阅读说明：本技术 一种海参牡蛎提取物小分子肽配方及其制备方法 (Formula and preparation method of sea cucumber and oyster extract micromolecular peptide ) 是由 丛凤文 于 2021-09-18 设计创作，主要内容包括：本发明公开了一种海参牡蛎提取物小分子肽配方及其制备方法,该小分子肽配方由海参、牡蛎、雪蛤、珍珠贝、枸杞、草菇、鲍鱼和海马组成；将分子肽生物技术运用于海参牡蛎的加工过程,经酶解制成复方小分子肽功能食品,这种制作方法形成的小分子低聚肽,完全保留了各成分原有的营养成份,在人体摄入后比单一氨基酸或蛋白质吸收更快,更容易被机体吸收,在人体代谢方面有着更重要的生物活性,比常规药食同源制品有更高的生物效价、更重要的生理功能；而且,由于小分子肽具有的强大的承载能力,各原料的有效成分能充分被人体吸收,纯天然,全营养,达到一定的保健功效。(The invention discloses a formula of small molecular peptide of a sea cucumber and oyster extract and a preparation method thereof, wherein the formula of the small molecular peptide consists of sea cucumber, oyster, Chinese forest frog, pearl oyster, medlar, straw mushroom, abalone and sea horse; the micromolecule oligopeptide formed by the preparation method completely reserves the original nutritional ingredients of each ingredient, is absorbed more quickly than single amino acid or protein after being ingested by a human body, is absorbed by the body more easily, has more important biological activity in the aspect of human metabolism, and has higher biological value and more important physiological function than the conventional medicine and food homologous products; moreover, due to the strong carrying capacity of the small molecular peptide, the effective components of the raw materials can be fully absorbed by human bodies, and the small molecular peptide is pure natural and full-nutritional and achieves a certain health-care effect.)

1. The formula of the sea cucumber and oyster extract micromolecule peptide is characterized by comprising the following components: sea cucumber, oyster, Chinese forest frog, pearl oyster, medlar, straw mushroom, abalone and sea horse.

2. The formula of the sea cucumber oyster extract small-molecule peptide according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 30-50 parts of sea cucumber, 35-45 parts of oyster, 1-3 parts of Chinese forest frog, 2-5 parts of pearl shell, 1-3 parts of medlar, 1-3 parts of straw mushroom, 2-5 parts of abalone and 2-5 parts of sea horse.

3. The formula of the sea cucumber oyster extract small-molecule peptide as claimed in claim 2, is characterized by comprising the following raw materials in parts by weight: 40 parts of sea cucumber, 40 parts of oyster, 2 parts of Chinese forest frog, 3.5 parts of pearl oyster, 2 parts of medlar, 2 parts of straw mushroom, 3.5 parts of abalone and 3.5 parts of sea horse.

4. The preparation method of the sea cucumber and oyster extract micromolecular peptide formula is characterized by comprising the following steps:

s1: weighing raw materials of sea cucumber, oyster, Chinese forest frog, pearl oyster, medlar, straw mushroom, abalone and sea horse according to parts by mass, cleaning, airing, draining surface water, and crushing into original slurry for later use;

s2: adding one or more of papain, flavourzyme and animal protease into the original slurry, wherein the addition amount of the protease is 4000-;

s3: sequentially passing the supernatant in the S2 through a reverse osmosis membrane with the molecular weight cutoff of 5000 and a reverse osmosis membrane with the molecular weight cutoff of 300 to obtain a small molecular peptide mixed solution;

s4: and (3) placing the small molecular peptide mixed solution in a vacuum concentrator for concentration and drying to obtain a small molecular active peptide powder product.

Technical Field

The invention relates to the technical field of small molecule peptides, in particular to a formula of a sea cucumber and oyster extract small molecule peptide and a preparation method thereof.

Background

The small molecular peptide is a biochemical substance between amino acid and protein, has a molecular weight smaller than that of protein and larger than that of amino acid, and is a fragment of protein. The small molecular peptide has the characteristics of simple structure, small molecular weight, capability of being quickly absorbed through small intestinal mucosa without being digested again, no energy consumption and 100% absorption. The absorption, transformation and utilization of the small molecule active peptide are efficient and complete. The important embodiment of the biological activity of the small molecule active peptide is that the small molecule active peptide can directly enter cells. The small molecule peptide can directly enter cells through skin barriers, blood brain barriers, placenta barriers and gastrointestinal mucosa barriers. The small molecular peptide has important physiological functions, relates to the fields of hormone, nerve, cell growth and reproduction of human bodies, can regulate the physiological functions of various systems and cells in the human bodies, and maintains the normal physiological activities of the systems of nerve, digestion, reproduction, growth, motor metabolism, circulation and the like of the human bodies. The small molecular peptide not only can provide nutrient substances required by growth and development of a human body, but also has special biological functions, and can prevent and treat thrombus, hyperlipidemia and hypertension, delay senility, resist fatigue and improve the immunity of the organism. The sea cucumber and the oyster have good effects of benefiting qi and nourishing blood, but the sea cucumber and the oyster are used as medicine and food in the prior art, the formula is simple, the maximum effect cannot be exerted, and the efficiency of directly absorbing amino acid contained in the sea cucumber and the oyster by a human body is slow.

Disclosure of Invention

The invention aims to provide a formula of sea cucumber and oyster extract micromolecular peptide and a preparation method thereof, and aims to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme: a formula of sea cucumber and oyster extract micromolecular peptide comprises the following components: sea cucumber, oyster, Chinese forest frog, pearl oyster, medlar, straw mushroom, abalone and sea horse.

Preferably, the small molecule peptide formula comprises the following raw materials in parts by weight: 30-50 parts of sea cucumber, 35-45 parts of oyster, 1-3 parts of Chinese forest frog, 2-5 parts of pearl shell, 1-3 parts of medlar, 1-3 parts of straw mushroom, 2-5 parts of abalone and 2-5 parts of sea horse.

Preferably, the small molecule peptide formula comprises the following raw materials in parts by weight: 40 parts of sea cucumber, 40 parts of oyster, 2 parts of Chinese forest frog, 3.5 parts of pearl oyster, 2 parts of medlar, 2 parts of straw mushroom, 3.5 parts of abalone and 3.5 parts of sea horse.

The invention provides a preparation method of a sea cucumber and oyster extract micromolecular peptide formula, which comprises the following steps:

s1: weighing raw materials of sea cucumber, oyster, Chinese forest frog, pearl oyster, medlar, straw mushroom, abalone and sea horse according to parts by mass, cleaning, airing, draining surface water, and crushing into original slurry for later use;

s2: adding one or more of papain, flavourzyme and animal protease into the original slurry, wherein the addition amount of the protease is 4000-;

s3: sequentially passing the supernatant in the S2 through a reverse osmosis membrane with the molecular weight cutoff of 5000 and a reverse osmosis membrane with the molecular weight cutoff of 300 to obtain a small molecular peptide mixed solution;

s4: and (3) placing the small molecular peptide mixed solution in a vacuum concentrator for concentration and drying to obtain a small molecular active peptide powder product.

Pharmacological description:

sea cucumber: sweet, salty and neutral in nature. Tonify kidney, replenish essence, nourish blood and moisten dryness. Can be used for treating essence and blood deficiency, sexual impotence, nocturnal emission, frequent micturition, constipation due to intestinal dryness, etc.

Oyster shell: salty in taste and neutral in nature. Nourishing yin and suppressing hyperactive yang, tranquilizing mind and arresting convulsion, softening hard mass and eliminating phlegm and resolving masses, and astringing essence and arresting sweating. Can be used for treating epilepsy, vertigo, spontaneous perspiration, night sweat, spermatorrhea, stranguria with turbid urine, metrorrhagia, leukorrhagia, scrofula, and goiter.

Snow clams: the nature is flat; salty taste; it enters spleen, stomach and bladder meridians. Has effects in invigorating kidney, replenishing vital essence, nourishing yin, and moistening lung, and can be used for treating asthenia, disorder after illness, listlessness, kidney deficiency, mental deficiency, palpitation, insomnia, night sweat, tuberculosis, cough, and hemoptysis.

Pearl shell: salty and cold. It enters liver and heart meridians. Pacify liver, subdue yang, arrest convulsion and stop bleeding. It is indicated for dizziness, tinnitus, palpitation, insomnia, mania, fright epilepsy, hematemesis, epistaxis, and female metrorrhagia.

Medlar: sweet in taste and neutral in nature; mainly enters liver, kidney and lung channels, and has the effects of nourishing liver, nourishing kidney and moistening lung.

Straw mushroom: sweet in flavor and cold in nature. Has the effects of invigorating spleen, invigorating qi, and clearing away summer-heat. Can be used for treating spleen and stomach weakness, hypoimmunity, or slow wound healing; summer-heat, restlessness. Modern times also used for hypertension and various tumors.

Abalone: salty in taste and neutral in nature. Calming liver, suppressing yang hyperactivity, calming endogenous wind, tranquilizing mind, relieving fever, improving eyesight, treating stranguria, and stopping bleeding. Can be used for treating dizziness, bone steaming, fatigue, cataract, gonorrhea, hematemesis, and insomnia.

Sea horse: sweet, salty and warm in nature. Invigorating kidney, supporting yang, warming and dredging channels and collaterals, regulating qi and blood, resolving hard mass, relieving swelling, relieving cough and asthma. Can be used for treating sexual impotence, enuresis, asthma of deficiency type, female dystocia, abdominal mass, furuncle, toxic swelling, lymphoid tuberculosis, and goiter.

Has the advantages that: the invention has the beneficial effects that: the micromolecule oligopeptide formed by the preparation method completely reserves the original nutritional ingredients of each ingredient, is absorbed more quickly than single amino acid or protein after being ingested by a human body, is absorbed by the body more easily, has more important biological activity in the aspect of human metabolism, and has higher biological value and more important physiological function than the conventional medicine and food homologous products; moreover, due to the strong carrying capacity of the small molecular peptide, the effective components of the raw materials can be fully absorbed by human bodies, and the small molecular peptide is pure natural and full-nutritional and achieves a certain health-care effect.

Detailed Description

The technical solution of the present patent will be described in further detail with reference to the following embodiments.

Example 1

The formula of the sea cucumber and oyster extract micromolecule peptide comprises the following components in parts by weight: 30 parts of sea cucumber, 35 parts of oyster, 1 part of Chinese forest frog, 2 parts of pearl oyster, 1 part of medlar, 1 part of straw mushroom, 2 parts of abalone and 2 parts of sea horse.

Example 2

The formula of the sea cucumber and oyster extract micromolecule peptide comprises the following components in parts by weight: 40 parts of sea cucumber, 40 parts of oyster, 2 parts of Chinese forest frog, 3.5 parts of pearl oyster, 2 parts of medlar, 2 parts of straw mushroom, 3.5 parts of abalone and 3.5 parts of sea horse.

Example 3

The formula of the sea cucumber and oyster extract micromolecule peptide comprises the following components in parts by weight: 50 parts of sea cucumber, 45 parts of oyster, 3 parts of Chinese forest frog, 5 parts of pearl oyster, 3 parts of medlar, 3 parts of straw mushroom, 5 parts of abalone and 5 parts of sea horse.

The preparation method of the sea cucumber and oyster extract micromolecular peptide formula in the above embodiments 1-3 comprises the following steps:

s1: weighing raw materials of sea cucumber, oyster, Chinese forest frog, pearl oyster, medlar, straw mushroom, abalone and sea horse according to parts by mass, cleaning, airing, draining surface water, and crushing into original slurry for later use;

s2: adding one or more of papain, flavourzyme and animal protease into the original slurry, wherein the addition amount of the protease is 4000-;

s3: sequentially passing the supernatant in the S2 through a reverse osmosis membrane with the molecular weight cutoff of 5000 and a reverse osmosis membrane with the molecular weight cutoff of 300 to obtain a small molecular peptide mixed solution;

s4: and (3) placing the small molecular peptide mixed solution in a vacuum concentrator for concentration and drying to obtain a small molecular active peptide powder product.

According to the formula and the preparation method of the sea cucumber and oyster extract micromolecule peptide, the molecular peptide biotechnology is applied to the processing process of sea cucumber and oyster, and the compound micromolecule peptide functional food is prepared through enzymolysis, the micromolecule oligopeptide formed by the preparation method completely reserves the original nutritional ingredients of all the ingredients, is absorbed more quickly than single amino acid or protein after being ingested by a human body, is absorbed by the human body more easily, has more important biological activity in the aspect of human body metabolism, and has higher biological value and more important physiological function than the conventional medicine and food homologous products; moreover, due to the strong carrying capacity of the small molecular peptide, the effective components of the raw materials can be fully absorbed by human bodies, and the small molecular peptide is pure natural and full-nutritional and achieves a certain health-care effect.

The embodiments described above are preferred embodiments of the present invention, and not all embodiments. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.