阅读说明：本技术 一种治疗婴幼儿湿疹的修护凝胶及其制备方法 (Repairing gel for treating infantile eczema and preparation method thereof ) 是由 范兴勇 魏元刚 于 2020-12-28 设计创作，主要内容包括：本发明公开了一种治疗婴幼儿湿疹的修护凝胶及其制备方法,以重量计算包括以下制备原料：甘草提取物0.5～10％、紫草素0.01～0.5％、黄芩提取物1％～5％、元胡提取物1％～5％、甘油1％～10％、薄荷精油0.01～0.5％、冰晶剂AVC 0.5～5％、PEG-60氢化蓖麻油1％～5％、去离子水余量。活性成分源自天然植物,通过合理的工艺提取出来并添加在修护凝胶中；在没有副作用的情况下,起效快,有效减轻婴幼儿湿疹患者的痛苦,缩短湿疹的治愈时间。(The invention discloses a repair gel for treating infantile eczema and a preparation method thereof, wherein the repair gel comprises the following preparation raw materials in parts by weight: 0.5-10% of licorice extract, 0.01-0.5% of alkannin, 1-5% of scutellaria extract, 1-5% of rhizoma corydalis extract, 1-10% of glycerol, 0.01-0.5% of mint essential oil, 0.5-5% of ice crystal agent AVC, 1-5% of PEG-60 hydrogenated castor oil and the balance of deionized water. The active ingredients are derived from natural plants, extracted by a reasonable process and added into the repair gel; under the condition of no side effect, the traditional Chinese medicine composition has quick response, effectively relieves the pain of infant eczema patients, and shortens the curing time of eczema.)

1. The repairing gel for treating infantile eczema is characterized by comprising the following preparation raw materials in parts by weight: 0.5-10% of licorice extract, 0.01-0.5% of alkannin, 1-5% of scutellaria extract, 1-5% of rhizoma corydalis extract, 1-10% of glycerol, 0.01-0.5% of mint essential oil, 0.5-5% of ice crystal agent AVC, 1-5% of PEG-60 hydrogenated castor oil and the balance of deionized water.

2. The repairing gel for treating infantile eczema as claimed in claim 1, which comprises the following raw materials by weight: 0.5-5% of licorice extract, 0.01-0.2% of alkannin, 1-3% of scutellaria extract, 1-3% of rhizoma corydalis extract, 2-8% of glycerol, 0.01-0.3% of mint essential oil, 1-4% of cryolite AVC, 1-4% of PEG-60 hydrogenated castor oil and the balance of deionized water.

3. The repairing gel for treating infantile eczema as claimed in claim 2, which comprises the following raw materials by weight: 0.5-2% of licorice extract, 0.01-0.05% of alkannin, 1.5-2.5% of scutellaria extract, 1.5-2.5% of rhizoma corydalis extract, 3-7% of glycerol, 0.02-0.1% of mint essential oil, 1.5-3% of cryolite AVC, 1.5-3% of PEG-60 hydrogenated castor oil and the balance of deionized water.

4. A healing gel for treating infantile eczema according to any one of claims 1 to 3, wherein: the Glycyrrhrizae radix extract is glycyrrhetinic acid monoglucuronide.

5. A healing gel for treating infantile eczema according to any one of claims 1 to 3, wherein: the preparation method of the scutellaria baicalensis extract and the rhizoma corydalis extract comprises the following steps: crushing the scutellaria baicalensis and the rhizoma corydalis, respectively extracting with water of which the weight ratio is 8-10 times for 1-3 times at the temperature of 70-90 ℃ for 1-3 hours, filtering to obtain filtrate, and concentrating and drying by using a rotary evaporator to obtain the extract.

6. A healing gel for the treatment of infantile eczema according to any one of claims 1 to 3, characterized in that: the purity of the alkannin is not lower than 80%.

7. A method for preparing a repairing gel for treating infantile eczema as claimed in claim 1, which comprises the following steps:

(1) weighing the raw materials according to the weight part of the mixture ratio;

(2) adding glycerol and an ice crystal agent AVC into deionized water, stirring and heating to 70-90 ℃ until the mixture is completely dissolved;

(3) cooling to 50-70 ℃, adding the liquorice extract, the scutellaria baicalensis extract, the rhizoma corydalis extract and the PEG-60 hydrogenated castor oil, and stirring to dissolve;

(4) cooling to 35-45 ℃, adding alkannin and peppermint essential oil, stirring and dissolving to obtain the repairing gel.

Technical Field

The invention relates to the field of eczema repairing gel, in particular to repairing gel for treating infantile eczema and a preparation method thereof.

Background

Infantile eczema is a common allergic dermatitis, is an allergic dermatitis caused by various internal and external factors, and is one of the most common skin diseases in infancy. Skin lesions are polymorphic lesions mainly caused by herpes simplex, tend to exude, have repeated outbreaks, alternate between acute and chronic periods, are accompanied by severe pruritus, and have difficult-to-determine etiology. Intrinsic factors such as immune dysfunction or immunodeficiency of the body; endocrine diseases, dystrophism, chronic infection, tumors and other systemic diseases can also become the intrinsic cause of eczema; hereditary or acquired skin barrier dysfunction. The external factors include food allergens ingested by digestive tract, such as milk, fish, shrimp, beef and mutton, egg, etc., or allergens in the environment, which can cause type I allergy in vivo. In addition, mechanical friction, such as saliva and milk spillage, are often irritating and are also the cause of the disease. Improper care, such as excessive use of strong alkaline soap, excessive nutrition, and abnormal digestion in the intestine, can also cause this condition. External factors such as physical factors including sunlight, ultraviolet rays, cold, damp-heat, etc., exposure to silk or rayon, external drugs, and bacterial infections of the skin can cause eczema or aggravate the condition.

At present, most of medicines for treating infantile eczema are chemical preparations such as calcium agents, corticosteroid hormones, antihistamine medicines, antibiotics and the like, but the eczema symptoms can be relieved only within a certain time, radical treatment cannot be realized, and dependence and various adverse reactions are easy to generate. To date, no safe and effective treatment medicine for infantile eczema exists, so that the development of a novel medicine for treating infantile eczema, which is high in safety and curative effect, is a problem to be solved urgently.

Disclosure of Invention

The purpose of the invention is as follows: in order to overcome the problems in the prior art, the invention provides a repair gel for treating infantile eczema and a preparation method thereof, wherein the repair gel has no side effect and shortens the healing time.

The technical scheme is as follows: in order to solve the technical problems, the technical scheme adopted by the invention is as follows:

the repairing gel for treating infantile eczema comprises the following preparation raw materials in parts by weight: 0.5-10% of licorice extract, 0.01-0.5% of alkannin, 1-5% of scutellaria extract, 1-5% of rhizoma corydalis extract, 1-10% of glycerol, 0.01-0.5% of mint essential oil, 0.5-5% of ice crystal agent AVC, 1-5% of PEG-60 hydrogenated castor oil and the balance of deionized water.

As a further improvement of the formula, the repairing gel for treating infantile eczema comprises the following preparation raw materials in parts by weight: 0.5-5% of licorice extract, 0.01-0.2% of alkannin, 1-3% of scutellaria extract, 1-3% of rhizoma corydalis extract, 2-8% of glycerol, 0.01-0.3% of mint essential oil, 1-4% of cryolite AVC, 1-4% of PEG-60 hydrogenated castor oil and the balance of deionized water.

As a further improvement of the formula, the repairing gel for treating infantile eczema comprises the following preparation raw materials in parts by weight: 0.5-2% of licorice extract, 0.01-0.05% of alkannin, 1.5-2.5% of scutellaria extract, 1.5-2.5% of rhizoma corydalis extract, 3-7% of glycerol, 0.02-0.1% of mint essential oil, 1.5-3% of cryolite AVC, 1.5-3% of PEG-60 hydrogenated castor oil and the balance of deionized water.

Further, the licorice extract is glycyrrhetinic acid monoglucuronide.

Furthermore, the preparation method of the scutellaria baicalensis extract and the rhizoma corydalis extract comprises the following steps: crushing the scutellaria baicalensis and the rhizoma corydalis, respectively extracting with water of which the weight ratio is 8-10 times for 1-3 times at the temperature of 70-90 ℃ for 1-3 hours, filtering to obtain filtrate, and concentrating and drying by using a rotary evaporator to obtain the extract.

Further, the purity of the alkannin is not less than 80%.

The invention also discloses a preparation method of the repair gel for treating infantile eczema, which comprises the following steps:

weighing the raw materials according to the weight parts of the mixture ratio;

(2) adding glycerol and an ice crystal agent AVC into deionized water, stirring and heating to 70-90 ℃ until the mixture is completely dissolved;

(3) cooling to 50-70 ℃, adding the liquorice extract, the scutellaria baicalensis extract, the rhizoma corydalis extract and the PEG-60 hydrogenated castor oil, and stirring to dissolve;

(4) cooling to 35-45 ℃, adding alkannin and peppermint essential oil, stirring and dissolving to obtain the repairing gel.

Has the advantages that:

compared with the prior art, the invention has the following advantages: the active ingredients are derived from natural plants, extracted by a reasonable process and added into the repair gel; the alkannin adopted is a patented high-purity product, and has obvious anti-inflammatory repair effect; the anti-inflammatory composition has various types and moderate content, takes effect quickly under the condition of no side effect, effectively relieves the pain of infant eczema patients, and shortens the curing time of eczema.

Detailed Description

The present invention will be described in further detail with reference to the following examples:

in examples 1-3, the source of shikonin was the high purity shikonin prepared in example 3 of chinese patent 201510881298.6.

In examples 1-3, the licorice extract was glycyrrhetinic acid monoglucuronide, available from Yillili Quezuelian Biotech, Inc.

The preparation method of the traditional Chinese medicine extract comprises the following steps: pulverizing Scutellariae radix and rhizoma corydalis, respectively extracting with 8 times of water at 80 deg.C for 2 hr for 2 times to obtain effective components, filtering, mixing the filtrates, concentrating and drying with rotary evaporator to obtain the extract.

Example 1:

a repairing gel for treating infantile eczema comprises the following components by weight: 0.5% of liquorice extract, 0.01% of alkannin, 1% of scutellaria baicalensis extract, 1% of rhizoma corydalis extract, 2% of glycerol, 0.01% of mint essential oil, 1% of cryolite AVC, 1% of PEG-60 hydrogenated castor oil and the balance of deionized water.

The preparation method of the repairing gel comprises the following steps:

(1) weighing the raw materials according to the proportion;

(2) adding glycerol and an ice crystal agent AVC into deionized water, stirring and heating to 70 ℃ until the glycerol and the ice crystal agent are completely dissolved;

(3) cooling to 50 deg.C, adding Glycyrrhrizae radix extract, Scutellariae radix extract, rhizoma corydalis extract, and PEG-60 hydrogenated castor oil, stirring, and dissolving;

(4) cooling to 35 deg.C, adding alkannin and herba Menthae essential oil, stirring and dissolving to obtain repairing gel.

Example 2:

a repairing gel for treating infantile eczema comprises the following components by weight: 2% of liquorice extract, 0.1% of alkannin, 3% of scutellaria baicalensis extract, 3% of rhizoma corydalis extract, 8% of glycerol, 0.1% of mint essential oil, 3% of cryolite AVC, 3% of PEG-60 hydrogenated castor oil and the balance of deionized water.

The preparation method of the repairing gel comprises the following steps:

(1) weighing the raw materials according to the proportion;

(2) adding glycerol and an ice crystal agent AVC into deionized water, stirring and heating to 85 ℃ until the glycerol and the ice crystal agent are completely dissolved;

(3) cooling to 60 deg.C, adding Glycyrrhrizae radix extract, Scutellariae radix extract, rhizoma corydalis extract, and PEG-60 hydrogenated castor oil, stirring, and dissolving;

(4) cooling to 40 deg.C, adding alkannin and herba Menthae essential oil, stirring and dissolving to obtain repairing gel.

Example 3:

a repairing gel for treating infantile eczema comprises the following components by weight: 1% of liquorice extract, 0.02% of alkannin, 2% of scutellaria baicalensis extract, 2% of rhizoma corydalis extract, 4% of glycerol, 0.04% of mint essential oil, 2% of cryolite AVC, 2.5% of PEG-60 hydrogenated castor oil and the balance of deionized water.

The preparation method of the repairing gel comprises the following steps:

(1) weighing the raw materials according to the proportion;

(2) adding glycerol and an ice crystal agent AVC into deionized water, stirring and heating to 90 ℃ until the glycerol and the ice crystal agent are completely dissolved;

(3) cooling to 70 deg.C, adding Glycyrrhrizae radix extract, Scutellariae radix extract, rhizoma corydalis extract, and PEG-60 hydrogenated castor oil, stirring, and dissolving;

(4) cooling to 45 deg.C, adding alkannin and peppermint essential oil, stirring and dissolving to obtain repairing gel.

Performance test experiments:

the repair gels of examples 1 to 3 and the comparative examples were subjected to clinical trials as follows:

(1) case selection: 120 volunteers aged 0-6 years are selected, which have eczema problem and are divided into 4 groups of 30 persons in each group.

(2) The treatment method comprises the following steps: wherein 3 groups used the repair gels prepared in examples 1 to 3; 1 group adopts conventional eczema-removing products; the conventional dampness eliminating rash removing product adopts Qingbai powder, and the formula is as follows: 30g of natural indigo, 90g of cuttlebone, 370g of calcined gypsum powder and 3g of borneol. The trial is carried out continuously for 2 weeks, once in the morning and once in the evening, and the pictures are taken for archiving. Relapse was observed for 1 month of follow-up.

(3) The treatment effect evaluation standard is as follows: the effect is shown: eczema symptoms are completely eliminated;

the method has the following advantages: the symptoms of eczema are relieved;

and (4) invalidation: eczema symptoms do not change significantly;

the results of the tests are shown in table 1:

TABLE 1 repair gels of examples 1-3 and comparative performance

Statistical conditions	Show effect	Is effective	Invalidation	Recurrent conditions
					Example 1	15	13	2	Is free of
Example 2	19	10	1	Is free of
					Example 3	21	8	1	Is free of
Comparative example	12	14	4	2

As can be seen from the data shown in Table 1, compared with the prior art, the repairing gel prepared by the invention has more remarkable effect of treating eczema and has no recurrence.

It should be noted that the above-mentioned embodiments illustrate rather than limit the scope of the invention, and that those skilled in the art will be able to modify the invention in its various equivalent forms after reading the present disclosure without departing from the scope of the invention as defined by the appended claims.