阅读说明：本技术 透明质酸和/或透明质酸盐在制备防晒增效剂中用途、含其防晒化妆品组合物及制备方法 (Application of hyaluronic acid and/or hyaluronate in preparation of sunscreen synergist, sunscreen cosmetic composition containing hyaluronic acid and/or hyaluronate and preparation method ) 是由 安冬 陈晗俊 邓笑颖 吴旭 张晨琦 于 2021-07-28 设计创作，主要内容包括：本发明涉及透明质酸和/或透明质酸盐在制备防晒增效剂中的用途,所述透明质酸和/或透明质酸盐的分子量不高于200wDa。本发明还提供一种含透明质酸和/或透明质酸盐的防晒化妆品组合物,按质量百分含量计包括如下组分：透明质酸和/或透明质酸盐0.01％-1％；防晒剂0.5％-50％；辅助组分0.01％-50％；其中,所述透明质酸和/或透明质酸盐的分子量为135-200wDa。本发明还提供一种如上所述的含透明质酸和/或其盐的防晒化妆品组合物的制备方法。本发明采用分子量为135-200wDa的透明质酸和/或其盐在添加量为0.01％-1％时对防晒化妆品具有显著的广谱增效作用,透明质酸和/或其盐分子量优选180-200wDa,添加量优选0.1％-0.5％。本发明的含透明质酸和/或其盐的防晒化妆品组合物可广泛应用于防晒化妆品中。(The invention relates to the use of hyaluronic acid and/or a salt of hyaluronic acid, the molecular weight of which is not higher than 200wDa, for the preparation of a sunscreen synergist. The invention also provides a sunscreen cosmetic composition containing hyaluronic acid and/or hyaluronate, which comprises the following components in percentage by mass: 0.01% -1% of hyaluronic acid and/or hyaluronate; 0.5 to 50 percent of sun-screening agent; 0.01 to 50 percent of auxiliary component; wherein the molecular weight of the hyaluronic acid and/or the hyaluronate is 135-200 wDa. The invention also provides a preparation method of the sunscreen cosmetic composition containing the hyaluronic acid and/or the salt thereof. The hyaluronic acid and/or the salt thereof with the molecular weight of 135-200wDa has a remarkable broad-spectrum synergistic effect on the sunscreen cosmetics when the addition amount is 0.01-1%, the molecular weight of the hyaluronic acid and/or the salt thereof is preferably 180-200wDa, and the addition amount is preferably 0.1-0.5%. The sunscreen cosmetic composition containing hyaluronic acid and/or salt thereof can be widely applied to sunscreen cosmetics.)

1. Use of hyaluronic acid and/or a hyaluronate salt for the preparation of a sunscreen booster, characterised in that the hyaluronic acid and/or hyaluronate salt has a molecular weight not higher than 200 wDa.

2. Use of hyaluronic acid and/or hyaluronate according to claim 1, characterized in that the sunscreen synergist is a synergist in enhancing the UV absorption or reducing the UV transmission of a sunscreen product.

3. A sunscreen cosmetic composition containing hyaluronic acid and/or a hyaluronate salt, characterized in that the content of hyaluronic acid and/or hyaluronate salt is not higher than 1% by mass and the molecular weight is not higher than 200 wDa.

4. The sunscreen cosmetic composition containing hyaluronic acid and/or hyaluronate according to claim 3, characterized by comprising the following components in percentage by mass:

0.01% -1% of hyaluronic acid and/or hyaluronate;

0.5 to 50 percent of sun-screening agent;

wherein the molecular weight of the hyaluronic acid and/or the hyaluronate is 135-200 wDa.

5. The sunscreen cosmetic composition containing hyaluronic acid and/or hyaluronate according to claim 3 or 4, characterized in that the content of hyaluronic acid and/or hyaluronate by mass is 0.1% -0.5%, and the molecular weight is 180-200 wDa.

6. The sunscreen cosmetic composition containing hyaluronic acid and/or its salt according to claim 3 or 4, wherein the hyaluronic acid salt is one or more of sodium salt, potassium salt, magnesium salt, calcium salt and zinc salt of hyaluronic acid.

7. The sunscreen cosmetic composition containing hyaluronic acid and/or hyaluronate according to claim 4, characterized in that the sunscreen agent is one or more of water-soluble sunscreen agent and oil-soluble sunscreen agent;

wherein the water-soluble sun-screening agent is selected from one or more of benzophenone-4, benzophenone-5, benzal camphor sulfonic acid and salts thereof, camphor benzalkonium methyl sulfate, phenyl dibenzoimidazole tetrasulfonate disodium, phenyl benzimidazole sulfonic acid and potassium, sodium and triethanolamine salts thereof, and p-xylylene dicamphor sulfonic acid and salts thereof;

the oil-soluble sun-screening agent is selected from one or more of 3-benzylidene camphor, 4-methylbenzylidene camphor, benzophenone-3, bis-ethylhexyloxyphenol methoxyphenyl triazine, butyl methoxy dibenzoyl methane, diethylamino oxybenzoyl hexyl benzoate, diethyl hexyl butyryl amino triazone, cresol trozole trisiloxane, dimethyl PBPA ethylhexyl ester, ethylhexyl methoxycinnamate, ethylhexyl salicylate, ethylhexyl triazone, homosalate, isoamyl p-methoxycinnamate, methylene bis-benzotriazolyl tetramethyl butylphenol, octocrylene, PEG-25-p-aminobenzoic acid, polyacrylamide methyl benzylidene camphor, polysiloxane-15, titanium dioxide and zinc oxide;

preferably, the mass percentage of the sun-screening agent is 5% -30%.

8. The sunscreen cosmetic composition containing hyaluronic acid and/or hyaluronate according to claim 4, characterized in that the composition further comprises 0.01-50% by weight of auxiliary components, preferably the auxiliary components comprise the following components by weight percent: 0.01-20% of emollient, 0.01-10% of thickening agent, 0.01-10% of emulsifier, 0.01-5% of preservative, 0.01-2% of chelating agent, 0.01-20% of humectant and 0.001-20% of other active ingredients.

9. The sunscreen cosmetic composition containing hyaluronic acid and/or its salt according to claim 8, wherein the emollient comprises one or more of C12-15 alcohol benzoate, diethylhexyl carbonate, butyl octanol salicylate, caprylic/capric triglyceride, and ethylhexyl palmitate;

the humectant comprises one or more of polyalcohol, amino acid, polysaccharide and inorganic humectant;

the thickening agent comprises one or more of carbomer, xanthan gum, cellulose gum, silicate and reverse thickening agent;

the emulsifier comprises one or more of an anionic emulsifier, a cationic emulsifier and a nonionic emulsifier;

the chelating agent comprises an EDTA salt;

the other active ingredients comprise one or more of an antioxidant, an anti-inflammatory agent and a sunscreen synergist;

the antiseptic comprises one or more of parabens, phenoxyethanol, iodopropynyl butylcarbamate, bis (hydroxymethyl) imidazolidinyl urea, p-hydroxyacetophenone, caprylyl hydroxamic acid, caprylyl glycol, ethylhexyl glycerol, hexylene glycol and pentanediol.

10. A process for the preparation of a cosmetic sunscreen composition comprising hyaluronic acid and/or a salt thereof according to any of claims 8 to 9, comprising the following steps:

step 1: adding water, hyaluronic acid and/or hyaluronate, humectant, thickener, water-soluble sunscreen agent, emulsifier, chelating agent and antiseptic into a water kettle, heating, stirring, and dissolving;

step 2: adding the emollient, the oil-soluble sunscreen agent and the emulsifier into an oil pan, heating and stirring uniformly;

and step 3: pumping the water phase raw materials into a main pot, starting homogenization, slowly pumping the oil phase raw materials, and quickly homogenizing after pumping;

and 4, step 4: cooling, adding other active ingredients into the main pot, and uniformly stirring;

and 5: and (6) discharging.

11. The method according to claim 10, wherein the molecular weight of the hyaluronic acid and/or hyaluronate in step 1 is 135-200wDa, preferably 180-200 wDa; the heating temperature in the step 1 is 80-85 ℃; the heating temperature in the step 2 is 80-85 ℃; the homogenizing speed in the step 3 is more than 3000rpm, the homogenizing time is 3-5 minutes, and the operating temperature in the step is 80-85 ℃; the operation temperature in the step 4 is 40-50 ℃; the operating temperature in step 5 is 30-35 ℃.

Technical Field

The invention relates to the technical field of sunscreen cosmetics, in particular to application of hyaluronic acid and/or hyaluronate in preparation of a sunscreen synergist, and also relates to a sunscreen cosmetic composition containing hyaluronic acid and/or hyaluronate and a preparation method thereof.

Background

In recent years, sunscreen cosmetics are well known and generally accepted by consumers, and the awareness of using sunscreen cosmetics is getting stronger, and the requirements on sunscreen cosmetics mainly include good sunscreen performance, fresh skin feel, good safety and the like. In the prior art, the sun protection and synergy can be realized by adding a film-forming agent, solid particles, a coating technology and other means, so that the dosage of the sun protection agent is reduced, and the skin feel and safety in use are improved. The common sunscreen synergistic technology has the problems of heavy skin feel, easiness in mud rubbing, difficulty in degradation and the like.

Hyaluronic acid is one of the most ideal natural moisturizing factors found in nature, has the functions of moisturizing, nourishing, repairing, resisting bacteria and diminishing inflammation and the like, and is the most common component in cosmetics. Researchers mostly focus on the effects of moisturizing, repairing and the like of hyaluronic acid, and apply the hyaluronic acid to skin care products.

In the prior art, hyaluronic acid is added into sunscreen products, but is generally used for moisturizing or repairing skin, and few studies mention that hyaluronic acid can repair ultraviolet injury to skin and protect skin in sunscreen cosmetics, for example, chinese patent CN104706545A discloses a sunscreen hydrogel composition comprising 2% -10% sodium hyaluronate.

Disclosure of Invention

The prior art does not find the sun protection synergistic effect of hyaluronic acid on sun protection cosmetics, and does not explicitly consider the molecular weight of hyaluronic acid which can be used for sun protection synergistic effect.

Based on the problems of heavy skin feeling, difficult degradation and the like existing in the existing sunscreen synergistic technology, the invention aims to optimally select hyaluronic acid and/or hyaluronate with optimal molecular weight for broad-spectrum sunscreen synergistic and solve the technical problems. Therefore, the invention provides a sunscreen cosmetic composition containing hyaluronic acid and/or hyaluronate and a preparation method thereof.

In a first aspect, the present invention provides the use of hyaluronic acid and/or a salt of hyaluronic acid, having a molecular weight not higher than 200wDa, for the preparation of a sunscreen synergist, said sunscreen synergist being a synergist in enhancing the uv absorption or reducing the uv transmission of a sunscreen product.

In a second aspect, the invention provides a sunscreen cosmetic composition comprising hyaluronic acid and/or a salt of hyaluronic acid, wherein the mass percentage of hyaluronic acid and/or salt of hyaluronic acid is not higher than 1%, and the molecular weight is not higher than 200 wDa.

Optionally, the sunscreen cosmetic composition comprises the following components in percentage by mass: 0.01% -1% of hyaluronic acid and/or hyaluronate; 0.5 to 50 percent of sun-screening agent; 0.01 to 50 percent of auxiliary component; wherein the molecular weight of the hyaluronic acid and/or the hyaluronate is 135-200 wDa.

Optionally, in the sunscreen cosmetic composition, the content of the hyaluronic acid and/or the hyaluronic acid salt is 0.05 to 1% by mass, preferably 0.1% to 0.5% by mass, and more preferably 0.1%, 0.2%, 0.3%, 0.4%, 0.5% by mass.

Optionally, the molecular weight of the hyaluronic acid and/or hyaluronate salt is 180-200 wDa.

Optionally, the hyaluronic acid salt is one or more than two of sodium salt, potassium salt, magnesium salt, calcium salt and zinc salt of hyaluronic acid.

Optionally, the sunscreen agent is one or more of a water-soluble sunscreen agent and an oil-soluble sunscreen agent.

Optionally, the water-soluble sunscreen agent is selected from one or more of benzophenone-4, benzophenone-5, benzalcamphor sulfonic acid and salts thereof, camphor benzalkonium methyl sulfate, phenyl dibenzoimidazole tetrasulfonate disodium, phenyl benzimidazole sulfonic acid and potassium, sodium and triethanolamine salts thereof, and p-xylylene dicamphor sulfonic acid and salts thereof;

the oil-soluble sun-screening agent is selected from one or more of 3-benzylidene camphor, 4-methylbenzylidene camphor, benzophenone-3, bis-ethylhexyloxyphenol methoxyphenyl triazine, butyl methoxy dibenzoyl methane, diethylamino oxybenzoyl hexyl benzoate, diethyl hexyl butyryl amino triazone, cresol trozole trisiloxane, dimethyl PBPA ethylhexyl ester, ethylhexyl methoxycinnamate, ethylhexyl salicylate, ethylhexyl triazone, homosalate, isoamyl p-methoxycinnamate, methylene bis-benzotriazolyl tetramethyl butylphenol, octocrylene, PEG-25-p-aminobenzoic acid, polyacrylamide methyl benzylidene camphor, polysiloxane-15, titanium dioxide and zinc oxide.

Optionally, the sunscreen agent is 5% to 30% by mass.

Optionally, the auxiliary components comprise the following components in percentage by mass: 0.01-20% of emollient, 0.01-10% of thickening agent, 0.01-10% of emulsifier, 0.01-5% of preservative, 0.01-2% of chelating agent, 0.01-20% of humectant and 0.001-20% of other active ingredients.

Optionally, the emollient comprises one or more of C12-15 alcohol benzoate, diethylhexyl carbonate, butyl octanol salicylate, caprylic/capric triglyceride, and ethylhexyl palmitate;

the humectant comprises one or more of polyalcohol, amino acid, polysaccharide and inorganic humectant;

the thickening agent comprises one or more of carbomer, xanthan gum, cellulose gum, silicate and reverse thickening agent;

the emulsifier comprises one or more of an anionic emulsifier, a cationic emulsifier and a nonionic emulsifier;

the chelating agent comprises an EDTA salt;

the other active ingredients comprise one or more of an antioxidant, an anti-inflammatory agent and a sunscreen synergist;

the antiseptic comprises one or more of parabens, phenoxyethanol, iodopropynyl butylcarbamate, bis (hydroxymethyl) imidazolidinyl urea and other common antiseptic in cosmetics and other antibacterial p-hydroxyacetophenone, caprylyl hydroxamic acid, caprylyl glycol, ethylhexyl glycerol, hexylene glycol and pentanediol.

Further, the present invention also provides a method for preparing a sunscreen cosmetic composition containing hyaluronic acid and/or a hyaluronic acid salt as described above, comprising the steps of:

step 1: adding water, hyaluronic acid and/or hyaluronate, humectant, thickener, water-soluble sunscreen agent, emulsifier, chelating agent and antiseptic into a water kettle, heating, stirring, and dissolving;

step 2: adding the emollient, the oil-soluble sunscreen agent and the emulsifier into an oil pan, heating and stirring uniformly;

and step 3: pumping the water phase raw materials into a main pot, starting homogenization, slowly pumping the oil phase raw materials, and quickly homogenizing after pumping;

and 4, step 4: cooling, adding other active ingredients into the main pot, and uniformly stirring;

and 5: and (6) discharging.

Optionally, the molecular weight of the hyaluronic acid and/or the hyaluronate in the step 1 is 135-200 wDa; the heating temperature in the step 1 is 80-85 ℃; the heating temperature in the step 2 is 80-85 ℃; the homogenizing speed in the step 3 is more than 3000rpm, the homogenizing time is 3-5 minutes, and the operating temperature in the step is 80-85 ℃; the operation temperature in the step 4 is 40-50 ℃; the operation temperature in the step 5 is about 30-35 ℃.

Optionally, the molecular weight of the hyaluronic acid and/or hyaluronate in step 1 is 180-200 wDa.

The invention uses polysaccharide hyaluronic acid and/or hyaluronate of natural fermentation source for broad spectrum sunscreen synergy, and preferably the molecular weight of hyaluronic acid and/or hyaluronate is 135-200 wDa. Most of the current common sunscreen synergists are synthetic macromolecular film forming agents or synthetic polymeric microspheres and the like, have certain hidden dangers to the environment, and have the problems of heavy skin feel, easiness in mud rubbing, difficulty in degradation and the like when applied to sunscreen products. According to the invention, hyaluronic acid and/or hyaluronate is innovatively used for broad-spectrum sunscreen synergy, the problems of thick skin feel, easiness in mud rubbing, difficulty in degradation and the like of the common sunscreen synergy technology are solved, and hidden dangers to the environment are eliminated. Meanwhile, the molecular weight of the hyaluronic acid and/or the hyaluronate is 135-200wDa, because the molecular weight of the hyaluronic acid and/or the hyaluronate is smaller than 135wDa, the function of assisting sun protection is obviously reduced, and if the molecular weight of the hyaluronic acid and/or the hyaluronate is larger than 200wDa, the hyaluronic acid and/or the hyaluronate is not easy to disperse, has poor smearing feeling and is easy to rub mud, and is not easy to be added into sun protection cosmetics.

Compared with the prior art, the invention has the following beneficial effects:

the hyaluronic acid and/or the hyaluronate with the molecular weight of 135-200wDa has a remarkable broad-spectrum synergistic effect on the sunscreen cosmetics when the addition amount is 0.01-1%, the molecular weight of the hyaluronic acid and/or the hyaluronate is preferably 180-200wDa, and the addition amount is preferably 0.1-0.5%. According to the sun protection index test result, the hyaluronic acid and/or hyaluronic acid salt with the molecular weight of 180-200wDa has good sun protection promoting effect on both SPF and PFA, the increase rate of SPF can reach more than 15%, the increase rate of PFA can reach more than 10%, and the hyaluronic acid and/or hyaluronic acid salt has good broad-spectrum sun protection promoting effect. The addition amount of 0.1-0.5% has the best sun-screening promotion effect, the increase rate of SPF reaches more than 20%, and the increase rate of PFA reaches 14% or more. The sunscreen cosmetic composition containing hyaluronic acid and/or hyaluronate can be widely applied to sunscreen cosmetics.

Drawings

Other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments with reference to the following drawings:

FIG. 1 is a graph showing the effect of sodium hyaluronate with molecular weight of 180-200wDa on the enhancement of sun protection index provided in examples 1-5 of the present invention;

FIG. 2 is a graph showing the effect of sodium hyaluronate of different molecular weights on sun protection factor enhancement provided in examples 2, 6-11 of the present invention;

FIG. 3 shows the effect of sodium hyaluronate with molecular weight of 160-180wDa on the sun protection index promotion provided in examples 6, 12-16 of the present invention.

Fig. 4 is a graph showing the effect of sodium hyaluronate addition in promoting the sun protection index of different sun protection formulations according to examples 17 and 18 of the present invention.

Detailed Description

The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that it would be obvious to those skilled in the art that various changes and modifications can be made without departing from the spirit of the invention. All falling within the scope of the present invention.

Materials, reagents and the like used in the following examples are commercially available unless otherwise specified.

Sodium hyaluronate for use in the following examples was purchased from Huaxi Biotech Ltd.

Examples 1 to 5:

a sunscreen matrix formula comprises the following components in percentage by mass: 0.05-1% of sodium hyaluronate, 0.5-50% of sun-screening agent, 0.01-20% of emollient, 0.01-10% of thickening agent, 0.01-10% of emulsifier, 0.01-5% of preservative, 0.01-2% of chelating agent, 0.01-20% of humectant, 0.001-20% of other active ingredients and the balance of water. The preparation method comprises the following steps:

(1) putting the raw materials No. 1-10 in the table 1 into a water kettle, heating to 80-85 ℃, stirring to dissolve uniformly, and pumping into an emulsifying kettle;

(2) adding No. 11-20 raw materials into an oil pan, heating to 80-85 ℃, and uniformly stirring;

(3) starting the emulsifying pot, homogenizing, and slowly pumping the oil phase into the emulsifying pot; homogenizing at 3000rpm for 5-8min after pumping;

(4) grinding No. 21-22 raw materials uniformly without agglomeration; adding into emulsifying pan, homogenizing at 3000rpm for 2-4 min;

(5) adding No. 23 raw materials into a main pot, and homogenizing at a rotation speed of 3000rpm for 2-4 min;

(6) cooling to 35 ℃, and discharging.

Wherein, the molecular weight of the sodium hyaluronate in the step (1) is 180-200 wDa.

The sunscreen cosmetic prepared by the method is prepared by weighing the required raw materials according to the table 1.

TABLE 1

After the above blank control example 1 and examples were prepared, the sun protection factor SPF and PFA values were tested on each sample using UV-2000S as follows:

the sample was aspirated using a pipette and dropped uniformly onto a PMMA plate (1.3 mg/cm)²) And then the finger stall is worn to be smeared uniformly, and the time is not suitable to be too long (the sample adding amount is accurately calculated by an analytical balance). The PMMA board coated with the sun-proof sample is horizontally placed at a dark direct light place at normal temperature, dried and balanced for 15-20 minutes, then placed into a UV2000S (blue-phenanthrene optical ultraviolet transmittance analyzer) for testing, 12 different positions are tested on each carrier board, the transmittance of 290-400 nm is tested at each position, and the SPF and PFA values of the sample to be tested are calculated according to the following formulas respectively according to the transmittance of 290-400 nm and the transmittance of 320-400 nm.

The results are shown in Table 2.

TABLE 2

Sun protection index	Blank control example 1	Example 1	Example 2	Example 3	Example 4	Example 5
							SPF	37.1	47.2	49.7	45.5	44.1	42.8
PFA	7.6	9.3	9.4	8.7	8.4	8.4

Examples 1-5 the results of the increase in the sun protection factor with the addition of different amounts of sodium hyaluronate are shown in figure 1. Wherein the SPF increase rate is (SPF)_Examples-SPF_{Blank control example})/SPF_{Blank control example}100%, PFA growth rate ═ PFA (PFA)_Examples-PFA_{Blank control example})/PFA_{Blank control example}*100％。

From the results of the sun protection index tests of the above examples 1-5, it can be seen that sodium hyaluronate with molecular weight of 180-200wDa has good sun protection promoting effects on both SPF and PFA, the SPF growth rate can reach more than 15%, the PFA growth rate can reach more than 10%, and the sodium hyaluronate has good broad-spectrum sun protection promoting effects. Preferably, the sunscreen promoting effect is best when the addition amount is 0.1% -0.5%, the increase rate of SPF is more than 20%, and the increase rate of PFA is more than 14%.

Examples 6 to 11:

examples 6-11 were prepared in the same manner as in example 2, except that the sodium hyaluronate of example 2 was replaced with sodium hyaluronate of different molecular weight (as shown in Table 3).

TABLE 3

After preparation, each sample was tested for sun protection factor SPF and PFA values using UV-2000S. The test results are shown in table 4, wherein the results of example 2 are synchronously summarized in table 4.

TABLE 4

Examples 6-11 the results of the increase in the sun protection factor with the addition of sodium hyaluronate of different molecular weights are shown in figure 2.

From examples 6-11, it is known that sodium hyaluronate has a certain SPF and PFA promoting effect at molecular weight of 135-200wDa, wherein the SPF promoting effect is more than 20%. From the above results, it is known that sodium hyaluronate with molecular weight of 135-200wDa has significant SPF promoting effect, and preferably, sodium hyaluronate with molecular weight of 180-200wDa has significant broad spectrum sunscreen promoting effect.

Examples 12 to 16:

examples 12-16 were prepared in the same manner as in examples 1-5, except that the sodium hyaluronate of examples 1-4 was replaced with sodium hyaluronate of 160-180wDa in terms of molecular weight (in detail, Table 5) in different amounts (w/w%), and the balance was made up with water.

TABLE 5

After preparation, each sample was tested for sun protection factor SPF and PFA values using UV-2000S. The test results are shown in Table 6, wherein the results of example 6 are synchronously summarized in Table 6.

TABLE 6

The results of the increase rate of sun protection factor for the different amounts of sodium hyaluronate added for examples 6, 12-16 are shown in figure 3.

From examples 6 and 12-16, it is known that sodium hyaluronate with a molecular weight of 160-180wDa has an effect of promoting SPF and PFA at an addition amount of 0.1-1%, preferably 0.1-0.5%. Example 12 had little effect on the sun protection index due to a low sodium hyaluronate content, and example 16 had a too high sodium hyaluronate content and the samples were not uniform.

Example 17:

the amounts of sunscreen agent (15.50% of the total amount of sunscreen agent) and corresponding amounts of emulsifier, thickener, etc. in blank control 1 and example 2 were adjusted in accordance with the amounts of ingredients in Table 7, and blank control 2 and example 17 (29.50% of the total amount of sunscreen agent) were prepared in the same manner as in blank control 1 and example 2.

TABLE 7

Wherein, the molecular weight of the sodium hyaluronate in the example 17 is 180-200 wDa.

After preparation, each sample was tested for sun protection factor SPF and PFA values using UV-2000S. The test results are shown in Table 8, wherein the results of blank control 1 and example 2 are synchronously summarized in Table 8.

TABLE 8

Examples 2, 17 the results of increasing sun protection factor for different sun protection factor products with the addition of sodium hyaluronate are shown in fig. 4.

As can be seen from blank control examples 1, 2 and 17, 180-200wDa sodium hyaluronate has significant effect on the sun protection factor SPF and PFA of formulations with 15.5% and 29.5% sun protection agent content.

Example 18:

blank controls 1, 2 and examples 1-17, where the sunscreen agents were oil soluble sunscreen agents, are augmented with blank control 3 and example 18 to demonstrate that the present invention is equally applicable to other formulations containing water soluble sunscreen agents.

A sunscreen matrix formula comprises the following components in percentage by mass: 0.2 percent of sodium hyaluronate, 0.5 to 50 percent of sun-screening agent, 0.01 to 20 percent of emollient, 0.01 to 10 percent of thickening agent, 0.01 to 10 percent of emulsifier, 0.01 to 5 percent of preservative, 0.01 to 2 percent of chelating agent, 0.01 to 20 percent of humectant, 0.001 to 20 percent of other active ingredients and the balance of water. The preparation method comprises the following steps:

(1) putting the raw materials No. 1-12 in the table 1 into a water kettle, heating to 80-85 ℃, stirring to dissolve uniformly, and pumping into an emulsifying kettle;

(2) adding No. 13-20 raw materials into an oil pan, heating to 80-85 deg.C, and stirring;

(3) starting the emulsifying pot, homogenizing, and slowly pumping the oil phase into the emulsifying pot; homogenizing at 3000rpm for 5-8min after pumping;

(4) cooling to 50-55 deg.C, adding No. 21 into emulsifying pan, homogenizing at 3000rpm for 1-2 min;

(5) cooling to 35 ℃, and discharging.

Wherein, the molecular weight of the sodium hyaluronate in the step (1) is 180-200 wDa.

The sunscreen cosmetic prepared by the above method comprises the raw materials weighed according to table 9.

TABLE 9

After preparation, each sample was tested for sun protection factor SPF and PFA values using UV-2000S. The test results are shown in Table 10.

Watch 10

Sun protection index	Blank control example 1	Example 2	Blank control example 3	Example 18
					SPF	37.1	49.7	32.3	39.8
PFA	7.6	9.4	7.2	8.6

Example 18 results of the rate of increase of the sun protection index with the addition of sodium hyaluronate for different sun protection formulations are shown in figure 4.

From example 18, it can be seen that sodium hyaluronate of 180-200wDa has a significant effect on enhancing both SPF and PFA in different formulation systems.

From the above examples, it is known that the sodium hyaluronate of 135-200wDa has broad spectrum synergistic effect on sunscreen cosmetics when added in an amount of 0.01-1%, and the molecular weight of the sodium hyaluronate is preferably 180-200wDa, and the added amount is preferably 0.1-0.5%. The sunscreen cosmetic composition containing the sodium hyaluronate can be widely applied to sunscreen cosmetics.

The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes or modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention. The embodiments and features of the embodiments of the present application may be combined with each other arbitrarily without conflict.