阅读说明：本技术 一种AgNWs复合导电抗菌水凝胶及制备和使用方法 (AgNWs composite conductive antibacterial hydrogel and preparation and use methods thereof ) 是由 王腾蛟 苏扬 宋江 陈婧婕 李鹏 黄维 于 2020-08-06 设计创作，主要内容包括：本发明涉及一种AgNWs复合导电抗菌水凝胶及制备和使用方法,化学组分为AgNWs、异丙基丙烯酰胺单体、N,N’～亚甲基双丙烯酰胺、过硫酸钾十二烷基硫酸钠和四甲基乙二胺；内部物理结构为：交联的网状结构和致密的相互联通的微孔。制备方法采用下述步骤：(1)制备AgNWs；(2)控制反应时间和反应温度制备得到纳米前驱凝胶,再通过与AgNWs的复合并进行第二步聚合得到AgNWs复合导电抗菌水凝胶。经过一系列的力学性能、热稳定性能、微观形貌、电响应性能、抗菌性能、应变传感性能、温敏性能的分析测试,确定制备得到的水凝胶具有优良的力学性能、电响应性能和抗菌性能,可以作为优良的柔性电子传感器。(The invention relates to AgNWs composite conductive antibacterial hydrogel and a preparation and use method thereof, wherein the chemical components comprise AgNWs, an isopropyl acrylamide monomer, N' -methylene bisacrylamide, potassium lauryl sodium sulfate and tetramethylethylenediamine; the internal physical structure is as follows: a cross-linked network structure and dense interconnected micropores. The preparation method comprises the following steps: (1) preparing AgNWs; (2) and controlling the reaction time and the reaction temperature to prepare the nano precursor gel, compounding the nano precursor gel with AgNWs, and performing second-step polymerization to obtain the AgNWs composite conductive antibacterial hydrogel. Through a series of analysis tests on mechanical property, thermal stability, micro morphology, electric response property, antibacterial property, strain sensing property and temperature-sensitive property, the hydrogel prepared by the method has excellent mechanical property, electric response property and antibacterial property, and can be used as an excellent flexible electronic sensor.)

1. The AgNWs composite conductive antibacterial hydrogel is characterized by comprising the chemical components of 0.01-1 g of AgNWs, 225-227mg of isopropyl acrylamide monomer, 12.2-12.4mg of N, N' -methylene bisacrylamide, 53-55mg of potassium persulfate, 53-55mg of sodium dodecyl sulfate and 7-8 mu L of tetramethyl ethylenediamine; the internal physical structure is as follows: a cross-linked network structure and dense interconnected micropores.

2. The AgNWs composite conductive antibacterial hydrogel of claim 1, wherein: the AgNWs comprises the following chemical components: 0.25-0.26g NaCl, 0.08-0.082g Fe (NO)₃)₃1.04-1.06g of polyvinylpyrrolidone and 1.04-1.06g of AgNO₃。

3. A preparation method of the AgNWs composite conductive antibacterial hydrogel of claim 1 or 2 is characterized by comprising the following steps:

step 1, AgNWs preparation: mixing NaCl and Fe (NO)₃)₃Polyvinyl pyrrolidone PVP and AgNO₃Adding the solution into glycol which is subjected to oil bath for 50-60 minutes, reacting at 140-150 ℃ for 120-125 minutes, and then performing centrifugal purification to obtain an AgNWs solution; the above-mentioned

Step 2, preparation of AgNWs composite conductive antibacterial hydrogel:

taking an isopropyl acrylamide monomer, N' -methylene bisacrylamide, potassium persulfate, sodium dodecyl sulfate and pure water, removing air, sealing, reacting for 30-35min at 60-65 ℃ in an environment of 300-310rpm, and cooling in an ice water bath to obtain a nano precursor gel solution;

and (2) carrying out ultrasonic oscillation on the AgNWs solution, an isopropyl acrylamide monomer NIPAM, a nano precursor gel solution, potassium persulfate KPS, tetramethylethylenediamine TEMED and pure water, uniformly mixing, sealing after air removal, placing in an ice water bath for 120 plus one time and 125 minutes, taking out, and standing for 22-24 hours to obtain the AgNWs composite conductive antibacterial hydrogel.

4. The use method of the AgNWs composite conductive antibacterial hydrogel of claim 1 or 2, characterized in that: a flexible electronic sensor for carrying on human body measurement.

Technical Field

The invention belongs to the technical field of high polymer materials, and relates to AgNWs composite conductive antibacterial hydrogel and preparation and use methods thereof.

Background

Flexible electronics is a new electronic technology revolution, drawing widespread attention and developing rapidly around the world. Generally, the flexible conductive material is prepared by effectively compounding a conductive component with a flexible polymer matrix, and the finally obtained material can have no fatigue or obvious reduction of electrical properties under the action of certain stress for multiple cycles. In recent years, hydrogel materials are used as matrixes, conductive hydrogel with adjustable mechanical property, excellent processability and excellent biocompatibility is prepared by compounding various conductive materials, and the conductive hydrogel has prominent application in flexible bioelectronic devices.

For flexible bioelectronic devices to be applied to the human body, complicated mechanical behavior and high-intensity cyclic stress need to be borne. The single-chemical crosslinked conductive hydrogel can not bear periodic bending, kinking and other mechanical behaviors due to generally low fracture energy, and is applied to the conductive hydrogel in the field of flexible bioelectronics, and the required elastic modulus is matched with the elastic modulus of human tissues, so the actual application range is greatly reduced. On the other hand, since the hydrogel has a high water content, the conductive hydrogel often causes problems such as bacterial infection when used as a flexible bioelectronic device, and promotes the surface of the wearable flexible electronic device to grow a large amount of bacteria, and lacks antibacterial performance, so that the caused inflammatory reaction or wound infection is likely to cause serious health threat to patients, and is greatly limited in the long-term use of many flexible wearable devices. Therefore, the preparation of the conductive hydrogel with high mechanical property, sensitive electric response characteristic and excellent antibacterial property has very important significance.

Disclosure of Invention

Technical problem to be solved

In order to avoid the defects of the prior art, the invention provides AgNWs composite conductive antibacterial hydrogel and a preparation and use method thereof.

Technical scheme

The AgNWs composite conductive antibacterial hydrogel is characterized by comprising the chemical components of 0.01-1 g of AgNWs, 225-227mg of isopropyl acrylamide monomer, 12.2-12.4mg of N, N' -methylene bisacrylamide, 53-55mg of potassium persulfate, 53-55mg of sodium dodecyl sulfate and 7-8 mu L of tetramethyl ethylenediamine; the internal physical structure is as follows: a cross-linked network structure and dense interconnected micropores.

The AgNWs comprises the following chemical components: 0.25-0.26g NaCl, 0.08-0.082g Fe (NO)₃)₃1.04-1.06g of polyvinylpyrrolidone and 1.04-1.06g of AgNO₃。

A preparation method of the AgNWs composite conductive antibacterial hydrogel is characterized by comprising the following steps:

step 1, AgNWs preparation: mixing NaCl and Fe (NO)₃)₃Polyvinyl pyrrolidone PVP and AgNO₃Adding the solution into glycol which is subjected to oil bath for 50-60 minutes, reacting at 140-150 ℃ for 120-125 minutes, and then performing centrifugal purification to obtain an AgNWs solution; the above-mentioned

Step 2, preparation of AgNWs composite conductive antibacterial hydrogel:

taking an isopropyl acrylamide monomer, N' -methylene bisacrylamide, potassium persulfate, sodium dodecyl sulfate and pure water, removing air, sealing, reacting for 30-35min at 60-65 ℃ in an environment of 300-310rpm, and cooling in an ice water bath to obtain a nano precursor gel solution;

and (2) carrying out ultrasonic oscillation on the AgNWs solution, an isopropyl acrylamide monomer NIPAM, a nano precursor gel solution, potassium persulfate KPS, tetramethylethylenediamine TEMED and pure water, uniformly mixing, sealing after air removal, placing in an ice water bath for 120 plus one time and 125 minutes, taking out, and standing for 22-24 hours to obtain the AgNWs composite conductive antibacterial hydrogel.

The application method of the AgNWs composite conductive antibacterial hydrogel is characterized by comprising the following steps: a flexible electronic sensor for carrying on human body measurement.

Advantageous effects

The invention provides AgNWs composite conductive antibacterial hydrogel and a preparation and use method thereof, wherein the chemical components comprise AgNWs, an isopropyl acrylamide monomer, N' -methylene bisacrylamide, potassium persulfate sodium dodecyl sulfate and tetramethylethylenediamine; the internal physical structure is as follows: a cross-linked network structure and dense interconnected micropores. The preparation method comprises the following steps: (1) preparing AgNWs; (2) and controlling the reaction time and the reaction temperature to prepare the nano precursor gel, compounding the nano precursor gel with AgNWs, and performing second-step polymerization to obtain the AgNWs composite conductive antibacterial hydrogel. Through a series of analysis tests on mechanical property, thermal stability, micro morphology, electric response property, antibacterial property, strain sensing property and temperature-sensitive property, the hydrogel prepared by the method has excellent mechanical property, electric response property and antibacterial property, and can be used as an excellent flexible electronic sensor.

In the effect detection, a mechanical testing machine is used for measuring the mechanical property of the hydrogel, a differential scanning calorimeter and a thermogravimetric analyzer are used for measuring the thermal stability of the hydrogel, a field emission scanning electron microscope is used for observing the microscopic morphology of the hydrogel, a digital source meter is used for measuring the electrical response characteristic of the hydrogel, a bacteriostatic ring method and a flat plate bacterial colony counting method are used for measuring the antibacterial property of the hydrogel, the hydrogel is carried on a human body to measure the strain sensing characteristic of the hydrogel, and the temperature-sensitive characteristic and the electrowhitening characteristic of the hydrogel are measured.

The invention has the beneficial effects that: the prepared hydrogel has excellent mechanical property, sensitive electric response characteristic and excellent antibacterial property, and can be used as an excellent flexible electronic sensor.

Drawings

FIG. 1: preparation flow chart of AgNWs composite conductive antibacterial hydrogel

FIG. 2: evaluation of mechanical Properties of hydrogels

FIG. 3: evaluation of thermal stability of hydrogel

FIG. 4: microscopic topography analysis of hydrogels

FIG. 5: evaluation of electric response Properties of hydrogel

FIG. 6: evaluation of antibacterial Properties of hydrogels

FIG. 7: evaluation of Strain sensing Properties of hydrogels

FIG. 8: evaluation of temperature-sensitive Properties of hydrogel

Detailed Description

The invention will now be further described with reference to the following examples and drawings:

the hydrogel of the invention comprises the following chemical components in percentage by weight: the hydrogel comprises NaCl and Fe (NO)₃)₃Polyvinylpyrrolidone (PVP), AgNO₃Isopropyl acrylamide (NIPAM) monomer, N, N ' -Methylene Bisacrylamide (MBA), Potassium persulfate (KPS), Sodium Dodecyl Sulfate (SDS), and Tetramethylethylenediamine (N, N, N ', N ' -Tetramethylethylenediamine, TEMED). The hydrogel is columnar, has a diameter of 10-12mm and a height of 9-11 mm. The freeze-dried hydrogel shows a cross-linked network structure and compact interconnected micropores under an electron microscope.

The preparation method comprises the following steps:

(1) preparation of AgNWs: taking NaCl and Fe (NO)₃)₃Polyvinylpyrrolidone (PVP), AgNO₃Adding the mixture into EG after being put in an oil bath for 1 hour, reacting at 140 ℃ for 2 hours, and then centrifuging and purifying to obtain AgNWs solution.

(2) Preparing AgNWs composite conductive antibacterial hydrogel: taking an isopropyl acrylamide (N-ISOPROPYLACRYLAMIDE, NIPAM) monomer, N' -Methylene Bisacrylamide (MBA), Potassium persulfate (KPS), Sodium Dodecyl Sulfate (SDS) and pure water, removing air, sealing, reacting at 60 ℃ and 300rpm for 30min, and cooling in an ice water bath to obtain a nano Precursor gel (PNG) solution. Taking AgNWs solution, NIPAM monomer, PNG solution, KPS, Tetramethylethylenediamine (N, N, N ', N' -tetramethylenediamine, TEMED) and pure water, carrying out ultrasonic oscillation, mixing uniformly, sealing after removing air, placing in an ice-water bath for 2h, taking out, and standing for 24h to obtain the AgNWs composite conductive antibacterial hydrogel.