阅读说明：本技术 一种两亲性嵌段共聚物及其制备方法和纳米胶束载药系统 (Amphiphilic block copolymer, preparation method thereof and nano micelle drug loading system ) 是由 张富尧 邵玉湘 李火明 于 2019-02-12 设计创作，主要内容包括：本发明涉及一种如式I所示的两亲性嵌段共聚物及其制备方法,以及该共聚物与难溶性药物形成的纳米胶束载药系统。该两亲性嵌段共聚物包括亲水性链段、疏水性链段以及用于连接亲水性链段和疏水性链段的连接子。连接子含有不饱和结构,可以增强难溶性药物与共聚物的相互作用,提高胶束的载药能力和稳定性。本发明还涉及了一种纳米载药胶束系统及其制备方法,以及该纳米载药胶束系统用于制备治疗肿瘤、炎症、糖尿病、中枢神经疾病、心血管疾病、精神疾病药物方面的用途。<Image he="208" wi="700" file="DDA0002631331580000011.GIF" imgContent="drawing" imgFormat="GIF" orientation="portrait" inline="no"></Image>(The invention relates to an amphiphilic block copolymer shown as a formula I, a preparation method thereof and a nano micelle drug-carrying system formed by the copolymer and an insoluble drug. The amphiphilic block copolymer comprises a hydrophilic chain segment, a hydrophobic chain segment and a linker for connecting the hydrophilic chain segment and the hydrophobic chain segment. The linker contains an unsaturated structure, so that the interaction between the insoluble drug and the copolymer can be enhanced, and the drug loading capacity and stability of the micelle are improved. The invention also relates to a nano drug-carrying micelle system and a preparation method thereof, and application of the nano drug-carrying micelle system in preparing drugs for treating tumors, inflammations, diabetes, central nervous diseases, cardiovascular diseases and mental diseases.)