阅读说明：本技术 抗体-药物缀合物冻干制剂 (Antibody-drug conjugate lyophilized formulation ) 是由 J.瓦布乔恩 X.京 K.A.罗拜 T.W.鲍尔 G.A.萨查 N.A.皮塞 B.维鲁姆 于 2014-11-21 设计创作，主要内容包括：本发明涉及抗体-药物缀合物冻干制剂。本文公开了抗体-药物缀合物(ADC)、例如抗-组织因子ADC的不含表面活性剂的冻干制剂,和其重构制剂、方法和用途。所述制剂特别适用于基于奥里斯他汀衍生物或其它类似疏水性药物的抗-TF ADC。通常,制剂的赋形剂包括组氨酸、蔗糖、海藻糖、甘露醇和甘氨酸,或由它们组成。(The present invention relates to antibody-drug conjugate lyophilized formulations. Disclosed herein are surfactant-free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, methods and uses thereof. The formulations are particularly useful for anti-TF ADCs based on auristatin derivatives or other similar hydrophobic drugs. Typically, excipients of the formulation include or consist of histidine, sucrose, trehalose, mannitol and glycine.)