阅读说明：本技术 用于耗尽cd2+细胞的组合物和方法 (Compositions and methods for depleting CD2+ cells ) 是由 安东尼·博伊坦诺 迈克尔·库克 拉胡尔·帕尔乔杜里 肖恩·麦克唐纳 于 2018-11-29 设计创作，主要内容包括：本发明提供了用作治疗干细胞紊乱、癌症或自身免疫性疾病以及其他血液学疾病和增殖性疾病的剂的抗CD2抗体、其抗原结合片段及其抗体-药物缀合物。本文描述的组合物和方法可以用于耗尽CD2+细胞诸如CD2+癌细胞和CD2+免疫细胞的群体,并且可以用于使患者准备好进行造血干细胞移植。(The present invention provides anti-CD 2 antibodies, antigen-binding fragments thereof, and antibody-drug conjugates thereof, for use as agents for treating stem cell disorders, cancer or autoimmune diseases, as well as other hematologic and proliferative diseases. The compositions and methods described herein can be used to deplete populations of CD2+ cells, such as CD2+ cancer cells and CD2+ immune cells, and can be used to prepare patients for hematopoietic stem cell transplantation.)