阅读说明：本技术 血栓清除装置 (Thrombus removing device ) 是由 张梅慧 姜程文 梁玉晨 于 2021-08-16 设计创作，主要内容包括：本发明属于医疗器械技术领域,具体涉及血栓清除装置。一种血栓清除装置,包括血栓容纳结构,血栓容纳结构包括：一内管；一血栓容纳腔,一端为开口端,另一端为密封端,开口端的开口方向朝向内管；至少一收拢部件,一端设置于血栓容纳腔的开口端,另一端从内管的远端穿过内管的近端后与外部操作手柄连接。本发明结构巧妙,血栓取出过程不易脱落,且安全性较高,对血管的伤害性较小,同时能够有效降低血栓流出的概率,提高清除效率,可以安全可靠的实现血栓的清除,有利于在医疗器械技术领域的推广及应用。(The invention belongs to the technical field of medical instruments, and particularly relates to a thrombus removal device. A thrombus removal device comprising a thrombus containment structure, the thrombus containment structure comprising: an inner tube; the thrombus accommodating cavity is provided with an opening end at one end and a sealing end at the other end, and the opening direction of the opening end faces to the inner tube; and one end of the furling component is arranged at the opening end of the thrombus accommodating cavity, and the other end of the furling component penetrates through the near end of the inner tube from the far end of the inner tube and then is connected with an external operating handle. The thrombus taking device is ingenious in structure, not easy to fall off in the thrombus taking-out process, high in safety and small in injury to blood vessels, can effectively reduce the probability of thrombus outflow, improves the clearing efficiency, can safely and reliably clear thrombus, and is favorable for popularization and application in the technical field of medical instruments.)

1. A thrombus removal device comprising a thrombus containment structure, wherein the thrombus containment structure comprises:

an inner tube;

the thrombus accommodating cavity is provided with an opening end at one end and a sealing end at the other end, and the opening direction of the opening end faces to the inner tube;

at least one furling component, one end of which is arranged at the opening end of the thrombus containing cavity, and the other end of which passes through the near end of the inner tube from the far end of the inner tube and then is connected with an external operating handle;

when the thrombus removal device is used, the thrombus removal device comprises the following steps:

the thrombus accommodating cavity is furled under the action of tension by pulling the furling component through an external operating handle, so that the thrombus accommodating cavity is ready to enter a blood vessel;

after puncture hole and reaming are established to the position predetermine at the body surface, will thrombus clearing device gets into in the blood vessel, the thrombus holds the open end in chamber and crosses the thrombus after, draws in the part in through the release of outside operating handle, the thrombus holds the chamber and struts, draws back to the near-end the inner tube, the thrombus gets into the thrombus holds the intracavity, continues to draw back the inner tube will thrombus clearing device draws out the blood vessel, takes out the thrombus.

2. The thrombectomy device of claim 1, wherein the furling member is a pull wire;

the outer wall of the inner pipe is provided with stay wire channels with the same number as the stay wires;

one end of the pull wire is fixed with the open end of the thrombus accommodating cavity, and the other end of the pull wire penetrates through the pull wire channel to be connected with the external operating handle;

the sealing end of the thrombus accommodating cavity is inwards sunken and extends to the far end of the inner tube to be fixedly connected with the inner tube.

3. The thrombus removal device of claim 1, wherein the thrombus-accommodating chamber comprises:

one end of the accommodating cavity is open, and the other end of the accommodating cavity is a sealing end of the thrombus accommodating cavity;

and one end of the hollow bracket is connected with the opening of the accommodating cavity, and the other end of the hollow bracket is the opening end of the thrombus accommodating cavity.

4. The thrombectomy device of claim 3, wherein at least one of the receiving cavity and the hollow stent is formed of a self-expanding material;

the hollow bracket is formed by surrounding a plurality of hollow diamond-shaped pieces, and the width of the edge of each hollow diamond-shaped piece is 0.05-0.5 mm, preferably 0.06-0.3 mm, and more preferably 0.07-0.1 mm;

the wall thickness of the hollow bracket is 0.05mm-0.5 mm;

the surface of cavity support is equipped with:

the anti-leakage membrane is connected with the hollow bracket in a bonding or sewing way;

the leakage-proof membrane is made of one or more mixed materials of PET, polyurethane, PTFE or e-PTFE;

the thickness of the leakage-proof film is 0.01mm-1 mm;

at least one of the outer surface of the accommodating cavity or the outer surface of the leakage-proof film is provided with a bioactive coating.

5. The thrombus removal device of claim 1, further comprising a thrombus-leakage prevention structure comprising:

a middle tube, which has a larger diameter than the inner tube and can be penetrated by the inner tube;

one end of the protective cover is connected to the outer circumferential surface of the middle pipe, and the other end of the protective cover is an openable open end and faces to the open end of the thrombus accommodating cavity;

when the thrombus removal device is used, the thrombus removal device comprises the following steps:

the inner tube penetrates through the middle tube, the furling part penetrates through the near end of the middle tube, and the thrombus containing cavity and the protective cover are both in an expanded state;

the thrombus accommodating cavity is furled under the action of tension by pulling the furling component through an external operating handle, so that the thrombus accommodating cavity is ready to enter a blood vessel;

after puncture hole and reaming are established to the position predetermine at the body surface, will thrombus clearing device gets into in the blood vessel, the thrombus holds the open end in chamber and crosses the thrombus after, draws in the part in through the release of outside operating handle, the thrombus holds the chamber and struts, draws back to the near-end the inner tube, the thrombus gets into the thrombus holds the intracavity, continues to draw back the inner tube, causes the thrombus hold the open end in chamber with the laminating of the open end inner wall of protection casing, perhaps the thrombus hold the open end inner wall in chamber with the laminating of the open end terminal surface of protection casing, the thrombus hold the chamber with protection casing formation seal structure prevents that thrombus or thrombus fragment from scattering in the blood vessel, will thrombus clearing device draws out the blood vessel, takes away the thrombus.

6. The thrombus removal device according to claim 5, wherein the maximum cross-sectional diameter of the open end of the protective cover is larger than the diameter of the open end of the thrombus-accommodating chamber, and the thrombus-accommodating chamber and the protective cover enclose a sealed hollow cavity.

7. The thrombus removal device of claim 5, wherein the protective cover is made of a self-expanding material;

the protective cover is formed by enclosing a plurality of hollow diamond-shaped pieces, and the width of the edge of each hollow diamond-shaped piece is 0.05-0.5 mm, preferably 0.06-0.3 mm, and more preferably 0.07-0.1 mm;

the wall thickness of the protective cover is 0.05mm-0.5 mm;

the surface of protection casing is equipped with:

the leakage-proof film is connected with the protective cover in a bonding or sewing way;

the leakage-proof membrane is made of one or more mixed materials of PET, polyurethane, PTFE or e-PTFE;

the thickness of the leakage-proof film is 0.01mm-1 mm;

and a bioactive coating is arranged on the outer surface of the leakage-proof film.

8. The thrombus removal device of claim 5, further comprising a constriction structure comprising:

an outer tube, the diameter of which is larger than that of the middle tube, and the outer tube can be penetrated by the middle tube and can restrain the protective cover and the thrombus containing cavity;

when the thrombus removal device is used, the thrombus removal device comprises the following steps:

the inner tube penetrates through the middle tube, the middle tube penetrates through the outer tube, the furling part penetrates through the proximal end of the outer tube, and the thrombus containing cavity and the protective cover are both in an expanded state at the moment;

the thrombus accommodating cavity and the protective cover are furled in the outer tube under the action of tension by pulling the furling component through an external operating handle, so that the thrombus accommodating cavity and the protective cover are ready to enter a blood vessel;

after puncture hole and reaming are established to the position in the body surface predetermine, will thrombus clearing device gets into in the blood vessel, the thrombus holds the open end in chamber and crosses behind the thrombus, to the distal end propelling movement well pipe with the inner tube, the thrombus holds the chamber and struts, draws back to the near-end the outer tube makes the protection casing release struts, draws back well pipe with inner tube, thrombus gets into the thrombus holds the intracavity, draws back the inner tube to the near-end, causes the thrombus hold the chamber with the protection casing forms seal structure, prevents that thrombus or thrombus fragment from scattering in the blood vessel, will thrombus clearing device draws out the blood vessel, takes out the thrombus.

9. The thrombectomy device of claim 8, wherein the distal end of the outer tube has a flared configuration, wherein the diameter of the cross section of the flared configuration decreases from the proximal end to the distal end and then increases;

the outer side wall of the longitudinal section of the outer expanding structure comprises a first curved surface section, a second curved surface section and a third curved surface section which are sequentially connected with one another, the slope of the first curved surface section is a negative value, the slope of the second curved surface section and the slope of the third curved surface section are positive values, and the slope of the second curved surface section is larger than that of the third curved surface section.

10. The thrombus removal device of claim 8, further comprising:

at least one developing piece fixedly connected to at least one of the proximal end or the distal end of the thrombus containing cavity or the proximal end or the distal end of the protective cover;

when the thrombus removing device enters a blood vessel and the thrombus is displayed to be positioned between the thrombus containing cavity and the protective cover by the developing piece under the coordination of external imaging equipment, the middle tube and the inner tube are continuously pushed to the far end to release and expand the thrombus containing cavity, the outer tube is pulled back to the near end to release and expand the protective cover, the middle tube and the inner tube are pulled back, and the thrombus enters the thrombus containing cavity;

the developing piece is a developing point or a developing ring and is fixedly connected to the near end or the far end of the thrombus accommodating cavity or at least one of the near end or the far end of the protective cover in a sewing or welding mode.

Technical Field

The invention belongs to the technical field of medical instruments, and particularly relates to a thrombus removal device.

Background

Deep Venous Thrombosis (DVT) is better developed in lower limbs, is a frequently-occurring disease in the field of vascular surgery, is frequently followed by risk factors such as operation, parturition, tumor and the like, the incidence rate of DVT is continuously increased every year, the incidence rate of American Venous Thromboembolism (VTE) is (104-117)/10 ten thousands of times per year, European countries are (110-183)/10 ten thousands of times per year, and Asian regions are (13-57)/10 ten thousands of times. An epidemiological survey in the European Union suggests that the total number of symptomatic DVT occurrences per year is 404664-538189.

Anticoagulant therapy, which effectively reduces the risk of thrombus formation and the probability of thrombus recurrence, is the basis of acute phase DVT treatment. However, standard anticoagulation methods have several drawbacks, such as the inconvenience of patient administration of parenteral anticoagulation drugs, narrow therapeutic range of VKA, the need for sophisticated laboratory tests for INR and potentially significant bleeding risk.

DVT has become a common, frequently encountered disease in the clinic. With the continuous development of medicine, the increasing diagnosis and treatment level of doctors and the continuous updating of treatment guidelines, a complete set of DVT treatment schemes has been developed. In recent years, the development of intraluminal techniques has provided new approaches to the treatment of DVT and its complications. Such as percutaneous thrombectomy, venoplasty, inferior vena cava filter implantation, and the like. However, although the therapeutic level of DVT has been greatly improved, the treatment of more complex DVT, such as large area central DVT, still faces many difficulties, such as thrombus outflow, location inaccuracy, and unsatisfactory therapeutic effect, and there are many controversies regarding the choice of anti-thrombolysis drugs and the use of interventional therapies.

Disclosure of Invention

The present invention addresses many difficult technical problems that still face with respect to the treatment of more complex DVTs, and it is an object of the present invention to provide a thrombectomy device.

A thrombus removal device comprising a thrombus containment structure, the thrombus containment structure comprising:

an inner tube;

the thrombus accommodating cavity is provided with an opening end at one end and a sealing end at the other end, and the opening direction of the opening end faces to the inner tube;

at least one furling component, one end of which is arranged at the opening end of the thrombus containing cavity, and the other end of which passes through the near end of the inner tube from the far end of the inner tube and then is connected with an external operating handle;

when the thrombus removal device is used, the thrombus removal device comprises the following steps:

the thrombus accommodating cavity is furled under the action of tension by pulling the furling component through an external operating handle, so that the thrombus accommodating cavity is ready to enter a blood vessel;

after puncture hole and reaming are established to the position predetermine at the body surface, will thrombus clearing device gets into in the blood vessel, the thrombus holds the open end in chamber and crosses the thrombus after, draws in the part in through the release of outside operating handle, the thrombus holds the chamber and struts, draws back to the near-end the inner tube, the thrombus gets into the thrombus holds the intracavity, continues to draw back the inner tube will thrombus clearing device draws out the blood vessel, takes out the thrombus.

The furling component is a pull wire;

the outer wall of the inner pipe is provided with stay wire channels with the same number as the stay wires;

one end of the pull wire is fixed with the open end of the thrombus accommodating cavity, and the other end of the pull wire penetrates through the pull wire channel to be connected with the external operating handle.

The sealing end of the thrombus accommodating cavity is inwards sunken and extends to the far end of the inner tube to be fixedly connected with the inner tube.

The thrombus-accommodating chamber includes:

one end of the accommodating cavity is open, and the other end of the accommodating cavity is a sealing end of the thrombus accommodating cavity;

and one end of the hollow bracket is connected with the opening of the accommodating cavity, and the other end of the hollow bracket is the opening end of the thrombus accommodating cavity.

At least one of the receiving cavity and the hollow support is made of a self-expanding material.

The hollow bracket is formed by surrounding a plurality of hollow diamond-shaped pieces, and the width of the edge of each hollow diamond-shaped piece is 0.05-0.5 mm, preferably 0.06-0.3 mm, and more preferably 0.07-0.1 mm;

the wall thickness of the hollow bracket is 0.05mm-0.5 mm.

The surface of cavity support is equipped with:

and the leakage-proof membrane is connected with the hollow bracket in a bonding or sewing way.

The leakage-proof membrane is made of one or more mixed materials of PET, polyurethane, PTFE or e-PTFE;

the thickness of the leakage-proof film is 0.01mm-1 mm.

At least one of the outer surface of the accommodating cavity or the outer surface of the leakage-proof film is provided with a bioactive coating.

The thrombus removal device further comprises a thrombus leakage-proof structure, and the thrombus leakage-proof structure comprises:

a middle tube, which has a larger diameter than the inner tube and can be penetrated by the inner tube;

one end of the protective cover is connected to the outer circumferential surface of the middle pipe, and the other end of the protective cover is an openable open end and faces to the open end of the thrombus accommodating cavity;

when the thrombus removal device is used, the thrombus removal device comprises the following steps:

the inner tube penetrates through the middle tube, the furling part penetrates through the near end of the middle tube, and the thrombus containing cavity and the protective cover are both in an expanded state;

the thrombus accommodating cavity is furled under the action of tension by pulling the furling component through an external operating handle, so that the thrombus accommodating cavity is ready to enter a blood vessel;

after puncture hole and reaming are established to the position predetermine at the body surface, will thrombus clearing device gets into in the blood vessel, the thrombus holds the open end in chamber and crosses the thrombus after, draws in the part in through the release of outside operating handle, the thrombus holds the chamber and struts, draws back to the near-end the inner tube, the thrombus gets into the thrombus holds the intracavity, continues to draw back the inner tube, causes the thrombus hold the open end in chamber with the laminating of the open end inner wall of protection casing, perhaps the thrombus hold the open end inner wall in chamber with the laminating of the open end terminal surface of protection casing, the thrombus hold the chamber with protection casing formation seal structure prevents that thrombus or thrombus fragment from scattering in the blood vessel, will thrombus clearing device draws out the blood vessel, takes away the thrombus.

The maximum cross section diameter of the opening end of the protective cover is larger than the diameter of the opening end of the thrombus accommodating cavity, and the thrombus accommodating cavity and the protective cover can enclose a sealed hollow cavity.

The protective cover is made of self-expanding materials.

The protective cover is formed by enclosing a plurality of hollow diamond-shaped pieces, and the width of the edge of each hollow diamond-shaped piece is 0.05-0.5 mm, preferably 0.06-0.3 mm, and more preferably 0.07-0.1 mm;

the wall thickness of the protective cover is 0.05mm-0.5 mm.

The surface of protection casing is equipped with:

and the leakage-proof film is connected with the protective cover in an adhesion or sewing mode.

The leakage-proof membrane is made of one or more mixed materials of PET, polyurethane, PTFE or e-PTFE;

the thickness of the leakage-proof film is 0.01mm-1 mm.

And a bioactive coating is arranged on the outer surface of the leakage-proof film.

The thrombus removal device further comprises a constriction structure comprising:

an outer tube, the diameter of which is larger than that of the middle tube, and the outer tube can be penetrated by the middle tube and can restrain the protective cover and the thrombus containing cavity;

when the thrombus removal device is used, the thrombus removal device comprises the following steps:

the inner tube penetrates through the middle tube, the middle tube penetrates through the outer tube, the furling part penetrates through the proximal end of the outer tube, and the thrombus containing cavity and the protective cover are both in an expanded state at the moment;

the thrombus accommodating cavity and the protective cover are furled in the outer tube under the action of tension by pulling the furling component through an external operating handle, so that the thrombus accommodating cavity and the protective cover are ready to enter a blood vessel;

after puncture hole and reaming are established to the position in the body surface predetermine, will thrombus clearing device gets into in the blood vessel, the thrombus holds the open end in chamber and crosses behind the thrombus, to the distal end propelling movement well pipe with the inner tube, the thrombus holds the chamber and struts, draws back to the near-end the outer tube makes the protection casing release struts, draws back well pipe with inner tube, thrombus gets into the thrombus holds the intracavity, draws back the inner tube to the near-end, causes the thrombus hold the chamber with the protection casing forms seal structure, prevents that thrombus or thrombus fragment from scattering in the blood vessel, will thrombus clearing device draws out the blood vessel, takes out the thrombus.

The far end of the outer tube is provided with an external expanding structure, and the diameter of the cross section of the external expanding structure is reduced from the near end to the far end and then is increased.

The outer side wall of the longitudinal section of the outer expanding structure comprises a first curved surface section, a second curved surface section and a third curved surface section which are sequentially connected with one another, the slope of the first curved surface section is a negative value, the slope of the second curved surface section and the slope of the third curved surface section are positive values, and the slope of the second curved surface section is larger than that of the third curved surface section.

The inner pipe, the middle pipe and the outer pipe are all made of a pipe body made of one or more mixed materials of PTFE, HDPE or PEBAX.

The thrombus removal device further comprises:

at least one developing piece fixedly connected to at least one of the proximal end or the distal end of the thrombus containing cavity or the proximal end or the distal end of the protective cover;

when the thrombus clearing device enters the blood vessel, under the cooperation of external imaging equipment, the developing part shows that the thrombus is located the thrombus holds the chamber with when the protection casing between, continue to the propelling movement of distal end well pipe and inner tube make the thrombus holds the chamber release and struts, draws back the outer tube to the near-end, makes the protection casing release struts the back, draws back well pipe and inner tube, and the thrombus gets into the thrombus holds the intracavity.

The developing piece is a developing point or a developing ring and is fixedly connected to the near end or the far end of the thrombus accommodating cavity or at least one of the near end or the far end of the protective cover in a sewing or welding mode.

The developing member is made of alloy material, preferably platinum, iridium or tantalum alloy material.

The positive progress effects of the invention are as follows: the thrombus clearing device is adopted, the requirements on the size of thrombus and the size of the cross section of the blood vessel are not met, the structure of the thrombus clearing device is ingenious, the thrombus is not easy to fall off in the thrombus taking-out process, the safety is high, the injury to the blood vessel is small, the probability of thrombus outflow can be effectively reduced, the clearing efficiency is improved, the thrombus can be safely and reliably cleared, and the popularization and the application in the technical field of medical instruments are facilitated.

Drawings

FIG. 1 is a schematic view of one embodiment of a thrombus-containing structure of the present invention;

FIG. 2 is a schematic structural view of a thrombus-leakage preventing structure according to the present invention;

FIG. 3 is a schematic structural diagram of the present invention;

FIG. 4 is an enlarged view of a portion of the constricting structure of the present invention;

FIG. 5 is a schematic illustration of the invention after delivery in a blood vessel;

fig. 6 is a schematic view of the expanded state in a blood vessel in the practice of the present invention.

Detailed Description

In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific drawings.

Referring to fig. 1, a thrombus removal device comprises a thrombus-accommodating structure 1, wherein the thrombus-accommodating structure 1 comprises an inner tube 11, a thrombus-accommodating chamber 12 and at least one furling member 13.

The inner pipe 11 is a hollow pipe with two open ends, and the inner pipe 11 is made of one or more mixed materials of PTFE, HDPE and PEBAX. The outer wall of the inner tube 11 is preferably provided with the same number of pull wire passages as the number of pull wires, so that a plurality of pull wires pass through the proximal end of the inner tube 11 from the distal end of the inner tube 11 through the corresponding pull wire passages, as shown in fig. 1, the distal end of the inner tube 11 is the lower part, and the proximal end of the inner tube 11 is the upper part.

One end of the thrombus accommodating cavity 12 is an open end, the other end of the thrombus accommodating cavity 12 is a sealed end, and the opening direction of the open end faces the inner tube 11. The sealing end of the thrombus accommodating chamber 12 is recessed inward and extends to the distal end of the inner tube 11 to be fixedly connected to the distal end of the inner tube 11. The outer surface of the thrombus-accommodating chamber 12 is provided with a bioactive coating. The thrombus receiving chamber 12 may be a chamber made of a self-expanding material, which may be nitinol. Preferably, the thrombus-accommodating chamber 12 includes an accommodating chamber 121, a hollow stent 122, and a leakage-preventing membrane 123. One end of the accommodating cavity 121 is open, and the other end of the accommodating cavity 121 is a sealed end of the thrombus accommodating cavity 12. One end of the hollow stent 122 is connected to the opening of the accommodating chamber 121, and the other end of the hollow stent 122 is an opening end of the thrombus accommodating chamber 12. At least one of the receiving cavity 121 and the hollow supporter 122 is made of a self-expanding material. The receiving cavity 121 may be formed by weaving. The hollow bracket 122 is formed by welding a plurality of hollow diamonds, and the hollow bracket 122 can also be cut by laser cutting to form a plurality of hollow diamonds. The width of the edge of the hollow diamond is 0.05mm to 0.5mm, preferably 0.06mm to 0.3mm, more preferably 0.07mm to 0.1 mm; the wall thickness of the hollow stent 122 is 0.05mm to 0.5 mm. The outer surface of the hollow bracket 122 is provided with a leakage-proof membrane 123, and the leakage-proof membrane 123 is connected with the hollow bracket 122 by means of adhesion or sewing. The leakage-proof membrane 123 is made of one or more of PET, polyurethane, PTFE or e-PTFE. The thickness of the leakage-proof film is 0.01mm to 1mm, preferably 0.02 mm. At least one of the outer surface of the receiving cavity 121 or the outer surface of the leakage preventing film 123 is provided with a bioactive coating.

One end of the furling part 13 is arranged at the opening end of the thrombus accommodating cavity 12, and the other end of the furling part 13 passes through the near end of the inner tube 11 from the far end of the inner tube 11 and then is connected with an external operating handle. The furling part 13 is preferably a pull wire, one end of the pull wire is fixed with the opening end of the thrombus containing cavity 12, and the other end of the pull wire passes through the pull wire channel to be connected with an external operating handle. As shown in fig. 1, two pull wires are fixed at the opening end of the thrombus accommodating cavity 12, the two pull wires are arranged at the left and right sides, two pull wire channels are arranged in the inner tube 11, and the two pull wires respectively correspondingly penetrate through one pull wire channel and then are connected with an external operating handle.

When the thrombus removal device is used, the method comprises the following steps:

the furling component 13 is pulled by an external operating handle, the thrombus accommodating cavity 12 is furled under the action of pulling force, and the preparation for entering blood vessels is made; after puncture hole and reaming are established to the position predetermine at the body surface, in getting into the blood vessel with thrombus clearing device, the thrombus holds the open end in chamber 12 and crosses the thrombus after, draw in part 13 in through the release of outside operating handle, the thrombus holds chamber 12 and struts, pull back inner tube 11 to the near-end, the thrombus gets into in the thrombus holds chamber 12, when the thrombus is great, the inside bending segment 124 that the thrombus held chamber 12 is stretched, cause the volume grow that can hold the thrombus, continue to pull back inner tube 11, pull out the blood vessel with thrombus clearing device, take out the thrombus.

The thrombus removing device further comprises at least one developing part 4, the developing part 4 is a developing point or a developing ring, and the developing part 4 is made of an alloy material, preferably an alloy material of platinum, iridium or tantalum. The developing piece 4 is fixedly connected with the near end or the far end of the thrombus containing cavity 12, and the developing piece 4 is fixedly connected with the near end or the far end of the thrombus containing cavity 12 by means of sewing or welding. As shown in fig. 1, the developing members 4 fixed to the thrombus accommodating chamber 12 are four developing points, two of which are fixed to the proximal end of the thrombus accommodating chamber 12, respectively, and two of which are fixed to the distal end of the thrombus accommodating chamber 12, respectively. Further, four visualization points are fixed at the proximal and distal ends of the hollow stent 122, respectively.

In this case, the thrombus removal device, when used, includes the steps of:

the furling component 13 is pulled by an external operating handle, the thrombus accommodating cavity 12 is furled under the action of pulling force, and the preparation for entering blood vessels is made; establish puncture hole and reaming back in the position is predetermine to the body surface, in getting into the blood vessel thrombus clearing device, under outside image equipment's cooperation, develop 4 open ends that show the thrombus and hold chamber 12 and cross the thrombus after, draw in the part through the release of outside operating handle, make the thrombus hold chamber 12 release and strut, pull back inner tube 11 to the near-end, the thrombus gets into in the thrombus holds chamber 12, when the thrombus is great, the inside bending segment 124 that the thrombus held chamber 12 is stretched, cause the volume grow that can hold the thrombus, treat that all thrombi all get into the thrombus and hold chamber 12 after, continue to pull back inner tube 11, pull out blood vessel with thrombus clearing device, take out the thrombus.

Referring to fig. 2, the thrombus removal device further includes a thrombus-leakage preventing structure 2, and the thrombus-leakage preventing structure 2 includes a middle tube 21 and a shield 22.

The middle pipe 21 is a hollow pipe with two open ends, and the middle pipe 21 is made of one or more of PTFE, HDPE and PEBAX. The diameter of the middle tube 21 is larger than that of the inner tube 11, and the middle tube 21 can be penetrated by the inner tube 11.

One end of the protective cover 22 is connected to the outer circumferential surface of the middle tube 21, and the other end of the protective cover 22 is an openable and closable open end facing the open end of the thrombus accommodating chamber 12. The shield 22 may have a hollow truncated cone shape with a diameter gradually increasing from the proximal end to the distal end, and an open end thereof has a flared shape toward the thrombus-accommodating chamber 12. Preferably, the maximum cross-sectional diameter of the open end of the protective cover 22 is larger than the diameter of the open end of the thrombus containing chamber 12, and the thrombus containing chamber 12 and the protective cover 22 can enclose a sealed hollow cavity. In the process of thrombus recovery, the sealed hollow cavity can prevent the thrombus from leaving sporadic small thrombus particles in the blood vessel to become the center of thrombus re-agglomeration in the process of thrombus recovery.

The shield 22 is made of a self-expanding material. The shield 22 is formed by welding a plurality of hollow diamond-shaped members, and the shield 22 may also be cut by laser cutting to form a plurality of hollow diamond-shaped members. The width of the edge of the hollow diamond is 0.05mm to 0.5mm, preferably 0.06mm to 0.3mm, more preferably 0.07mm to 0.1 mm; the wall thickness of the shield 22 is 0.05mm to 0.5 mm.

The outer surface of the protection cover 22 is provided with a leakage-proof film 23, and the leakage-proof film 23 is connected with the protection cover 22 by means of adhesion or sewing. The leakage-proof membrane 23 is made of one or more of PET, polyurethane, PTFE or e-PTFE. The thickness of the leakage-proof film 23 is 0.01mm-1 mm. The outer surface of the leakage-proof film 23 is provided with a bioactive coating.

When the thrombus removal device is used, the method comprises the following steps:

the inner tube 11 passes through the middle tube 21, the furling part 13 passes through the near end of the middle tube 21, and the thrombus accommodating cavity 12 and the protective cover 22 are both in an expansion state; the furling component 13 is pulled by an external operating handle, the thrombus accommodating cavity 12 is furled under the action of pulling force, and the preparation for entering blood vessels is made; establish puncture hole and reaming back in the position is predetermine to the body surface, in getting into the blood vessel with thrombus clearing device, the thrombus holds the open end in chamber 12 and crosses behind the thrombus, draw in part 13 in through the release of outside operating handle, the thrombus holds chamber 12 and struts, pull back inner tube 11 and well 21 to the near-end, the thrombus gets into in the thrombus holds chamber 12, when the thrombus is great, the inside bending section 124 that the thrombus held chamber 12 is stretched, the volume grow that causes to hold the thrombus, continue to pull back inner tube 11, the open end that causes the thrombus to hold chamber 12 and the laminating of the open end inner wall of protection casing 22, the thrombus holds chamber 12 and protection casing 22 formation seal structure, prevent that thrombus or thrombus fragment from scattering in the blood vessel, pull out the blood vessel with thrombus clearing device, take off the thrombus.

The developing member 4 is fixedly attached to the proximal or distal end of the shield 22, and the developing member 4 is fixedly attached to the proximal or distal end of the shield 22 by sewing or welding. As shown in fig. 2, the developing member 4 fixed to the protection cover 22 is two developing points and one developing ring. A developing ring is fixed to the proximal end of the shield 22, and two developing spots are fixed to the distal end of the shield 22, the two developing spots being arranged left and right.

In this case, the thrombus removal device, when used, includes the steps of:

the inner tube 11 passes through the middle tube 21, the furling part 13 passes through the near end of the middle tube 21, and the thrombus accommodating cavity 12 and the protective cover 22 are both in an expansion state; the furling component 13 is pulled by an external operating handle, the thrombus accommodating cavity 12 is furled under the action of pulling force, and the preparation for entering blood vessels is made; after a puncture hole is arranged at a preset position on the body surface and the thrombus is expanded, the thrombus removing device is put into a blood vessel, when the developing part 4 displays that the thrombus is positioned between the thrombus containing cavity 12 and the protective cover 22 under the coordination of external imaging equipment, the furling part 13 is released through an external operating handle, the thrombus containing cavity 12 is released and expanded, the protective cover 22 is released and expanded, the middle tube 21 and the inner tube 11 are pulled back towards the near end, the thrombus enters the thrombus containing cavity 12, when the thrombus is large, the internal bending section 124 of the thrombus containing cavity 12 is stretched, the volume capable of containing the thrombus is enlarged, after all the thrombus enters the thrombus containing cavity 12, the inner tube 11 is continuously pulled back, the open end of the thrombus containing cavity 12 is attached to the inner wall of the open end of the protective cover 22, the thrombus containing cavity 12 and the protective cover 22 form a sealing structure, thrombus or thrombus fragments are prevented from being scattered in the blood vessel, and the thrombus removing device is pulled out of the blood vessel, bringing out the thrombus.

Referring to fig. 3, the thrombus removal device further comprises a constriction structure 3, the constriction structure 3 comprises an outer tube 31, the outer tube 31 is a tube with two open ends and a hollow interior, and the outer tube 31 is a tube body made of one or more mixed materials of PTFE, HDPE and PEBAX. The outer tube 31 has a diameter larger than that of the middle tube 21, the outer tube 31 can be penetrated through by the middle tube 21, and the outer tube 31 can contain the protective cover 22 and the thrombus-accommodating chamber 12.

Referring to FIG. 4, the distal end of the outer tube 31 has a flaring configuration that facilitates the binding of the shield 22 and the thrombus-accommodating chamber 12. The diameter of the cross section of the external expanding structure is reduced from the near end to the far end and then is enlarged. The outer side wall of the longitudinal section of the external expanding structure comprises a first curved surface section 311, a second curved surface section 312 and a third curved surface section 313 which are sequentially connected with one another, the slope of the first curved surface section 311 is a negative value, the slopes of the second curved surface section 312 and the third curved surface section 313 are positive values, and the slope of the second curved surface section 312 is greater than the slope of the third curved surface section 313.

When the thrombus removal device is used, the method comprises the following steps:

the inner tube 11 passes through the middle tube 21, the middle tube 21 passes through the outer tube 31, the furling part 13 passes through the near end of the outer tube 31, and the thrombus accommodating cavity 12 and the protective cover 22 are both in an expansion state; the external operating handle pulls the furling component 13, the thrombus containing cavity 12 and the protective cover 22 are furled in the outer tube 31 under the action of pulling force, and the preparation for entering blood vessels is made; referring to fig. 5, after puncture hole and reaming are established to the position predetermine at the body surface, in getting into blood vessel 5 with thrombus clearing device, the open end that the thrombus held chamber 12 is after crossing the thrombus, to distal end propelling movement well pipe 21 and inner tube 11, referring to fig. 6, the thrombus holds chamber 12 and struts, draw back outer tube 31 to the near-end, make protection casing 22 release strut, draw back well pipe 21 and inner tube 11, the thrombus gets into the thrombus and holds in chamber 12, when the thrombus is great, the inside bending segment 124 that the thrombus held chamber 12 is stretched, cause the volume grow that can hold the thrombus, draw back inner tube 11 to the near-end, cause the thrombus to hold chamber 12 and protection casing 22 and form seal structure, prevent thrombus or thrombus fragment from scattering in blood vessel 5, pull out blood vessel 5 with thrombus clearing device, take out the thrombus.

When the developing member 4 is provided on the thrombus-accommodating chamber 12 or the shield cap 22, the thrombus removal device is used, and comprises the steps of:

the inner tube 11 passes through the middle tube 21, the middle tube 21 passes through the outer tube 31, the furling part 13 passes through the near end of the outer tube 31, and the thrombus accommodating cavity 12 and the protective cover 22 are both in an expansion state; the external operating handle pulls the furling component 13, the thrombus containing cavity 12 and the protective cover 22 are furled in the outer tube 31 under the action of pulling force, and the preparation for entering blood vessels is made; referring to fig. 5, after a puncture hole is formed at a preset position on the body surface and the thrombus is enlarged, the thrombus removing device is put into a blood vessel 5, under the coordination of external imaging equipment, when the developing part 4 displays that the thrombus 6 is positioned between the thrombus accommodating cavity 12 and the protective cover 22, the middle tube 21 and the inner tube 11 are continuously pushed to the far end, referring to fig. 6, the thrombus accommodating cavity 12 is expanded, the outer tube 31 is pulled back to the near end to release and expand the protective cover 22, the middle tube 21 and the inner tube 11 are pulled back, the thrombus 6 enters the thrombus accommodating cavity 12, when the thrombus 6 is large, the inner bending section 124 of the thrombus accommodating cavity 12 is stretched to enlarge the volume capable of accommodating the thrombus, after all the thrombus 6 enters the thrombus accommodating cavity 12, the inner tube 11 is pulled back to the near end to form a sealing structure, the thrombus 6 or thrombus fragments are prevented from scattering in the blood vessel 5, the thrombus removing device is pulled out of the blood vessel 5, carrying out the thrombus 6.

The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.