阅读说明：本技术 一种医用防辐射护理凝胶及其制备方法 (Medical radiation-proof nursing gel and preparation method thereof ) 是由 窦静 刘学军 于 2021-07-15 设计创作，主要内容包括：本发明涉及一种医用防辐射护理凝胶及其制备方法,由以下重量百分比的物质组成：70％的芦荟凝胶、8％的银杏提取物、2％的尿囊素、1％的甘草次酸、1％的维生素E干粉、10％的透明质酸、2％的藏红花提取物、2％的葡萄籽提取物以及1％的稳定剂,稳定剂为阿拉伯胶；本发明由纯天然的植物精华提取物制备而成,不含化学合成物及激素类合成制剂成分,安全无毒、无副作用,能显著改善因放疗而引起的皮肤炎症,且使用简单方便。(The invention relates to a medical radiation-proof nursing gel and a preparation method thereof, wherein the medical radiation-proof nursing gel comprises the following substances in percentage by weight: 70% of aloe gel, 8% of ginkgo biloba extract, 2% of allantoin, 1% of glycyrrhetinic acid, 1% of vitamin E dry powder, 10% of hyaluronic acid, 2% of saffron extract, 2% of grape seed extract and 1% of stabilizer, wherein the stabilizer is Arabic gum; the invention is prepared from pure natural plant essence extracts, does not contain chemical compounds and hormone synthetic preparation components, is safe, non-toxic and free of side effects, can obviously improve the dermatitis caused by radiotherapy, and is simple and convenient to use.)

1. The medical radiation-proof nursing gel is characterized by comprising the following substances in percentage by weight: 70% of aloe gel, 8% of ginkgo biloba extract, 2% of allantoin, 1% of glycyrrhetinic acid, 1% of vitamin E dry powder, 10% of hyaluronic acid, 2% of saffron extract, 2% of grape seed extract and 1% of stabilizer.

2. The medical radiation protection gel of claim 1, wherein the content of oligomeric proanthocyanidin OPC in said grape seed extract is > 80%.

3. The medical radiation protection gel of claim 1, wherein said stabilizer is gum arabic.

4. A preparation method of medical radiation-proof nursing gel is characterized by comprising the following steps:

s1: dissolving the ginkgo biloba extract, the hyaluronic acid, the saffron crocus extract and the grape seed extract respectively with normal temperature distilled water to respectively prepare a ginkgo biloba extract aqueous solution, a hyaluronic acid aqueous solution, a saffron crocus extract aqueous solution and a grape seed extract aqueous solution for standby;

s2: dissolving allantoin with 60 deg.C distilled water to obtain allantoin water solution, and cooling;

s3: dissolving glycyrrhetinic acid in 95% ethanol solution to obtain glycyrrhetinic acid ethanol solution;

s4: dissolving vitamin E dry powder with absolute ethyl alcohol to prepare vitamin E ethanol solution for later use;

s5: placing aloe gel in a stirrer, sequentially adding allantoin aqueous solution, semen Ginkgo extract aqueous solution and stigma croci Sativi extract aqueous solution, continuously stirring, sequentially adding vitamin E ethanol solution, glycyrrhetinic acid solution and grape seed extract aqueous solution, continuously stirring, clockwise adding hyaluronic acid aqueous solution, continuously stirring, adding stabilizer, and continuously stirring for 2 hr.

5. The method for preparing medical radiation-proof nursing gel according to claim 4, characterized in that the stirring temperature in step S5 is always kept at 27 degrees, and the stirrer blade is ensured to be always immersed in the solution and not higher than the liquid level.

Technical Field

The invention relates to a medical radiation-proof nursing gel and a preparation method thereof.

Background

The skin inflammation of the radiotherapy patient is not caused by infection, but is caused by dryness and chapping of the mucosal skin caused by radiation of radiotherapy rays, because the radiotherapy rays damage the skin, the normal division of skin basal cells is reduced, and the skin is irreversibly damaged if the duration is longer; radiation dermatitis, if improperly protected, can cause skin damage symptoms to change from I degree to II degree or even III degree, seriously jeopardize the quality of life of the patient and also cause the forced interruption of radiation therapy to suspend treatment.

At present, no particularly good prevention and treatment method exists clinically aiming at the skin inflammation caused by radiotherapy, mainly chemicals with anti-inflammatory effect are taken as main raw materials, but the effect is very little, the side effect is large, and solution is urgently needed.

Disclosure of Invention

In view of the current situation of the prior art, the technical problem to be solved by the invention is to provide a medical radiation-proof nursing gel which is prepared from pure natural plant essence extracts, does not contain chemical compounds and hormone synthetic preparation components, is safe, non-toxic and free of side effects, can obviously improve skin inflammation caused by radiotherapy, and is simple and convenient to use, and a preparation method thereof.

The technical scheme adopted by the invention for solving the technical problems is as follows: the medical radiation-proof nursing gel is characterized by comprising the following substances in percentage by weight: 70% of aloe gel, 8% of ginkgo biloba extract, 2% of allantoin, 1% of glycyrrhetinic acid, 1% of vitamin E dry powder, 10% of hyaluronic acid, 2% of saffron extract, 2% of grape seed extract and 1% of stabilizer.

Preferably, the content of oligomeric procyanidins OPC in the grape seed extract is > 80%.

Preferably, the stabilizer is gum arabic.

A preparation method of medical radiation-proof nursing gel is characterized by comprising the following steps:

s1: dissolving the ginkgo biloba extract, the hyaluronic acid, the saffron crocus extract and the grape seed extract respectively with normal temperature distilled water to respectively prepare a ginkgo biloba extract aqueous solution, a hyaluronic acid aqueous solution, a saffron crocus extract aqueous solution and a grape seed extract aqueous solution for standby;

s2: dissolving allantoin with 60 deg.C distilled water to obtain allantoin water solution, and cooling;

s3: dissolving glycyrrhetinic acid in 95% ethanol solution to obtain glycyrrhetinic acid ethanol solution;

s4: dissolving vitamin E dry powder with absolute ethyl alcohol to prepare vitamin E ethanol solution for later use;

s5: placing aloe gel in a stirrer, sequentially adding allantoin aqueous solution, semen Ginkgo extract aqueous solution and stigma croci Sativi extract aqueous solution, continuously stirring, sequentially adding vitamin E ethanol solution, glycyrrhetinic acid solution and grape seed extract aqueous solution, continuously stirring, clockwise adding hyaluronic acid aqueous solution, continuously stirring, adding stabilizer, and continuously stirring for 2 hr.

Preferably, the stirring temperature in step S5 is always kept at 27 degrees, and it is ensured that the stirrer blade is always immersed in the solution and not higher than the liquid level.

Compared with the prior art, the invention has the advantages that: the invention is prepared from pure natural plant essence extracts, does not contain chemical compounds and hormone synthetic preparation components, is safe, non-toxic and free of side effects, can obviously improve the dermatitis caused by radiotherapy, and is simple and convenient to use.

Detailed Description

Unless defined otherwise, technical or scientific terms used herein shall have the ordinary meaning as understood by one of ordinary skill in the art to which this invention belongs. The use of "first," "second," and similar terms in the present application do not denote any order, quantity, or importance, but rather the terms are used to distinguish one element from another. The word "comprising" or "comprises", and the like, means that the element or item listed before the word covers the element or item listed after the word and its equivalents, but does not exclude other elements or items. The terms "connected" or "coupled" and the like are not restricted to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "upper", "lower", "left", "right", and the like are used merely to indicate relative positional relationships, and when the absolute position of the object being described is changed, the relative positional relationships may also be changed accordingly.

To maintain the following description of the embodiments of the present invention clear and concise, a detailed description of known functions and known components of the invention have been omitted.

A medical radiation-proof nursing gel is composed of the following substances in percentage by weight: 70% of aloe gel, 8% of ginkgo biloba extract, 2% of allantoin, 1% of glycyrrhetinic acid, 1% of vitamin E dry powder, 10% of hyaluronic acid, 2% of saffron extract, 2% of grape seed extract and 1% of stabilizer.

The content of oligomeric procyanidin OPC in grape seed extract is more than 80%.

Aloe contains abundant polysaccharides, proteins, amino acids, vitamins, active enzymes and trace elements beneficial to human body, and has healing and re-epithelialization properties due to the presence of mannose (glucomannan) polysaccharide in Aloe, which can stimulate macrophage activity, promote collagen synthesis, and promote cell regeneration.

The Ginkgo biloba extract is dry leaf extract of Ginkgo biloba of Ginkgoaceae, is light yellow brown flowable powder, has bitter taste, has effects of promoting blood circulation, removing blood stasis, dredging collaterals, showing obvious anti-free radical activity, improving cell metabolism, preventing lipid peroxidation of membrane, also having remarkable effect on protecting vascular endothelial activity, and stabilizing capillary permeability to improve microcirculation function.

Allantoin is a purine derivative (glyoxal urea) with urea terminal, and has molecular formula of C4H6N4O 3; the extract has moisturizing and anti-reddening effects at low concentration (0.1-0.5%), and has effects of removing cutin and promoting cell proliferation at high concentration (1-5%);

the allantoin has the first functions of absorbing water and preserving moisture, can directly act on the outermost horny layer of the skin, enhances the water absorbing capacity of the horny layer, increases the water content of the horny layer and reduces the loss of water, so that the allantoin has the functions of moistening and protecting the skin and enables the skin to be smooth, moist and flexible, and can be used for treating a plurality of dry skin diseases and also can be used as a component of a skin care product.

The second function of allantoin is to promote skin regeneration and repair, so it can be used for wound healing, and has slight anti-inflammatory and anti-infectious effects.

In addition, the allantoin has small irritation and high safety, so the allantoin can be used as a component of various skin medicaments and skin care products; allantoin is not a hormone drug and therefore does not cause dependency.

Glycyrrhetinic acid is extracted from glycyrrhiza plants (glycyrrhiza glabra), is a classic anti-inflammatory drug, can be applied to cosmetics to adjust the immune function of skin, enhance the disease resistance of the skin, eliminate inflammation, prevent allergy and clean the skin, and can also relieve the toxic and side effects of related components in the cosmetics and other external factors on the skin; glycyrrhetinic acid can effectively inhibit tyrosinase activation, prevent melanin generation, whiten skin, and relieve skin inflammatory reaction and redness.

Vitamin E has high antioxidant activity because they inhibit the reactivity of free radicals, blocking cascade events that are critical to oxidative stress that can cause damage to cells; vitamin E is significantly lipophilic and therefore very similar to cell membranes, and can effectively counteract excess free radicals and protect the skin from damage.

Hyaluronic acid is a glycosaminoglycan produced in large quantities in the extracellular matrix and is synthesized in parallel filaments that serve as "tracks" for the arrangement and sliding of fibrous cells into sites of new connective tissue deposition; it has strong water binding capacity, is beneficial to cell migration and promotes cell movement; in particular, it can create an optimal microenvironment, stimulate the increase, proliferation and migration of fibroblasts, endothelial cells and keratin cells, and promote neovascularization; it has effects in promoting extracellular matrix formation, and accelerating regeneration and neovascularization process; in addition, the water-locking capacity of hyaluronic acid is favorable for dissolving a small amount or less of fibrin, promoting re-epithelialization, and creating an environment favorable for cell survival, so that the hyaluronic acid is also commonly used for promoting deep hydration of skin, brightening skin color and improving skin quality in cosmetology.

The saffron extract mainly acts as a skin conditioner in cosmetics and skin care products, is relatively safe, generally has no influence on pregnant women, and has no acne-causing property; the natural pigments such as safflower yellow and safflower red extracted from saffron are safe and edible and can be used as coloring agent of high-grade cosmetics; the stigma croci Sativi extract has effects of promoting blood circulation, resisting inflammation, resisting oxidation, improving skin blood circulation, promoting skin metabolism, scavenging free radicals, inhibiting melanin deposition, accelerating speckle and decolorizing, absorbing ultraviolet rays, whitening skin, preventing sunburn, and resisting aging, and can be used for treating contact dermatitis, seborrheic dermatitis, pruritus, and neurodermatitis.

The clinical saffron is used for treating various chronic diseases of a human body, and the saffron enhances the endurance of the human body and enhances the proliferation reaction of lymphocytes through the effects of promoting blood circulation to remove blood stasis, resisting bacteria and diminishing inflammation, so that the cellular immunity and the humoral immunity of the human body are enhanced, and the effects of regulating the qi activity of the human body and balancing the yin and yang of the human body are achieved; proteoglycan extracted from stigma croci Sativi can rapidly activate protein kinase C and NF-kappa B, promote macrophage activity, and has immunoregulatory and anti-invasion functions; especially, the crocin can effectively inhibit the activity of oxygen free radicals and xanthine oxidase, shows antioxidant bioactivity, has the effects of promoting blood circulation, removing blood stasis, resisting bacteria, diminishing inflammation and the like, and further enhances the endurance of organisms, increases the content of immune cells and improves the immunity.

The stabilizer is acacia gum, which is a safe and harmless thickener with high solubility, and is prepared by drying the gum exudate of trunk or branch of Acacia tree of African Leguminosae or similar tree species.

Solubility: the Arabic gum can be slowly dissolved at normal temperature, the dissolving speed is accelerated along with the increase of the temperature, and finally the arabic gum is completely dissolved; when cooled to room temperature, the product still keeps a stable state, and no gel or precipitate exists. Gum arabic has high water solubility and low solution viscosity, can be easily dissolved in cold/hot water, can be formulated into 50% aqueous solution with fluidity, which is one of the characteristics that other hydrocolloids do not have, but is insoluble in organic solvents such as ethanol.

Acid stability: because the gum arabic is structurally provided with acidic groups, the natural pH value of the solution is also weakly acidic, the change of the pH value within the range of 4-8 has little influence on the character of the gum arabic, and the gum arabic has the characteristic of relatively stable acid environment.

Emulsion stability: as the gum arabic structurally has partial protein substances and rhamnose with the structural appearance, the gum arabic has very good hydrophile lipophilicity and is a very good natural oil-in-water emulsion stabilizer.

A preparation method of medical radiation-proof nursing gel comprises the following steps:

s1: dissolving the ginkgo biloba extract, the hyaluronic acid, the saffron crocus extract and the grape seed extract respectively with normal temperature distilled water to respectively prepare a ginkgo biloba extract aqueous solution, a hyaluronic acid aqueous solution, a saffron crocus extract aqueous solution and a grape seed extract aqueous solution for standby;

s2: dissolving allantoin with 60 deg.C distilled water to obtain allantoin water solution, and cooling;

s3: dissolving glycyrrhetinic acid in 95% ethanol solution to obtain glycyrrhetinic acid ethanol solution;

s4: dissolving vitamin E dry powder with absolute ethyl alcohol to prepare vitamin E ethanol solution for later use;

s5: placing aloe gel in a stirrer, sequentially adding allantoin aqueous solution, semen Ginkgo extract aqueous solution and stigma croci Sativi extract aqueous solution, continuously stirring, sequentially adding vitamin E ethanol solution, glycyrrhetinic acid solution and grape seed extract aqueous solution, continuously stirring, clockwise adding hyaluronic acid aqueous solution, adding stabilizer, and continuously stirring for 2 hr; while stirring, the temperature was maintained at 27 degrees and it was ensured that the stirrer blades were always immersed in the solution and not above the liquid level to reduce air ingress and bubble generation.

The using method comprises the following steps:

opening the product, applying to affected part, covering the affected part for 1cm, waiting for formation of protective film, and applying if there is omission; the product can be used for 3 times per day, and can be used for multiple times as required; when no longer in use, the lid must be closed to maintain a sealed condition and stored in a cool, ventilated place to protect against direct sunlight and high temperatures.

The invention is prepared from pure natural plant essence extracts, does not contain chemical compounds and hormone synthetic preparation components, is safe, non-toxic and free of side effects, can obviously improve the dermatitis caused by radiotherapy, and is simple and convenient to use.

Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those skilled in the art that various changes in the embodiments and modifications thereof may be made, and equivalents may be substituted for elements thereof; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the spirit and scope of the technical solutions of the embodiments of the present invention.