阅读说明：本技术 一种治疗肢体痉挛性疾病的药物组合物及其制备方法、制剂与应用 (Pharmaceutical composition for treating limb spasmodic diseases, and preparation method, preparation and application thereof ) 是由 刘朵 顾力华 陈奇刚 和智娟 林珑 耿春梅 于 2020-06-28 设计创作，主要内容包括：本发明公开了一种治疗肢体痉挛性疾病的药物组合物及其制备方法、制剂与应用。所述的治疗肢体痉挛性疾病的药物组合物包括原料药重量份的木瓜100~120份、红花50~70份和制川乌80~100份,经前处理、提取和后处理步骤制备得到。制备方法包括前处理、提取和后处理步骤,制剂为所述的治疗肢体痉挛性疾病的药物组合物中加入药学上可接受的辅料制备成酊剂和外用洗剂。应用为所述的治疗肢体痉挛性疾病的药物组合物在制备治疗中风、颅脑外伤和脊髓损伤后肢体痉挛性疾病药物中的应用。本发明所述的治疗肢体痉挛性疾病的药物组合物在外用缓解瘫痪肢体肌张力增高或痉挛的疗效较好,且价格低廉。(The invention discloses a pharmaceutical composition for treating limb spasmodic diseases, and a preparation method, a preparation and application thereof. The pharmaceutical composition for treating the limb spasmodic diseases comprises, by weight, 100-120 parts of pawpaw, 50-70 parts of safflower and 80-100 parts of radix aconiti preparata, and is prepared through pretreatment, extraction and post-treatment steps. The preparation method comprises the steps of pretreatment, extraction and post-treatment, and the preparation is prepared by adding pharmaceutically acceptable auxiliary materials into the pharmaceutical composition for treating the spasmodic diseases of limbs and trunk and preparing tincture and external lotion. The application is the application of the pharmaceutical composition for treating the limb spasmodic diseases in preparing the medicines for treating the limb spasmodic diseases after stroke, craniocerebral trauma and spinal cord injury. The medicine composition for treating the spastic limb diseases has better curative effect of relieving the increase of the muscle tension or the spasm of the paralytic limbs by external use, and has low price.)

1. The pharmaceutical composition for treating the limb spasmodic diseases is characterized by comprising 100-120 parts by weight of pawpaw, 50-70 parts by weight of safflower and 80-100 parts by weight of prepared radix aconiti, and is prepared by the steps of pretreatment, extraction and post-treatment.

2. The pharmaceutical composition for treating limb spasmodic diseases according to claim 1, wherein the pharmaceutical composition for treating limb spasmodic diseases comprises, by weight, 100-120 parts of pawpaw, 50-70 parts of safflower, 80-100 parts of radix aconiti preparata, 80-100 parts of polygonum cuspidatum and 80-100 parts of ligusticum wallichii, and is prepared by the steps of pretreatment, extraction and post-treatment.

3. A method for preparing the pharmaceutical composition for treating spasmodic limb diseases of claim 1, comprising the steps of pre-treatment, extraction and post-treatment, and specifically comprising:

A. pretreatment: weighing the raw materials in the formula ratio, and crushing and sieving to obtain a material a for later use;

B. extraction: adding an alcohol solution which is 3-8 times of the weight of the material a into the material a, and extracting to obtain an extracting solution b;

C. and concentrating, drying, crushing and sieving the extracting solution b to obtain the target medicine composition for treating the spasmodic diseases of limbs.

4. The preparation method according to claim 3, wherein the grinding and sieving in the step A is to grind and sieve the mixture with a 10-50 mesh sieve.

5. The preparation method according to claim 3, wherein the extraction in step B is one or more of immersion extraction, percolation extraction and reflux extraction.

6. The method according to claim 3 or 5, wherein the extraction is a dipping extraction.

7. The method according to claim 6, wherein the temperature of the dipping extraction is 20 to 60 ℃ and the extraction time is 10 to 20 days.

8. The method according to claim 3, wherein the alcohol solution has a concentration of 60 to 80% by volume.

9. A preparation of the pharmaceutical composition for treating spasmodic limb diseases according to claim 1 or 2, wherein pharmaceutically acceptable auxiliary materials are added into the pharmaceutical composition for treating spasmodic limb diseases to prepare tincture or external lotion.

10. The use of the pharmaceutical composition for treating spasmodic limb diseases according to claim 1 or 2, wherein the pharmaceutical composition for treating spasmodic limb diseases is used for preparing a medicament for treating spasmodic limb diseases after stroke, craniocerebral trauma and spinal cord injury.

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition for treating limb spasmodic diseases, and a preparation method, a preparation and application thereof.

Background

Stroke is a disease with high morbidity, mortality, and disability rate. In the process of developing the paralysis of the limbs of the patient, the muscular tension of the paralyzed limbs is increased or spasm of the paralyzed limbs almost occurs, and the spastic paralysis is one of the common sequelae of the stroke patient. Along with the improvement of living standard, more and more people with private cars are provided, traffic accident injuries are in a rising trend due to various reasons, patients with craniocerebral trauma and spinal cord injury in the traffic accident injuries are increased day by day, paralytic limb muscle tension is increased or spasm is almost generated in the course of the disease, if the muscle tension is increased, the pain of the affected limb can be caused, the muscle atrophy of the affected limb, the joint contracture and deformation can be caused, the joint activity is limited and the rehabilitation training is difficult, and the recovery of the activity of the stroke patient is finally influenced. At present, the western medicines have fewer medicines for reducing the muscle tension, more side effects and higher cost, and the Chinese patent medicines for oral administration and external use for increasing the muscle tension or spasm of the paralytic limbs are also fewer, so the development of a product capable of fundamentally solving the problems is very necessary.

Disclosure of Invention

The first purpose of the invention is to provide a pharmaceutical composition for treating spastic limb diseases; the second purpose is to provide a preparation method of the pharmaceutical composition for treating spastic limb diseases; the third purpose is to provide the preparation of the pharmaceutical composition for treating the spastic diseases of limbs; the fourth purpose is to provide the application of the pharmaceutical composition for treating the spastic limb diseases.

The first purpose of the invention is realized in such a way that the pharmaceutical composition for treating the spasmodic limb diseases comprises 100-120 parts by weight of pawpaw, 50-70 parts by weight of safflower and 80-100 parts by weight of radix aconiti preparata, and is prepared by the steps of pretreatment, extraction and post-treatment.

The second purpose of the invention is realized by the following steps of pretreatment, extraction and post-treatment, and the method specifically comprises the following steps:

A. pretreatment: weighing the raw materials in the formula ratio, and crushing and sieving to obtain a material a for later use;

B. extraction: adding an alcohol solution which is 3-8 times of the weight of the material a into the material a, and extracting to obtain an extracting solution b;

C. and concentrating, drying, crushing and sieving the extracting solution b to obtain the target medicine composition for treating the spasmodic diseases of limbs.

The third purpose of the invention is realized by adding pharmaceutically acceptable auxiliary materials into the pharmaceutical composition for treating the spastic limb diseases to prepare tincture or external lotion.

The fourth purpose of the invention is realized by the application of the pharmaceutical composition for treating the spastic limb diseases in the preparation of medicines for treating the spastic limb diseases after stroke, craniocerebral trauma and spinal cord injury.

The increase of muscle tone after central nervous system injury is one of the main complications after central nervous system injury, mainly caused by hyperhyperstretch reflex, and is very troublesome to treat clinically. TCM often gives rise to muscular tension and convulsive limbs or spasm of muscles and tendons. Book three of the book "Shangshiming theory": "the tendons and the pulses of convulsions are acute, and the tendons and the pulses of convulsions are slow; the urgent one will contract with the guiding force, while the slow one will stretch longitudinally. Or shriveling or stretching, which is a convulsion. The expression "spasm of tendons" refers to the condition of the tendons and vessels failing to flex and stretch clonic convulsion. See Jingyue quan Shu & miscellaneous plan-plan. It is caused by consumption of yin and blood, invasion of exogenous pathogenic factors and malnutrition of tendons and vessels. According to traditional Chinese medicine, limb spasm is caused by liver-kidney yin deficiency, liver-yang hyperactivity, liver wind internal movement, blood deficiency and muscle and tendon spasm. Convulsive limbs are caused by excessive heat damaging yin, wind-fire flaring up, phlegm-fire accumulation or wind-phlegm and phlegm-heat. For it is indicated for calming liver wind, clearing heart fire, dispelling wind and removing phlegm. Liver governs tendons, healthy qi is deficient due to chronic diseases, phlegm stasis and glue are blocked in channels, so muscle contracture and joint movement are unfavorable, and tendon relaxing, collateral dredging, blood circulation promoting and blood stasis removing are suitable for treatment. The external application of the contracture tincture and rehabilitation training can inhibit stretch reflex, relax spastic muscles, promote the elastic recovery of muscles, ligaments and tendons, strengthen local blood circulation, relieve soft tissue adhesion around joints, relax muscles and tendons, promote blood circulation to disperse blood clots, nourish channels and collaterals, promote joint movement and reduce muscle tension.

In the formula, the pawpaw has the effects of calming the liver, relaxing the muscles and tendons, harmonizing the spleen and eliminating dampness; radix Aconiti Preparata has effects of dispelling pathogenic wind, removing dampness, warming channels and relieving pain; giant knotweed rhizome has the effects of dispelling wind and removing dampness, breaking blood and stimulating menstrual flow, diminishing inflammation and relieving pain; safflower promotes blood circulation and stimulates the menstrual flow, removes blood stasis and relieves pain; the rhizoma ligustici wallichii is used for promoting qi circulation and relieving depression, eliminating dampness by wind therapy, and promoting blood circulation to stop pain; the prepared nutgrass galingale rhizome regulates qi, relieves depression, regulates menstruation and relieves pain. Alcohol has the effects of promoting blood circulation, resisting cold and activating the action of herbs. Modern pharmacological research shows that the pawpaw has the functions of easing pain, resisting inflammation and blocking nerve conduction, the radix aconiti has the functions of resisting inflammation and easing pain, and the safflower has the functions of expanding blood vessels and improving microcirculation. The whole formula treats both principal and secondary aspect of disease, and has the effects of promoting blood circulation by removing blood stasis, warming channels and dredging collaterals. The pawpaw in the preparation can dredge channels and collaterals, treat tendon spasm, is a monarch drug, is prepared from radix aconiti, can dispel wind and remove dampness, and is a ministerial drug for warming channels and relieving pain; the polygonum cuspidatum is an adjuvant drug for treating sexual acidity, entering liver, moving tendons to relieve spasm and urgency, relaxing muscles and tendons and dredging collaterals; chuan Xiong, hong Hua and Xiang Fu can activate blood and move qi, remove blood stasis and dredge meridians as guiding drugs. Borneol is easy to dissolve in ethanol and easy to be absorbed through mucosa and subcutaneous tissues, and the transdermal effect of the medicament is mainly enhanced in the preparation. The medicine composition for treating the spastic limb diseases has better curative effect of relieving the increase of the muscle tension or the spasm of the paralytic limbs by external use, and has low price.

Detailed Description

The present invention is further illustrated by the following examples, which are not intended to be limiting in any way, and any modifications or alterations based on the teachings of the present invention are intended to fall within the scope of the present invention.

The pharmaceutical composition for treating the spasmodic limb diseases comprises, by weight, 100-120 parts of pawpaw, 50-70 parts of safflower and 80-100 parts of radix aconiti preparata, and is prepared through pretreatment, extraction and post-treatment.

The pharmaceutical composition for treating the limb spasmodic diseases comprises, by weight, 100-120 parts of pawpaw, 50-70 parts of safflower, 80-100 parts of prepared radix aconiti, 80-100 parts of giant knotweed and 80-100 parts of ligusticum wallichii, and is prepared by pretreatment, extraction and post-treatment steps.

The preparation method of the pharmaceutical composition for treating the spasmodic limb diseases comprises the steps of pretreatment, extraction and post-treatment, and specifically comprises the following steps:

A. pretreatment: weighing the raw materials in the formula ratio, and crushing and sieving to obtain a material a for later use;

B. extraction: adding an alcohol solution which is 3-8 times of the weight of the material a into the material a, and extracting to obtain an extracting solution b;

C. and concentrating, drying, crushing and sieving the extracting solution b to obtain the target medicine composition for treating the spasmodic diseases of limbs.

And the crushing and sieving in the step A is to crush and sieve the mixture through a sieve with 10-50 meshes.

And the extraction in the step B is one or more of dipping extraction, percolation extraction and reflux extraction.

The extraction is dipping extraction.

The temperature of the dipping extraction is 20-60 ℃, and the extraction time is 10-20 days.

The volume percentage concentration of the alcohol solution is 60-80%.

The preparation of the pharmaceutical composition for treating the spasmodic limb diseases is prepared by adding pharmaceutically acceptable auxiliary materials into the pharmaceutical composition for treating the spasmodic limb diseases and preparing the pharmaceutical composition into tincture or external lotion.

The application of the pharmaceutical composition for treating the limb spasmodic diseases is the application of the pharmaceutical composition for treating the limb spasmodic diseases in preparing medicines for treating the limb spasmodic diseases after stroke, craniocerebral trauma and spinal cord injury.

The invention is further illustrated by the following specific examples: