阅读说明：本技术 一种含有透明质酸的精华液及其制备方法 (Essence containing hyaluronic acid and preparation method thereof ) 是由 耿凤 王静 王玉玲 李红红 郭学平 于 2020-05-26 设计创作，主要内容包括：本发明公开了一种含有透明质酸的精华液及其制备方法,包含以下有效成分：透明质酸加工物、凝胶、肤感调节剂、以及功效成分,透明质酸加工物呈颗粒状,分步加入到由凝胶、肤感调节剂、功效成分组成的混合相中,形成的以凝胶为主体带有透明质酸颗粒的体系稳定、不分层,透明质酸颗粒能够均匀分散在体系中,不会出现颗粒聚集、沉淀的现象,保证了产品的功效性。(The invention discloses an essence containing hyaluronic acid and a preparation method thereof, wherein the essence comprises the following effective components: the hyaluronic acid skin-feel modifier comprises a hyaluronic acid processed product, a gel, a skin-feel modifier and an effective component, wherein the hyaluronic acid processed product is granular and is added into a mixed phase consisting of the gel, the skin-feel modifier and the effective component step by step, a formed system taking the gel as a main body and provided with hyaluronic acid particles is stable and does not delaminate, the hyaluronic acid particles can be uniformly dispersed in the system, the phenomena of particle aggregation and precipitation cannot occur, and the effectiveness of the product is ensured.)

1. The essence containing hyaluronic acid is characterized in that: comprises the following effective components: hyaluronic acid processed product, gel, skin feeling regulator, and effective component.

2. The essence according to claim 1, characterized by comprising the following active ingredients: 2-5% of hyaluronic acid processed product, 25-45% of gel, 0.5-5% of skin feel regulator, 20-40% of effective component and the balance of purified water.

3. The essence according to claim 1 or 2, characterized in that: the hyaluronic acid processed product is granular.

4. The essence according to claim 1, 2 or 3, characterized in that: the hyaluronic acid processed product is prepared by sieving a sodium hyaluronate cross-linked polymer with a 50-mesh sieve, collecting, pressing into a sheet shape by using a pressing roller, and crushing into granules, wherein the particle size of the granules is less than 0.15 mm.

5. The essence of claim 4, wherein: the pressure of the compression roller is 3-5Mpa, and the compression speed of the compression roller is 10-20 r/min.

6. The essence according to claim 1 or 2, characterized in that: the gel is composed of polyacrylic acid, poloxamer and purified water, wherein the polyacrylic acid: poloxamer: the weight ratio of the purified water is 1: 1: 20-5: 3: 20.

7. the essence of claim 1, wherein: the skin feeling regulator is at least one of hyaluronic acid elastomer, silicone elastomer and polyglycerol-10.

8. The essence of claim 1, wherein: the functional components consist of water-soluble amino acid, water-soluble vitamin, hyaluronate and purified water, wherein the water-soluble amino acid: water-soluble vitamins: hyaluronic acid salt: the weight ratio of the purified water is 0.05: 0.05: 0.05: 100-0.5: 0.5: 0.125: 100.

9. the essence of claim 7, wherein: the hyaluronic acid elastomer is an elastomer of hyaluronic acid or a hyaluronate cross-linked polymer.

10. The essence of claim 7, wherein: the organic silicon elastomer is an elastomer of a polydimethylsiloxane cross-linked polymer or a polydimethylsiloxane/phenyl vinyl polydimethylsiloxane cross-linked polymer.

11. A preparation method of essence containing hyaluronic acid is characterized by comprising the following steps: the method comprises the following steps: the serum containing hyaluronic acid according to any of claims 1-10, comprising the steps of:

s1, pressing and crushing a hyaluronic acid processed object to form hyaluronic acid particles;

s2, adding purified water into an emulsification tank, heating to 75-90 ℃, keeping for 15-30min, adding polyacrylic acid and poloxamer, stirring (20-60rpm/min) for 1-2h, adjusting the pH to 3.0-3.5 by using a pH value regulator to obtain gel, and cooling to 40-50 ℃ for keeping to obtain a to-be-mixed phase A;

s3, mixing the skin feel modifier with a proper amount of purified water, heating to 40-50 ℃, and stirring (20-60rpm/min) for 2-4 hours to obtain a phase B to be mixed;

s4, mixing water-soluble amino acid, water-soluble vitamin, hyaluronate with purified water, heating to 40-50 ℃, and stirring (20-60rpm/min) for 2-4 hours to obtain a phase C to be mixed;

s5, mixing the phase A to be mixed, the phase B to be mixed and the phase C to be mixed, heating to 40-50 ℃, and stirring (20-60rpm/min) for 2-4h to obtain a phase D to be mixed;

s6, adding hyaluronic acid particles into the mixed phase D step by step according to the following steps, and adjusting the pH value by using a pH value regulator to obtain the essence:

。

Technical Field

The invention relates to the technical field of hyaluronic acid, and particularly relates to an essence containing hyaluronic acid and a preparation method thereof.

Background

Hyaluronic acid, also known as hyaluronic acid, is an acidic macromolecular mucopolysaccharide composed of N D-glucuronic acid and N-acetylglucosamine disaccharide units. The hyaluronic acid molecule can carry more than 500 times of water, so the hyaluronic acid molecule is the best natural moisturizing ingredient recognized at present and is widely applied to skin care products and cosmetics.

However, when the hyaluronic acid with large molecular weight is used in cosmetics, the hyaluronic acid is easy to be drawn and smeared during application, and the skin is easy to be sticky and poor in skin feel when sweating or in a relatively humid environment. Meanwhile, hyaluronic acid has poor stability and is easily degraded by acid, alkali, heat, free radicals, hyaluronidase and the like, so that the application of hyaluronic acid is limited. The cross-linked or modified hyaluronic acid has better stability on the basis of keeping the original skin feeling, moisturizing and other effects of the natural hyaluronic acid, and the application of the cross-linked or modified hyaluronic acid in the field of cosmetics can be possibly perfected.

Disclosure of Invention

The invention aims to provide an essence containing hyaluronic acid and a preparation method thereof, so as to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme: a hyaluronic acid-containing essence comprises the following effective components: hyaluronic acid processed product, gel, skin feeling regulator, and effective component.

As a further optimization of the scheme, the essence consists of 2-5% of hyaluronic acid processed product, 25-45% of gel, 0.5-5% of skin feel conditioning agent, 20-40% of effective components and the balance of purified water.

As a further optimization of the above scheme, the hyaluronic acid processed product is in a granular shape.

As a further optimization of the scheme, the hyaluronic acid processed product is prepared by sieving a hyaluronic acid cross-linked polymer with a 50-mesh sieve, collecting, pressing into a sheet shape by using a pressing roller, and crushing into granules with the particle size of less than 0.15 mm.

As a further optimization of the scheme, the pressure of the compression roller is 3-5Mpa, and the compression speed of the compression roller is 10-20 r/min.

As a further optimization of the above scheme, the gel is composed of polyacrylic acid, poloxamer, purified water, polyacrylic acid: poloxamer: the weight ratio of the purified water is 1: 1: 20-5: 3: 20.

as a further optimization of the scheme, the skin feeling regulator is at least one of hyaluronic acid elastomer, silicone elastomer and polyglycerol-10

As a further optimization of the scheme, the effective components consist of water-soluble amino acids, water-soluble vitamins, hyaluronate and purified water, wherein the water-soluble amino acids: water-soluble vitamins: hyaluronic acid salt: the weight ratio of the purified water is 0.05: 0.05: 0.05: 100-0.5: 0.5: 0.125: 100.

as a further optimization of the above scheme, the water-soluble amino acid may be water-soluble amino acid reported in the prior art and capable of being applied in skin care products, such as at least one of glycine, proline, hydroxyproline, lysine hydrochloride, isoleucine, leucine, serine, alanine, aspartic acid, tyrosine, glutamic acid, phenylalanine, arginine hydrochloride, valine, threonine, histidine hydrochloride, tryptophan, methionine, cystine, cysteine, and the like. The water-soluble vitamin can be water-soluble vitamins which are reported in the prior art and can be applied to skin care products, such as at least one of vitamin B1, vitamin B2, nicotinamide, vitamin B6, vitamin B12, folic acid, vitamin C and the like. The hyaluronic acid salt can be at least one of sodium salt, potassium salt, calcium salt, magnesium salt and zinc salt of hyaluronic acid.

As a further optimization of the above solution, the hyaluronic acid elastomer is an elastomer of hyaluronic acid or a hyaluronate cross-linked polymer.

As a further optimization of the above solution, the silicone elastomer is an elastomer of a dimethicone crosspolymer or a dimethicone/phenyl vinyl dimethicone crosspolymer.

A method for preparing an essence containing hyaluronic acid, the method comprising the steps of:

s1, pressing and crushing a hyaluronic acid processed object to form hyaluronic acid particles;

s2, adding purified water into an emulsification tank, heating to 75-90 ℃, keeping for 15-30min, adding polyacrylic acid and poloxamer, stirring (20-60rpm/min) for 1-2h, adjusting the pH to 3.0-3.5 by using a pH value regulator to obtain gel, and cooling to 40-50 ℃ for keeping to obtain a to-be-mixed phase A;

s3, mixing the skin feel modifier with a proper amount of purified water, heating to 40-50 ℃, and stirring (20-60rpm/min) for 2-4 hours to obtain a phase B to be mixed;

s4, mixing water-soluble amino acid, water-soluble vitamin, hyaluronate with purified water, heating to 40-50 ℃, and stirring (20-60rpm/min) for 2-4 hours to obtain a phase C to be mixed;

s5, mixing the phase A to be mixed, the phase B to be mixed and the phase C to be mixed, heating to 40-50 ℃, and stirring (20-60rpm/min) for 2-4h to obtain a phase D to be mixed;

s6, adding the hyaluronic acid particles into the mixed phase D step by step according to the following steps, and adjusting the pH value by using a pH value regulator to obtain the essence.

Step (ii) of	Time of day	Temperature of	Procedure for the preparation of the	Hyaluronic acid particle addition	pH value
						1	0-15min	50℃	Stirring (20-40rpm/min)	60～80％	3.5-4.5
2	15-30min	35℃	Stirring (10-20rpm/min)	Balance of	4.5-5.5
						3	31-60min	35℃	Stirring (10-20rpm/min)	——	6.5-7.0

The above-mentioned pH regulators are well known in the art and can be selected by the person skilled in the art from the prior art.

Compared with the prior art, the invention has the following advantages:

according to the invention, the hyaluronic acid processed product is granular and is added into the mixed phase consisting of the gel, the skin feel regulator and the functional components step by step, and the formed system taking the gel as a main body and provided with hyaluronic acid particles is stable and not layered, and can uniformly disperse the hyaluronic acid particles, so that the phenomena of aggregation and precipitation of the hyaluronic acid particles due to uneven distribution are avoided, the maximum effect of the effective components is exerted, and the efficacy of the product is ensured; in addition, the skin feel regulator can promote essence smearing and leveling, improve the adhesiveness of the essence, is not easy to run off and waste, and helps the skin to better absorb the essence.

Detailed Description

The following description of the exemplary embodiments of the present application, including various details of the embodiments of the present application to assist in understanding, should be taken as exemplary only. Accordingly, those of ordinary skill in the art will recognize that various changes and modifications of the embodiments described herein can be made without departing from the scope and spirit of the present application. Also, descriptions of well-known functions and constructions are omitted in the following description for clarity and conciseness.