阅读说明：本技术 一种多模态内窥镜及内窥成像系统 (Multi-mode endoscope and endoscopic imaging system ) 是由 戴翠霞 杜奉献 孔瑞明 邱锐 高磊 葛坚坚 董柏文 于 2020-03-13 设计创作，主要内容包括：本发明涉及一种多模态内窥镜及内窥成像系统,通过结合超声成像,光学相干层析成像,荧光成像和电子内窥镜成像,具有拍摄光学系统和拍摄元件,被向被检体的消化道(食道、胃、十二指肠、大肠)或者呼吸道(气管、支气管)插入,能够进行消化道、呼吸道的拍摄；设有成像原理不同的光学相干成像装置和荧光成像装置,二者分别与图像处理装置信号连接,且利用波分复用器相结合作为荧光成像系统,可结合各种成像装置的优点获取组织器官的医学影像,有助于捕获更准确的组织器官的层析图。与现有技术相比,本发明可以提供一种性能优异的一种多模态成像内窥镜及内窥系统。(The present invention relates to a multi-modal endoscope and endoscopic imaging system, which combines ultrasonic imaging, optical coherence tomography, fluorescence imaging and electronic endoscopic imaging, and has an imaging optical system and an imaging element, which is inserted into the alimentary tract (esophagus, stomach, duodenum, large intestine) or respiratory tract (trachea, bronchus) of a subject to be examined, and can image the alimentary tract and the respiratory tract; the device is provided with an optical coherent imaging device and a fluorescence imaging device which have different imaging principles, are respectively in signal connection with an image processing device, and are combined by a wavelength division multiplexer to be used as a fluorescence imaging system, so that medical images of tissues and organs can be acquired by combining the advantages of various imaging devices, and more accurate tomograms of the tissues and organs are captured. Compared with the prior art, the invention can provide a multi-mode imaging endoscope and an endoscopic system with excellent performance.)

1. A multi-modality endoscope, comprising:

the inserting part is used for converting the optical signal into an electric signal, transmitting the signal to the connecting part through a signal wire after receiving the electric signal, and displaying the transmitted electric signal after image processing in the electronic endoscope system device; the insertion part comprises a front end part, a bending part and a flexible tube part which are sequentially arranged, wherein the front end part comprises ultrasonic transducers which are arranged in a side row and are used for being connected with an ultrasonic endoscopic imaging device through a signal line, a probe, an optical focusing module which is used for being connected with an OCT imaging observation device through an optical fiber, an image pickup element used for receiving optical signals and a treatment instrument channel used for placing a biopsy forceps and other therapeutic instruments;

an operation section for performing air supply, water supply, and negative pressure suction operations to the distal end portion of the insertion section, performing a bending operation to the bending portion of the insertion section, and controlling the treatment instrument to be conveyed to the body cavity through the treatment instrument channel;

a connecting portion for connecting the insertion portion with the electronic endoscope system device.

2. The multi-modality endoscope according to claim 1, wherein the distal end portion is a rigid distal end structure, and the plurality of ultrasonic transducers are laterally arranged in a row on an outer surface of the distal end portion of the rigid distal end structure.

3. The multi-modality endoscope of claim 1, wherein the optical focusing module is a hemispherical focusing ball lens, a gold-plated reflective film is disposed on a horizontal bottom surface of the hemispherical focusing ball lens, the horizontal bottom surface forms an angle of 45 ° with an axial direction of the optical fiber, and the hemispherical focusing ball lens is fused with the multi-mode optical fiber except for the horizontal bottom surface.

4. The multi-modality endoscope of claim 1, wherein the insertion portion further comprises an illumination window and a single mode optical fiber for transmitting light to the illumination window for illumination.

5. The multi-modality endoscope according to claim 1, wherein the image capture component converts the received optical signals into electrical signals, transmits the electrical signals to the electronic endoscope imaging device via a signal line, and then displays the electrical signals through the image processing device.

6. The multi-modal endoscope according to claim 1, wherein the operation section is provided on a proximal end side of the insertion section, and the operation section includes a bending knob for bending the bending section, an air supply/water supply tube for supplying air and water to a distal end portion of the insertion section, a negative pressure suction tube for sucking excess liquid at the distal end portion of the insertion section through the inside of the endoscope, and a treatment instrument insertion port for connecting to a treatment instrument channel of the operation section.

7. The multi-modality endoscope according to claim 4, wherein the probe includes the illumination window for holding illumination of the forward field of view, an end portion negative pressure suction device window for sucking out an unnecessary liquid tube, an end portion water supply/air supply window for holding an end portion of a water supply tube and for holding an end portion of an air supply tube, a treatment instrument channel window for holding an end portion of a treatment instrument channel in communication with a treatment instrument insertion port, and an imaging device observation window for data transmission of an electronic endoscope device.

8. A multi-modal endoscopic imaging system comprising the multi-modal endoscope of any of claims 1 to 7, the system further comprising:

the image processing device is respectively in signal connection with the OCT imaging observation device, the fluorescence imaging device and the ultrasonic imaging device, and is used for outputting a control signal according to the operation of a user and generating a multi-mode image of the tissue organ according to the received feedback signal;

the ultrasonic imaging device is connected with an ultrasonic transducer of the multi-mode endoscope through a signal line and used for outputting an ultrasonic control signal according to the control signal, so that the ultrasonic transducer emits ultrasonic waves to a sample tissue to be detected and converts the returned feedback ultrasonic waves into ultrasonic feedback signals;

the OCT imaging observation device is connected with the hemispherical focusing ball lens through an optical fiber and used for outputting an optical signal according to a control signal, and the optical signal reaches the tissue of the sample to be detected through the hemispherical focusing ball lens and receives an optical signal fed back by the collected tissue of the sample to be detected;

the fluorescence imaging observation device forms a fluorescence imaging system by utilizing the wavelength division multiplexer and the OCT imaging observation device and is used for integrating an optical coherent imaging sample arm light source and a fluorescence excitation light source into the same single-mode broadband optical fiber light path;

and the electronic endoscope system device is connected with the insertion part of the multi-mode endoscope and is used for carrying out image processing and displaying on the electric signal transmitted back by the insertion part.

9. The system of claim 8, wherein the system employs a double-clad fiber coupler to collect the emitted light and semiconductor laser as an excitation light source for fluorescence imaging.

10. The system of claim 8, wherein the OCT imaging and visualization device employs a high-speed VECSE L light source, and the fluorescence imaging system employs 680-750nm band of semiconductor tunable laser as an excitation light source.

Technical Field

The invention relates to the technical field of medical instruments, in particular to a multi-mode endoscope and an endoscopic imaging system.

Background

In recent years, the continuous development of new imaging techniques has provided new tools for early diagnosis of diseases, including endoscopic ultrasound imaging, optical coherence tomography, fluorescence imaging, confocal imaging, and the like.

An ultrasonic Endoscope (EUS) is a medical device that integrates ultrasonic waves and an endoscope. After the bending portion of the ultrasonic endoscope is inserted into the human body, the internal organs are tomographic-scanned by the endoscope probe at the distal end portion, and an ultrasonic image of the internal organs is obtained. Because the detection depth of ultrasonic imaging is very deep, the ultrasonic endoscope plays an important role in diagnosis and treatment of endoscope rooms in domestic large hospitals.

Optical Coherence Tomography (OCT) has several features including high resolution, no contact, and no damage. Endoscopic OCT (Endoscopic OCT, E-OCT) is used as an important branch of OCT technology, light is guided to an organ tissue to be measured through a probe, the defect of limited light penetration depth can be overcome, a high-resolution tomographic image of organ depth in a human body is obtained, and early treatment of diseases is realized through research of tissue morphology.

Fluorescence Imaging (Fluorescence Imaging) is a linear relationship between the intensity of a Fluorescence signal emitted from a fluorescent substance after excitation and the amount of fluorescein in a certain range. Fluorescence is a molecule with high specificity, and the structure and the components of tissues can be simultaneously analyzed by combining fluorescence imaging and OCT, so that an accurate imaging means can be provided for early pancreaticobiliary tract lesions. However, there is currently no development of OCT/fluorescence endoscopic imaging for early lesions of organs.

In conclusion, for the diagnosis of early diseases in vivo, the clinical requirements in the aspects of body, tomography, high resolution and imaging depth are combined. By combining the characteristics of each imaging technology, it is important to provide a multi-modal endoscope and imaging system.

Chinese patent CN201910378525.1 provides an endoscope that can suppress breakage of optical fibers and is excellent in mountability and operability. The endoscope includes a light guide that guides illumination light generated by the light source device from the light source device to a distal end portion of an insertion portion of the endoscope through an operation portion of the endoscope through an inside of the endoscope. This design allows real-time imaging, but fails to provide multi-modality imaging and thus provides more accurate tomographic imaging of the tissue organ.

Disclosure of Invention

The present invention is directed to overcoming the above-mentioned drawbacks of the prior art and providing a multi-modal endoscope and an endoscopic imaging system.

The purpose of the invention can be realized by the following technical scheme:

a multi-modality endoscope, comprising:

the inserting part is used for converting the optical signal into an electric signal, transmitting the signal to the connecting part through a signal wire after receiving the electric signal, and displaying the transmitted electric signal after image processing in the electronic endoscope system device;

the insertion part comprises a front end part, a bending part and a flexible tube part which are sequentially arranged, wherein the front end part comprises ultrasonic transducers which are arranged in a side row and are used for being connected with an ultrasonic endoscopic imaging device through a signal line, a probe, an optical focusing module which is used for being connected with an OCT imaging observation device through an optical fiber, an image pickup element used for receiving optical signals and a treatment instrument channel used for placing a biopsy forceps and other therapeutic instruments;

an operation section for performing air supply, water supply, and negative pressure suction operations to the distal end portion of the insertion section, performing a bending operation to the bending portion of the insertion section, and controlling the treatment instrument to be conveyed to the body cavity through the treatment instrument channel;

a connecting portion for connecting the insertion portion with the electronic endoscope system device.

Furthermore, the front end part is a top end hard structure, and the plurality of ultrasonic transducers are arranged on the outer surface of the front end part of the hard structure in a side-to-side array mode.

Further, the insertion portion further includes an illumination window and a single mode optical fiber for transmitting light to the illumination window for illumination.

Further, the operation portion is provided on the proximal end side of the insertion portion, and the operation portion includes a bending knob for bending the bending portion, an air supply/water supply tube for supplying air and water to the distal end portion of the insertion portion, a negative pressure suction tube for sucking excess liquid at the distal end portion of the insertion portion through the inside of the endoscope, and a treatment instrument insertion port for connecting to a treatment instrument channel of the operation portion.

The probe includes the illumination window for holding illumination in a forward view, an end portion negative pressure suction device window for sucking out an unnecessary liquid tube, a water supply/air supply window for holding an end portion of a water supply tube and for holding an end portion of an air supply tube, a treatment instrument channel window for holding an end portion of a treatment instrument channel and communicating with a treatment instrument insertion port, and an imaging device observation window for data transmission of an electronic endoscope device.

The optical focusing module is a hemispherical focusing ball lens, a gold-plated reflecting film is arranged on the horizontal bottom surface of the hemispherical focusing ball lens, the horizontal bottom surface and the axial direction of the optical fiber form an angle of 45 degrees, and other parts of the hemispherical focusing ball lens except the horizontal bottom surface are fused with the multimode optical fiber.

The image pickup element converts the received optical signal into an electric signal, transmits the electric signal to the electronic endoscope imaging device through a signal line, and then displays the electric signal through the image processing device.

A multi-modality endoscopic imaging system, the system comprising:

the multi-modal endoscope;

the image processing device is respectively in signal connection with the OCT imaging observation device, the fluorescence imaging device and the ultrasonic imaging device, and is used for outputting a control signal according to the operation of a user and generating a multi-mode image of the tissue organ according to the received feedback signal;

the ultrasonic imaging device is connected with an ultrasonic transducer of the multi-mode endoscope through a signal line and used for outputting an ultrasonic control signal according to the control signal, so that the ultrasonic transducer emits ultrasonic waves to a sample tissue to be detected and converts the returned feedback ultrasonic waves into ultrasonic feedback signals;

the OCT imaging observation device is connected with the hemispherical focusing ball lens through an optical fiber and used for outputting an optical signal according to a control signal, and the optical signal reaches the tissue of the sample to be detected through the hemispherical focusing ball lens and receives an optical signal fed back by the collected tissue of the sample to be detected;

the fluorescence imaging observation device forms a fluorescence imaging system by utilizing the wavelength division multiplexer and the OCT imaging observation device and is used for integrating an optical coherent imaging sample arm light source and a fluorescence excitation light source into the same single-mode broadband optical fiber light path;

and the electronic endoscope system device is connected with the insertion part of the multi-mode endoscope and is used for carrying out image processing and displaying on the electric signal transmitted back by the insertion part.

Furthermore, the multi-mode endoscopic imaging system adopts the double-clad fiber coupler to collect the emitted light, and adopts semiconductor laser as an excitation light source for fluorescence imaging.

Furthermore, the OCT imaging observation device adopts a high-speed VECSE L light source, and the fluorescence imaging system adopts a 680-750nm waveband of semiconductor adjustable laser as an excitation light source.

Compared with the prior art, the invention has the following advantages:

1) the multimode endoscopic imaging system is provided with a first optical imaging device, namely an optical coherent imaging device and a second optical imaging device, namely a fluorescence imaging device, which have different imaging principles, wherein compared with other technologies, the optical coherent imaging technology has non-invasion and high resolution and can detect the internal microstructure of the biological tissue in vivo, and the OCT endoscopic imaging technology after being combined with the endoscopic technology can directly image the biological tissue, can finish high-precision scanning of the tissue, and further can carry out early diagnosis on early canceration and atherosclerosis; fluorescence imaging is that the intensity of a fluorescence signal emitted after a fluorescent substance is excited is in a linear relation with the amount of fluorescein within a certain range; the multi-mode system can fully utilize the deep tissue imaging capability of the ultrasound, the high-resolution tissue imaging capability of the OCT and the high sensitivity and specificity of the fluorescent molecule targeted imaging to realize real-time visualized multi-mode imaging.

2) Compared with the single-mode endoscope, the multi-mode endoscope has the characteristics of singleness, instability and poor imaging resolution, the lens of the multi-mode endoscope can convert an acoustic signal-electric signal and an optical signal-electric signal into each other through a signal line and an optical fiber, has the clinical characteristics of integrating the aspects of body, tomography, high resolution and imaging depth, comprehensively balances the series of problems, is suitable for diagnosing early diseases in the body, and provides an accurate image means for early canceration and the like; in addition, compared with the traditional single-mode endoscope, the multi-mode endoscope can realize tomography of the gastrointestinal tract, can detect micro pathological changes of various gastrointestinal diseases, is beneficial to patients to treat in advance and improves the cure rate.

3) The special hemispherical focusing ball lens and the ultrasonic transducer in the lens of the multi-mode endoscope can ensure that multiple functions are realized by one-time endoscope descending, the hemispherical focusing ball lens is used for being connected with an OCT imaging observation device through an optical fiber, the ultrasonic transducer is used for being connected with an ultrasonic endoscopic imaging device through a signal line, different devices use respective independent channels, and the normal and stable work of the devices can be ensured without mutual interference.

4) The optical coherent imaging device and the fluorescence imaging device are respectively in signal connection with the image processing device, and the wavelength division multiplexer is combined to be used as a fluorescence imaging system, so that medical images of tissues and organs can be acquired by combining the advantages of various imaging devices, and more accurate tomograms of the tissues and organs are captured.

Drawings

FIG. 1 is a side sectional view schematically showing the insertion section and the operation section of a multi-modal endoscope in accordance with an embodiment of the present invention;

FIG. 2 is a schematic structural view of a probe at the distal end of an insertion section of a multi-modal endoscope in accordance with an embodiment of the present invention;

FIG. 3 is a schematic structural diagram of a multi-modality endoscopic imaging system according to an embodiment of the present invention;

the reference numbers in the figures indicate:

101. a multi-modal endoscopic imaging system 102, a multi-modal endoscope 103, an ultrasonic observation device 104, an electronic endoscopic observation device 105, an OCT imaging observation device 106, a fluorescence imaging observation device 107, a computer 108, a wavelength division multiplexer 109, a water supply tank 110, an insertion portion 111, an operation portion 112, a treatment instrument insertion port 113, a universal cable 114, and a connector; 203. sample tissues to be detected, 204, an ultrasonic transducer, 205, a hemispherical focusing ball lens, 206, a first signal line, 207, a multimode optical fiber, 208, a single-mode optical fiber, 209, a second signal line, 210, a negative pressure suction tube, 211, an air and water supply tube, 212 and a treatment instrument channel; 301. a probe 302, an illumination window 303, a negative pressure suction device window 304, a water supply/air supply window 305, a treatment instrument channel window 306, and an imaging device observation window.

Detailed Description

The invention is described in detail below with reference to the figures and specific embodiments. It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, shall fall within the scope of protection of the present invention.