阅读说明：本技术 一种药剂稀释注入装置及反应装置 (Medicament dilution injection device and reaction device ) 是由 吴南屏 黄祥谦 娄海生 张文超 徐永伟 于 2019-12-09 设计创作，主要内容包括：本发明提供一种药剂稀释注入装置及反应装置,药剂稀释注入装置包括溶剂循环系统、药剂供给系统、混匀管路和计量泵,通过控制药剂罐以及溶剂输送管路中的压力,保证进入计量泵的药剂量和溶剂量保持不变,从而保证稀释后药液的药液量、药液浓度和质量。通过控制第二压力控制阀向溶剂循环管路提供压力降,再由第二流量控制阀根据该压力降控制溶剂循环管路中的溶剂循环量,进一步保证了进入流量计的溶剂的量。溶剂循环系统中还设置有溶剂冷却器,冷却回流至溶剂罐的溶剂,保证溶剂罐中溶剂的温度不变,消除由于溶剂温度变化引起的溶剂密度的变化,进而消除由此引起的对溶剂的精确剂量,保证进入计量泵的溶剂量的精确度。(The invention provides a medicament diluting and injecting device and a reaction device, wherein the medicament diluting and injecting device comprises a solvent circulating system, a medicament supply system, a blending pipeline and a metering pump, and the amount of the medicament and the amount of the solvent entering the metering pump are kept unchanged by controlling the pressure in a medicament tank and a solvent conveying pipeline, so that the liquid medicine amount, the concentration and the quality of the diluted liquid medicine are ensured. The second pressure control valve is controlled to provide pressure drop for the solvent circulation pipeline, and then the second flow control valve controls the solvent circulation volume in the solvent circulation pipeline according to the pressure drop, so that the volume of the solvent entering the flow meter is further ensured. The solvent circulating system is also provided with a solvent cooler which cools and reflows to the solvent in the solvent tank, so that the temperature of the solvent in the solvent tank is ensured to be unchanged, the change of the solvent density caused by the temperature change of the solvent is eliminated, the accurate dosage of the solvent caused by the change of the solvent density is further eliminated, and the accuracy of the dosage of the solvent entering the metering pump is ensured.)

1. The medicament dilution injection device is characterized by comprising a solvent circulating system, a medicament supply system, a blending pipeline and a metering pump, wherein the solvent circulating system and the medicament supply system are communicated to a first end of the blending pipeline in parallel, a second end of the blending pipeline is communicated to a liquid inlet of the metering pump,

the solvent circulating system comprises a solvent tank, a solvent conveying pipeline and a solvent circulating pipeline, the solvent conveying pipeline is communicated with the blending pipeline, and solvent conveying equipment, a first flowmeter, a first flow control valve and a first pressure control valve are sequentially arranged on the solvent conveying pipeline along the flowing direction of the solvent;

one end of the solvent circulating pipeline is connected between the first flow control valve and the first pressure control valve, and the other end of the solvent circulating pipeline is connected to the solvent tank; the solvent circulating pipeline is provided with a second pressure control valve and a second flow control valve which are respectively communicated with the solvent conveying pipeline;

the medicine supply system comprises a medicine tank and a medicine supply pipeline, the two ends of the medicine supply pipeline are respectively communicated with the medicine tank and the blending pipeline, and a second flowmeter and a third flow control valve are arranged on the medicine supply pipeline along the medicine supply direction.

2. The drug dilution injection device according to claim 1, wherein a cooler is further provided on the solvent circulation line; the cooler is disposed at a front end of the second pressure control valve and the second flow control valve in a solvent flow direction.

3. A medicament dilution infusion device according to claim 1 or 2, wherein the solvent delivery conduit further comprises a first one-way valve disposed at a forward end of the first pressure control valve in the direction of solvent flow.

4. The diluted pharmaceutical injection apparatus according to claim 1, wherein the pharmaceutical supply line further comprises a second check valve provided at a front end of the third flow rate control valve in the pharmaceutical supply direction.

5. The device for diluting and injecting a medicament according to claim 1, wherein the medicament supply system is provided in plurality, the mixing lines correspond to the medicament supply system one to one, the solvent delivery line includes a plurality of branch delivery lines corresponding to the medicament supply system one to one,

the plurality of branch conveying pipelines are respectively connected with the plurality of medicament supply systems in a one-to-one correspondence mode to the plurality of mixing pipelines.

6. The drug dilution injection device according to claim 5, wherein a plurality of the branch delivery pipes are provided at a rear end of the first pressure control valve in a solvent flow direction, and each of the branch delivery pipes includes the first pressure control valve.

7. The dilute infusion device of claim 6, wherein each of the branch delivery lines further includes a first one-way valve disposed rearward of the first pressure control valve.

8. The diluting and injecting apparatus for medicament according to claim 1, wherein said medicament tank top portion is provided with an air inlet and an air outlet, said air inlet is provided with an air inlet valve, and said air outlet is provided with an air outlet valve.

9. A reaction apparatus for preparing α -olefin by polymerizing ethylene, the reaction apparatus comprising a chemical liquid supply system and a reaction system for preparing α -olefin by polymerizing ethylene while receiving a chemical liquid required for reaction supplied from the chemical liquid supply system, wherein the chemical liquid supply system comprises the chemical dilution injection apparatus according to any one of claims 1 to 8.

Technical Field

The invention relates to the technical field of medicament dilution in chemical reaction, in particular to a medicament dilution injection device and a reaction device.

Background

For example, in the production of α -olefin by polymerization of ethylene, various chemical reactions are involved, and one or more agents are generally required to be injected into the reaction system.

However, if the pharmaceutical factory provides the manufacturing factory with the pre-diluted concentration, on the one hand, the transportation resources are wasted due to the excessive weight/volume of the diluted solution, which also increases the risk of transportation. On the other hand, if the medicament is a time-sensitive medicament, a large amount of waste is caused over time.

In view of the above drawbacks or disadvantages, there is an urgent need for a device or system capable of diluting a solvent before a reaction and precisely controlling the supply amount of a diluted drug solution.

Disclosure of Invention

In order to overcome the defects in the aspects of diluting and injecting the medicament in the prior art, the invention aims to provide a medicament diluting and injecting device and a reaction device.

According to a first aspect of the present invention, the present invention provides a drug dilution injection device, which comprises a solvent circulation system, a drug supply system, a blending pipeline and a metering pump, wherein the solvent circulation system and the drug supply system are communicated in parallel to a first end of the blending pipeline, a second end of the blending pipeline is communicated to a liquid inlet of the metering pump,

the solvent circulating system comprises a solvent tank, a solvent conveying pipeline and a solvent circulating pipeline, the solvent conveying pipeline is communicated with the blending pipeline, and solvent conveying equipment, a first flowmeter, a first flow control valve and a first pressure control valve are sequentially arranged on the solvent conveying pipeline along the flowing direction of the solvent;

one end of the solvent circulating pipeline is connected between the first flow control valve and the first pressure control valve, and the other end of the solvent circulating pipeline is connected to the solvent tank; the solvent circulating pipeline is provided with a second pressure control valve and a second flow control valve which are respectively communicated with the solvent conveying pipeline;

the medicine supply system comprises a medicine tank and a medicine supply pipeline, the two ends of the medicine supply pipeline are respectively communicated with the medicine tank and the blending pipeline, and a second flowmeter and a third flow control valve are arranged on the medicine supply pipeline along the medicine supply direction.

Optionally, a cooler is further arranged on the solvent circulation pipeline; the cooler is disposed at a front end of the second pressure control valve and the second flow control valve in a solvent flow direction.

Optionally, the solvent delivery line further comprises a first check valve disposed at a front end of the first pressure control valve in a solvent flow direction.

Optionally, the medicine supply line further includes a second check valve provided at a front end of the third flow rate control valve in the medicine supply direction.

Optionally, the number of the medicament supply systems is multiple, the blending pipelines correspond to the medicament supply systems one by one, the solvent delivery pipelines include a plurality of branch delivery pipelines corresponding to the medicament supply systems one by one,

the plurality of branch conveying pipelines are respectively connected with the plurality of medicament supply systems in a one-to-one correspondence mode to the plurality of mixing pipelines.

Alternatively, a plurality of the branch delivery pipes are provided at a rear end of the first pressure control valve in a solvent flow direction, and each of the branch delivery pipes includes the first pressure control valve.

Optionally, each of the branch delivery pipes further includes a first check valve disposed at a rear end of the first pressure control valve.

Optionally, the top of the medicament tank is provided with an air inlet and an air outlet, the air inlet is provided with an air inlet valve, and the air outlet is provided with an air outlet valve.

According to a second aspect of the present invention, there is provided a reaction apparatus for preparing α -olefin by ethylene polymerization, the reaction apparatus comprising a chemical liquid supply system and a reaction system for receiving a chemical liquid required for reaction supplied from the chemical liquid supply system and performing ethylene polymerization to prepare α -olefin, wherein the chemical liquid supply system comprises the chemical dilution injection apparatus of the present invention.

The medicament diluting and injecting device and the reaction device have the following technical effects:

the medicament diluting and injecting device is provided with the solvent circulating system, and the medicament quantity and the solvent quantity entering the metering pump can be kept unchanged by controlling the pressure in the medicament tank and the solvent conveying pipeline, so that the liquid medicament quantity, the liquid medicament concentration and the quality of the diluted liquid medicament are ensured.

The solvent circulating system is internally provided with a second pressure control valve and a second flow control valve which are respectively communicated with the solvent circulating pipeline, the second pressure control valve is controlled to provide pressure drop for the solvent circulating pipeline, and then the second flow control valve controls the solvent circulating amount in the solvent circulating pipeline according to the pressure drop, so that the amount of the solvent entering the flow meter is further ensured.

The solvent circulating system is also provided with a solvent cooler, the solvent cooler can cool the solvent which flows back to the solvent tank, and the temperature of the solvent in the solvent tank is ensured to be unchanged, so that the change of the solvent density caused by the temperature change of the solvent is eliminated, the accurate dosage of the solvent caused by the change of the solvent density is further eliminated, and the accuracy of the dosage of the solvent entering the metering pump is ensured.

When a plurality of medicaments are required to be diluted and the solvents for dilution are the same, the medicament coefficient injection device can also be provided with a plurality of medicament supply systems, and the solvent conveying pipeline of the solvent circulating system is correspondingly provided with a plurality of branch conveying pipelines which are respectively communicated with the plurality of medicament supply systems. Thereby greatly increasing the range of use of the medicament dilution infusion device.

The reaction device comprising the medicament dilution and injection device also has the beneficial effects.

Drawings

Fig. 1 is a schematic structural diagram of a drug dilution injection device according to an embodiment of the present invention.

Fig. 2 is a schematic structural diagram of a medicament dilution injection device according to a preferred embodiment of the first embodiment of the present invention.

Fig. 3 is a schematic structural diagram of a medicament dilution injection device according to a second embodiment of the present invention.

List of reference numerals

100 solvent circulation system

101 solvent tank

102 solvent conveying equipment

103 first flowmeter

104 first flow control valve

105 first pressure control valve

106 second pressure control valve

107 second flow control valve

108 first check valve

109 cooler

200, 200' medicament delivery system

201 medicament pot

202 second flow meter

203 third flow rate control valve

204 air inlet valve

205 gas outlet valve

206 second check valve

300 metering pump

301 mixing pipeline

Liquid inlet of 302 metering pump

400 reaction device

500 reaction system

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all embodiments of the present invention.

In the following embodiments of the present invention, words indicating orientations, such as "upper", "lower", "left", "right", "horizontal", "vertical", etc., are referred to only to enable those skilled in the art to better understand the present invention, and should not be construed as limiting the present invention.