阅读说明：本技术 一种18f标记的气溶胶化正电子显像剂及其制备方法 (A kind of18F-labeled aerosolised positron imaging agent and preparation method thereof ) 是由 范兼睿 刘小姣 徐风友 张昕婷 汪玥 沈高青 李志林 曹盼 鲍育泓 于 2021-08-19 设计创作，主要内容包括：本发明提供了一种～(18)F标记的气溶胶化正电子显像剂及其制备方法,该具体步骤如附图1所示：先用射流比例器将HF溶液按一定比例加入到超纯水中,配成所需浓度的HF溶液,再用回旋加速器产生含H～(18)F的H-(2)～(18)O溶液,分别通过螺杆泵和空气压缩机给H～(18)F溶液和气体加压,最后输送到超音速气溶胶化喷嘴进行气溶胶化,得到～(18)F标记的气溶胶化正电子显像剂。该显像剂适用于腔体内部不能直接填充液态或固态溶剂的待检测复杂件,利用正电子湮没技术可研究凝聚态物质的缺陷和相变,能得到待检测复杂件内部有关缺陷种类、尺寸及其分布的详尽信息,可广泛应用于无损检测领域。(The invention provides a 18 An F-labeled aerosolized positron imaging agent and a preparation method thereof, the specific steps are shown in the attached figure 1: adding HF solution into ultrapure water according to a certain proportion by using a jet flow proportioner to prepare HF solution with required concentration, and then using a cyclotron to produce H-containing solution 18 H of F 2 18 O solution, and feeding H through screw pump and air compressor 18 Pressurizing the solution F and gas, and delivering to supersonic aerosolation nozzle for aerosolation to obtain 18 An F-labelled aerosolized positron emission tomography agent. The imaging agent is suitable for complex parts to be detected, wherein liquid or solid solvents cannot be directly filled in a cavity, and defects and phase changes of condensed substances can be researched by using positron annihilation technology, so that related matters in the complex parts to be detected can be obtainedThe detailed information of the defect types, sizes and distribution thereof can be widely applied to the field of nondestructive testing.)

1. A kind of¹⁸An F-labelled aerosolized positron emission tomography agent characterized by: the imaging agent is suitable for complex parts to be detected, wherein liquid or solid solvents cannot be directly filled in a cavity, defects and phase change of condensed substances can be researched by using positron annihilation technology, and detailed information about types, sizes and distribution of defects in the complex parts to be detected can be obtained.

2. The method of claim 1¹⁸A method for preparing an F-labelled aerosolized positron emission tomography agent, characterized by the steps of:

step 1, adding an HF solution into ultrapure water according to a certain proportion by using a jet flow proportioner to prepare the HF solution with the required concentration;

step 2: generation of H-containing gas by cyclotron¹⁸H of F₂ ¹⁸O solution;

and step 3: screw pump H¹⁸F solution is pressurized toA set pressure;

and 4, step 4: pressurizing the gas to a desired pressure with an air compressor;

and 5: delivering liquid and air under certain pressure to supersonic aerosolation nozzle for aerosolation¹⁸An F-labelled aerosolized positron emission tomography agent.

Technical Field

The invention belongs to the technical field of imaging agents, and particularly relates to a fluorescent powder¹⁸An F-labeled aerosol positron imaging agent and a preparation method thereof.

Background

In 1932 the american physicist Carl d.andeson et al demonstrated the presence of positrons predicted by Paul a.dirac when studying the trajectory of cosmic rays, and in 1950 the american scientist david.e.kurl first proposed the concept of positron emission tomography. The study of defects and phase transition energy of condensed species using positron annihilation yields a wealth of detailed information about defect type, size and distribution. The positron annihilation technology can carry out in-situ measurement, and the temperature and other conditions of the sample can be changed in the measurement process, thereby having important value for nondestructive detection.

When the imaging agent is injected into the complex to be detected, positron is generated inside the complex to be detected, the complex to be detected can be subjected to nondestructive detection by adopting a positron emission tomography imaging technology, and the injection type positron annihilation gamma photon 3D imaging nondestructive detection method has the advantages of strong penetrating power, high imaging precision, capability of being developed in severe environments such as high temperature, high pressure and the like.

Positrons are unstable in a natural state, and are combined with electrons to generate annihilation events to generate gamma photons, and the acquisition routes of the conventional positrons are two: nuclide beta⁺Decay and bremsstrahlung photons induce positrons.

Nuclide beta⁺The positive-electron-producing decay method is to use a cyclotron or reactor to produce a nuclear species lacking neutrons, e.g.²²Na，⁶⁴Cu，⁵⁸Co，¹⁸F, for example nuclides, are widely used in the medical field to synthesize ultra-short half-life positron imaging agents, label nuclides to certain organic solutions and generate half-livesThe positron imaging agents such as fluorodeoxyglucose, fatty acid, protein and the like which are in different time from several minutes to several hours can be absorbed by specific human organs and present the pathological changes of the absorption parts, the purpose of disease diagnosis is achieved according to the absorption conditions of the imaging agents by the organs, and the technology can be widely used in the medical industry because the technology can be used for diagnosing diseases such as early cancer, tumor and the like.

The bremsstrahlung photon-induced positron annihilation method is characterized in that a linear accelerator with energy of tens of megaelectron volts is used for generating high-energy gamma rays, the gamma rays are directly injected into a material after being collimated, bremsstrahlung is generated with atomic nuclei in the material, and then positron is generated through electron pair effect.

The method for annihilating positron induced by bremsstrahlung photons is high in cost and great in radiation hazard, and nuclide beta⁺The decay method is used as a positron acquisition way commonly used by people, nuclides exist in an ion form, and for the nuclides to generate positrons during industrial detection, the nuclides must be uniformly marked into a solvent in advance, and when the solvent is gas, such as air and CO₂And the solvent can continuously generate positrons when the physical or chemical reaction occurs in the inner cavity of the complex to be detected. The developer is in the form of an aerosol, which refers to a dispersion of solid or liquid particles stably suspended in a gaseous medium, wherein the particulate material is referred to as suspended particles having a particle size of more than 0.01 to 10 μm.

Imaging positron nuclides currently produced by cyclotron¹⁸F，¹³N，¹¹C and¹⁵o, etc., except¹⁸F has a physical half-life of 109min, and the physical half-lives of the rest nuclides are very short, wherein¹⁵O is only 122s, so¹⁸F facilitates the synthesis of the tag. Fluorine is chemically reactive and readily oxidizes compounds to fluoride. The fluorine and the organic compound are subjected to substitution reaction to form the organic fluorine compound, and the organic fluorine compound has high surface activity, thermal stability, chemical stability and oxidation resistance due to extremely high bond energy of a C-F bond. Most commonly used at present¹⁸F has chemical properties similar to H and hydroxyl OH and is easy to mark variousAn organic compound, which is made into a radioactive substance emitting positrons.

Disclosure of Invention

The purpose of the invention is as follows: aiming at the problem of adding developer into gaseous solvent, provides a method for preparing a high-performance liquid developer¹⁸An F-labeled aerosol positron imaging agent and a preparation method thereof, thereby providing a design idea for preparing a gaseous solvent positron-labeled imaging agent. In order to achieve the purpose, the method adopts the following steps:

the technical scheme is as follows: a kind of¹⁸An F-labeled aerosolized positron imaging agent and a method for preparing the same, comprising the steps of:

step 1: adding the HF solution into ultrapure water according to a certain proportion by using a jet flow proportioner to prepare the HF solution with the required concentration;

step 2: generation of H-containing gas by cyclotron¹⁸H of F₂ ¹⁸O solution;

and step 3: screw pump H¹⁸Pressurizing the solution F to a set pressure;

and 4, step 4: pressurizing the gas to a desired pressure with an air compressor;

and 5: delivering liquid and air under certain pressure to supersonic aerosolation nozzle for aerosolation¹⁸An F-labelled aerosolized positron emission tomography agent.

Has the advantages that: according to the invention¹⁸The preparation method of the F-labeled aerosol positron imaging agent provides a design idea for carrying out positron labeling on a gaseous solvent, and the prepared imaging material can be applied to the field of nondestructive testing.

Drawings

FIG. 1 is¹⁸Schematic flow diagram of the preparation of F-labeled aerosolized positron imaging agents.

Detailed Description

The technical solution of the present invention will be further described with reference to the accompanying drawings and embodiments.

As shown in fig. 1, is the invention¹⁸The preparation process of the F-marked aerosol positron imaging agent is shown in a schematic diagram, and the concrete content of the example 1 is as follows:

preparation equipment:

the device 1: combined pressure flowmeter

The device 2: cyclotron

The device 3: air compressor

The device 4: screw water pump

The device 5: the supersonic aerosolising nozzle has one supersonic wave generator of titanium alloy material in the front end of the nozzle, and the supersonic wave generator produces high frequency oscillation with the energy of the fluid impacting titanium metal at high speed. The nozzle has wide working pressure, high sound pressure of airflow under the condition of subsonic velocity, large aerosol treatment capacity, simple structure, reliable work and low cost.

The device 6: test pipeline

The device 7: stop valve

The device 8: industrial protractor

The device 9: time-meter

The device 10: spray laser particle size analyzer

(II) preparing materials:

material 1: HF solution

Material 2: ultrapure water

(III) preparation steps:

step 1: after the test platform is connected as shown in fig. 1, the screw pump is started to observe whether the water supply pipeline leaks water or not, and the tightness of the water pipeline is ensured. Starting an air compressor to observe whether the air supply pipeline leaks air or not, and ensuring the air tightness of the air supply pipeline;

step 2: adding the HF solution into ultrapure water according to a required proportion by using a jet flow proportioner to prepare the HF solution with a certain concentration;

and step 3: production of H-containing by cyclotron¹⁸H of F₂ ¹⁸O solution;

and 4, step 4: opening the stop valve, aerosolizing with a supersonic aerosolization nozzle, adjusting the screw pump to cause the liquid to flowThe pressure of the pipeline reaches the set pressure to obtain¹⁸An F-labelled aerosolized positron emission tomography agent;

(IV) quality control experiment:

the main purpose is to confirm the content of H¹⁸The aerosol of F is uniformly distributed.

Step 1: observing gas pressure and liquid pressure, starting a spray laser particle size analyzer after the pressure is stable, and selecting 3 positions 300, 500 and 700mm away from a spray head along the axial direction of the spray to measure the distribution condition of the particle size of the liquid drops;

step 2: and (3) vertically and continuously moving the nozzle at a constant speed, so that the light beam scans on the cross section of the aerosol, and the particle distribution condition of the whole cross section of the aerosol is recorded. Each measurement is set to 15min, and measurement related data are recorded: time, air pressure, water pressure, air volume, water volume, aerosol mean particle size;

and step 3: performing 3 times or more than 3 times of tests under the same water pressure, air pressure and time, comparing relevant data of each time, and confirming that the data is valid if the data is not deviated; if the data are large in difference, the reason is analyzed, and errors are eliminated.