阅读说明：本技术 一种青蒿素复合银离子消毒剂及其制备方法 (Artemisinin composite silver ion disinfectant and preparation method thereof ) 是由 李克寒 吉晖晖 邱智军 杨晓涛 齐国庆 于 2021-10-20 设计创作，主要内容包括：发明涉及一种青蒿素银离子复合消毒剂及其制备方法,各原料质量百分比为：甘油2-5％、乙二醇30-35％、聚氧乙烯醚0.5-0.8％、苹果酸4-6％、硝酸银5-10％、青蒿素6-8％过氧化氢10-15％、十二烷基苯磺酸钠0.5-1％、亲水剂5-7％、其余为去离子水,以上各组分之和为100％。通过在青蒿素银离子复合消毒剂中添加亲水剂,有效提高了消毒剂浸渍医用敷料、无纺布材料、过滤材料的浸渍效果,同时进一步提高了医用敷料、无纺布材料、过滤材料的抗菌和消毒的效果。(The invention relates to an artemisinin silver ion composite disinfectant and a preparation method thereof, wherein the artemisinin silver ion composite disinfectant comprises the following raw materials in percentage by mass: 2-5% of glycerol, 30-35% of ethylene glycol, 0.5-0.8% of polyoxyethylene ether, 4-6% of malic acid, 5-10% of silver nitrate, 6-8% of artemisinin, 10-15% of hydrogen peroxide, 0.5-1% of sodium dodecyl benzene sulfonate, 5-7% of a hydrophilic agent and the balance of deionized water, wherein the sum of the components is 100%. By adding the hydrophilic agent into the artemisinin silver ion composite disinfectant, the impregnation effect of the disinfectant for impregnating the medical dressing, the non-woven fabric material and the filtering material is effectively improved, and the antibacterial and disinfection effects of the medical dressing, the non-woven fabric material and the filtering material are further improved.)

1. An artemisinin silver ion composite disinfectant comprises the following raw materials in percentage by mass: 2-5% of glycerol, 30-35% of ethylene glycol, 0.5-0.8% of polyoxyethylene ether, 4-6% of malic acid, 5-10% of silver nitrate, 6-8% of artemisinin, 10-15% of hydrogen peroxide, 0.5-1% of sodium dodecyl benzene sulfonate, 5-7% of a hydrophilic agent and the balance of deionized water, wherein the sum of the components is 100%.

2. The artemisinin silver ion compound disinfectant as claimed in claim 1, wherein:

the hydrophilic agent is a hydrophilic polymer comprising the following structure (I):

3. a method for preparing the artemisinin silver ion compound disinfectant as described in claim 1, comprising the following steps:

s1: preparing a hydrophilic agent, namely carrying out interfacial reaction on hexafluorobutanol substituted aromatic diamine and aromatic acid chloride in an aqueous solution to prepare the hydrophilic agent with the structural formula (I).

S2: the following composition: 2-5% of glycerol, 30-35% of ethylene glycol, 0.5-0.8% of polyoxyethylene ether, 4-6% of malic acid, 5-10% of silver nitrate, 6-8% of artemisinin, 10-15% of hydrogen peroxide, 0.5-1% of sodium dodecyl benzene sulfonate, 5-7% of a hydrophilic agent and the balance of deionized water, wherein the sum of the components is 100%; mixing and stirring for 45-60min, and standing to obtain the disinfectant.

4. The method for disinfecting the medical dressing, the non-woven fabric material and the filter material impregnated with the artemisinin silver ion compound disinfectant as claimed in claim 1, comprising the step of impregnating the medical dressing, the non-woven fabric material and the filter material with the artemisinin silver ion compound disinfectant.

Technical Field

The invention relates to the field of medical biology, in particular to an artemisinin composite silver ion disinfectant and a preparation method thereof.

Background

Silver (Ag) ion is known as an important component of an antibacterial agent, and has the characteristics of broad-spectrum antibacterial property, safety and no toxicity.

It is believed that the antimicrobial properties of silver include the following: firstly, silver ions can combine with metabolic enzymes containing sulfydryl in fungal cells to cause the death of bacteria and fungi; the second silver ion is associated with the binding of proteins and nucleic acids, i.e., binds to the DNA of bacteria and fungi, resulting in a structural change that inhibits DNA replication and leads to the inactivation of fungi. Currently known silver ion disinfection and antibiosis mainly aims at drug-resistant pathogenic bacteria such as drug-resistant escherichia coli, drug-resistant staphylococcus aureus, drug-resistant pseudomonas aeruginosa, streptococcus pyogenes, drug-resistant enterococcus, anaerobe, candida albicans and the like, and has comprehensive antibacterial activity;

meanwhile, at present, a disinfectant containing silver ions is applied to a material of a medical dressing for wrapping a wound in the field of medicine, and a disinfectant containing silver ions is also applied to a disinfection wiping material or a filtering material in the field of public services. For example, CN113041389A an antibacterial hydrophilic polyurethane foam medical dressing relates to the technical field of medical dressings. The antibacterial hydrophilic polyurethane foam medical dressing comprises the following formula raw materials in parts by weight: non-woven adhesive fabric, deionized water, monovalent silver ion solution, glycerol, carbomer, triethanolamine, cationic polymer antibacterial agent, hydrophilic fiber, foam stabilizer, surfactant, silicone oil, polyurethane part and medical auxiliary material. According to the antibacterial hydrophilic polyurethane foam medical dressing, hydrophilic fibers and monovalent silver ion solution are added into raw materials, the hydrophilic fiber dressing is composed of natural fibers, can be tightly attached to a wound, is strong in absorption capacity, can absorb exudate of the wound, forms a layer of gel, can keep the surface of the wound moist, is beneficial to wound healing, helps to remove necrotic tissue of the wound without damaging new tissues, and avoids secondary injury to the wound. For example, CN111437660A is a nano-silver disinfection and antibiosis air filter element, which adopts a four-layer structure mode of hydrophobic layer nano-silver disinfection and antibiosis non-woven fabric-activated carbon-HEPA high efficiency filter screen-hydrophilic layer nano-silver disinfection and antibiosis non-woven fabric, and can effectively filter out bacteria, viruses, toxic gases and the like in particles, ash layers and liquid, improve the filtering efficiency, and prolong the service life of the machine; in addition, the nano silver particles are a material with a long-acting disinfection and antibiosis effect, the combination of the nano silver and the silver ions can achieve the effects of rapid sterilization and long-acting disinfection and antibiosis, the nano silver and the silver ions have good safety and long-acting performance, the spherical nano silver and the silver ions are loaded on the reticular fiber material of the air filter element, bacteria on the air filter element can be effectively killed, and the long-acting disinfection and antibiosis are realized, so that the air filter element is not easy to mildew and breed bacteria after being used for a long time. In addition, the invention also provides a preparation method of the nano-silver disinfection antibacterial air filter element.

The artemisinin (artemisin) is an artemisinin medicine extracted from medicinal plant artemisia annua (artemisia annua L), is a sesquiterpene lactone compound containing peroxide groups, is an internationally recognized Chinese herbal medicine extract developed according to western medicines, is an antimalarial bulk drug and has a certain antibacterial effect. In the prior art, a technical scheme of applying artemisinin and silver ions to materials together for sterilization and disinfection is also provided, for example, a high-efficiency sterilizing and disinfecting virus bacteria quantum indoor air purifier is disclosed in CN112728698A, wherein an EP-GO filter screen is disclosed, and the filter screen is characterized by comprising the following raw materials in parts by weight: 25-40 parts of activated carbon, 8-16 parts of nano silver, 4-10 parts of nano titanium dioxide, 6-14 parts of carrageenan, 10-30 parts of high rare earth, 4-8 parts of D-sodium erythorbate, 10-20 parts of sodium benzoate, 10-16 parts of artemisinin and a proper amount of deionized water or an alcohol-water mixture.

It can be seen that the silver ion disinfectant containing artemisinin is widely applied to various materials which need to be disinfected and sterilized, but the prior art has the defects that the efficiency of soaking the silver ion disinfectant containing artemisinin into the materials is low due to the problem of hydrophilicity of the silver ion disinfectant containing artemisinin, so that the upper limit of the content of the disinfectant in the materials is not high, and a method for improving the hydrophilicity of the silver ion soaked materials containing artemisinin is needed to solve the problems.

Disclosure of Invention

The invention provides an artemisinin silver ion composite disinfectant and a preparation method thereof, aiming at solving the technical problem that the upper limit of the content of artemisinin silver ion disinfectant in a material is not high because the efficiency of impregnating the artemisinin silver ion disinfectant in the material is low.

The invention relates to an artemisinin silver ion composite disinfectant, which comprises the following raw materials in percentage by mass: 2-5% of glycerol, 30-35% of ethylene glycol, 0.5-0.8% of polyoxyethylene ether, 4-6% of malic acid, 5-10% of silver nitrate, 6-8% of artemisinin, 10-15% of hydrogen peroxide, 0.5-1% of sodium dodecyl benzene sulfonate, 5-7% of a hydrophilic agent and the balance of deionized water, wherein the sum of the components is 100%.

Further, the hydrophilic agent is a hydrophilic polymer comprising the following structure (I):

in the formula (I), R⁰Is a group of aromatic or heterocyclic groups and combinations thereof, n is an integer in the range of 7. gtoreq.n.gtoreq.1; m is an integer of more than or equal to 20 and more than or equal to 2;

furthermore, due to the existence of amino groups in the structural formula (I), the hydrophilic performance of the artemisinin composite silver ion disinfectant on materials is promoted.

The invention also relates to a preparation method of the artemisinin silver ion composite disinfectant.

The method comprises the following steps:

s1: preparing a hydrophilic agent, namely carrying out interfacial reaction on hexafluorobutanol-substituted aromatic diamine and aromatic acid chloride in an aqueous solution to prepare the hydrophilic agent with the structural formula (I).

S2: the following composition: 2-5% of glycerol, 30-35% of ethylene glycol, 0.5-0.8% of polyoxyethylene ether, 4-6% of malic acid, 5-10% of silver nitrate, 6-8% of artemisinin, 10-15% of hydrogen peroxide, 0.5-1% of sodium dodecyl benzene sulfonate, 5-7% of a hydrophilic agent and the balance of deionized water, wherein the sum of the components is 100%; mixing and stirring for 45-60min, and standing to obtain the disinfectant.

The invention also relates to a method for disinfecting medical dressing, non-woven fabric material and filter material impregnated with the artemisinin silver ion compound disinfectant.

Effects of the invention

According to the invention, the hydrophilic agent obtained by the interfacial reaction of the hexafluorobutanol-substituted aromatic diamine and the aromatic acid chloride is added into the artemisinin silver ion composite disinfectant, so that the impregnation effect of the disinfectant for impregnating medical dressings, non-woven fabrics and filter materials is effectively improved, and the antibacterial and disinfection effects of the medical dressings, non-woven fabrics and filter materials are further improved.

Examples

Example 1

Comprises the following components: 2% of glycerol, 30% of ethylene glycol, 0.5% of polyoxyethylene ether, 4% of malic acid, 5% of silver nitrate, 6% of artemisinin, 10% of hydrogen peroxide, 0.5% of sodium dodecyl benzene sulfonate, 5% of hydrophilic agent and the balance of deionized water, wherein the sum of the components is 100%; mixing and stirring for 45min, and standing to obtain the artemisinin composite silver ion disinfectant.

Weighing 200g of the artemisinin compound silver ion disinfectant, and mixing the artemisinin compound silver ion disinfectant with the thickness of 2 mm and the area of 5cm²The non-woven fabric is soaked in the artemisinin composite silver ion disinfectant, and the weight of the non-woven fabric is increased by 13.5g after the non-woven fabric is soaked for 5 hours.

Example 2

Comprises the following components: 3% of glycerol, 33% of ethylene glycol, 0.7% of polyoxyethylene ether, 5% of malic acid, 8% of silver nitrate, 7% of artemisinin, 12% of hydrogen peroxide, 0.6% of sodium dodecyl benzene sulfonate, 6% of hydrophilic agent and the balance of deionized water, wherein the sum of the components is 100%; mixing and stirring for 45min, and standing to obtain the artemisinin composite silver ion disinfectant.

Weighing 200g of the artemisinin compound silver ion disinfectant, and mixing the artemisinin compound silver ion disinfectant with the thickness of 2 mm and the area of 5cm²The non-woven fabric is soaked in the artemisinin composite silver ion disinfectant, and the weight of the non-woven fabric is increased by 14.7g after 5h of soaking.

Example 3

Comprises the following components: 5% of glycerol, 36% of ethylene glycol, 0.8% of polyoxyethylene ether, 6% of malic acid, 10% of silver nitrate, 8% of artemisinin, 15% of hydrogen peroxide, 1% of sodium dodecyl benzene sulfonate, 7% of hydrophilic agent and the balance of deionized water, wherein the sum of the components is 100%; mixing and stirring for 45min, and standing to obtain the artemisinin composite silver ion disinfectant.

Weighing 200g of the artemisinin compound silver ion disinfectant, and mixing the artemisinin compound silver ion disinfectant with the thickness of 2 mm and the area of 5cm²The non-woven fabric is soaked in the artemisinin composite silver ion disinfectant, and the weight of the non-woven fabric is increased by 16.3g after the non-woven fabric is soaked for 5 hours.

Example 4

Comprises the following components: 2% of glycerol, 30% of ethylene glycol, 0.5% of polyoxyethylene ether, 4% of malic acid, 5% of silver nitrate, 6% of artemisinin, 10% of hydrogen peroxide, 0.5% of sodium dodecyl benzene sulfonate, 6% of hydrophilic agent and the balance of deionized water, wherein the sum of the components is 100%; mixing and stirring for 45min, and standing to obtain the artemisinin composite silver ion disinfectant.

Weighing 200g of the artemisinin compound silver ion disinfectant, and mixing the artemisinin compound silver ion disinfectant with the thickness of 2 mm and the area of 5cm²The non-woven fabric is soaked in the artemisinin composite silver ion disinfectant, and the weight of the non-woven fabric is increased by 14.4g after the non-woven fabric is soaked for 5 hours.

Example 5

Comprises the following components: 2% of glycerol, 30% of ethylene glycol, 0.5% of polyoxyethylene ether, 4% of malic acid, 5% of silver nitrate, 6% of artemisinin, 10% of hydrogen peroxide, 0.5% of sodium dodecyl benzene sulfonate, 7% of hydrophilic agent and the balance of deionized water, wherein the sum of the components is 100%; mixing and stirring for 45min, and standing to obtain the artemisinin composite silver ion disinfectant.

Weighing 200g of the artemisinin compound silver ion disinfectant, and mixing the artemisinin compound silver ion disinfectant with the thickness of 2 mm and the area of 5cm²The non-woven fabric is soaked in the artemisinin composite silver ion disinfectant, and the weight of the non-woven fabric is increased by 15.9g after the non-woven fabric is soaked for 5 hours.

Comparative example 1

Comprises the following components: 2% of glycerol, 30% of ethylene glycol, 0.5% of polyoxyethylene ether, 4% of malic acid, 5% of silver nitrate, 6% of artemisinin, 10% of hydrogen peroxide, 0.5% of sodium dodecyl benzene sulfonate and the balance of deionized water, wherein the sum of the components is 100%; mixing and stirring for 45min, and standing to obtain the artemisinin composite silver ion disinfectant.

Weighing 200g of the artemisinin compound silver ion disinfectant, and mixing the artemisinin compound silver ion disinfectant with the thickness of 2 mm and the area of 5cm²The non-woven fabric is soaked in the artemisinin composite silver ion disinfectant, and the weight of the non-woven fabric is increased by 9.4g after the non-woven fabric is soaked for 5 hours.

After the impregnation, the hydrophilic agent is shown to effectively improve the impregnation amount of the artemisinin composite silver ion disinfectant.

Finally, it should be noted that: the above embodiments are only for illustrating the technical solutions of the present invention and not for limiting the same, and although the present invention is described in detail with reference to the above embodiments, those of ordinary skill in the art should understand that: modifications and equivalents may be made to the embodiments of the invention without departing from the spirit and scope of the invention, which is to be covered by the claims.