阅读说明：本技术 可穿戴式汗液pH值检测装置 (Wearable sweat pH value detection device ) 是由 黄海波 申浩 文震 陈立国 雷浩 戴辞海 刘吉柱 王阳俊 于 2020-06-10 设计创作，主要内容包括：本发明公开了一种可穿戴式汗液pH值检测装置,其包括：汗液采集贴,用于贴在皮肤上收集汗液；所述汗液采集贴中形成有汗液流道；pH检测模块；所述pH检测模块包括电极对、以及连接在所述电极对之间的碳纳米管桥；所述碳纳米管桥由羧基化的碳纳米管对齐排列而成；所述碳纳米管桥位于汗液流道中；检测电路,用于检测所述碳纳米管桥的电阻信息；以及摩擦纳米发电机,用于给所述检测电路供电。上述可穿戴式汗液pH值检测装置,可以将汗液采集贴粘贴在皮肤上,即可实现对汗液的pH值检测,实时,简单,快捷。(The invention discloses a wearable sweat pH value detection device, which comprises: the sweat collecting patch is used for being attached to the skin to collect sweat; a sweat flow channel is formed in the sweat collection patch; a pH detection module; the pH detection module comprises an electrode pair and a carbon nanotube bridge connected between the electrode pair; the carbon nanotube bridge is formed by aligning and arranging carboxylated carbon nanotubes; the carbon nanotube bridge is located in the sweat flow channel; the detection circuit is used for detecting the resistance information of the carbon nanotube bridge; and the friction nano generator is used for supplying power to the detection circuit. Above-mentioned wearable sweat pH value detection device can gather the sweat and paste on skin, can realize detecting the pH value of sweat, and is real-time, simple, swift.)

1. A wearable sweat pH value detection device, comprising:

the sweat collecting patch is used for being attached to the skin to collect sweat; a sweat flow channel is formed in the sweat collection patch;

a pH detection module; the pH detection module comprises an electrode pair and a carbon nanotube bridge connected between the electrode pair; the carbon nanotube bridge is formed by aligning and arranging carboxylated carbon nanotubes; the carbon nanotube bridge is located in the sweat flow channel;

the detection circuit is used for detecting the resistance information of the carbon nanotube bridge;

and the friction nano generator is used for supplying power to the detection circuit.

2. The wearable sweat pH detection device of claim 1, wherein the sweat flow channel comprises a vertical channel that is perpendicular to the sweat collection patch, and a horizontal flow channel for directing sweat in the vertical channel to the carbon nanotube bridge.

3. The wearable sweat pH detection device of claim 2, wherein the horizontal flow channels are archimedes spirals.

4. The wearable sweat pH detection device of claim 1, wherein the sweat collection patch includes a substrate and a PET layer formed on the substrate; the sweat flow channel is located within the PET layer.

5. The wearable sweat pH detection device of claim 1, wherein the sweat collection patch further comprises medical tape for adhering to skin, and double sided tape for bonding the medical tape to the substrate.

6. The wearable sweat pH detection device of claim 1, wherein the electrode pairs are integrated into the sweat flow channel.

7. The wearable sweat pH detection device of claim 1, where the carbon nanotube bridge is formed by dielectrophoresis.

8. The wearable sweat pH detection device of claim 1, wherein the carboxylated carbon nanotubes are carboxylated single-walled carbon nanotubes.

9. The wearable sweat pH detection device of claim 1, wherein the friction nanogenerator is connected to the detection circuitry through a bridge rectifier circuit.

10. The wearable sweat pH detection device of claim 1, wherein the detection circuitry includes an ammeter and a voltmeter.

Technical Field

The invention belongs to the technical field of sweat pH detection, and relates to a wearable sweat pH value detection device.

Background

With the continuous improvement of the living standard of the substances, the requirements of people on health are also continuously improved. Sweat is liquid secreted by a human body through sweat glands, and the secretion amount, the secretion speed, the pH value, the ion concentration, the glucose concentration and other indexes of the sweat can reflect the health condition of the human body. Under normal conditions, skin sweat is a slightly acidic biological fluid (pH value is 4.0-6.8). The change of the pH value of the sweat plays an important role in the pathogenesis of dermatitis, acne, fungal infection, diabetes and other diseases. Today the detection of sweat can only be done in hospitals.

Therefore, a real-time, simple and personal detection device is a problem that needs to be solved.

Disclosure of Invention

Based on this, there is a need for a wearable sweat pH detection device.

A wearable sweat pH detection device comprising:

the sweat collecting patch is used for being attached to the skin to collect sweat; a sweat flow channel is formed in the sweat collection patch;

a pH detection module; the pH detection module comprises an electrode pair and a carbon nanotube bridge connected between the electrode pair; the carbon nanotube bridge is formed by aligning and arranging carboxylated carbon nanotubes; the carbon nanotube bridge is located in the sweat flow channel;

the detection circuit is used for detecting the resistance information of the carbon nanotube bridge;

and the friction nano generator is used for supplying power to the detection circuit.

Above-mentioned wearable sweat pH value detection device can gather the sweat and paste on skin, can realize detecting the pH value of sweat, and is real-time, simple, swift.

In one embodiment, the sweat flow channel comprises a vertical channel perpendicular to the sweat collection patch, and a horizontal flow channel for directing sweat in the vertical channel to the carbon nanotube bridge.

In one embodiment, the horizontal flow passages are in the shape of an archimedes spiral.

In one embodiment, the sweat collection patch includes a substrate and a PET layer formed on the substrate; the sweat flow channel is located within the PET layer.

In one embodiment, the sweat collection patch further comprises medical tape for adhering to the skin, and double-sided adhesive tape for bonding the medical tape to the substrate.

In one embodiment, the pair of electrodes is integrated in the sweat flow channel.

In one embodiment, the carbon nanotube bridge is formed by dielectrophoresis.

In one embodiment, the carboxylated carbon nanotubes are carboxylated single-walled carbon nanotubes.

In one embodiment, the friction nano-generator is connected with the detection circuit through a bridge rectifier circuit.

In one embodiment, the detection circuit comprises an ammeter and a voltmeter.

Drawings

Fig. 1 is a schematic structural diagram of a wearable sweat pH detection device according to an embodiment of the invention.

Fig. 2 is a schematic cross-sectional structure view of the sweat collection patch of fig. 1.

Fig. 3 is a schematic view of the structure of the electrode pair.

Fig. 4 is a schematic diagram of a process for preparing a carbon nanotube bridge.

Fig. 5 is a schematic structural view of an electrode pair and a carbon nanotube bridge.

Fig. 6 is a partially enlarged structural diagram of the electrode pair and the carbon nanotube bridge.

Fig. 7 is a power generation principle diagram of the friction nano-generator.

Fig. 8 is a schematic circuit diagram of the wearable sweat pH detection device.

In the figure, 1, a sweat collection patch, 2, a friction nanogenerator, 3, an electrode pair, 4, skin, 5, a first lead, 6, a second lead, 7, a droplet containing carbon nanotubes, 8, sweat, 11, a PET layer, 12, a medical adhesive tape, 13, a double-sided adhesive tape, 14, a substrate, 15, a horizontal flow channel, 16, a vertical channel, 21, a first friction electrode, 22, a first friction material, 23, a second friction material, 24, a second friction electrode, 25, a bridge rectifier circuit, 26, an ammeter, 27, a voltmeter, 31, a first electrode, 32, a second electrode, 33 and a carbon nanotube bridge.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to specific embodiments. It should be understood that the detailed description and specific examples, while indicating the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

With reference to fig. 1-8 and with particular reference to fig. 1, a wearable sweat pH detection device includes a sweat collection patch 1, a pH detection module, a detection circuit, and a friction nanogenerator 2.

The sweat collection patch 1 is mainly used for being attached to the skin to collect sweat.

Specifically, referring with emphasis to fig. 2, a sweat flow path is formed in the sweat collection patch 1. The sweat flow channel is used for collecting and draining sweat 8 on the skin 4 to the pH detection module. More specifically, the sweat flow path includes a vertical channel 16 perpendicular to the sweat collection patch, and a horizontal flow path 15 for directing sweat 8 in the vertical channel 16 to the pH detection module.

In one of the preferred embodiments, the horizontal flow channels 15 are in the form of archimedes spirals (as shown in fig. 1). This is more conducive to the drainage of sweat. Of course, it is understood that the horizontal flow path is not limited to an archimedes spiral, and may be other spirals or other shapes.

Specifically, the sweat collection patch includes a substrate 14 and a PET layer 11 formed on the substrate 14; the sweat flow channel is located within the PET layer 11. Preferably, the vertical channels 16 and the horizontal flow channels 15 are machined in the PET layer by photolithographic techniques.

The sweat collection patch made of the PET material is non-toxic and harmless to human skin, has good biocompatibility and good flexibility, is suitable for manufacturing wearable equipment, and hardly has influence on the measurement of the pH value after deformation.

Preferably, the sweat collection patch 1 further comprises a medical adhesive tape 12 for adhering to the skin 4, and a double-sided adhesive tape 13 for bonding the medical adhesive tape 12 to the base 14. In this way, the medical tape 12 is in contact with the skin 4, thereby preventing other non-medical products from directly contacting the skin 4, and further avoiding the skin discomfort caused thereby.

Wherein, the pH detection module is a core component for pH detection. The pH detection module is integrated in the sweat collection patch 1. With particular reference to fig. 5, the pH detection module includes a pair of electrodes 3, and a carbon nanotube bridge 33 connected between the pair of electrodes 3; the electrode pair 3 is composed of a first electrode 31 and a second electrode 32 which are provided at an interval. A carbon nanotube bridge 33 is located between the first electrode 31 and the second electrode 32, and the carbon nanotube bridge 33 electrically connects the first electrode 31 and the second electrode 32.

The carbon nanotube bridge 33 is formed by aligning carboxylated carbon nanotubes; the carbon nanotube bridge 33 is located in the sweat flow channel; thus, when sweat flows into the sweat flow channel, the pH detection module detects the sweat flowing through.

In one preferred embodiment, the electrode pair is integrated into the sweat flow channel. This makes the structure more compact. More preferably, the PET film 11 is spin-coated on the substrate 14, the sweat flow channel is processed by photolithography, and the electrode pair 3 is fabricated at the corresponding position using photolithography and lift-off processes.

In one embodiment thereof, the carbon nanotube bridge 33 is formed by dielectrophoresis.

Dielectrophoresis (DEP) refers to the phenomenon of displacement of dielectric particles in a non-uniform electric field due to polarization effects. When a drop of liquid containing carbon nanotubes is introduced to the parallel electrodes by an alternating electric field, the electric field induces a dipole moment in the carbon nanotubes. The dielectrophoretic torque acting on the carbon nanotubes causes their longitudinal axis to be parallel to the electric field lines. The dielectrophoretic force on the elongated carbon nanotubes aligned with the electric field lines is as follows:

is the electric field gradient at the carbon nanotube location, m is the induced dipole moment, which for the elongated carbon nanotube is:

m(t)＝_mV_CNTKE(t)

_mand V_CNTIs the real part of the physical permittivity of the volume of the medium and carbon nanotubes, respectively, and K is the real part of the clausius moxysti Coefficient (CMF). Derived from the above formula, the average force magnitude of dielectrophoresis is:

since the dielectrophoretic torque acting on the carbon nanotubes causes their longitudinal axis to be parallel to the electric field lines, when a droplet 7 of solution containing carbon nanotubes is placed between the pair of electrodes 3, as shown in fig. 4, an alternating current is applied to the pair of electrodes 3, and after a period of deposition, the carbon nanotubes form an ordered bridge 33 of carbon nanotubes between the pair of electrodes 3, connecting the first electrode 31 to the second electrode 32, and thus rendering the detection circuit conductive.

In one embodiment, the carboxylated carbon nanotubes are carboxylated single-walled carbon nanotubes.

Single-walled carbon nanotubes were identifiedFor p-type semiconductors with holes as the main carrier, carboxyl functionalized single-walled carbon nanotubes also show p-type semiconductor behavior. When sweat is applied to these carboxyl-functionalized single-walled carbon nanotubes, H⁺And OH^-The ions are able to interact with and affect the generation of holes and electrons in the carboxyl-functionalized single-walled carbon nanotubes, resulting in a change in the resistance of the carbon nanotube bridge 33. The pH response was determined as the relative change in resistance as:

wherein R and R₀The resistance of the electrode pair 3 in the presence and absence of sweat 8, respectively. According to the data, the pH value and the resistance change are in a linear relationship, and the relative resistance change is 0.285 with each increase of the pH value, so that the resistance change and the pH value have the following relationship:

a first lead 5 is led out from a first electrode of the sweat collection patch 1, a second lead 6 is led out from a second electrode, and the first lead and the second lead are electrically connected with a detection circuit.

The friction nano-generator 2 is mainly used for supplying power to the detection circuit.

The power generation principle of the friction nanogenerator is shown in fig. 7, when two friction materials with different electron binding capacities are contacted, a material with a strong electron binding capacity is negatively charged, a material with a weak electron binding capacity is positively charged, and when the two friction materials are repeatedly contacted, one friction material is saturated. The other material is still getting/losing electrons, and the electrodes connected to it generate electron transfer. Then, a potential difference is formed between the two electrodes.

The friction nano-generator 2 comprises a first friction electrode 21 and a second friction electrode 24, wherein the first friction electrode 21 is positioned on the first friction material 22 and is used for leading out electric charges generated by the first friction material 22; the second friction electrode 24 is located on the second friction material 23 and is used for conducting out the electric charges generated by the second friction material 23.

When the examinee moves, the first friction material 22 and the second friction material 23 are continuously opened and closed, and potential differences are generated on the corresponding electrodes (the first friction electrode 21 and the second friction electrode 24).

Referring to fig. 8, the friction nanogenerator 2 is connected to the detection circuit through a bridge rectifier circuit 25. The resistance was measured by rectifying the ac power generated by the tribo-nanogenerator 2 into a stable dc power using a bridge rectifier circuit 25.

In one embodiment, the detection circuit further comprises an ammeter 26 and a voltmeter 27. The ammeter and the voltmeter can be used for measuring the resistance value, namely, the resistance value of the electrode pair is measured by using a voltammetry method.

The working principle of the wearable sweat pH detection device is explained below.

Paste sweat collection subsides 1 on the skin surface, when the person that awaits measuring moves, sweat from sweat gland secretion, gather the region that pastes 1 covers at sweat collection, because medical sticky tape 12's effect, sweat can't flow to the outside, can only constantly gather in vertical passage 16, until getting into horizontal runner 15. When sweat flows across the electrode pair 3, H + or OH "in the sweat interacts with the carboxyl groups and affects the generation of holes and electrons in the carbon nanotubes, resulting in a change in resistance in the carbon nanotube bridge. Meanwhile, when the examiner moves, the first friction material 22 and the second friction material 23 of the friction nano-generator 2 are continuously opened and closed, and a potential difference is generated on the corresponding electrodes (the first friction electrode 21 and the second friction electrode 24). The alternating current generated by the friction nano-generator 2 is rectified into direct current through the bridge rectifier circuit 25, and the resistance value of the electrode pair is measured by using voltammetry.

The invention uses the friction nanometer generator 2 as the power supply of the detection circuit to replace the traditional motor, simplifies the structure of the device and realizes real-time detection while moving. And rectifying the alternating current generated by the friction nano generator into stable direct current by using a bridge rectifier circuit, and measuring the resistance.

The detection part of the invention adopts carboxylated carbon nano tubes, can detect liquid with pH value of 3-9, and is suitable for sweat detection.

The wearable device is made of the PET material, the PET material is non-toxic and harmless to human skin, has good biocompatibility and good flexibility, is suitable for manufacturing the wearable device, and hardly influences the measurement of the pH value after deformation.

The invention realizes the micro-scale sweat detection based on the micro-fluidic technology, and the detection aim can be achieved by detecting a small amount of sweat in the channel. And meanwhile, the friction nano generator is matched and used as a detection power supply, so that the wearable sweat pH value detection device is realized.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.