阅读说明：本技术 一种医用铝箔包装用粘合剂及其加工处理工艺 (Adhesive for medical aluminum foil packaging and processing technology thereof ) 是由 付志泉 于 2020-12-23 设计创作，主要内容包括：本发明公开了一种医用铝箔包装用粘合剂及其加工处理工艺,该粘合剂由以下重量份数的原料制备而成：马来酸酐接枝乙烯丙烯二烯单体橡胶：40-60份；高结晶聚丙烯：20-30份；高反应性聚丁烯：6-15份；聚氯乙烯：10-20份；聚乙烯亚胺：5-10份；主乳化剂：1-3份；辅助乳化剂：0.7-2.5份；增塑剂：5-7份；抗氧剂：0.8-1.2份；加粘剂：1-3份；引发剂：1-2份；偶联剂：0.3-0.5份；稀释剂：0.5-1份；去离子水：10-20份；本发明得到的粘合剂通过对重量组分进行合理选择,并采用适当的步骤进行调配,使得粘合剂的粘结强度高、粘结性能好；且制备方法简单,工艺条件低,产品品质稳定。(The invention discloses an adhesive for medical aluminum foil packaging and a processing technology thereof, wherein the adhesive is prepared from the following raw materials in parts by weight: maleic anhydride grafted ethylene propylene diene monomer rubber: 40-60 parts; high crystalline polypropylene: 20-30 parts of a solvent; highly reactive polybutene: 6-15 parts; polyvinyl chloride: 10-20 parts; polyethyleneimine: 5-10 parts; a main emulsifier: 1-3 parts; auxiliary emulsifier: 0.7-2.5 parts; plasticizer: 5-7 parts; antioxidant: 0.8-1.2 parts; adding an adhesive: 1-3 parts; initiator: 1-2 parts; coupling agent: 0.3-0.5 part; diluent agent: 0.5-1 part; deionized water: 10-20 parts; the adhesive obtained by the invention has high bonding strength and good bonding performance by reasonably selecting the weight components and adopting proper steps for blending; and the preparation method is simple, the process conditions are low, and the product quality is stable.)

1. An adhesive for medical aluminum foil packaging and a processing technique thereof are characterized in that: the adhesive is prepared from the following raw materials in parts by weight: maleic anhydride grafted ethylene propylene diene monomer rubber: 40-60 parts; high crystalline polypropylene: 20-30 parts of a solvent; highly reactive polybutene: 6-15 parts; polyvinyl chloride: 10-20 parts; polyethyleneimine: 5-10 parts; a main emulsifier: 1-3 parts; auxiliary emulsifier: 0.7-2.5 parts; plasticizer: 5-7 parts; antioxidant: 0.8-1.2 parts; adding an adhesive: 1-3 parts; initiator: 1-2 parts; coupling agent: 0.3-0.5 part; diluent agent: 0.5-1 part; deionized water: 10-20 parts; the adhesive is prepared by the following steps: (1) adding a co-emulsifier into a plasticizer, and then stirring to obtain a dispersion; (2) then, slowly dropwise adding deionized water dissolved with a main emulsifier into the dispersion obtained in the step (1), and after dropwise adding is finished, continuously homogenizing for 20min in a high-speed dispersion machine at the rotating speed of 800rpm to form an oil-in-water type emulsion; (3) dissolving maleic anhydride grafted ethylene propylene diene monomer rubber, high-crystalline polypropylene, polyvinyl chloride and polyethyleneimine in xylene, uniformly mixing, adding high-reactivity polybutylene and a coupling agent into the mixed solution under the condition of nitrogen, and mechanically stirring the solution for 1-2 hours at 110 ℃ to obtain a mixture; (4) and (3) mixing and stirring the emulsion obtained in the step (2), the mixture obtained in the step (3), an antioxidant, a tackifier, a diluent, an initiator and deionized water at 25 ℃ and at a stirring speed of 800rpm for 30min to obtain the adhesive.

2. The adhesive for medical aluminum foil packaging and the processing technology thereof according to claim 1 are characterized in that: the main emulsifier is polyoxyethylene octyl phenol ether-10, the auxiliary emulsifier is sorbitan monooleate, and the weight part ratio of the main emulsifier to the auxiliary emulsifier is 4: 3.

3. The adhesive for medical aluminum foil packaging and the processing technology thereof as claimed in claim 2, wherein the adhesive comprises the following components: the plasticizer is diisononyl phthalate.

4. The adhesive for medical aluminum foil packaging and the processing technology thereof as claimed in claim 3, wherein the adhesive comprises the following components: the diluent is one of methyl caprylate and epoxidized soybean oil.

5. The adhesive for medical aluminum foil packaging and the processing technology thereof as claimed in claim 4, wherein the adhesive comprises the following components: the initiator is azodibutyrronitrile.

6. The adhesive for packaging medical aluminum foil and the processing technology thereof according to claim 5 are characterized in that: the coupling agent is (3-aminopropyl) triethoxysilane.

7. The adhesive for medical aluminum foil packaging and the processing technology thereof according to any one of claims 1 to 6, wherein the adhesive comprises the following components in parts by weight: the stirring conditions in the step (1) are as follows: performing oil bath, stirring at 50 deg.C for 20 min.

8. The adhesive for packaging medical aluminum foil and the processing technology thereof according to claim 7 are characterized in that: the amount of the deionized water in the step (2) and the step (4) is the same.

Technical Field

The invention relates to the technical field of medicine packaging materials, in particular to an adhesive for medical aluminum foil packaging and a processing technology thereof.

Background

A medicament is a substance or preparation for the prophylaxis or treatment or diagnosis of diseases in humans and livestock. The medicine is divided into natural medicine and synthetic medicine according to the source. The medicine can also be used for preventing diseases, treating diseases, relieving pain, promoting health, enhancing body resistance to diseases or helping to diagnose diseases. The packaging is to protect the product in the process of circulation, facilitate storage and transportation, promote sale, and is according to the general names of containers, materials, auxiliary materials and the like used by a certain technical method; also means the operations of applying technical methods and the like in the process of using containers, materials and accessories for the above purpose. The items that are not introduced into the field of circulation cannot be referred to as packages, but only as "packs", "boxes", "containers", etc. Because the package has the function of containing the package box, the decoration of the articles is an important role of the package, and the package is favored by the public.

Biopharmaceuticals are industries closely related to the people, most of medicine packages are made of aluminum foils and transparent PVC (polyvinyl chloride) hard sheets, the two base materials are adhered together by virtue of adhesives, solvent type chlorine-vinegar ternary resin and polyurethane resin are mostly used in the current market, but 50% -70% of the adhesives are solvents, the adhesives containing a large amount of volatile solvents do not accord with the development direction of green, environment-friendly and energy-saving industries, the concentration of working solution of solvent type polyurethane adhesive products sold in the current domestic market is 28% -30%, and the large amount of volatile solvents are discharged into the atmosphere, so that serious environmental pollution is caused; the adhesive property of the existing adhesive needs to be improved, and the preparation and processing method needs to be optimized; the adhesive needs to be diluted before use, and raw materials are easily adhered to stirring equipment in the dilution process, so that the defects of raw material waste, insufficient and uniform stirring and low efficiency exist, and therefore, the adhesive which can be directly used without dilution has important practical significance.

Disclosure of Invention

The invention mainly aims to provide an adhesive which has excellent adhesive performance and can be directly used without dilution, aiming at the problems that the existing adhesive is complicated in dilution process and easily causes resource waste.

In order to achieve the purpose, the invention provides the following technical scheme, an adhesive for medical aluminum foil packaging and a processing technology thereof, wherein the adhesive is prepared from the following raw materials in parts by weight: maleic anhydride grafted ethylene propylene diene monomer rubber: 40-60 parts; high crystalline polypropylene: 20-30 parts of a solvent; highly reactive polybutene: 6-15 parts; polyvinyl chloride: 10-20 parts; polyethyleneimine: 5-10 parts; a main emulsifier: 1-3 parts; auxiliary emulsifier: 0.7-2.5 parts; plasticizer: 5-7 parts; antioxidant: 0.8-1.2 parts; adding an adhesive: 1-3 parts; initiator: 1-2 parts; coupling agent: 0.3-0.5 part; diluent agent: 0.5-1 part; deionized water: 10-20 parts; the adhesive is prepared by the following steps: (1) adding a co-emulsifier into a plasticizer, and then stirring to obtain a dispersion; (2) then, slowly dropwise adding deionized water dissolved with a main emulsifier into the dispersion obtained in the step (1), and after dropwise adding is finished, continuously homogenizing for 20min in a high-speed dispersion machine at the rotating speed of 800rpm to form an oil-in-water type emulsion; (3) dissolving maleic anhydride grafted ethylene propylene diene monomer rubber, high-crystalline polypropylene, polyvinyl chloride and polyethyleneimine in xylene, uniformly mixing, adding high-reactivity polybutylene and a coupling agent into the mixed solution under the condition of nitrogen, and mechanically stirring the solution for 1-2 hours at 110 ℃ to obtain a mixture; (4) and (3) mixing and stirring the emulsion obtained in the step (2), the mixture obtained in the step (3), an antioxidant, a tackifier, a diluent, an initiator and deionized water at 25 ℃ and at a stirring speed of 800rpm for 30min to obtain the adhesive.

The main emulsifier is polyoxyethylene octyl phenol ether-10, the auxiliary emulsifier is sorbitan monooleate, and the weight part ratio of the main emulsifier to the auxiliary emulsifier is 4: 3.

The plasticizer is diisononyl phthalate.

The diluent is one of methyl caprylate and epoxidized soybean oil.

The initiator is azodibutyrronitrile.

The coupling agent is (3-aminopropyl) triethoxysilane.

The stirring conditions in the step (1) are as follows: performing oil bath, stirring at 50 deg.C for 20 min.

The amount of deionized water used in the step (2) and the step (4) is the same.

Compared with the prior art, the invention has the following advantages:

1. the maleic anhydride grafted ethylene propylene diene monomer rubber has good compatibility, the double bond of the high-reactivity polybutylene can be highly crosslinked with the maleic anhydride grafted ethylene propylene diene monomer rubber under the action of the initiator azodibutyrronitrile, the high-reactivity polybutylene has the function of a compatibilizer, and is used as a potential crosslinking agent of an adhesive and an aluminum foil, so that the adhesive strength is greatly improved; methyl caprylate is used as a coupling agent of a plant source, has low toxicity and incombustibility, and belongs to an environment-friendly material;

2. the lipophilic end structure of the emulsifier polyoxyethylene octyl phenol ether-10 has certain similarity with the plasticizer diisononyl phthalate, compared with the single emulsifier polyoxyethylene octyl phenol ether-10, the addition of the auxiliary emulsifier sorbitan monooleate can adjust the HLB value of the polyoxyethylene octyl phenol ether-10, generate firm interfacial films among liquid drops and prevent instability, and has the best emulsifying property for the diisononyl phthalate; the emulsifier molecules can be aggregated into micelles by selecting a proper emulsifier proportion and using amount, so that the viscosity is greatly increased;

3. the adhesive obtained by the invention has high bonding strength and good bonding performance by reasonably selecting the weight components and adopting proper steps for blending; and the preparation method is simple, the process conditions are low, and the product quality is stable.

Detailed Description

The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1:

(1) adding 1.5 parts of auxiliary emulsifier sorbitan monooleate into 5 parts of plasticizer diisononyl phthalate, and stirring in an oil bath pan at 50 ℃ for 20min to obtain a dispersion;

(2) then, slowly dripping 5 parts of deionized water dissolved with 2 parts of main emulsifier polyoxyethylene octyl phenol ether-10 into the dispersion obtained in the step (1), and after finishing dripping, continuously homogenizing for 20min in a high-speed dispersion machine at the rotating speed of 800rpm to form an oil-in-water type emulsion;

(3) dissolving 50 parts of maleic anhydride grafted ethylene propylene diene monomer rubber, 20 parts of high-crystalline polypropylene, 10 parts of polyvinyl chloride and 10 parts of polyethyleneimine in xylene, uniformly mixing, adding 10 parts of high-reactivity polybutylene and 0.3 part of coupling agent (3-aminopropyl) triethoxysilane into the mixed solution under the condition of nitrogen, and then mechanically stirring the solution for 1-2 hours at the temperature of 110 ℃ to obtain a mixture;

(4) and (3) mixing and stirring the emulsion obtained in the step (2), the mixture obtained in the step (3), 1 part of antioxidant, 1 part of tackifier, 0.5 part of diluent methyl caprylate, 1.5 parts of initiator azodibutyrronitrile and 5 parts of deionized water at 25 ℃ and at the stirring speed of 800rpm for 30min to obtain the adhesive.

Example 2:

(1) adding 2.25 parts of auxiliary emulsifier sorbitan monooleate into 7 parts of plasticizer diisononyl phthalate, and stirring in an oil bath pan at 50 ℃ for 20min to obtain a dispersion;

(2) then, slowly dripping 10 parts of deionized water dissolved with 3 parts of main emulsifier polyoxyethylene octyl phenol ether-10 into the dispersion obtained in the step (1), and after finishing dripping, continuously homogenizing for 20min in a high-speed dispersion machine at the rotating speed of 800rpm to form an oil-in-water type emulsion;

(3) dissolving 40 parts of maleic anhydride grafted ethylene propylene diene monomer rubber, 30 parts of high-crystalline polypropylene, 15 parts of polyvinyl chloride and 8 parts of polyethyleneimine in xylene, uniformly mixing, adding 15 parts of high-reactivity polybutylene and 0.5 part of coupling agent (3-aminopropyl) triethoxysilane into the mixed solution under the condition of nitrogen, and mechanically stirring the solution at 110 ℃ for 1-2 hours to obtain a mixture;

(4) and (3) mixing and stirring the emulsion obtained in the step (2), the mixture obtained in the step (3), 1.2 parts of antioxidant, 3 parts of tackifier, 1 part of diluent methyl caprylate, 2 parts of initiator azodibutyrronitrile and 10 parts of deionized water at 25 ℃ and at the stirring speed of 800rpm for 30min to obtain the adhesive.

Example 3:

(1) adding 0.75 part of auxiliary emulsifier sorbitan monooleate into 6 parts of plasticizer diisononyl phthalate, and stirring in an oil bath pan at 50 ℃ for 20min to obtain a dispersion;

(2) then, slowly dripping 8 parts of deionized water dissolved with 1 part of main emulsifier polyoxyethylene octyl phenol ether-10 into the dispersion obtained in the step (1), and after finishing dripping, continuously homogenizing for 20min in a high-speed dispersion machine at the rotating speed of 800rpm to form an oil-in-water type emulsion;

(3) dissolving 60 parts of maleic anhydride grafted ethylene propylene diene monomer rubber, 25 parts of high-crystalline polypropylene, 10 parts of polyvinyl chloride and 5 parts of polyethyleneimine in xylene, uniformly mixing, adding 6 parts of high-reactivity polybutylene and 0.4 part of coupling agent (3-aminopropyl) triethoxysilane into the mixed solution under the condition of nitrogen, and then mechanically stirring the solution for 1-2 hours at the temperature of 110 ℃ to obtain a mixture;

(4) and (3) mixing and stirring the emulsion obtained in the step (2), the mixture obtained in the step (3), 0.8 part of antioxidant, 2 parts of tackifier, 0.8 part of diluent methyl octanoate, 1 part of initiator azodibutyrronitrile and 8 parts of deionized water at 25 ℃ and at the stirring speed of 800rpm for 30min to obtain the adhesive.

Example 4:

(1) adding 0.75 part of auxiliary emulsifier sorbitan monooleate into 6 parts of plasticizer diisononyl phthalate, and stirring in an oil bath pan at 50 ℃ for 20min to obtain a dispersion;

(2) then, slowly dripping 8 parts of deionized water dissolved with 1 part of main emulsifier polyoxyethylene octyl phenol ether-10 into the dispersion obtained in the step (1), and after finishing dripping, continuously homogenizing for 20min in a high-speed dispersion machine at the rotating speed of 800rpm to form an oil-in-water type emulsion;

(3) dissolving 60 parts of maleic anhydride grafted ethylene propylene diene monomer rubber, 25 parts of high-crystalline polypropylene, 10 parts of polyvinyl chloride and 5 parts of polyethyleneimine in xylene, uniformly mixing, adding 6 parts of high-reactivity polybutylene and 0.4 part of coupling agent (3-aminopropyl) triethoxysilane into the mixed solution under the condition of nitrogen, and then mechanically stirring the solution for 1-2 hours at the temperature of 110 ℃ to obtain a mixture;

(4) and (3) mixing and stirring the emulsion obtained in the step (2), the mixture obtained in the step (3), 0.8 part of antioxidant, 2 parts of tackifier, 0.8 part of diluent epoxidized soybean oil, 1 part of initiator azobisbutyronitrile and 8 parts of deionized water at 25 ℃ and at the stirring speed of 800rpm for 30min to obtain the adhesive.

Example 5:

(1) adding 0.75 part of auxiliary emulsifier sorbitan monooleate into 6 parts of plasticizer diisononyl phthalate, and stirring in an oil bath pan at 50 ℃ for 20min to obtain a dispersion;

(2) then, slowly dripping 8 parts of deionized water dissolved with 1 part of main emulsifier polyoxyethylene octyl phenol ether-10 into the dispersion obtained in the step (1), and after finishing dripping, continuously homogenizing for 20min in a high-speed dispersion machine at the rotating speed of 800rpm to form an oil-in-water type emulsion;

(3) dissolving 60 parts of maleic anhydride grafted ethylene propylene diene monomer rubber, 25 parts of high-crystalline polypropylene, 10 parts of polyvinyl chloride and 5 parts of polyethyleneimine in xylene, uniformly mixing, adding 6 parts of high-reactivity polybutylene and 0.4 part of coupling agent (3-aminopropyl) triethoxysilane into the mixed solution under the condition of nitrogen, and then mechanically stirring the solution for 1-2 hours at the temperature of 110 ℃ to obtain a mixture;

(4) and (3) mixing and stirring the emulsion obtained in the step (2), the mixture obtained in the step (3), 0.8 part of antioxidant, 2 parts of tackifier, 0.8 part of diluent epoxidized soybean oil and 8 parts of deionized water at 25 ℃ and at the stirring speed of 800rpm for 30min to obtain the adhesive.

Example 6:

(1) slowly dripping 8 parts of deionized water of 1 part of main emulsifier polyoxyethylene octyl phenol ether-10 into 6 parts of plasticizer diisononyl phthalate, and stirring in an oil bath kettle at 50 ℃ for 20min to obtain a dispersion;

(2) subsequently, continuously homogenizing the dispersion obtained in the step (1) in a high-speed disperser at the rotating speed of 800rpm for 20min to form an oil-in-water emulsion;

(3) dissolving 60 parts of maleic anhydride grafted ethylene propylene diene monomer rubber, 25 parts of high-crystalline polypropylene, 10 parts of polyvinyl chloride and 5 parts of polyethyleneimine in xylene, uniformly mixing, adding 6 parts of high-reactivity polybutylene and 0.4 part of coupling agent (3-aminopropyl) triethoxysilane into the mixed solution under the condition of nitrogen, and then mechanically stirring the solution for 1-2 hours at the temperature of 110 ℃ to obtain a mixture;

(4) and (3) mixing and stirring the emulsion obtained in the step (2), the mixture obtained in the step (3), 0.8 part of antioxidant, 2 parts of tackifier, 0.8 part of diluent epoxidized soybean oil, 1 part of initiator azobisbutyronitrile and 8 parts of deionized water at 25 ℃ and at the stirring speed of 800rpm for 30min to obtain the adhesive.

The adhesives obtained in examples 1 to 6 were subjected to performance tests, respectively, and the test results are shown in table 1 below;

table 1:

according to the test results, the adhesive obtained by the raw material proportion and the preparation method provided by the invention has high bonding strength and good bonding performance by reasonably selecting the weight components and adopting proper steps for blending; the preparation method is simple, the process condition is low, and the product quality is stable; the comparison of example 3 and example 4 shows that the methyl caprylate is used as the coupling agent, which is more effective in improving the performance of the adhesive, and the methyl caprylate is used as the coupling agent of vegetable origin, has low toxicity and incombustibility, and belongs to an environment-friendly material; the comparison between the embodiment 3 and the embodiment 5 shows that under the action of the initiator azobisbutyronitrile, the double bond of the high-reactivity polybutylene and the maleic anhydride grafted ethylene propylene diene monomer rubber are highly crosslinked, so that the high-reactivity polybutylene terephthalate not only plays a role of a compatibilizer, but also serves as a potential crosslinking agent of an adhesive and an aluminum foil, and the adhesive strength is greatly improved; the experiment of example 6 shows that the addition of the co-emulsifier sorbitan monooleate can adjust the HLB value of polyoxyethylene octylphenol ether-10, produce a firm interfacial film between droplets and prevent instability, and have the best emulsifying properties for diisononyl phthalate; the emulsifier molecules can be aggregated into micelles by selecting a proper emulsifier proportion and using amount, so that the viscosity is greatly increased, and the emulsifier has a better practical effect compared with a single emulsifier polyoxyethylene octyl phenol ether-10.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.