阅读说明：本技术 一种核桃楸青果皮饮片及其制备方法 (Walnut Chinese walnut and Chinese olive peel decoction pieces and preparation method thereof ) 是由 郭姗姗 吴秀坤 刘今方 刘君 于 2020-05-25 设计创作，主要内容包括：本发明属于生物医药技术领域,具体涉及一种核桃楸青果皮饮片及其制备方法,该饮片中胡桃醌重量百分含量为0.004％-0.30％,胡桃酮重量百分含量为0.50％-2.00％。研究表明,研究表明,本发明经炮制后饮片,更优效以及更高的安全性。(The invention belongs to the technical field of biological medicines, and particularly relates to a juglone and Chinese walnut peel decoction piece and a preparation method thereof, wherein the juglone is 0.004-0.30 wt% and the juglone is 0.50-2.00 wt% in the decoction piece. Researches show that the processed decoction pieces have better effect and higher safety.)

1. The juglans mandshurica bunge Chinese olive peel decoction piece is characterized in that the juglone decoction piece contains 0.004-0.30 wt% of juglone and 0.50-2.00 wt% of juglone.

2. The walnut Chinese olive peel decoction piece as claimed in claim 1, wherein the juglone is 0.004-0.20% by weight of the decoction piece, and the juglone is 1.00-2.00% by weight of the decoction piece.

3. The walnut Chinese olive peel decoction piece as claimed in claim 1, wherein the juglone is 0.004-0.20% by weight of the decoction piece, and the juglone is 1.00-1.50% by weight of the decoction piece.

4. The walnut Chinese olive peel decoction piece as claimed in claim 1, wherein the juglone is 0.004-0.10 wt% and the juglone is 1.00-1.50 wt% in the decoction piece.

5. The juglans mandshurica oliv decoction piece according to any one of claims 1 to 4, which is characterized in that the preparation method of the juglans mandshurica oliv decoction piece comprises the following steps:

(1) harvesting immature green walnut peels within 15-20 days after the green walnut peels are lodged;

(2) putting green walnut peels into an environment at 30-40 ℃, drying for 3-5 hours, and then putting the green walnut peels into a place at 0-10 ℃ for ventilation and keeping for 2-4 hours; taking out, drying for 4-6 hours at the temperature of 60-65 ℃ to obtain the walnut Chinese walnut and Chinese olive peel decoction pieces.

6. The walnut peel decoction piece of claim 5, wherein the green walnut peel is derived from: the northeast region.

7. The juglans mandshurica bunge Chinese olive peel decoction pieces according to any one of claims 1 to 5, which are characterized by containing the traditional Chinese medicine composition of the juglans mandshurica bunge fruit peel decoction pieces.

8. The walnut Chinese ash Chinese olive peel decoction piece according to claim 7, wherein the traditional Chinese medicine composition contains one or more of bezoar bovis, radix astragali, rhizoma typhonii and cortex dictamni.

9. The juglans mandshurica peel decoction piece as claimed in claim 8, wherein the juglans mandshurica peel decoction piece is subjected to water decoction and/or ethanol extraction and/or ethanol precipitation to obtain a juglans mandshurica extract.

10. The juglans mandshurica bunge Chinese olive peel decoction piece as claimed in any one of claims 1 to 5, wherein the decoction piece is applied to antitumor or anticancer drugs.

Technical Field

The invention belongs to the technical field of biological medicines, and particularly relates to a novel walnut Chinese walnut and Chinese olive peel decoction piece and a preparation method thereof.

Technical Field

Walnut mountain ash green peel, named as traditional Chinese medicine. The product is Mandshurica Maxim, Juglans mandshurica of Juglandaceae, and is prepared from semen Juglandis, fructus Canarii albi and bark. Mashing fructus Canarii albi in summer and autumn and soaking in wine for use; in autumn, mature fruit is picked, the epicarp is removed, and the fruit is cleaned and dried in the sun or the endocarp (shell) is removed to take kernels. Collecting bark more than the cross of spring and summer, and sun drying. The main functional indications are as follows: kernel: astringe lung, relieve asthma, warm kidney and moisten intestine. Can be used for treating asthenia, cough due to lung deficiency, lumbago due to kidney deficiency, constipation, spermatorrhea, sexual impotence, lithangiuria, and milk deficiency. And (3) carrying out olive: can be used for relieving pain. Can be used for treating gastric ulcer, duodenal ulcer, and gastralgia; it is used externally to treat neurodermatitis. Bark: clearing away heat and toxic material. Can be used for treating bacillary dysentery, bone tuberculosis, and hordeolum.

Juglans mandshurica also called walnut green husk is the immature exocarp of Juglans mandshurica Maxim of Juglandaceae. Mainly distributed in the east of the Heilongjiang province of China, such as lesser Khingan mountains, Wandashan mountains, vintage mountains and Zhang Guangdui mountains. As a folk medicine, the Chinese medicine has been used for a long time in China, and is originally recorded in Kai Bao Ben Cao, which is called as walnut Qinglong, in Jie Fang, which is called as Qing Ju Pi, and in Shandong Chinese herbal medicine handbook, which is called as Qing Long clothing, the folk medicine is widely used. The medicine is bitter and astringent in property, so ancient doctors mostly take the effects of clearing heat and removing toxicity, dispelling wind and treating tinea, and relieving pain and dysentery, and the medicine is widely concerned by scholars at home and abroad in recent years due to the prominent anti-tumor effect. In recent years, the traditional Chinese medicine composition is applied to treating digestive system tumors, and particularly has obvious curative effects on esophageal cancer and gastric cancer. The green peel of Juglans mandshurica is called as exocarpium Juglandis Immaturus in Chinese medicine, and contains juglone (5-hydroxy-1, 4-naphthoquinone) with high activity. The research finds that juglone has a specific inhibiting effect and is expected to be used for in vitro transcription research; the toxicity test of the aqueous solution culture solution proves that juglone has potential toxicological effect on human; it shows toxicity in culture solution, but also has antiviral, antibacterial, antifungal, anticancer, etc. activity. Therefore, when the juglans mandshurica bunge Chinese olive peel decoction pieces are prepared, a certain processing method (preparation method) is adopted, so that the content of juglone is controlled, and the important significance is achieved.

Disclosure of Invention

Through multiple creative tests, the applicant finds that the juglans mandshurica bunge Chinese olive peel decoction pieces have the effects of resisting tumors and relieving pain, but have certain toxicity, and the main component of the toxicity is juglone. Researches show that the decoction pieces prepared by the method have better effect and higher safety. .

The invention is realized by the following scheme.

A juglone decoction piece is prepared from juglone 0.004-0.30 wt% and juglone 0.50-2.00 wt%.

The juglone and juglone decoction piece is characterized in that the juglone decoction piece contains 0.004-0.20 wt% and juglone 1.00-2.00 wt%.

The juglone and juglone decoction piece is characterized in that the juglone is 0.004-0.20 wt% and the juglone is 1.00-1.50 wt%.

The juglone and juglone decoction piece is characterized in that the juglone decoction piece contains 0.004-0.10 wt% and juglone 1.00-1.50 wt%.

The preparation method of the juglans mandshurica peel decoction pieces comprises the following steps of:

(1) harvesting immature green walnut peels within 15-20 days after the green walnut peels are lodged;

(2) putting green walnut peels into an environment at 30-40 ℃, drying for 3-5 hours, and then putting the green walnut peels into a place at 0-10 ℃ for ventilation and keeping for 2-4 hours; taking out, drying for 4-6 hours at the temperature of 60-65 ℃ to obtain the walnut Chinese walnut and Chinese olive peel decoction pieces.

The lodging is as follows: entering three volt days; the number of the days from summer to summer begins to fall back, and the number of the days from the summer to the third 'heptyl' begins to fall. The "day of the seventh year" here refers to the ancient "day of the first year with the letter" G ".

The Chinese walnut peel decoction pieces are prepared from the following Chinese walnut peels: the northeast region.

The traditional Chinese medicine composition containing the juglans mandshurica oliv peel decoction pieces.

Wherein the Chinese medicinal composition contains one or more of calculus bovis, radix astragali, rhizoma Typhonii, and cortex Dictamni Radicis.

Wherein the juglans mandshurica maxim peel decoction pieces are subjected to water decoction and/or ethanol extraction and/or ethanol precipitation to obtain the juglans mandshurica maxim extract.

The decoction pieces can be used in anti-tumor or anticancer medicine. Wherein the cancer includes but is not limited to gastric cancer, liver cancer, lymph cancer, breast cancer, leukemia.

The decoction pieces of the invention also have the functions of regulating immunity, relieving pain and avoiding tumor cell metastasis, and the decoction pieces of the invention also have the synergistic effect with chemotherapeutic drugs, targeting drugs and the like.

The invention rearranges the information of each component in the decoction pieces through vibration by a quantum science method, thereby further improving the efficacy.

The invention applies quantum science to the processing of traditional Chinese medicines, reaction products of the components are orderly arranged, and a basis is provided for the mechanism of attenuation and synergy of the processing of the traditional Chinese medicines. The processing mechanism research of the juglone and the juglone is to simulate the processing of juglone and juglone, analyze the hydrolysis change rule of monomer components under different conditions of temperature, time and the like, combine pharmacological toxicological experiments, clarify the interaction of the components and hydrolysate thereof, and lay a good foundation for the processing mechanism research of decoction pieces. Moreover, simulation processing research is carried out on the drug effect part, the interaction of juglone and juglone under the common processing condition and the influence of other components such as flavone and polysaccharide are discussed, and the processing mechanism is more clear by combining with a pharmacological toxicological experiment. The traditional Chinese medicine is finally prepared by decoction pieces, and the processing mechanism of attenuation and synergism can be finally clarified only by combining the specific clinical application of the decoction pieces, researching the change rule of the components processed integrally by the decoction pieces and the pharmacological and toxicological research of the whole animal.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the description is intended to be exemplary only, and is not intended to limit the scope of the present invention. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention.

Preparation examples