阅读说明：本技术 Lna-二元羧酸衍生物以及它们的制备方法 (LNA-dicarboxylic acid derivatives and process for their preparation ) 是由 K·普恩特纳 C·罗森博姆 F·斯拉多耶维奇 于 2019-03-12 设计创作，主要内容包括：本发明包括式I的LNA-二元羧酸衍生物或其盐,其中R<Sup>1</Sup>是核碱基或经修饰的核碱基,R<Sup>2</Sup>是羟基保护基,且n是1至5的整数。式I的LNA-二元羧酸衍生物可用于式III的预载固体载体,照此可用作适于寡核苷酸合成的起始材料。<Image he="282" wi="700" file="DDA0002668560140000011.GIF" imgContent="drawing" imgFormat="GIF" orientation="portrait" inline="no"></Image>(The invention comprises LNA-dicarboxylic acid derivatives of formula I or salts thereof, wherein R 1 Is a nucleobase or a modified nucleobase, R 2 Is a hydroxyl protecting group, and n is an integer of 1 to 5. LNA-dicarboxylic acid derivatives of formula I are useful in preloaded solid supports of formula III and as such are useful as starting materials for oligonucleotide synthesis.)