阅读说明：本技术 包含tnfr2结构域的新型car构建体 (Novel CAR constructs comprising TNFR2 domains ) 是由 T·亚伯 达维德·弗纳尔 J·格特纳-达登内 F·迈耶 于 2019-08-09 设计创作，主要内容包括：本发明涉及包含人TNFR2跨膜结构域(TM)或其片段或变体和/或人TNFR2共刺激性细胞内信号传导结构域或其片段或变体的嵌合抗原受体(CAR),以及表达上述CAR的免疫细胞。本发明进一步涉及包括施用表达嵌合抗原受体(CAR)的免疫细胞的治疗方法,所述嵌合抗原受体(CAR)包含人TNFR2跨膜结构域(TM)或其片段或变体和/或人TNFR2共刺激性细胞内信号传导结构域或其片段或变体。(The present invention relates to Chimeric Antigen Receptors (CARs) comprising the human TNFR2 transmembrane domain (TM) or a fragment or variant thereof and/or the human TNFR2 co-stimulatory intracellular signaling domain or a fragment or variant thereof, and immune cells expressing the above CARs. The invention further relates to methods of treatment comprising administering an immune cell expressing a Chimeric Antigen Receptor (CAR) comprising human TNFR2 transmembrane domain (TM) or a fragment or variant thereof and/or human TNFR2 co-stimulatory intracellular signaling domain or a fragment or variant thereof.)