阅读说明：本技术 一种消毒组合物及其方法和用途 (Disinfecting composition and method and use thereof ) 是由 吕斌 张泽敏 吴迪 于 2021-06-24 设计创作，主要内容包括：本发明公开了一种消毒组合物及其方法和用途,包括4-甲苯基-二碘甲基砜、聚六亚甲基胍、纳米二氧化硅。本发明：1、本发明的使用4-甲苯基-二碘甲基砜的优点在于,它是极其有效的消毒剂；在若干间接食品接触应用方面,在较宽的pH范围内(2-11)有效；对皮肤无刺激。2、本发明的组合物使用聚六亚甲基胍的优点在于,它杀菌广谱、有效浓度低、作用速度快、性质稳定、易溶于水、可在常温下使用、长期抑菌、无副作用、无腐蚀性、无色、无嗅、无毒、不燃、不爆、使用安全、价格适中、运输方便。3、本发明具有优良的粘结性、成膜性、活性、大比表面积及无毒、无味等性能,广泛应用于电子、催化剂、耐火材料,涂料、油墨、纺织、食品等行业。(The invention discloses a disinfection composition, a method and application thereof, wherein the disinfection composition comprises 4-tolyl-diiodomethyl sulfone, polyhexamethylene guanidine and nano silicon dioxide. The invention comprises the following steps: 1. the use of 4-tolyl-diiodomethyl sulfone in the present invention is advantageous in that it is an extremely effective disinfectant; in several indirect food contact applications, effective over a wide pH range (2-11); has no irritation to skin. 2. The polyhexamethylene guanidine used in the composition has the advantages of broad sterilization spectrum, low effective concentration, high action speed, stable property, easy water solubility, long-term bacteriostasis, no side effect, no corrosivity, no color, no odor, no toxicity, no combustion, no explosion, safe use, moderate price and convenient transportation. 3. The invention has the advantages of excellent cohesiveness, film forming property, activity, large specific surface area, no toxicity, no odor and the like, and can be widely applied to the industries of electronics, catalysts, refractory materials, coatings, printing ink, textiles, food and the like.)

1. A disinfecting composition comprising 4-tolyl-diiodomethyl sulfone, polyhexamethylene guanidine, and nanosilica.

2. The sanitizing composition according to claim 1 wherein: further comprising deionized water.

3. The sanitizing composition according to claim 1 wherein: 0.02-2 parts of 4-tolyl-diiodomethylsulfone, 0.02-2 parts of polyhexamethylene guanidine and 5-40 parts of nano silicon dioxide.

4. The sanitizing composition according to claim 2, wherein: taking 60-95 parts of ionized water by weight.

5. A disinfecting composition as claimed in claim 3, characterized in that the parts by weight of 4-tolyl-diiodomethyl sulfone are 0.3 parts, of polyhexamethylene guanidine 0.3 parts and of nanosilica 16 parts.

6. A disinfecting composition as claimed in claim 4, characterized in that the part by weight of the ionized water is 83.4 parts.

7. A process for preparing a disinfecting composition according to any one of claims 2 to 6, characterized in that: adding nano-silica into ionized water, dissolving the nano-silica by ultrasonic oscillation and stirring to obtain a nano-silica solution, adding 4-tolyl-diiodomethyl sulfone and polyhexamethylene guanidine into the nano-silica solution, and mixing and stirring to prepare the disinfection composition.

8. The sanitizing composition according to claim 8 wherein: taking 83.4 parts of ionized water, adding 16 parts of nano-silica, dissolving the nano-silica by ultrasonic oscillation and stirring to obtain a nano-silica solution, adding 0.3 part of 4-tolyl-diiodomethylsulfone and 0.3 part of polyhexamethylene guanidine into the nano-silica solution, and mixing and stirring to prepare 100 parts of the disinfection composition.

9. The sanitizing composition, method and use thereof according to claim 8 wherein: taking 74 parts of ionized water, adding 25 parts of nano-silica, oscillating by ultrasonic waves and stirring to dissolve the nano-silica to obtain a nano-silica solution, adding 0.5 part of 4-tolyl-diiodomethylsulfone and 0.5 part of polyhexamethylene guanidine into the nano-silica solution, and mixing and stirring to prepare 100 parts of the disinfection composition.

10. A disinfecting composition as claimed in any one of claims 1 to 6 characterized by: use in a medicament or disinfectant for the prevention or treatment of a novel coronavirus.

Technical Field

The invention relates to a disinfection composition, a method and application thereof, belonging to the technical field of novel coronavirus disinfectants.

Background

The clinical manifestations of patients with pneumonia infected by the novel coronavirus are: the symptoms of fever, hypodynamia and dry cough are mainly manifested, and symptoms of upper respiratory tract such as nasal obstruction, watery nasal discharge and the like are rare, and the hypoxia and hypoxia state can occur. Approximately half of patients develop dyspnea after one week, and severe patients rapidly progress to acute respiratory distress syndrome, septic shock, refractory metabolic acidosis, and procoagulant dysfunction. It is noted that the severe and critically ill patients may have moderate or low fever during their course, even without significant fever. Some patients have slight onset symptoms, but no fever, and recover after a week. The prognosis is good for most patients, and the disease is critical or even death for a few patients.

The novel routes of coronavirus transmission are mainly direct transmission, aerosol transmission and contact transmission. Direct transmission refers to infection caused by sneezing, coughing, speaking droplets and direct inhalation of exhaled air in close proximity; aerosol transmission refers to the mixing of droplets in the air to form an aerosol which causes infection after inhalation; contact transmission refers to the condition that droplets are deposited on the surface of an article and contact with mucous membranes such as oral cavity, nasal cavity, eyes and the like after contacting with contaminated hands, so that infection is caused.

Currently, the main disinfection methods for the novel coronavirus are: ultraviolet rays, ozone, 75% alcohol, chlorine-containing disinfectants, and the like. These disinfection methods all have a certain degree of influence on the indoor environment or have a certain degree of risk to human health. Therefore, there is a strong need for a disinfecting composition, method and use thereof to solve the problems of the prior art.

In order to solve the technical problems, a new technical scheme is especially provided.

Disclosure of Invention

The present invention aims to provide a disinfecting composition, a method and a use thereof to solve the problems set forth in the background art.

In order to achieve the purpose, the invention provides the following technical scheme: a disinfectant composition comprises 4-tolyl-diiodomethyl sulfone, polyhexamethylene guanidine, and nano-silica

Preferably, deionized water is further included.

Preferably, the weight portion of the 4-tolyl-diiodomethyl sulfone is 0.02-2, the weight portion of the polyhexamethylene guanidine is 0.02-2, and the weight portion of the nano silicon dioxide is 5-40.

Preferably, the weight part of the ionized water is 60-95 parts.

Preferably, the weight portion of the 4-tolyl-diiodomethyl sulfone is 0.3 portion, the weight portion of the polyhexamethylene guanidine is 0.3 portion, and the weight portion of the nano-silica is 16 portions.

Preferably, the weight part of the ionized water is 83.4 parts.

A method for preparing the disinfectant composition as claimed in any one of claims 2 to 6, wherein the disinfectant composition of the present invention is prepared by adding nano-silica to ionized water, dissolving the nano-silica by ultrasonic oscillation and stirring to obtain a nano-silica solution, adding 4-tolyl-diiodomethyl sulfone and polyhexamethylene guanidine to the nano-silica solution, mixing and stirring.

Preferably, 83.4 parts of ionized water is taken, 16 parts of nano-silica is added, the nano-silica is dissolved by ultrasonic oscillation and stirring to obtain a nano-silica solution, 0.3 part of 4-tolyl-diiodomethyl sulfone and 0.3 part of polyhexamethylene guanidine are added into the nano-silica solution, and the mixture is mixed and stirred to prepare 100 parts of the disinfection composition.

Preferably, 74 parts of ionized water is taken, 25 parts of nano-silica is added, the nano-silica is dissolved by ultrasonic oscillation and stirring to obtain a nano-silica solution, 0.5 part of 4-tolyl-diiodomethylsulfone and 0.5 part of polyhexamethylene guanidine are added into the nano-silica solution, and the mixture is mixed and stirred to prepare 100 parts of the disinfection composition.

Use of a disinfecting composition as claimed in any one of claims 1 to 6 in a medicament or disinfectant for the prophylaxis or treatment of a novel coronavirus.

Compared with the prior art, the invention has the beneficial effects that:

1. the use of 4-tolyl-diiodomethyl sulfone in the present invention is advantageous in that it is an extremely effective disinfectant; in several indirect food contact applications, effective over a wide pH range (2-11); has no irritation to skin.

2. The polyhexamethylene guanidine used in the composition has the advantages of broad sterilization spectrum, low effective concentration, high action speed, stable property, easy water solubility, long-term bacteriostasis, no side effect, no corrosivity, no color, no odor, no toxicity, no combustion, no explosion, safe use, moderate price and convenient transportation. It is an environment-friendly multipurpose novel polymer, and has wide application in industry, agriculture, medical use and daily life.

3. The composition of the present invention comprises nanosilica and deionized water. The nano silicon dioxide and the deionized water are mixed to form the nano silicon oxide transparent liquid, the pH value range is 6.8-8.3, the nano silicon oxide transparent liquid has excellent cohesiveness, film forming property, activity, large specific surface area, no toxicity, no odor and other properties, and is widely applied to the industries of electronics, catalysts, refractory materials, coatings, printing ink, textiles, food and the like.

Drawings

FIG. 1 is a block diagram of the experiment of the present invention during different experimental periods of the antibacterial experiment.

FIG. 2 is a photograph of a medium on which AF disinfectant has been sprayed 14 days after the course of the antibiotic experiment of the present invention.

FIG. 3 is a photograph of a medium which was not sterilized after 14 days during the course of the antibiotic experiment of the present invention.

FIG. 4 is a block diagram of experiments performed during different experimental periods during the antifungal testing process of the present invention.

FIG. 5 is a photograph of a dry cloth that has been sprayed with AF disinfectant after 14 days during the antifungal testing of FIG. 5.

FIG. 6 is a photograph of the dried cloth of FIG. 5 after 14 days of the antifungal testing procedure without a disinfecting treatment.

FIG. 7 is a block diagram 1 showing the analysis and detection results of the disinfectant solution containing silica according to the present invention.

FIG. 8 is a block diagram 2 showing the analysis and detection results of the disinfectant solution containing silica according to the present invention.

FIG. 9 is a block diagram 3 showing the analysis and detection results of the disinfectant solution containing silica according to the present invention.

FIG. 10 is a block diagram 4 showing the analysis and detection results of the disinfectant solution containing silica according to the present invention.

FIG. 11 is a block diagram 5 showing the analysis and detection results of the disinfectant solution containing silica according to the present invention.

FIG. 12 is a schematic diagram showing comparison of the inactivation effect of AF on influenza A (non-enveloped virus) in the test result diagram of the virus according to the present invention.

FIG. 13 is a block diagram showing the time variation of the virus infection rate versus the reduction value in the block diagram of the test results of AF versus virus according to the present invention.

FIG. 14 is a block diagram showing the detection of Staphylococcus aureus reduction of more than 99.9% at the end of the sterilization experiment according to the present invention.

FIG. 15 is a diagram showing the detection of the decrease of Escherichia coli by 99.9% or more at the end of the sterilization experiment according to the present invention.

FIG. 16 is a block diagram showing the measurement of ammonia gas in the deodorization measurement according to the present invention.

FIG. 17 is a block diagram showing the measurement of (acetic) acid gas in the deodorization measurement according to the present invention.

FIG. 18 is a block diagram of isovaleric acid testing in the deodorization test according to the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The invention provides a technical scheme that: a disinfectant composition comprises 4-tolyl-diiodomethyl sulfone, polyhexamethylene guanidine, nano silicon dioxide and ionized water, wherein the disinfectant comprises the following components in percentage by weight: 0.02-2 parts of 4-tolyl-diiodomethyl sulfone, 0.02-2 parts of polyhexamethylene guanidine, 5-40 parts of nano silicon dioxide and 60-95 parts of ionic water.

Preferably, the disinfectant comprises the following components in percentage by weight: 0.3 part of 4-tolyl-diiodomethyl sulfone, 0.3 part of polyhexamethylene guanidine, 16 parts of nano silicon dioxide and 83.4 parts of ionized water.

Preferably, 83.4 parts of ionized water is taken, 16 parts of nano-silica is added, and the nano-silica is dissolved by ultrasonic oscillation and stirring to obtain a nano-silica solution.

Preferably, 0.3 part of 4-tolyl-diiodomethylsulfone and 0.3 part of polyhexamethylene guanidine are added into the nano-silica solution, and the mixture is mixed and stirred to prepare 100 parts of the disinfection composition, namely the AF disinfection solution.

Preferably, 74 parts of ionized water is taken, 25 parts of nano-silica is added, and the nano-silica is dissolved by ultrasonic oscillation and stirring to obtain a nano-silica solution.

Preferably, 0.5 part of 4-tolyl-diiodomethylsulfone and 0.5 part of polyhexamethylene guanidine are added to the nano-silica solution, and mixed and stirred to prepare 100 parts of the sterilizing composition of the present invention.

The composition of the present invention comprises 4-tolyl-diiodomethyl sulfone. 4-tolyl-diiodomethyl sulfone has a CAS registry number of 20018-09-1. Other designations for 4-tolyl-diiodomethyl sulfone are as follows: diiodomethyl-p-tolylsulfone, p-tolyl-diiodomethyl sulfone, diiodomethyl-tolyl sulfone. 4-tolyl-diiodomethyl sulfone is an antimicrobial agent that is widely used to control degradation by bacteria. It has been EPA certified registration for use in adhesives, paper coatings, plastics, tanned leather, caulks, metal working fluids, textiles, coatings and wood preservation. The advantage of using 4-tolyl-diiodomethyl sulfone is that it is an extremely effective disinfectant; in several indirect food contact applications, approved by the U.S. FDA; effective over a wide pH range (2-11); has no irritation to skin.

The composition of the present invention comprises polyhexamethylene guanidine. Polyhexamethylene guanidine is an environment-friendly high-molecular polymer disinfectant, and is also named as polyhexamethylene guanidine (hydrochloride). The polyhexamethylene guanidine has the advantages of broad sterilization spectrum, low effective concentration, high action speed, stable property, easy water solubility, long-term bacteriostasis, no side effect, no corrosiveness, no color, no odor, no toxicity, no combustion, no explosion, safe use, moderate price and convenient transportation. It is an environment-friendly multipurpose novel polymer, and has wide application in industry, agriculture, medical use and daily life.

The invention uses a combination of 4-tolyl-diiodomethyl sulfone, polyhexamethylene guanidine, and nanosilica in the disinfecting composition. The aging test report of the silicon dioxide disinfectant is as follows:

first, antibacterial experiment.

As shown in fig. 1 to 3, 100% all-cotton textiles purchased in the market were divided into two. And the dried sample was used as a mold growth test. The above is 28 degrees + -2 degrees. And 100% of all-cotton textile fabric samples are pasted on the inorganic agar culture medium. The same amount is added.

And II, antifungal testing.

As shown in figures 4 to 6, 100% of all-cotton cloth purchased from the market was divided in half, one half of which was sprayed with AF cleaning disinfectant on the surface and the other half was subjected to the mold growth test in the normal manner. The sample is pasted on an inorganic agar culture medium, the temperature is controlled to be about thirty degrees, and the humidity is controlled to be about 85 percent, so that the test is carried out. And (5) carrying out wet process and placing.

Moreover, the above test environment was converted into a practical evaluation standard, and seven days were about three months, and 14 days were about one year.

The composition of the present invention comprises nanosilica and deionized water. The nano silicon dioxide and the deionized water are mixed to form the nano silicon oxide transparent liquid, the pH value range is 6.8-8.3, the nano silicon oxide transparent liquid has excellent cohesiveness, film forming property, activity, large specific surface area, non-toxicity, tasteless and other properties, is widely applied to the industries of electronics, catalysts, refractory materials, coatings, printing ink, textiles, food and the like, and has specific application scenes that: bedding and pillowcase. Blankets, sponge mattresses, shoe cabinets, leather shoes, boots, socks, western-style clothes and underwear. Curtain, wall paper, sofa, air conditioner filter, garbage bin. Washing machines, washing rooms, toilets and the like have a space around the water. Beds and living spaces, bathrooms. Sporting goods, bags, and the like.

In the experiment, as shown in fig. 12 and 13, the test results of AF on virus were that the virus infection rate was reduced by 3.7 x 10 after 15 minutes of use¹⁰The above.

As shown in fig. 14 and 15, the detection results of the sterilization test: after 1 minute of use, staphylococcus aureus and escherichia coli both decreased by more than 99.9%.

As shown in fig. 16, 17 and 18, the experimental conclusion of the deodorization test is: the odor generated by ammonia gas, (acetic) acid gas and isovaleric acid is basically eliminated in a short time. The principle of benefiting is that the bad smell of the mould is generated when the spores are divided and propagated, AF disinfection solution is directly sprayed on the mould, the mould stops being propagated and died immediately, and the mould smell disappears.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.