阅读说明：本技术 一种（r）-3-氨基丁醇的制备方法 (Preparation method of (R) -3-aminobutanol ) 是由 陈佳慧 严间浪 于 2021-10-25 设计创作，主要内容包括：本发明属于医药化工领域,具体涉及一种(R)-3-氨基丁醇的制备方法,包括如下步骤：a,将还原剂与(R)-3-氨基丁酸进行还原反应,从而得到含(R)-3-氨基丁醇的混合物,且所述还原剂为硼氢化锂；b,对(R)-3-氨基丁醇的混合物进行提纯处理,得到(R)-3-氨基丁醇。本发明解决了现有工艺的缺陷,采用硼氢化锂作为还原剂,并且通过乙醚溶解稀释后缓慢滴加反应,不仅能够有效的提升收率,而且有效的控制反应的进行,降低反应的风险,易于操作。(The invention belongs to the field of pharmaceutical chemicals, and particularly relates to a preparation method of (R) -3-aminobutanol, which comprises the following steps: a, carrying out reduction reaction on a reducing agent and (R) -3-aminobutyric acid to obtain a mixture containing (R) -3-aminobutanol, wherein the reducing agent is lithium borohydride; and b, purifying the mixture of the (R) -3-aminobutanol to obtain the (R) -3-aminobutanol. The invention overcomes the defects of the prior art, adopts lithium borohydride as a reducing agent, and slowly dropwise adds the reducing agent after dissolving and diluting the reducing agent by ether for reaction, thereby not only effectively improving the yield, but also effectively controlling the reaction, reducing the risk of the reaction and being easy to operate.)

1. A method for synthesizing (R) -3-aminobutanol is characterized in that: the method comprises the following steps:

a, carrying out reduction reaction on a reducing agent and (R) -3-aminobutyric acid to obtain a mixture containing (R) -3-aminobutanol, wherein the reducing agent is lithium borohydride;

and b, purifying the mixture of the (R) -3-aminobutanol to obtain the (R) -3-aminobutanol.

2. The method for synthesizing (R) -3-aminobutanol according to claim 1, wherein: the specific steps in the step a are as follows:

a1, adding a reducing agent into anhydrous ether, and uniformly stirring to form ether solution;

a2, adding (R) -3-aminobutyric acid into tetrahydrofuran, stirring for 20-40min, and then introducing a small amount of hydrogen chloride gas to form a dissolved solution;

a3, slowly dripping the ether solution into the dissolved solution for low-temperature reaction, concentrating at constant temperature, refluxing at constant temperature for overnight reaction to obtain a mixture containing (R) -3-aminobutanol.

3. The method for synthesizing (R) -3-aminobutanol according to claim 2, wherein: the concentration of the reducing agent in the a1 in the anhydrous ether is 400g/L, the temperature is 5-10 ℃, and the stirring speed is 300-800 r/min.

4. The method for synthesizing (R) -3-aminobutanol according to claim 2, wherein: the concentration of the (R) -3-aminobutyric acid in the a2 in the tetrahydrofuran is 200-500g/L, the temperature is 10-20 ℃, the stirring speed is 1000-2000R/min, and the introduction amount of the hydrogen chloride is 0.5-1.0 percent of the molar amount of the (R) -3-aminobutyric acid.

5. The method for synthesizing (R) -3-aminobutanol according to claim 2, wherein: the molar ratio of the lithium borohydride in the diethyl ether solution in the a3 to the (R) -3-aminobutanol in the dissolving solution is 2.1-3.0:1, the dropping speed of the diethyl ether solution is 3-5mL/min, the temperature of the low-temperature reaction is 5-10 ℃, the temperature of the constant-temperature concentration is 35-45 ℃, the time is 30-50min, and the temperature of the constant-temperature reflux overnight is 65-70 ℃.

6. The method for synthesizing (R) -3-aminobutanol according to claim 1, wherein: the specific steps in b are as follows:

b1, standing the mixture containing the (R) -3-aminobutanol at constant temperature until the mixture is dried to obtain mixed solid;

b2, adding the mixed solid into anhydrous ether, stirring uniformly to form a suspension, then filtering to obtain filter residue, and drying to obtain a crude product;

b3, adding the crude product into distilled water, stirring for 20-30min, filtering, putting the filter residue into anhydrous ether, stirring and standing, fixing porous water-absorbing particles in the supernatant, standing for 3-6h, filtering, and drying to obtain the product.

7. The method for synthesizing (R) -3-aminobutanol according to claim 6, wherein: and the constant-temperature standing temperature in b1 is 70-80 ℃, and the evaporated tetrahydrofuran is recovered to obtain tetrahydrofuran liquid.

8. The method for synthesizing (R) -3-aminobutanol according to claim 6, wherein: the drying temperature in b2 is 50-60 ℃.

9. The method for synthesizing (R) -3-aminobutanol according to claim 6, wherein: the porous water-absorbing particles in b3 are made of water-absorbing materials with porous alumina as a shell and vermiculite as an inner core.

10. The method for synthesizing (R) -3-aminobutanol according to claim 6, wherein: the drying temperature in the b3 is 50-60 ℃.

Technical Field

The invention belongs to the field of pharmaceutical chemicals, and particularly relates to a preparation method of (R) -3-aminobutanol.

Background

(R) -3-aminobutanol, formula: c₄H₁₁NO, molecular weight: 89.14, physical and chemical properties: colorless transparent liquid, soluble in ethyl acetate, methanol and DMF, insoluble in water.

The (R) -3-aminobutanol is an important raw material of a dolutegravir synthetic route, is an intermediate of antineoplastic 4-methyl cyclophosphamide, and can also be derived into beta-lactam which is used as an important intermediate for synthesizing penem antibiotics.

At present, (R) -3-aminobutanol is mainly produced by foreign manufacturers through a chemical synthesis method, the yield is 60-70 wt%, the domestic market of the (R) -3-aminobutanol is blank, and the market demand of the (R) -3-aminobutanol is increased with the increasing influence of dolutegravir on the international market.

For example, Chinese patent CN201710219841 reports a method for preparing (R) -3-aminobutanol by using (R) -3-aminobutyric acid as a raw material and performing one-step reduction by using borohydride and protonic acid. The protonic acid adopted in the reaction process is concentrated sulfuric acid which has strong oxidizing property and can react rapidly when meeting water, particularly react with borohydride directly, and the reaction heat is huge and has potential safety hazards such as carelessness, severe temperature rise, material flushing and the like.

Therefore, a method for producing (R) -3-aminobutanol with high yield and high purity is urgently needed in the market.

Disclosure of Invention

Aiming at the problems in the prior art, the invention provides a method for synthesizing (R) -3-aminobutanol, which solves the defects of the prior art, adopts lithium borohydride as a reducing agent, and slowly dropwise adds the reducing agent after dissolving and diluting with diethyl ether for reaction, thereby not only effectively improving the yield, but also effectively controlling the reaction, reducing the risk of the reaction and being easy to operate.

In order to achieve the technical purpose, the technical scheme of the invention is as follows:

a method for synthesizing (R) -3-aminobutanol comprises the following steps:

a, carrying out reduction reaction on a reducing agent and (R) -3-aminobutyric acid to obtain a mixture containing (R) -3-aminobutanol, wherein the reducing agent is lithium borohydride;

and b, purifying the mixture of the (R) -3-aminobutanol to obtain the (R) -3-aminobutanol.

The specific steps in the step a are as follows:

a1, adding a reducing agent into anhydrous ether, and uniformly stirring to form an ether solution, wherein the concentration of the reducing agent in the anhydrous ether is 400g/L, the temperature is 5-10 ℃, and the stirring speed is 800 r/min;

a2, adding (R) -3-aminobutyric acid into tetrahydrofuran, stirring for 20-40min, and then introducing a small amount of hydrogen chloride gas to form a dissolved solution; the concentration of the (R) -3-aminobutyric acid in tetrahydrofuran is 200-500g/L, the temperature is 10-20 ℃, the stirring speed is 1000-2000R/min, and the introduction amount of the hydrogen chloride is 0.5-1.0 percent of the molar amount of the (R) -3-aminobutyric acid;

3, slowly dripping an ether solution into a dissolved solution for low-temperature reaction, concentrating at constant temperature, refluxing at constant temperature for overnight reaction to obtain a mixture containing (R) -3-aminobutanol, wherein the molar ratio of lithium borohydride in the ether solution to (R) -3-aminobutanol in the dissolved solution is 2.1-3.0:1, the dripping speed of the ether solution is 3-5mL/min, the temperature of the low-temperature reaction is 5-10 ℃, the temperature of the constant-temperature concentration is 35-45 ℃, the time is 30-50min, and the temperature of the constant-temperature reflux for overnight reaction is 65-70 ℃; the constant-temperature concentration mainly removes the ether, converts the original ether-tetrahydrofuran mixed system into a tetrahydrofuran system, and simultaneously recovers and reuses the ether.

The specific steps in b are as follows:

b1, standing the mixture containing the (R) -3-aminobutanol at constant temperature until the mixture is dried to obtain mixed solid; standing at a constant temperature of 70-80 deg.C, and recovering evaporated tetrahydrofuran to obtain tetrahydrofuran solution;

b2, adding the mixed solid into anhydrous ether, stirring uniformly to form a suspension, then filtering to obtain filter residue, and drying to obtain a crude product; the drying temperature is 50-60 ℃;

b3, adding the crude product into distilled water, stirring for 20-30min, filtering, putting the filter residue into anhydrous ether, stirring and standing, fixing porous water-absorbing particles in the supernatant, standing for 3-6h, filtering, and drying to obtain a product; the porous water-absorbing particles are made of a water-absorbing material which takes porous alumina as a shell and vermiculite as an inner core. The drying temperature is 50-60 ℃.

The porous water-absorbing particles are positioned in the supernatant in the ether, and continuously absorb the distilled water slightly soluble in the ether, and simultaneously, the water molecules in the crude product are quickly removed by continuous absorption of water and slight solubility, so that the effect of complete drying is achieved. The preparation method of the porous water-absorbing particles comprises the following steps: c1, adding vermiculite into ether, performing low-temperature ball milling reaction to obtain fine powder slurry, wherein the mass ratio of the vermiculite to the ether is 8-10:1, the low-temperature ball milling temperature is 5-10 ℃, and the ball milling pressure is 0.8-0.9 MPa; c2, adding ethyl cellulose into the fine powder slurry, adding diethyl ether to form a micro-thick material, distilling and granulating to form mixed particles, wherein the ethyl cellulose is ethylThe mass ratio of the cellulose to the vermiculite is 1:6-9, the concentration of the ethyl cellulose of the micro-thick material is 80-150g/L, the distillation temperature is 40-50 ℃, the volume after distillation is 10-30% of the volume of the micro-thick material, and the granulation temperature is 50-70 ℃; recovering ether vapor generated by distillation and ether vapor formed by granulation to obtain ether liquid; c3, adding ethyl cellulose into anhydrous ether, stirring uniformly, then spraying on the mixed particles, drying to obtain the coated mixed particles, wherein the concentration of the ethyl cellulose in the anhydrous ether is 800g/L, the stirring speed is 500r/min, and the spraying amount of the spraying is 20-40mL/cm²C4, dissolving aluminum isopropoxide in isopropanol, spraying on the surface of the coated mixed particle, and repeatedly spraying and drying for multiple times to obtain secondary coated particles, wherein the concentration of aluminum isopropoxide in isopropanol is 500-800g/L, and the single spraying amount of spraying is 2-5mL/cm²The drying temperature is 70-80 ℃, and the times are 5-20; c5, standing the secondary coated particles for 30-60min, and then carrying out constant-temperature illumination treatment for 2-5h to obtain porous water-absorbing particles, wherein the standing atmosphere is as follows: the volume ratio of water vapor is 8-10%, the rest is nitrogen, the standing temperature is 60-80 ℃, the temperature of the constant-temperature illumination treatment is 200-²。

From the above description, it can be seen that the present invention has the following advantages:

1. the invention overcomes the defects of the prior art, adopts lithium borohydride as a reducing agent, and slowly dropwise adds the reducing agent after dissolving and diluting the reducing agent by ether for reaction, thereby not only effectively improving the yield, but also effectively controlling the reaction, reducing the risk of the reaction and being easy to operate.

2. The invention uses the ether as a dissolving agent, an impurity removing agent and a diluting agent, and the ether is recycled in the process, thereby reducing the cost and effectively improving the product purity.

3. The invention utilizes the slightly soluble characteristic of the ether and the distilled water and the water absorption effect of the water absorption material to form a slow water absorption and removal effect, and quickly removes the water on the (R) -3-aminobutanol.

4. The invention provides a protonic acid system in ether by using hydrogen chloride, and has the effect of improving the efficiency.

Detailed Description

The present invention is described in detail with reference to examples, but the present invention is not limited to the claims.

Example 1

A method for synthesizing (R) -3-aminobutanol comprises the following steps:

a, carrying out reduction reaction on a reducing agent and (R) -3-aminobutyric acid to obtain a mixture containing (R) -3-aminobutanol, wherein the reducing agent is lithium borohydride;

the method comprises the following specific steps:

a1, adding a reducing agent into anhydrous ether, and uniformly stirring to form an ether solution, wherein the concentration of the reducing agent in the anhydrous ether is 100g/L, the temperature is 5 ℃, and the stirring speed is 300 r/min;

a2, adding (R) -3-aminobutyric acid into tetrahydrofuran, stirring for 20min, and then introducing a small amount of hydrogen chloride gas to form a dissolved solution; the concentration of the (R) -3-aminobutyric acid in tetrahydrofuran is 200g/L, the temperature is 10 ℃, the stirring speed is 1000R/min, and the introduction amount of the hydrogen chloride is 0.5 percent of the molar amount of the (R) -3-aminobutyric acid;

3, slowly dripping an ether solution into a dissolved solution for low-temperature reaction, concentrating at a constant temperature, refluxing at the constant temperature for overnight reaction to obtain a mixture containing (R) -3-aminobutanol, wherein the molar ratio of lithium borohydride in the ether solution to (R) -3-aminobutanol in the dissolved solution is 2.1:1, the dripping speed of the ether solution is 3mL/min, the temperature of the low-temperature reaction is 5 ℃, the temperature of the constant-temperature concentration is 35 ℃, the time is 30min, and the temperature of the constant-temperature reflux for overnight reaction is 65 ℃; the constant-temperature concentration mainly removes the ether, converts the original ether-tetrahydrofuran mixed system into a tetrahydrofuran system, and simultaneously recovers the ether for reuse;

b, purifying the mixture of the (R) -3-aminobutanol to obtain the (R) -3-aminobutanol;

the method comprises the following specific steps:

b1, standing the mixture containing the (R) -3-aminobutanol at constant temperature until the mixture is dried to obtain mixed solid; standing at a constant temperature of 70 ℃, and recovering evaporated tetrahydrofuran to obtain tetrahydrofuran liquid;

b2, adding the mixed solid into anhydrous ether, stirring uniformly to form a suspension, then filtering to obtain filter residue, and drying to obtain a crude product; the drying temperature is 50 ℃;

b3, adding the crude product into distilled water, stirring for 20min, filtering, putting the filter residue into anhydrous ether, stirring and standing, fixing porous water-absorbing particles in the supernatant, standing for 3h, filtering, and drying to obtain a product; the porous water-absorbing particles are made of a water-absorbing material which takes porous alumina as a shell and vermiculite as an inner core. The drying temperature is 50 ℃.

Wherein the porous water-absorbing particles are positioned in supernatant liquor in diethyl ether, and the preparation method of the porous water-absorbing particles comprises the following steps: c1, adding vermiculite into ether, performing low-temperature ball milling reaction to obtain fine powder slurry, wherein the mass ratio of the vermiculite to the ether is 8:1, the low-temperature ball milling temperature is 5 ℃, and the ball milling pressure is 0.8 MPa; c2, adding ethyl cellulose into the fine powder slurry, adding diethyl ether to form a micro-thick material, distilling and granulating to form mixed particles, wherein the mass ratio of the ethyl cellulose to the vermiculite is 1:6, the concentration of the ethyl cellulose of the micro-thick material is 80g/L, the distillation temperature is 40 ℃, the volume after distillation is 10% of the volume of the micro-thick material, and the granulation temperature is 50 ℃; recovering ether vapor generated by distillation and ether vapor formed by granulation to obtain ether liquid; c3, adding ethyl cellulose into anhydrous ether, uniformly stirring, spraying on the mixed particles, and drying to obtain coated mixed particles, wherein the concentration of the ethyl cellulose in the anhydrous ether is 300g/L, the stirring speed is 500r/min, and the spraying amount of the spraying is 20mL/cm²And c4, dissolving aluminum isopropoxide in isopropanol, spraying on the surface of the coated mixed particle, and repeatedly spraying and drying for multiple times to obtain a secondary coated particle, wherein the concentration of aluminum isopropoxide in isopropanol is 500g/L, and the single spraying amount of spraying is 2mL/cm²The drying temperature is 70 ℃, and the times are 5; c5, standing the secondary coating particles for 30min, and keeping the temperature constantAnd (3) performing light treatment for 2h to obtain porous water-absorbing particles, wherein the standing atmosphere is as follows: the water vapor volume ratio is 8%, the rest is nitrogen, the standing temperature is 60 deg.C, the constant temperature illumination treatment temperature is 200 deg.C, and the illumination intensity is 5W/cm²。

In this example, the yield of (R) -3-aminobutanol was 82.3% by weight, the purity was 99.1%, ee: 99.0 percent.

Example 2

A method for synthesizing (R) -3-aminobutanol comprises the following steps:

a, carrying out reduction reaction on a reducing agent and (R) -3-aminobutyric acid to obtain a mixture containing (R) -3-aminobutanol, wherein the reducing agent is lithium borohydride;

the method comprises the following specific steps:

a1, adding a reducing agent into anhydrous ether, and uniformly stirring to form an ether solution, wherein the concentration of the reducing agent in the anhydrous ether is 400g/L, the temperature is 10 ℃, and the stirring speed is 800 r/min;

a2, adding (R) -3-aminobutyric acid into tetrahydrofuran, stirring for 40min, and then introducing a small amount of hydrogen chloride gas to form a dissolved solution; the concentration of the (R) -3-aminobutyric acid in tetrahydrofuran is 500g/L, the temperature is 20 ℃, the stirring speed is 2000R/min, and the introduction amount of the hydrogen chloride is 1.0 percent of the molar amount of the (R) -3-aminobutyric acid;

a3, slowly dripping an ether solution into a dissolved solution for low-temperature reaction, concentrating at constant temperature, refluxing at constant temperature for overnight reaction to obtain a mixture containing (R) -3-aminobutanol, wherein the molar ratio of lithium borohydride in the ether solution to (R) -3-aminobutanol in the dissolved solution is 3.0:1, the dripping speed of the ether solution is 5mL/min, the temperature of the low-temperature reaction is 10 ℃, the temperature of the constant-temperature concentration is 45 ℃, the time is 50min, and the temperature of the constant-temperature reflux for overnight reaction is 70 ℃; the constant-temperature concentration mainly removes the ether, converts the original ether-tetrahydrofuran mixed system into a tetrahydrofuran system, and simultaneously recovers the ether for reuse;

b, purifying the mixture of the (R) -3-aminobutanol to obtain the (R) -3-aminobutanol;

the method comprises the following specific steps:

b1, standing the mixture containing the (R) -3-aminobutanol at constant temperature until the mixture is dried to obtain mixed solid; standing at a constant temperature of 80 ℃, and recovering evaporated tetrahydrofuran to obtain tetrahydrofuran liquid;

b2, adding the mixed solid into anhydrous ether, stirring uniformly to form a suspension, then filtering to obtain filter residue, and drying to obtain a crude product; the drying temperature is 60 ℃;

b3, adding the crude product into distilled water, stirring for 30min, filtering, putting the filter residue into anhydrous ether, stirring and standing, fixing porous water-absorbing particles in the supernatant, standing for 6h, filtering, and drying to obtain a product; the porous water-absorbing particles are made of a water-absorbing material which takes porous alumina as a shell and vermiculite as an inner core. The drying temperature is 60 ℃.

Wherein the porous water-absorbing particles are positioned in supernatant liquor in diethyl ether, and the preparation method of the porous water-absorbing particles comprises the following steps: c1, adding vermiculite into ether, performing low-temperature ball milling reaction to obtain fine powder slurry, wherein the mass ratio of the vermiculite to the ether is 10:1, the low-temperature ball milling temperature is 10 ℃, and the ball milling pressure is 0.9 MPa; c2, adding ethyl cellulose into the fine powder slurry, adding ether to form a micro-thick material, distilling and granulating to form mixed particles, wherein the mass ratio of the ethyl cellulose to the vermiculite is 1:9, the concentration of the ethyl cellulose of the micro-thick material is 150g/L, the distillation temperature is 50 ℃, the volume after distillation is 30% of the volume of the micro-thick material, and the granulation temperature is 70 ℃; recovering ether vapor generated by distillation and ether vapor formed by granulation to obtain ether liquid; c3, adding ethyl cellulose into anhydrous ether, uniformly stirring, spraying on the mixed particles, and drying to obtain coated mixed particles, wherein the concentration of the ethyl cellulose in the anhydrous ether is 800g/L, the stirring speed is 900r/min, and the spraying amount of the spraying is 40mL/cm²And c4, dissolving aluminum isopropoxide in isopropanol, spraying on the surface of the coated mixed particle, and repeatedly spraying and drying for multiple times to obtain a secondary coated particle, wherein the concentration of aluminum isopropoxide in isopropanol is 800g/L, and the single spraying amount of spraying is 5mL/cm²The drying temperature is 80 ℃, and the times are 20; c5, standing the secondary coating particles for 60min, and then carrying out constant-temperature illumination treatment for 5h to obtain porous water-absorbing particles, wherein the standing atmosphere is as follows: the water vapor accounts for 10% by volume, the rest is nitrogen, the standing temperature is 80 deg.C, the constant temperature illumination treatment temperature is 230 deg.C, and the illumination intensity is 10W/cm²。

In this example, the yield of (R) -3-aminobutanol was 84.1% by weight, the purity was 99.3%, ee: 99.0 percent.

Example 3

A method for synthesizing (R) -3-aminobutanol comprises the following steps:

a, carrying out reduction reaction on a reducing agent and (R) -3-aminobutyric acid to obtain a mixture containing (R) -3-aminobutanol, wherein the reducing agent is lithium borohydride;

the method comprises the following specific steps:

a1, adding a reducing agent into anhydrous ether, and uniformly stirring to form an ether solution, wherein the concentration of the reducing agent in the anhydrous ether is 300g/L, the temperature is 8 ℃, and the stirring speed is 600 r/min;

a2, adding (R) -3-aminobutyric acid into tetrahydrofuran, stirring for 30min, and then introducing a small amount of hydrogen chloride gas to form a dissolved solution; the concentration of the (R) -3-aminobutyric acid in tetrahydrofuran is 400g/L, the temperature is 15 ℃, the stirring speed is 1500R/min, and the introduction amount of the hydrogen chloride is 0.8 percent of the molar amount of the (R) -3-aminobutyric acid;

3, slowly dripping an ether solution into a dissolved solution for low-temperature reaction, concentrating at constant temperature, refluxing at constant temperature for overnight reaction to obtain a mixture containing (R) -3-aminobutanol, wherein the molar ratio of lithium borohydride in the ether solution to (R) -3-aminobutanol in the dissolved solution is 2.6:1, the dripping speed of the ether solution is 4mL/min, the temperature of the low-temperature reaction is 8 ℃, the temperature of the constant-temperature concentration is 40 ℃, the time is 40min, and the temperature of the constant-temperature reflux for overnight reaction is 70 ℃; the constant-temperature concentration mainly removes the ether, converts the original ether-tetrahydrofuran mixed system into a tetrahydrofuran system, and simultaneously recovers the ether for reuse;

b, purifying the mixture of the (R) -3-aminobutanol to obtain the (R) -3-aminobutanol;

the method comprises the following specific steps:

b1, standing the mixture containing the (R) -3-aminobutanol at constant temperature until the mixture is dried to obtain mixed solid; standing at a constant temperature of 75 ℃, and recovering evaporated tetrahydrofuran to obtain tetrahydrofuran liquid;

b2, adding the mixed solid into anhydrous ether, stirring uniformly to form a suspension, then filtering to obtain filter residue, and drying to obtain a crude product; the drying temperature is 55 ℃;

b3, adding the crude product into distilled water, stirring for 25min, filtering, putting the filter residue into anhydrous ether, stirring and standing, fixing porous water-absorbing particles in the supernatant, standing for 5h, filtering, and drying to obtain a product; the porous water-absorbing particles are made of a water-absorbing material which takes porous alumina as a shell and vermiculite as an inner core. The temperature of the drying is 55 ℃.

Wherein the porous water-absorbing particles are positioned in supernatant liquor in diethyl ether, and the preparation method of the porous water-absorbing particles comprises the following steps: c1, adding vermiculite into ether, performing low-temperature ball milling reaction to obtain fine powder slurry, wherein the mass ratio of the vermiculite to the ether is 9:1, the low-temperature ball milling temperature is 8 ℃, and the ball milling pressure is 0.9 MPa; c2, adding ethyl cellulose into the fine powder slurry, adding diethyl ether to form a micro-thick material, distilling and granulating to form mixed particles, wherein the mass ratio of the ethyl cellulose to the vermiculite is 1:8, the concentration of the ethyl cellulose of the micro-thick material is 120g/L, the distillation temperature is 45 ℃, the volume after distillation is 20% of the volume of the micro-thick material, and the granulation temperature is 60 ℃; recovering ether vapor generated by distillation and ether vapor formed by granulation to obtain ether liquid; c3, adding ethyl cellulose into anhydrous ether, uniformly stirring, spraying on the mixed particles, and drying to obtain coated mixed particles, wherein the concentration of the ethyl cellulose in the anhydrous ether is 600g/L, the stirring speed is 700r/min, and the spraying amount of the spraying is 30mL/cm²C4, dissolving aluminum isopropoxide in isopropanol, spraying on the surface of the coated mixed particles, and repeatedly spraying and drying for multiple times to obtain secondary coated particles, wherein the isopropanol is 70 ℃, and the drying temperature is c4The concentration of aluminum in isopropanol was 700g/L, and the single-pass spray volume of the spray was 4mL/cm²The drying temperature is 75 ℃, and the times are 10; c5, standing the secondary coated particles for 50min, and then carrying out constant-temperature illumination treatment for 4h to obtain porous water-absorbing particles, wherein the standing atmosphere is as follows: the volume ratio of water vapor is 9%, the rest is nitrogen, the standing temperature is 70 deg.C, the temperature of constant temperature illumination treatment is 220 deg.C, and the illumination intensity is 8W/cm²。

In this example, the yield of (R) -3-aminobutanol was 82.7% by weight, the purity was 99.3%, ee: 99.0 percent.

It should be understood that the detailed description of the invention is merely illustrative of the invention and is not intended to limit the invention to the specific embodiments described. It will be appreciated by those skilled in the art that the present invention may be modified or substituted equally as well to achieve the same technical result; as long as the use requirements are met, the method is within the protection scope of the invention.