阅读说明：本技术 一种心血管手术导管材料及其制备方法 (Cardiovascular surgery catheter material and preparation method thereof ) 是由 向兴力 于 2020-05-17 设计创作，主要内容包括：本发明公开了一种心血管手术导管材料,其特征在于,包括如下按重量份计的各组分组成：环氧基单封端硅油改性端羟基超支化聚碳酸酯20-30份、聚乳酸改性端羟基超支化聚碳酸酯30-40份、1,3-二环氧甘油醚甘油5-10份。本发明还公开了所述心血管手术导管材料的制备方法。本发明公开的心血管手术导管材料柔软性好,机械力学性能佳,无毒无害,生物相容性和可生物降解性能优异。(The invention discloses a cardiovascular surgery catheter material which is characterized by comprising the following components in parts by weight: 20-30 parts of epoxy group single-end-capped silicone oil modified hydroxyl-terminated hyperbranched polycarbonate, 30-40 parts of polylactic acid modified hydroxyl-terminated hyperbranched polycarbonate and 5-10 parts of 1, 3-diglycidyl ether glycerol. The invention also discloses a preparation method of the cardiovascular surgery catheter material. The cardiovascular operation catheter material disclosed by the invention has the advantages of good flexibility, good mechanical property, no toxicity, no harm, excellent biocompatibility and excellent biodegradability.)

1. The cardiovascular operation catheter material is characterized by comprising the following components in parts by weight: 20-30 parts of epoxy group single-end-capped silicone oil modified hydroxyl-terminated hyperbranched polycarbonate, 30-40 parts of polylactic acid modified hydroxyl-terminated hyperbranched polycarbonate and 5-10 parts of 1, 3-diglycidyl ether glycerol.

2. The cardiovascular surgery catheter material according to claim 1, wherein the preparation method of the epoxy group mono-terminated silicone oil modified hydroxyl-terminated hyperbranched polycarbonate comprises the following steps: adding epoxy group single-end-capped silicone oil, hydroxyl-end hyperbranched polycarbonate and an alkaline catalyst into a high-boiling-point solvent, stirring and reacting for 8-10 hours at 90-110 ℃, filtering to remove insoluble substances, and performing rotary evaporation to remove the solvent to obtain the epoxy group single-end-capped silicone oil modified hydroxyl-end hyperbranched polycarbonate.

3. The cardiovascular surgery catheter material of claim 2, wherein the mass ratio of the epoxy group mono-terminated silicone oil, the hydroxyl-terminated hyperbranched polycarbonate, the basic catalyst and the high boiling point solvent is 1 (3-5): (0.8-1.2): (20-30).

4. A cardiovascular surgical catheter material according to claim 2, wherein the basic catalyst is at least one of sodium hydroxide, potassium carbonate, and sodium carbonate.

5. A cardiovascular surgical catheter material according to claim 2, wherein the high boiling point solvent is at least one of dimethylsulfoxide, N-dimethylformamide, N-dimethylacetamide and N-methylpyrrolidone.

6. The cardiovascular surgery catheter material according to claim 1, wherein the preparation method of the polylactic acid modified hydroxyl-terminated hyperbranched polycarbonate comprises the following steps: adding polylactic acid, hydroxyl-terminated hyperbranched polycarbonate, 4-dimethylaminopyridine and 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride into N-methylpyrrolidone, stirring and reacting at 30-50 ℃ for 8-12 hours, precipitating in water, washing the product with ethanol for 3-7 times, and performing rotary evaporation to remove the ethanol to obtain the polylactic acid modified hydroxyl-terminated hyperbranched polycarbonate.

7. A cardiovascular surgery catheter material according to claim 6, wherein the mass ratio of the polylactic acid, the hydroxyl-terminated hyperbranched polycarbonate, the 4-dimethylaminopyridine, the 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride and the N-methylpyrrolidone is 1 (3-5) (0.4-0.8) to 0.5 (20-30).

8. A cardiovascular surgical catheter material according to claim 6, wherein the weight average molecular weight of the polylactic acid is 1 ten thousand.

9. A cardiovascular surgical catheter material according to any of claims 1-8, wherein the method of preparing the cardiovascular surgical catheter material comprises the steps of: adding epoxy group single-end-capped silicone oil modified hydroxyl-terminated hyperbranched polycarbonate, polylactic acid modified hydroxyl-terminated hyperbranched polycarbonate and 1, 3-diglycidyl ether glycerol into a high-speed mixer according to parts by weight, dispersing for 30-50 minutes at high speed, and then extruding and molding by an extrusion molding machine to obtain the cardiovascular surgery catheter material.

Technical Field

The invention relates to the technical field of medical materials, in particular to a cardiovascular surgery catheter material and a preparation method thereof.

Background

With the improvement of the living standard of people and the change of life style, the incidence of cardiovascular diseases is higher and higher, which is known as the first killer of human beings at present, and brings huge physiological pain and economic burden to patients, and the search of an efficient and cheap cardiovascular disease treatment scheme is very important.

At present, the vascular stent implantation is the most effective and most common medical means for treating cardiovascular diseases at present, and belongs to a minimally invasive treatment method, and the operation can change cardiac output and peripheral resistance and coordinate blood flow distribution among organs and tissues under the mediation of nerves and body fluid of a body so as to meet the requirement of the organs and tissues on blood flow. In cardiovascular surgery, stents are placed at the heart site by catheter introduction after arterial vessel opening in the leg. Therefore, the catheter is required to be relatively high, small, flexible and not deformable. In addition, the ideal cardiovascular surgery catheter material also needs to have better biocompatibility, biodegradability and smooth surface, and effectively avoids secondary damage to human bodies, thereby being beneficial to the implementation of cardiovascular surgery.

The Chinese patent with application number 201710127247.3 discloses a cardiovascular surgery catheter material, which consists of ABS resin, Kevlar fiber, glass fiber, phthalic acid ester, polyphenylene sulfide, N-butyl alcohol, styrene butadiene rubber, molybdenum trioxide, polyvinyl chloride, polystyrene, methyl acrylate, ethylene copolymer elastomer, epoxy resin glue, N-methylene bisacrylamide, trimethylsilyl dimethyl methylphosphonate, methyl methacrylate, isocyanate, nano graphene, o-hydroxybenzophenone, pitch-based carbon fiber, silicone rubber and hydroxyl silicone oil; compared with the prior art, the catheter synthesized by the material has higher flexibility, no toxicity and harm, no secondary damage to human body, contribution to the implementation of cardiovascular surgery, improvement of surgery efficiency and success rate and popularization and application value, and keeps soft under the condition of difficult deformation. However, the material has complex components, poor compatibility among the components, poor biodegradability and secondary operation, and brings secondary damage to patients.

Therefore, a cardiovascular operation catheter material with good flexibility, good mechanical properties, no toxicity, no harm, excellent biocompatibility and biodegradability is needed in the industry.

Disclosure of Invention

The invention aims to solve the problems and provides a cardiovascular surgery catheter material; the cardiovascular operation catheter material has good flexibility, good mechanical property, no toxicity, no harm, excellent biocompatibility and excellent biodegradability. Meanwhile, the invention also provides a preparation method of the cardiovascular operation catheter material, which is simple and easy to operate, has easily obtained preparation raw materials, low preparation cost, high preparation efficiency and high yield, is suitable for continuous large-scale production, and can effectively realize organic combination of economic benefit, social benefit and ecological benefit.

In order to achieve the purpose, the invention provides the following technical scheme, and the cardiovascular surgery catheter material is characterized by comprising the following components in parts by weight: 20-30 parts of epoxy group single-end-capped silicone oil modified hydroxyl-terminated hyperbranched polycarbonate, 30-40 parts of polylactic acid modified hydroxyl-terminated hyperbranched polycarbonate and 5-10 parts of 1, 3-diglycidyl ether glycerol.

Preferably, the preparation method of the epoxy group single-end-capped silicone oil modified hydroxyl-end hyperbranched polycarbonate comprises the following steps: adding epoxy group single-end-capped silicone oil, hydroxyl-end hyperbranched polycarbonate and an alkaline catalyst into a high-boiling-point solvent, stirring and reacting for 8-10 hours at 90-110 ℃, filtering to remove insoluble substances, and performing rotary evaporation to remove the solvent to obtain the epoxy group single-end-capped silicone oil modified hydroxyl-end hyperbranched polycarbonate.

Preferably, the mass ratio of the epoxy group single-end-capped silicone oil to the hydroxyl-terminated hyperbranched polycarbonate to the basic catalyst to the high-boiling-point solvent is 1 (3-5) to (0.8-1.2) to (20-30).

Preferably, the alkaline catalyst is at least one of sodium hydroxide, potassium carbonate and sodium carbonate.

Preferably, the high boiling point solvent is at least one of dimethyl sulfoxide, N-dimethylformamide, N-dimethylacetamide and N-methylpyrrolidone.

Preferably, the epoxy-based mono-terminated silicone oil is epoxy-based mono-terminated silicone oil IOTA8881F12 available from yota silicone oil limited, anhui.

Preferably, the preparation method of the polylactic acid modified hydroxyl-terminated hyperbranched polycarbonate comprises the following steps: adding polylactic acid, hydroxyl-terminated hyperbranched polycarbonate, 4-dimethylaminopyridine and 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride into N-methylpyrrolidone, stirring and reacting at 30-50 ℃ for 8-12 hours, precipitating in water, washing the product with ethanol for 3-7 times, and performing rotary evaporation to remove the ethanol to obtain the polylactic acid modified hydroxyl-terminated hyperbranched polycarbonate.

Preferably, the mass ratio of the polylactic acid, the hydroxyl-terminated hyperbranched polycarbonate, the 4-dimethylaminopyridine, the 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride and the N-methylpyrrolidone is 1 (3-5) to 0.4-0.8 to 0.5 (20-30).

Preferably, the weight average molecular weight of the polylactic acid is 1 ten thousand.

Preferably, the preparation method of the hydroxyl-terminated hyperbranched polycarbonate is described in application number 201710466507.X example 5.

Another object of the present invention is to provide a method for preparing the cardiovascular surgery catheter material, which comprises the following steps: adding epoxy group single-end-capped silicone oil modified hydroxyl-terminated hyperbranched polycarbonate, polylactic acid modified hydroxyl-terminated hyperbranched polycarbonate and 1, 3-diglycidyl ether glycerol into a high-speed mixer according to parts by weight, dispersing for 30-50 minutes at high speed, and then extruding and molding by an extrusion molding machine to obtain the cardiovascular surgery catheter material.

Due to the application of the technical scheme, compared with the prior art, the invention has the following advantages:

(1) the preparation method of the cardiovascular surgery catheter material provided by the invention is simple and easy to operate, the preparation raw materials are easy to obtain, the preparation cost is low, the preparation efficiency is high, the yield is high, the method is suitable for continuous large-scale production, and the organic combination of economic benefits, social benefits and ecological benefits can be effectively realized.

(2) The cardiovascular operation catheter material provided by the invention overcomes the defects that the flexibility and the dimensional stability of the traditional cardiovascular operation catheter material are required to be further improved, the biocompatibility and the biodegradability are insufficient, the components are complex, and the preparation cost is higher, and has the advantages of good flexibility, good mechanical property, no toxicity, no harm, and excellent biocompatibility and biodegradability.

(3) The cardiovascular surgery catheter material provided by the invention is prepared by blending epoxy group single-end-capped silicone oil modified hydroxyl-terminated hyperbranched polycarbonate, polylactic acid modified hydroxyl-terminated hyperbranched polycarbonate and 1, 3-diglycidyl ether glycerol, wherein epoxy groups on the 1, 3-diglycidyl ether glycerol are easy to generate ring-opening reaction with hydroxyl groups on the epoxy group single-end-capped silicone oil modified hydroxyl-terminated hyperbranched polycarbonate and the polylactic acid modified hydroxyl-terminated hyperbranched polycarbonate, so that all components are linked together by chemical bonds, and the comprehensive performance and the performance stability of the material are effectively improved; the materials are biodegradable materials, so that the finally obtained material also has better biodegradability.

(4) According to the cardiovascular surgery catheter material provided by the invention, the introduction of the silicone oil structure can improve the wear resistance of the material, and the introduction of the active hydroxyl groups on the components can improve the surface wettability of the material, so that the surface smoothness and the hydrophilicity are good; the components have synergistic effect, and the advantages of various materials such as polycarbonate, polylactic acid, silicone oil and hyperbranched polymer are combined, so that the material has good flexibility and good mechanical property.

Detailed Description

In order to make the technical solution of the present invention better understood by those skilled in the art, the following provides a detailed description of the product of the present invention with reference to the examples.

In the embodiment, the required raw materials are all purchased commercially; the epoxy group single-ended silicone oil is epoxy group single-ended silicone oil IOTA8881F12 which is purchased from Anhui Eyota silicone oil Co.Ltd; the weight average molecular weight of the polylactic acid is 1 ten thousand; the preparation method of the hydroxyl-terminated hyperbranched polycarbonate is disclosed in application number 201710466507.X, example 5.