阅读说明：本技术 工程化苯丙氨酸氨裂合酶多肽 (Engineered phenylalanine ammonia lyase polypeptides ) 是由 斯科特·J·诺维克 拉维·大卫·加西亚 沙琳·奇恩 尼基·德拉斯 大卫·恩特韦斯特尔 韦丝 于 2019-06-14 设计创作，主要内容包括：本发明提供了工程化苯丙氨酸氨裂合酶(PAL)多肽及其组合物,以及编码工程化苯丙氨酸氨裂合酶(PAL)多肽的多核苷酸。还提供了用于产生PAL酶的方法。在一些实施方案中,工程化PAL多肽被优化以提供增强的催化活性,所述催化活性可用于在工业工艺条件下产生药物化合物。(The present invention provides engineered Phenylalanine Ammonia Lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered Phenylalanine Ammonia Lyase (PAL) polypeptides. Methods for producing PAL enzymes are also provided. In some embodiments, engineered PAL polypeptides are optimized to provide enhanced catalytic activity useful for the production of pharmaceutical compounds under industrial process conditions.)