniformly mixed mixture for 20 minutes at 80 ℃ by using a dryer, crushing the dried mixture by using a crusher, and sieving the crushed mixture by using a 150-mesh sieve to obtain fine powder for later use;

and 4, step 4: preparing a finished product: 435 parts of gel plaster matrix are weighed according to the weight part ratio, and the fine powder prepared in the step 3 is uniformly mixed with the gel plaster matrix to prepare a finished product.

Clinical cases

Case one: qiuzu, male, 51 years old, national enterprise staff, case No. 062554, chief complaint "find sigmoid colon cancer for 8 months, pain around stoma with lump for 1 month" admission. Patients can be diagnosed with colon cancer in 10 months in 2020, surgical resection is performed, multi-course chemotherapy tumor continuously progresses later, peritoneal metastasis with obstruction is found in 3 months in 2021, colon fistulization is performed, and chemotherapy and targeted therapy are continued after surgery. The patients have pain around the stoma in about 1 month, can touch subcutaneous lumps, are hard, have poor mobility and have tenderness, and consider the tumor implantation metastasis around the stoma. The oxycodone hydrochloride sustained-release tablet 40mg Q12h orally taken before half a month has unsatisfactory analgesic effect, affects sleep, has serious constipation and abdominal distension, has unsatisfactory defecation effect such as oral lactulose and stoma enema, and is externally applied to the periphery of the stoma by the stasis-dissolving and tumor-eliminating analgesic patch after the doctor visits the periphery of the stoma for 2 times/day and 4 hours each time. The self-complaint pain condition of the patient is obviously improved on the 1 st day of the administration, the oral oxycodone hydrochloride sustained-release tablet dosage of the patient is adjusted to 20mg Q12h after 3 days, the patient can tolerate the complaint pain and can fall asleep for 5-6 hours at night, and the constipation and abdominal distension conditions are also improved. After the yang-warming tumor-eliminating pain-relieving plaster is used for 1 week, the pain condition is stable, the life quality of a patient is obviously improved, and the special anti-tumor treatment is planned to continue.

Case two: patient chenzhi, male, 59 years old, case number: 054302, 2019.11.15PET-CT shows inferior solid nodules of the posterior segment of the upper lobe of the right lung, considered as lung cancer of the right lung peripheral type; lymphatic metastasis was not seen in the lung and mediastinum. Shenzhen hospital of the university of hong Kong, 2019-11-27, Shenzhen, in the general anesthesia descending, "wedge resection of right upper lung lobe of thoracoscope + lung lobe resection + lymph node cleaning + wedge resection of right lower lung lobe". Postoperative pathology was invasive adenocarcinoma of the right upper lung, 2.1 cm. Postoperative diagnosis of right lung adenocarcinoma pT2N2M0, IIIA. The VP regimen chemotherapy of the 1 st cycle is carried out, namely, 134mg of cisplatin injection and 42mg of vinorelbine tartrate injection are added, and the vinorelbine on the 8 th day is cancelled when obvious digestive tract adverse reaction occurs after chemotherapy. 2020.02.05-02.12 begin cycle 2 VP programming. In the last 1 month, the patient has intermittent cough, the outpatient treatment effect is not good, and the patient goes to the home to see a doctor, and the outpatient treatment is based on lung cancer. The following symptoms are shown: clear spirit, good spirit, occasional cough, little white phlegm, weakness of lower limbs, pain of shoulders and joints, and limited movement. The patient refuses the MR examination to eliminate the bone metastasis, and after the patient is admitted, the yang warming, tumor eliminating and pain relieving plaster is externally applied to shoulders, so that the pain is obviously improved after 1 dose, and the activity limitation is also relieved after 3 days of medication.

Case three: patient xu certain, woman, age 39, case number: 062933, radical operation of colorectal cancer of 11 months patient in 2017, postoperative pathology: (rectal) adenocarcinoma. The postoperative adjuvant chemotherapy is carried out for 2 periods, and the specific scheme is not detailed. In 2021, in 3 months, multiple lumps of the lung, the pelvic cavity and the right inguinal region are found, and lymph node metastasis is considered in the complete examination. Chemotherapy with mXELIRI regimen (irinotecan 180mg/m2 d1+ capecitabine 800mg/m2, oral, bid.d. 1-14 q3 w) for 1 cycle was initiated on days 2021-03-12. And (3) post-perfection of gene detection: TP53(p.g199yv, mutation abundance 37.7%), TP53(p.v173e, mutation abundance 318%), APC (p.t14931f21, mutation abundance 30.5%), tumor mutation load (TMB) 4.112 muts/Mb, microsatellite stability (MSS), PD-L1 protein expression: TPS 0%, ICP 1%, IC 0%. KRAS, NRAS wild type. Then, the I am on the hospital mXELIRI + Cetussituo-anti-775 mg treatment for 2 cycles. The patient now plans to be admitted to the hospital for the next course of chemotherapy. Admission symptoms are as follows: shenqing, spiritual, soreness of the loins and groin and calf on the right side, NRS score 3 points. The pain of waist and the pain of right groin of a patient are related to tumor metastasis, the pain still exists after oral administration of the diclofenac sodium sustained-release tablet, the sleep at night is influenced, plain constipation of the patient is avoided, opioid analgesic drugs are not temporarily administered for preventing the constipation, and the yang warming, tumor eliminating and pain relieving patch is externally applied to the groin and the waist, so that the control of the pain is stable, and the patient can fall asleep stably at night.

In summary, the yang-warming, tumor-eliminating and pain-relieving patch has the functions of warming yang, dredging collaterals, promoting blood circulation, relieving pain, softening hardness and dissipating stagnation. Can be used for treating pain caused by various tumors, lumps, and nodules, which are caused by cold and blood stasis. The yang warming, tumor eliminating and pain relieving plaster is an external traditional Chinese medicine plaster prescription with better analgesic effect, on one hand, the plaster can improve the pain of cancer patients, reduce the dosage of opioid analgesic drugs and increase the compliance of patients, and on the other hand, a plurality of traditional Chinese medicines with anti-tumor effect are added in the plaster, so that the plaster can play a certain role in inhibiting the tumor growth and even achieving the effect of reducing the tumor volume.

The above embodiments are merely illustrative of the preferred embodiments of the present invention, and not restrictive, and various changes and modifications to the technical solutions of the present invention may be made by those skilled in the art without departing from the spirit of the present invention, and the technical solutions of the present invention are intended to fall within the scope of the present invention defined by the appended claims.