阅读说明：本技术 一种智能生物显微镜 (Intelligent biological microscope ) 是由 崔良玉 王灿芳 胡高峰 韩建鑫 靳刚 李占杰 贾静 须颖 黄旭栋 于 2019-11-28 设计创作，主要内容包括：本发明公开了一种智能生物显微镜,包括固定底座,所述固定底座上端固定安装有显微镜底板,所述显微镜底板上端固定安装有驱动控制芯片和控制芯片,所述显微镜底板上端通过平台支撑架可拆卸安装有滑动模块载物台。本发明涉及一种显微镜,特别涉及一种智能生物显微镜,属于显微镜技术领域。本发明通过平台支撑架使用磁铁将显微镜底板、滑动模块载物台和成像模块方便拆分,高度模块化,可自由拆卸组装,体积小,重量轻,方便携带,适用于各种工作环境,成本低、便携、可重构,具有很好地灵活性及适应性；改善原有操作人员对目标物统计分析的方式与效率,方便自动进行统计,有效降低人工统计错误的风险。(The invention discloses an intelligent biological microscope, which comprises a fixed base, wherein a microscope bottom plate is fixedly arranged at the upper end of the fixed base, a driving control chip and a control chip are fixedly arranged at the upper end of the microscope bottom plate, and a sliding module objective table is detachably arranged at the upper end of the microscope bottom plate through a platform supporting frame. The invention relates to a microscope, in particular to an intelligent biological microscope, and belongs to the technical field of microscopes. The microscope base plate, the sliding module objective table and the imaging module are conveniently disassembled and assembled by the platform support frame through the magnets, are highly modularized, can be freely disassembled and assembled, are small in size, light in weight, convenient to carry, suitable for various working environments, low in cost, portable and reconfigurable, and have good flexibility and adaptability; the method and the efficiency of the original operation personnel for statistical analysis of the target object are improved, automatic statistics is facilitated, and the risk of manual statistics errors is effectively reduced.)

1. An intelligent biological microscope comprises a fixed base (1), wherein a microscope bottom plate (2) is fixedly installed at the upper end of the fixed base (1), and is characterized in that a driving control chip (3) and a control chip (10) are fixedly installed at the upper end of the microscope bottom plate (2), a sliding module objective table (4) is detachably installed at the upper end of the microscope bottom plate (2) through a platform support frame (9), a sliding module (6) is movably installed at the upper end of the sliding module objective table (4), the sliding module (6) performs left-right and front-back movement through an X-axis lead screw displacement module (5) and a Y-axis lead screw displacement module (8), an imaging module (7) is detachably installed at the upper end of the sliding module objective table (4) through the platform support frame (9), and the imaging module (7) is arranged above the sliding module (6), imaging module (7) includes imaging module base (16), lead screw displacement module (11) about imaging module base (16) upper end fixed mounting has, movable mounting has microscope objective (14) about through upper and lower accommodate motor (12) on upper and lower lead screw displacement module (11), microscope objective (14) lower extreme fixed mounting has tube lens (15), and tube lens (15) run through imaging module base (16), microscope objective (14) upper end fixed mounting has CCD camera (13), slide module (6) upper end fixed mounting has the slide glass.

2. The intelligent biomicroscope of claim 1, wherein: the slide glass below is equipped with the through-hole of seting up at slip module (6) terminal surface, the through-hole extends to slip module (6) bottom, the light-transmitting window has been seted up at slip module objective table (4) middle part, microscope bottom plate (2) upper end fixed mounting has lighting module.

3. The intelligent biomicroscope of claim 2, wherein: the lighting module comprises a circular LED panel, a diffuser and a condenser, the diffuser is arranged below the diffuser, and the circular LED panel is arranged below the condenser.

4. The intelligent biomicroscope of claim 1, wherein: magnet is installed at both ends about platform support frame (9), just terminal surface, sliding module objective table (4) upper and lower both ends face and microscope bottom plate (2) up end fixed mounting have the magnet rather than looks adaptation under imaging module (7).

5. The intelligent biomicroscope of claim 4, wherein: platform support frame (9) between sliding module objective table (4) and microscope bottom plate (2) are equipped with threely, and three platform support frame (9) are the triangle-shaped and support sliding module objective table (4).

6. The intelligent biomicroscope of claim 1, wherein: x axle lead screw displacement module (5) and Y axle lead screw displacement module (8) are equipped with two respectively, two Y axle lead screw displacement module (8) lower extreme passes through fly leaf movable mounting two X axle lead screw displacement module (5) upper end, slip module (6) movable mounting is two between Y axle lead screw displacement module (8).

Technical Field

The invention relates to a microscope, in particular to an intelligent biological microscope, and belongs to the technical field of microscopes.

Background

In recent years, pathology analysis has gradually become the gold standard for diagnosis, prognostic analysis, and therapeutic guidance. About 12 thousands of pathological doctors are needed in 2017, but the number of trained doctors is less than 2 thousands, the personnel pressure is extremely high, the doctors need to operate the microscope to shoot pictures in person, one slide needs to switch a plurality of visual fields to carry out overall judgment, and the task is heavy. And a judgment error may occur due to human fatigue.

At present, the existing microscope of domestic hospitals mostly uses photomicrography software to photograph observed microscopic images, only extremely small local parts can be observed each time, the positions of slides are usually required to be moved for many times to obtain different visual fields, and the position and angle changes caused by each movement often cause the microscopic images to generate huge differences; moreover, images shot each time are independently imaged, which is not beneficial to the overall grasp of doctors; for some tiny lesions or difficult cases in microscopic images, a doctor only depends on naked eyes and is difficult to dig pathological features.

The current intelligent microscopic observation platform is high in cost and lack of flexibility, and particularly cannot be used in resource-poor areas or under severe field environments.

In view of the above defects, a low-cost and reconfigurable artificial intelligence microscope is developed and made to be more valuable.

Disclosure of Invention

The present invention is directed to an intelligent biomicroscope, which solves the above problems of the background art.

In order to achieve the purpose, the invention provides the following technical scheme: an intelligent biological microscope comprises a fixed base, a microscope bottom plate is fixedly arranged at the upper end of the fixed base, a driving control chip and a control chip are fixedly arranged at the upper end of the microscope bottom plate, a sliding module object stage is detachably arranged at the upper end of the microscope bottom plate through a platform support frame, a sliding module is movably arranged at the upper end of the sliding module object stage, the sliding module moves left and right and back and forth through an X-axis lead screw displacement module and a Y-axis lead screw displacement module, an imaging module is detachably arranged at the upper end of the sliding module object stage through the platform support frame and is arranged above the sliding module, the imaging module comprises an imaging module base, an upper lead screw displacement module and a lower lead screw displacement module are fixedly arranged at the upper end of the imaging module base, and a microscope objective is movably arranged up and, the lower end of the microscope objective is fixedly provided with a tube lens, the tube lens penetrates through the imaging module base, the upper end of the microscope objective is fixedly provided with a CCD camera, and the upper end of the sliding module is fixedly provided with a glass slide.

As a preferred technical scheme of the invention, a through hole arranged on the end face of the sliding module is arranged below the glass slide, the through hole extends to the bottom end of the sliding module, a light-transmitting window is arranged in the middle of the object stage of the sliding module, and an illuminating module is fixedly arranged at the upper end of the microscope bottom plate.

As a preferred technical solution of the present invention, the lighting module includes a circular LED panel, a diffuser and a condenser, the diffuser is installed below the diffuser, and the circular LED panel is installed below the condenser.

As a preferred technical scheme of the invention, the upper end and the lower end of the platform supporting frame are provided with magnets, and the lower end surface of the imaging module, the upper end surface and the lower end surface of the sliding module object stage and the upper end surface of the microscope bottom plate are fixedly provided with magnets matched with the magnets.

As a preferred technical solution of the present invention, three platform support frames are provided between the slide module object stage and the microscope base plate, and the three platform support frames support the slide module object stage in a triangular shape.

As a preferred technical solution of the present invention, two X-axis screw rod displacement modules and two Y-axis screw rod displacement modules are respectively provided, the lower ends of the two Y-axis screw rod displacement modules are movably mounted at the upper ends of the two X-axis screw rod displacement modules through a movable plate, and the sliding module is movably mounted between the two Y-axis screw rod displacement modules.

Compared with the prior art, the invention has the beneficial effects that:

the microscope base plate, the sliding module objective table and the imaging module are conveniently disassembled and assembled by the platform support frame through the magnets, are highly modularized, can be freely disassembled and assembled, are small in size, light in weight, convenient to carry, suitable for various working environments, low in cost, portable and reconfigurable, and have good flexibility and adaptability;

the position of an observed object on a glass slide at the upper end of the sliding module is automatically controlled through the X-axis lead screw displacement module and the Y-axis lead screw displacement module, so that the inspection precision and the inspection speed of an object to be observed by the microscope are improved, the original mode and efficiency of statistical analysis of an operator on the target object are improved, automatic statistics is facilitated, and the risk of manual statistics errors is effectively reduced; the invention greatly reduces the workload of doctors and has the capability of quickly identifying tiny pathological changes and difficult cases.

Drawings

FIG. 1 is a schematic structural view of the present invention;

fig. 2 is a schematic structural diagram of the present invention.

In the figure: 1. a fixed base; 2. a microscope base plate; 3. a driving control chip; 4. a sliding module stage; 5. an X-axis lead screw displacement module; 6. a sliding module; 7. an imaging module; 8. a Y-axis lead screw displacement module; 9. a platform support frame; 10. a control chip; 11. an upper and lower screw rod displacement module; 12. a vertical adjustment motor; 13. a CCD camera; 14. a microscope objective; 15. a tube lens; 16. an imaging module base.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1-2, the present invention provides an intelligent biological microscope, including a fixed base 1, a microscope base plate 2 fixedly installed on the upper end of the fixed base 1, a driving control chip 3 and a control chip 10 fixedly installed on the upper end of the microscope base plate 2, the control chip 10 being a Jetson Nano or Raspberry Pi, for implementing real-time and rapid image processing on the collected image, implementing accurate and rapid auto-focusing and automatic identification of the image content, completing rapid calculation based on a depth learning technique, a sliding module stage 4 detachably installed on the upper end of the microscope base plate 2 through a platform support frame 9, a sliding module 6 movably installed on the upper end of the sliding module stage 4, the sliding module 6 performing left and right and front and back movement through an X-axis screw rod displacement module 5 and a Y-axis screw rod displacement module 8, the screw rod module driving a screw rod through a motor to displace the mechanism on the screw rod (prior art, not shown in the figure), can accurately, rapidly and accurately focus and image, realize better image acquisition, the adjustment of the current position of an object to be observed can be realized so as to obtain images at different positions and meet the requirement of local image taking, an imaging module 7 is detachably mounted at the upper end of a sliding module objective table 4 through a platform support frame 9, the imaging module 7 is arranged above a sliding module 6, the imaging module 7 comprises an imaging module base 16, an upper lead screw displacement module and a lower lead screw displacement module 11 are fixedly mounted at the upper end of the imaging module base 16, a microscope objective 14 is movably mounted on the upper lead screw displacement module and the lower lead screw displacement module 11 up and down through an up-and-down adjusting motor 12, a tube lens 15 is fixedly mounted, and the tube lens 15 penetrates through the imaging module base 16, the CCD camera 13 is fixedly arranged at the upper end of the microscope objective 14 to convert physical optical imaging into a digital image, and the slide glass is fixedly arranged at the upper end of the sliding module 6.

A through hole arranged on the end face of the sliding module 6 is arranged below the glass slide, the through hole extends to the bottom end of the sliding module 6, a light transmission window is arranged in the middle of the sliding module object stage 4, an illuminating module is fixedly arranged at the upper end of the microscope base plate 2 and comprises a circular LED panel, a diffuser and a condenser, the diffuser is arranged below the diffuser, the condenser is arranged below the diffuser, the circular LED panel is arranged below the condenser to provide better illumination, and the color tone adjustment is carried out according to the color of an object to be observed to obtain clear and visual images, magnets are arranged at the upper end and the lower end of the platform supporting frame 9, and magnets matched with the magnets are fixedly arranged on the upper end face of the microscope base plate 2, the lower end face of the imaging module object stage 7, the upper end face and the lower end face of the sliding module object stage 4 and the upper, and three platform support frame 9 is the triangle form and supports sliding module objective table 4, makes intelligent microscopic imaging platform whole firm, is difficult for receiving external disturbance to disturb and causes the imaging error, and X axle lead screw displacement module 5 and Y axle lead screw displacement module 8 are equipped with two respectively, and two Y axle lead screw displacement module 8 lower extremes pass through fly leaf movable mounting at two X axle lead screw displacement module 5 upper ends, and sliding module 6 movable mounting is between two Y axle lead screw displacement module 8. The method comprises the steps that a trained artificial intelligence analysis model is downloaded from a cloud server aiming at an object to be micro-imaged, the artificial intelligence analysis model is downloaded to a local artificial intelligence chip, then automatic focusing and image splicing are completed through one-key operation, then the system processes the image based on the artificial intelligence model, an analysis report is given at a display end, the image and the analysis report can be uploaded to a cloud database, and in the using process, one-key operation is adopted, the workload of doctors is relieved, and the recognition capability of the micro pathological changes and difficult cases is improved.

The working principle of the present invention will be specifically explained below: when in use, the motors at the ends of the X-axis screw rod displacement module 5, the Y-axis screw rod displacement module 8 and the upper and lower screw rod displacement modules 11 are controlled by the control chip 10 and the driving control chip 3, cells and other materials to be observed are placed on a glass slide at the upper end of the sliding module 6, the sliding module 6 is driven by the rotation of the motor to perform left-right front-back displacement, objects on the glass slide are subjected to multi-position detection, a microscope objective 14 on the upper and lower screw rod displacement modules 11 is driven by the rotation of the up-down adjusting motor 12 to perform up-down displacement, the automatic focusing function is realized, the sliding module objective table 4 and the imaging module 7 are supported by the platform support frame 9, the platform support frame 9 is adsorbed and fixed by a magnet, the disassembly and assembly are convenient, different assemblies can be carried out on different filters or lens combinations, and the circular LED panel, the diffuser and the condenser adjust the light source, the light source penetrates through the sliding module object stage 4 and the sliding module 6 to irradiate the bottom of the glass slide, the CCD camera 13 images cells and other materials on the glass slide through the microscope objective 14 and the tube lens 15 and converts the images into electronic images, a trained artificial intelligence analysis model is downloaded in a cloud server for an object to be microscopically imaged and is downloaded to a local artificial intelligence chip, automatic focusing and image splicing are completed through one-key operation, then the system processes the images based on the artificial intelligence model, an analysis report is given at a display end, and the images and the analysis report can be uploaded to a cloud database.

In conclusion, the intelligent biological microscope is used for cell analysis and other material analysis, the microscope baseplate 2, the sliding module objective table 4 and the imaging module 7 are conveniently disassembled and assembled by the platform support frame 9 and the magnet, and are highly modularized, can be freely disassembled and assembled, are small in size, light in weight, convenient to carry, suitable for various working environments, low in cost, portable and reconfigurable, and have good flexibility and adaptability;

the position of an observed object on a glass slide at the upper end of the sliding module 6 is automatically controlled through the X-axis lead screw displacement module 5 and the Y-axis lead screw displacement module 8, so that the inspection precision and the inspection speed of an object to be observed by a microscope are improved, the original mode and efficiency of statistical analysis of an operator on the target object are improved, automatic statistics is facilitated, and the risk of manual statistics errors is effectively reduced; the invention greatly reduces the workload of doctors and has the capability of quickly identifying tiny pathological changes and difficult cases.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.