阅读说明：本技术 一种parp抑制剂微丸制剂及其制备工艺 (Pellet preparation of PARP inhibitor and preparation process thereof ) 是由 郭远静 王亦平 范文源 杜争鸣 仇罡 徐铄 吕会茹 于 2020-05-29 设计创作，主要内容包括：本发明涉及一种PARP抑制剂微丸组合物及其制备工艺,所述微丸组合物包含：微丸和任选地的外加赋形剂,所述的微丸包含(1)微丸丸芯；(2)含药层以及(3)任选地保护层；所述的含药层包含(a)活性成分和(b)粘合剂；当所述组合物包含保护层时,所述的保护层包含(c)包衣材料；所述的活性成分为(R)-2-氟-10a-甲基-7,8,9,10,10a,11-六氢-5,6,7a,11-四氮杂环庚三烯并[def]环戊二烯并[a]芴-4(5H)-酮、其药物上可接受的盐及其水合物。(The invention relates to a pellet composition of PARP inhibitor and a preparation process thereof, wherein the pellet composition comprises the following components: pellets comprising (1) a pellet core; (2) a drug-containing layer and (3) optionally a protective layer; the drug-containing layer comprises (a) an active ingredient and (b) a binder; when the composition comprises a protective layer, the protective layer comprises (c) a coating material; the active ingredient is (R) -2-fluoro-10 a-methyl-7, 8,9,10,10a, 11-hexahydro-5, 6,7a, 11-tetraazacyclohepta [ def ] cyclopenta [ a ] fluorene-4 (5H) -ketone, pharmaceutically acceptable salt and hydrate thereof.)