阅读说明：本技术 一种含nadh的组合物及其制作方法 (Composition containing NADH and preparation method thereof ) 是由 曹小霞 于 2021-08-03 设计创作，主要内容包括：本发明公开了一种含NADH的组合物,包括：3-12重量份β-烟酰胺单核苷酸、1-4重量份Y-氨基丁酸、3-5重量份鳄梨粉、1-4重量份针叶樱桃粉、1-2重量份酵母β-葡聚糖、3-10重量份氢化珊瑚钙。其制作方法包括如下步骤：S100、将上述各组分原料进行干燥,然后再粉碎,最后以400目的目筛过筛,得均匀原料颗粒；S200、按照上述重量份配比对各原料进行称取备用；S300、将步骤S200中获取的各原料先混合,再加热,最后搅拌即得所述组合物。本发明利用氢化珊瑚钙对β-烟酰胺单核苷酸进行氢化,且提供相应的制作方法,形成NADH,使得材料和工艺的成本降低,效果更好。(The invention discloses a composition containing NADH, which comprises the following components: 3-12 parts of beta-nicotinamide mononucleotide, 1-4 parts of Y-aminobutyric acid, 3-5 parts of avocado powder, 1-4 parts of acerola powder, 1-2 parts of yeast beta-glucan and 3-10 parts of coral calcium hydride. The manufacturing method comprises the following steps: s100, drying the raw materials of the components, then crushing, and finally sieving by using a 400-mesh sieve to obtain uniform raw material particles; s200, weighing the raw materials according to the weight ratio for later use; s300, mixing the raw materials obtained in the step S200, heating, and finally stirring to obtain the composition. The invention hydrogenates beta-nicotinamide mononucleotide with coral calcium hydride, and provides a corresponding preparation method to form NADH, so that the cost of materials and processes is reduced, and the effect is better.)

1. A NADH-containing composition comprising: 3-12 parts of beta-nicotinamide mononucleotide, 1-4 parts of Y-aminobutyric acid, 3-5 parts of avocado powder, 1-4 parts of acerola powder, 1-2 parts of yeast beta-glucan and 3-10 parts of coral calcium hydride.

2. The NADH-containing composition of claim 1 wherein: also comprises 2 to 4 weight portions of resveratrol.

3. The NADH-containing composition of claim 2 wherein: also comprises 2-6 parts by weight of yeast extract.

4. The NADH-containing composition of claim 3, wherein: also comprises 3-7 parts by weight of calcium carbonate.

5. The NADH-containing composition of claim 4, wherein: also comprises tricalcium phosphate in 4-9 weight portions.

6. The NADH-containing composition of claim 5, wherein: also comprises 2-6 parts by weight of silicon dioxide.

7. A method of making the composition of claim 6, comprising the steps of:

s100, drying the raw materials of the components, then crushing, and finally sieving by using a 400-mesh sieve to obtain uniform raw material particles;

s200, weighing the raw materials according to the weight ratio for later use;

s300, mixing the raw materials obtained in the step S200, heating, and finally stirring to obtain the composition.

8. A method of preparing a composition according to claim 7, wherein: the drying temperature in the step 100 is 30-40 ℃, and the drying time is 5-30 min.

9. A method of preparing a composition according to claim 8, wherein: 1-2 parts by weight of hot water is added during mixing in the step 300, and the temperature of the hot water is 30-50 ℃.

10. A method of preparing a composition according to claim 9, wherein: the heating temperature in the step 300 is 40-65 ℃.

Technical Field

The invention relates to a composition containing NADH and a preparation method thereof.

Background

NADH (Nicotinamide adenine dinucleotide) is a chemical substance, is the reduced state of nicotinamide adenine dinucleotide, namely reduced coenzyme I. N is nicotinamide, A is adenine and D is a dinucleotide. NAD is in an oxidized state, NADH is in a reduced state, and NAD is hydrogenated.

NADH is produced in the citrate cycle in glycolysis and cellular respiration. NADH molecules are control markers in the energy-producing chain in mitochondria. An increase in NADH levels indicates the occurrence of a metabolic imbalance. Monitoring the redox state of NADH is the best parameter to characterize mitochondrial function in vivo. The ultraviolet light can excite NADH in mitochondria to generate fluorescence, and is used for monitoring the functions of the mitochondria. Thus, NADH-containing compositions are sometimes also used as supplements.

The existing NADH complement agent has the disadvantages of high hydrogenation (reduction state) cost, complex preparation process, high preparation cost and unobvious effect.

Disclosure of Invention

In view of the above, it is an object of the present invention to provide a NADH-containing composition that satisfies better use effects, and the scheme is as follows:

a NADH-containing composition comprising: 3-12 parts of beta-nicotinamide mononucleotide, 1-4 parts of Y-aminobutyric acid, 3-5 parts of avocado powder, 1-4 parts of acerola powder, 1-2 parts of yeast beta-glucan and 3-10 parts of coral calcium hydride.

Further, 2-4 parts by weight of resveratrol.

Further, the yeast extract also comprises 2-6 parts by weight of yeast extract.

Further, the calcium carbonate also comprises 3-7 parts by weight of calcium carbonate.

Further, the coating also comprises 4 to 9 weight parts of tricalcium phosphate.

Further, the paint also comprises 2-6 parts by weight of silicon dioxide.

Another object of the present invention is to provide a method for preparing the above composition, comprising the steps of:

s100, drying the raw materials of the components, then crushing, and finally sieving by using a 400-mesh sieve to obtain uniform raw material particles;

s200, weighing the raw materials according to the weight ratio for later use;

s300, mixing the raw materials obtained in the step S200, heating, and finally stirring to obtain the composition.

Further, the drying temperature in the step 100 is 30-40 ℃, and the drying time is 5-30 min.

Further, 1-2 parts by weight of hot water is added during mixing in the step 300, and the temperature of the hot water is 30-50 ℃.

Further, the heating temperature in the step 300 is 40-65 ℃.

Has the advantages that: the invention has novel concept, reasonable design and convenient use, hydrogenates beta-nicotinamide mononucleotide by using coral calcium hydride, and provides a corresponding preparation method to form NADH, thereby reducing the cost of materials and processes and having better effect.

Detailed Description

The following examples illustrate the invention in further preference during its practice:

an NADH-containing composition comprising: 3-12 parts of beta-nicotinamide mononucleotide, 1-4 parts of Y-aminobutyric acid, 3-5 parts of avocado powder, 1-4 parts of acerola powder, 1-2 parts of yeast beta-glucan and 3-10 parts of coral calcium hydride.

Further, in a specific embodiment, the method comprises the following steps: 3 parts by weight of beta-nicotinamide mononucleotide, 1 part by weight of Y-aminobutyric acid, 3 parts by weight of avocado powder, 1 part by weight of acerola powder, 1 part by weight of yeast beta-glucan and 3 parts by weight of coral calcium hydride.

Further, in a specific embodiment, the method comprises the following steps: 12 parts by weight of beta-nicotinamide mononucleotide, 4 parts by weight of Y-aminobutyric acid, 5 parts by weight of avocado powder, 4 parts by weight of acerola powder, 2 parts by weight of yeast beta-glucan and 10 parts by weight of coral calcium hydride.

Further, in a specific embodiment, the method comprises the following steps: 5 parts by weight of beta-nicotinamide mononucleotide, 2 parts by weight of Y-aminobutyric acid, 4 parts by weight of avocado powder, 2 parts by weight of acerola powder, 1.5 parts by weight of yeast beta-glucan and 5 parts by weight of coral calcium hydride.

In some embodiments, 2-4 parts by weight of resveratrol is also included.

Further, in a specific implementation, 2 parts by weight of resveratrol is also included.

Further, in a specific implementation, 4 parts by weight of resveratrol is also included.

Further, in a specific implementation, the resveratrol-containing beverage also comprises 3 parts by weight of resveratrol.

In some embodiments, 2 to 6 parts by weight of yeast extract is also included.

Further, in a specific embodiment, the yeast extract is included in an amount of 2 parts by weight.

Further, in a specific implementation, 6 parts by weight of yeast extract is also included.

Further, in a specific implementation, the yeast extract also comprises 4 parts by weight of yeast extract.

In some embodiments, 3 to 7 parts by weight of calcium carbonate is also included.

Further, in one specific implementation, 3 parts by weight of calcium carbonate is included.

Further, in one specific implementation, 7 parts by weight of calcium carbonate is included.

Further, in one specific implementation, 5 parts by weight of calcium carbonate is included.

In some embodiments, 4 to 9 parts by weight of tricalcium phosphate is also included.

Further, in one specific implementation, 4 parts by weight of tricalcium phosphate is also included.

Further, in one specific implementation, 9 parts by weight of tricalcium phosphate is also included.

Further, in one specific implementation, 6 parts by weight of tricalcium phosphate is also included.

In some embodiments, 2 to 6 parts by weight of silica is also included.

Further, in one specific implementation, 2 parts by weight of silica is also included.

Further, in one specific implementation, 6 parts by weight of silica is also included.

Further, in one specific implementation, 4.5 parts by weight of silica is included.

The preparation method of the composition comprises the following steps:

s100, drying the raw materials of the components, then crushing, and finally sieving by using a 400-mesh sieve to obtain uniform raw material particles;

s200, weighing the raw materials according to the weight ratio for later use;

s300, mixing the raw materials obtained in the step S200, heating, and finally stirring to obtain the composition.

In some embodiments, the temperature of drying in step 100 is 30 ℃ to 40 ℃ and the time of drying is 5min to 30 min.

Further, in a specific implementation, the drying temperature in the step 100 is 30 ℃, and the drying time is 30 min.

Further, in a specific implementation, the drying temperature in the step 100 is 40 ℃, and the drying time is 5 min.

Further, in a specific implementation, the drying temperature in the step 100 is 35 ℃, and the drying time is 20 min.

In some embodiments, 1 to 2 parts by weight of hot water is added while mixing in the step 300, and the temperature of the hot water is 30 ℃ to 50 ℃.

Further, in a specific embodiment, 1 part by weight of hot water is added during the mixing in the step 300, and the temperature of the hot water is 30 ℃.

Further, in one specific implementation, 2 parts by weight of hot water is added during the mixing in the step 300, and the temperature of the hot water is 50 ℃.

Further, in a specific embodiment, 1.5 parts by weight of hot water is added during the mixing in the step 300, and the temperature of the hot water is 40 ℃.

In some embodiments, the temperature of heating in step 300 is from 40 ℃ to 65 ℃.

Further, in one specific implementation, the temperature of the heating in step 300 is 40 ℃.

Further, in one specific implementation, the temperature of the heating in step 300 is 65 ℃.

Further, in one specific implementation, the temperature of the heating in step 300 is 50 ℃.

By the above method, the stability and use effect of NADH in the finished composition were examined. As in the following table:

the foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.