阅读说明：本技术 具有与FcRn增强的结合及延长的半衰期的Fc变体 (Fc variants with enhanced binding to FcRn and extended half-life ) 是由 邱华伟 B·麦肯斯 于 2019-01-25 设计创作，主要内容包括：本公开提供包含经修饰的Fc结构域的结合多肽(例如,抗体和免疫粘附素)。本公开还提供编码该结合多肽的核酸、重组表达载体和用于制备此类结合多肽的宿主细胞。还提供使用本文公开的结合多肽治疗疾病的方法。(The present disclosure provides binding polypeptides (e.g., antibodies and immunoadhesins) comprising a modified Fc domain. The disclosure also provides nucleic acids encoding the binding polypeptides, recombinant expression vectors, and host cells for making such binding polypeptides. Also provided are methods of treating diseases using the binding polypeptides disclosed herein.)