阅读说明：本技术 用于治疗心房和心室的早博的胶囊及其制作方法 (Capsule for treating atrial and ventricular premature beat and its preparing process ) 是由 何德海 于 2021-09-22 设计创作，主要内容包括：本发明提出了一种用于治疗心房和心室的早博的胶囊,包括胶囊和置于胶囊内的药物组分,所述药物组分由如下组分组成：辅酶Q10、金枪鱼油以及β-葡聚糖,辅酶Q10与金枪鱼油质量比为1：18至1：22,金枪鱼油与β-葡聚糖的质量比为1：0.8至1：1.2。本发明还提出用于治疗心房和心室的早博的胶囊的制作方法。本发明具有成分简易、治疗效果好的优点,其制作方法简易,便于产业化。(The invention provides a capsule for treating atrial and ventricular premature beat, which comprises a capsule and medicinal components arranged in the capsule, wherein the medicinal components comprise the following components: coenzyme Q10, tuna oil and beta-glucan, wherein the mass ratio of the coenzyme Q10 to the tuna oil is 1: 18 to 1: 22, the mass ratio of the tuna oil to the beta-glucan is 1: 0.8 to 1: 1.2. the invention also provides a manufacturing method of the capsule for treating the premature beat of the atria and the ventricles. The invention has the advantages of simple components and good treatment effect, and the preparation method is simple and convenient for industrialization.)

1. A capsule for treating atrial and ventricular premature beat, comprising a capsule and a medicinal component arranged in the capsule, wherein the medicinal component consists of the following components: coenzyme Q10, tuna oil and beta-glucan, wherein the mass ratio of the coenzyme Q10 to the tuna oil is 1: 18 to 1: 22, the mass ratio of the tuna oil to the beta-glucan is 1: 0.8 to 1: 1.2.

2. a capsule for the treatment of atrial and ventricular premature beats as in claim 1, wherein: the mass ratio of the coenzyme Q10 to the tuna oil is 1: 20, the mass ratio of the tuna oil to the beta-glucan is 1:1.

3. the preparation method of the capsule for treating the premature beat of the atria and the ventricles is characterized in that coenzyme Q10 is dissolved in tuna oil to form mixed liquid, and the mass ratio of the coenzyme Q10 to the tuna oil is 1: 18 to 1: 22, crushing the beta-glucan into particles of 0.5 to 1.5 microns by using a jet mill, uniformly distributing the beta-glucan in the mixed solution by using an emulsification homogenizer, and then preparing into capsules, wherein the mass ratio of the tuna oil to the beta-glucan is 1: 0.8 to 1: 1.2.

4. a method of making a capsule for treating atrial and ventricular premature beats as in claim 3, wherein the β -glucan is made by: washing saccharomyces cerevisiae with deionized water to prepare a bacterial suspension, and filtering to remove impurities; performing enzymolysis treatment with mannanase and yeast extraction enzyme to obtain partially degraded cell membrane and yeast extract, and centrifuging to obtain cell membrane precipitate; preparing the cell membrane precipitate into suspension by adopting phosphate buffer solution, and performing enzymolysis treatment by using a complex enzyme consisting of mannanase, yeast extract enzyme and neutral protease; after enzymolysis, centrifugally washing the mixture by using deionized water until supernatant is clear and transparent, and centrifugally precipitating the supernatant to obtain wet beta 1,3-1,6 glucan; drying to obtain beta-glucan powder.

Technical Field

The invention relates to a capsule for treating premature beat of atria and ventricles and a preparation method thereof, belonging to the field of medicaments.

Background

Premature beat is also called extrasystole, which is called "premature beat" for short, and refers to the heart beat caused by the premature beat triggered by ectopic pacing point. Premature beats are the most common and common ectopic rhythms. According to the difference of the origin of ectopic beat, the premature beat can be divided into three types, namely atrial, atrioventricular junctional and ventricular. With ventricular nature being the most common, premature beats may be sporadic or sporadic, or may occur frequently. In the prior literature, there are medicines for treating premature heart beat disclosed, for example, in the chinese patent application entitled "chinese traditional medicine preparation for treating premature heart beat" with publication No. CN101579509B, a chinese traditional medicine preparation for treating premature heart beat is disclosed, the weight ratio of the raw materials for preparing the effective components is: 30-60 parts of radix cynanchi wilfordii, 20-40 parts of codonopsis pilosula, 15-30 parts of prepared rehmannia root, 10-30 parts of salvia miltiorrhiza, 10-30 parts of fructus trichosanthis, 15-30 parts of kudzuvine root, 15-30 parts of herba lycopi, 10-20 parts of radix curcumae, 10-20 parts of radix sophorae flavescentis, 10-30 parts of artemisia anomala, 5-10 parts of peach kernel and 10-20 parts of safflower. The existing medicine has complex components and relatively higher risk of generating side effects, and simultaneously increases the difficulty of manufacturing.

Accordingly, the present inventors have made extensive studies to solve the above problems and have made the present invention.

Disclosure of Invention

The invention aims to provide a capsule for treating atrial and ventricular premature beat, which has simple components and good treatment effect, and the invention also aims to provide a manufacturing method of the capsule.

In order to achieve the purpose, the invention adopts the following technical scheme:

a capsule for treating atrial and ventricular premature beat comprises a capsule and medicinal components arranged in the capsule, wherein the medicinal components consist of the following components: coenzyme Q10, tuna oil and beta-glucan, wherein the mass ratio of the coenzyme Q10 to the tuna oil is 1: 18 to 1: 22, the mass ratio of the tuna oil to the beta-glucan is 1: 0.8 to 1: 1.2.

in a preferred embodiment of the present invention, the mass ratio of coenzyme Q10 to tuna oil is 1: 20, the mass ratio of the tuna oil to the beta-glucan is 1:1.

the invention also provides a preparation method of the capsule for treating atrial and ventricular premature beat, which is characterized in that coenzyme Q10 is dissolved in tuna oil to form mixed liquid, and the mass ratio of the coenzyme Q10 to the tuna oil is 1: 18 to 1: 22, crushing the beta-glucan into particles of 0.5 to 1.5 microns by using a jet mill, uniformly distributing the beta-glucan in the mixed solution by using an emulsification homogenizer, and then preparing into capsules, wherein the mass ratio of the tuna oil to the beta-glucan is 1: 0.8 to 1: 1.2.

in a preferred embodiment of the present invention, the β -glucan is produced by: washing saccharomyces cerevisiae with deionized water to prepare a bacterial suspension, and filtering to remove impurities; performing enzymolysis treatment with mannanase and yeast extraction enzyme to obtain partially degraded cell membrane and yeast extract, and centrifuging to obtain cell membrane precipitate; preparing the cell membrane precipitate into suspension by adopting phosphate buffer solution, and performing enzymolysis treatment by using a complex enzyme consisting of mannanase, yeast extract enzyme and neutral protease; after enzymolysis, centrifugally washing the mixture by using deionized water until supernatant is clear and transparent, and centrifugally precipitating the supernatant to obtain wet beta 1,3-1,6 glucan; drying to obtain beta-glucan powder.

In the invention, the coenzyme Q10 is the only coenzyme Q substance naturally existing in cells in human bodies, also called ubiquinone, and is a fat-soluble polyene quinone compound; mainly exists on the inner membrane of the mitochondria of the cells of the heart, the liver and the kidney and is an important hydrogen donor in the respiratory chain of biological cells. Coenzyme Q10 is a natural antioxidant and activator of cellular metabolism synthesized by the cell itself. Coenzyme Q10 also directly affects the immune system and aging process of the body, and if coenzyme Q10 is deficient in the human body, the body has many health problems, such as arrhythmia, heart failure, arteriosclerosis, heart attack, hypertension or muscle atrophy and other symptoms. Coenzyme Q10 is present in the heart in the highest amounts and, as an important cofactor, plays a key role in the formation of ATP in the oxidative phosphorylation of mitochondria. It helps the biological energy conversion in vivo, and energy ATP is generated through an electron transfer chain in the tricarboxylic acid cycle, so that the myocardial cells continuously and repeatedly obtain ATP, and the heart can continuously keep beating.

In the present invention, the basic components of tuna oil are the Omega-3 series unsaturated fats EPA and DHA. EPA has effects of reducing blood viscosity, decomposing excessive fat in blood vessel wall, reducing triglyceride and cholesterol (LDL) concentration, cleaning thrombi, reducing blood lipid, and preventing and improving cardiovascular disease and cerebrovascular disease; DHA is the material basis for the generation of brain cells, and the lack of DHA causes brain development disorder, hypomnesis and senile dementia.

In the invention, the coenzyme Q10 provides sufficient energy and oxygen for the heart, protects the cardiovascular system and strengthens the heart function; tuna oil can reduce blood viscosity, dissolve redundant fat in blood vessel wall, reduce triglyceride and cholesterol (LDL) concentration, and achieve the effects of clearing thrombus, reducing blood lipid, and softening blood vessel; the beta-glucan can activate lymphocytes, generate antibodies to improve the immunity of the organism, remove free radicals and assist damaged tissues to accelerate the recovery of the generated cytokines.

Preferably, the beta-glucan of the invention adopts a unique mild purification process, has high product purity (the content is at least more than 95 percent), and maintains the natural three-dimensional structure and a pure anaerobic growth environment of the yeast, which are very important for the activity (similar to the three-dimensional structure in natural yeast cells). The beta-glucan can activate lymphocytes to generate antibodies, the antibodies and antigens are combined, then complement is combined, the complement activates and kills pathogens, and the beta-glucan can also activate stem cells and macrophages to secrete various cytokines (interleukins), promote proliferation and differentiation of target cells, and participate in regulating immune response of an organism and inhibiting inflammatory response.

Detailed Description

In order to further explain the technical solution of the present invention, the following detailed description is made with reference to the embodiments. Example 1:

the oil melting pot is operated in an oxygen-free state in advance, namely, the oil melting pot is vacuumized, the vacuum degree reaches more than minus 0.9Mpa, a vacuum valve is closed, and nitrogen is supplemented to the normal pressure. Repeating the operation for three times, opening the feed inlet, slightly opening nitrogen, adding coenzyme Q102 kg and tuna oil 36kg, closing the feed inlet, vacuumizing and filling the vacuum with nitrogen once. The stirring was switched on and the mixture was heated to an internal temperature of 55 ℃.

Removing oxygen from 174kg of purified water by thermal spraying, adding the purified water into an emulsified pan with the oxygen removed, and then adding 36kg of beta-glucan; and (4) deoxidizing the emulsifying pot again, and heating to dissolve. The dissolution temperature is 50-60 ℃, and the stirring is carried out for 20 minutes.

Adding the mixed solution of the dissolved coenzyme Q10 and the tuna oil into an emulsifying pot, starting a high-shear emulsifying machine in an anaerobic state, and emulsifying for 30-50 minutes at the emulsifying temperature of 45-60 ℃. Homogenizing the emulsified liquid under high pressure for five times, controlling the homogenizing pressure at 40Mpa, observing with an electron microscope, controlling the grain diameter of oil drops of the emulsified liquid to be 0.8 micron, adjusting the air inlet temperature of a spray dryer to be 200-240 ℃ and the air outlet temperature to be 90-130 ℃, obtaining 73.4kg of coenzyme Q10, tuna oil and beta-glucan powder, and further preparing into capsules, wherein the capsules are prepared by adopting a conventional method in the pharmaceutical field.

The capsule has the following administration effects:

liuyue Ling, female, 47 years old, and Yangzhou village under Yangzhou county, Yongchun county. The main symptoms are that after the atria are hospitalized for early time and three bottles of the medicine are taken, the symptoms disappear; after taking five bottles of the medicine, the medicine is stopped for more than one year till now, no relapse occurs, and the cure is successful. The dosage of the capsule is as follows: 1 granule/time, 1 time/day; the net content of 1 capsule is 1 g. Plum world Wei, male, 48 years old, home-holding Yongchun county Dong Ping Zhen Chin village 756. The main symptoms are that after three bottles of the medicine are taken after the ventricle is hospitalized, the symptoms disappear; after taking five bottles of the medicine, the medicine is stopped for more than one year till now, no relapse occurs, and the cure is successful. The dosage of the capsule is as follows: 1 granule/time, 1 time/day; the net content of 1 capsule is 1 g.

Example 2:

the oil melting pot is operated in an oxygen-free state in advance, namely, the oil melting pot is vacuumized, the vacuum degree reaches more than minus 0.9Mpa, a vacuum valve is closed, and nitrogen is supplemented to the normal pressure. After repeating the above operations three times, opening the charging hole, slightly opening nitrogen, adding coenzyme Q102 kg and tuna oil 40kg, closing the charging hole, vacuumizing and filling the vacuum with nitrogen once. The stirring was switched on and the mixture was heated to an internal temperature of 55 ℃.

Removing oxygen from 174kg of purified water by thermal spraying, adding the purified water into an emulsified pan with the oxygen removed, and then adding 40kg of beta-glucan; and (4) deoxidizing the emulsifying pot again, and heating to dissolve. The dissolution temperature is 50-60 ℃, and the stirring is carried out for 20 minutes.

Adding the mixed solution of the dissolved coenzyme Q10 and the tuna oil into an emulsifying pot, starting a high-shear emulsifying machine in an anaerobic state, and emulsifying for 30-50 minutes at the emulsifying temperature of 45-60 ℃. Homogenizing the emulsified liquid under high pressure at 40Mpa for five times, observing with electron microscope to obtain emulsion oil drop with particle size of 1.0 μm, adjusting air inlet temperature of spray dryer to 200-240 deg.C and air outlet temperature to 90-130 deg.C to obtain powder of coenzyme Q10, tuna oil and beta-glucan 81.6kg, and making into capsule.

Zhouwei material, male, 34 years old, home-hold Yongchun county peach town state road number 146. The main symptoms are that after the atrium is hospitalized for early time and takes two bottles of the medicine, the symptoms disappear; after four bottles of the medicine are taken, the medicine is stopped for more than one year till now, no relapse occurs, and the cure is successful. The dosage of the capsule is as follows: 1 granule/time, 1 time/day; the net content of 1 capsule is 1 g.

Chenliqing, female, 47 years old, home-hold Yongchun county grassy hill Shanzhen shop village No. 269. The main symptoms are that after the ventricle is taken with two bottles of the medicine after being hospitalized, the symptoms disappear; after four bottles of the medicine are taken, the medicine is stopped for more than one year till now, no relapse occurs, and the cure is successful. The dosage of the capsule is as follows: 1 granule/time, 1 time/day; the net content of 1 capsule is 1 g.

Example 3:

the oil melting pot is operated in an oxygen-free state in advance, namely, the oil melting pot is vacuumized, the vacuum degree reaches more than minus 0.9Mpa, a vacuum valve is closed, and nitrogen is supplemented to the normal pressure. After repeating the above operations three times, opening the charging hole, slightly opening nitrogen, adding coenzyme Q102 kg and tuna oil 44kg, closing the charging hole, vacuumizing and filling the vacuum with nitrogen once. The stirring was switched on and the mixture was heated to an internal temperature of 55 ℃.

Removing oxygen from 174kg of purified water by thermal spraying, adding the purified water into an emulsified pan with oxygen removed, and then adding 44kg of beta-glucan; and (4) deoxidizing the emulsifying pot again, and heating to dissolve. The dissolution temperature is 50-60 ℃, and the stirring is carried out for 20 minutes.

Adding the mixed solution of the dissolved coenzyme Q10 and the tuna oil into an emulsifying pot, starting a high-shear emulsifying machine in an anaerobic state, and emulsifying for 30-50 minutes at the emulsifying temperature of 45-60 ℃. Homogenizing the emulsified liquid under high pressure at 40Mpa for five times, observing with electron microscope to obtain emulsion oil droplet with particle size of 1.3 μm, adjusting air inlet temperature of spray dryer to 200-240 deg.C and air outlet temperature of 90-130 deg.C to obtain powder of 89kg coenzyme Q10, tuna oil and beta-dextran, and making into capsule.

Plum Yangjun, male, 46 years old, home-hold Yongchun county lake Yangzhou Jinfengcun No. 362. After the atria take three bottles of the medicine for medical treatment, the symptoms disappear; after taking five bottles of the medicine, the medicine is stopped for more than one year till now, no relapse occurs, and the cure is successful. The dosage of the capsule is as follows: 1 granule/time, 1 time/day; the net content of 1 capsule is 1 g. Huang nationality, man 57 years old, Shituzhen Zhen Qingqing Yuancun 841, Yongchun county. After the ventricle is hospitalized, the symptom disappears after taking three bottles of the medicine; after taking five bottles of the medicine, the medicine is stopped for more than one year till now, no relapse occurs, and the cure is successful. The dosage of the capsule is as follows: 1 granule/time, 1 time/day; the net content of 1 capsule is 1 g.

Example 4:

the beta-glucan is prepared by the following method: washing 2kg of saccharomyces cerevisiae with deionized water for three times, preparing bacterial suspension with the mass fraction of 20% by using the deionized water, and filtering by using a 100-mesh screen to remove impurities; adding 0.01kg mannanase and yeast extract enzyme (at a mass ratio of 1:1.5), performing enzymolysis at 35 deg.C and pH of 7.0 for 50min to obtain partially degraded cell membrane and yeast extract, and centrifuging to obtain cell membrane precipitate; preparing the cell membrane precipitate into 20% suspension by using 0.02mol/L phosphate buffer solution with pH 7.5, adding 0.015kg of complex enzyme (the mass ratio of the mannose to the yeast extract enzyme to the neutral protease is 1:1.5:1.5) consisting of mannase, yeast extract enzyme and neutral protease at 50 ℃ with pH 7.0, and carrying out enzymolysis for 60 min; after enzymolysis, centrifugally washing the mixture by using deionized water until supernatant is clear and transparent, and centrifugally precipitating the supernatant to obtain wet beta 1,3-1,6 glucan; spray drying: the air inlet temperature is 120 ℃, the air outlet temperature is 80 ℃, and the beta-glucan powder with uniform particles, good free flowability and purity of more than 95 percent is obtained. The mannase, the yeast extraction enzyme, the neutral protease and the saccharomyces cerevisiae used by the invention are provided by Ranen biochemistry Limited company of Quanzhou, and the enzyme activity is more than or equal to 50000 u/g.

The product form of the present invention is not limited to the embodiments, and any suitable changes or modifications of the similar ideas by anyone should be considered as not departing from the patent scope of the present invention.