阅读说明：本技术 1,3-丙二醇单乙酸酯的选择性生产 (Selective production of 1, 3-propanediol monoacetate ) 是由 亨利克斯·马蒂纳斯·玛丽亚·格拉尔杜斯·斯特罗特曼 马丁·斯库尔曼 彼得·汉斯·里布尔 于 2018-12-14 设计创作，主要内容包括：本发明涉及将一种用于将1,3-丙二醇二乙酸酯(PDDA)水解成1,3-丙二醇单乙酸酯(PDMA)的新颖选择性一步酶促方法。(The present invention relates to a novel selective one-step enzymatic process for the hydrolysis of 1, 3-propanediol diacetate (PDDA) to 1, 3-propanediol monoacetate (PDMA).)

1. A method for the production of 1, 3-propanediol monoacetate (PDMA), comprising the mono-deacetylation of 1, 3-propanediol diacetate (PDDA) catalyzed by a carboxylic ester hydrolase [ ec3.1.1], preferably an esterase or lipase, more preferably a lipase [ ec3.1.1.3], especially a candida lipase, preferably candida antarctica lipase b (calb).

2. Use of a carboxylic ester hydrolase [ EC3.1.1], preferably an esterase or lipase, more preferably a lipase [ EC3.1.1.3] for the mono-deacetylation of PDDA to PDMA.

3. The method or use according to claim 1 or 2, wherein the lipase is used in liquid or immobilized form.

4. A method or use according to claim 3 wherein the immobilised enzyme is adsorbed or covalently bound.

5. The method or use of claim 3 or 4, wherein the enzyme is reused at least 5 times.

6. The method or use of any one of the preceding claims, wherein PDDA is converted to PDMA at a rate of at least about 75%.

7. The method or use according to any one of the preceding claims, wherein the mono-deacetylation reaction is in NaHCO₃In the presence of oxygen.

8. The method or use according to any one of the preceding claims, wherein the mono-deacetylation reaction is carried out at a pH in the range of 7 to 8.

9. The method or use according to any one of the preceding claims, wherein the mono-deacetylation reaction is carried out at 28 ℃.

10. The method or use of any preceding claim, wherein the amount of PDDA is less than 40 wt%.

Examples