阅读说明：本技术 一种利用癞葡萄叶/苦瓜叶制备的β-环糊精组合物及其制备方法 (β -cyclodextrin composition prepared from fructus Momordicae Charantiae leaf/folium Momordicae Charantiae, and its preparation method ) 是由 任勇 陈洋 李文玎 郁桦 王荣昌 饶安平 于 2019-12-11 设计创作，主要内容包括：本发明公开了一种利用癞葡萄叶/苦瓜叶制备的β-环糊精组合物及其制备方法,所述组合物是由癞葡萄叶粗粉和/或苦瓜叶粗粉与β-环糊精混合粉碎后再进行包合所制得,其中癞葡萄叶粗粉和/或苦瓜叶粗粉与β-环糊精的质量比为1:(0.2～3.0)。相对于现有技术,本发明提供了一种新型的癞葡萄叶、苦瓜叶的相关产品及加工技术,有效利用了现有植物资源,扩大了癞葡萄或苦瓜保健食品的原料品种,所得组合物产品的溶解性强,癞葡萄叶和苦瓜叶的多种成分与β-环糊精存在明显包合作用,对改进粉体性能性质影响显著,并且产品稳定性好。(The invention discloses an β -cyclodextrin composition prepared from pellago grape leaves/bitter gourd leaves and a preparation method thereof, wherein the composition is prepared by mixing and crushing pellago grape leaf coarse powder and/or bitter gourd leaf coarse powder and β -cyclodextrin and then performing inclusion, wherein the mass ratio of the pellago grape leaf coarse powder and/or bitter gourd leaf coarse powder to β -cyclodextrin is 1 (0.2-3.0). compared with the prior art, the invention provides a novel relative product of pellago grape leaves and bitter gourd leaves and a processing technology, effectively utilizes the existing plant resources, enlarges the raw material varieties of pellago grape or bitter gourd health-care food, the obtained composition product has strong solubility, and the various components of the pellago grape leaves and bitter gourd leaves and β -cyclodextrin have obvious inclusion effect, have obvious influence on the performance and properties of improved powder, and have good product stability.)

1. An β -cyclodextrin composition prepared from pellago grape leaves/balsam pear leaves is characterized in that the composition is prepared by mixing and crushing pellago grape leaf coarse powder and/or balsam pear leaf coarse powder with β -cyclodextrin and then performing inclusion, wherein the mass ratio of the pellago grape leaf coarse powder and/or balsam pear leaf coarse powder to β -cyclodextrin is 1 (0.2-3.0).

2. The β -cyclodextrin composition prepared from fructus Momordicae Charantiae leaf/folium Momordicae Charantiae according to claim 1, wherein the mass ratio of the fructus Momordicae Charantiae leaf coarse powder and/or folium Momordicae Charantiae coarse powder to β -cyclodextrin is 1 (0.3-2.00).

3. The β -cyclodextrin composition prepared from balsam pear leaves/balsam pear leaves according to claim 1, which is prepared by mixing balsam pear leaf coarse powder, balsam pear leaf coarse powder and β -cyclodextrin, pulverizing, and clathrating, wherein the mass ratio of balsam pear leaves to balsam pear leaves is 1 (0.5-2).

4. The β -cyclodextrin composition prepared from fructus Momordicae Charantiae leaf/folium Momordicae Charantiae according to claim 1, wherein the folium Momordicae Charantiae coarse powder is prepared by drying fresh folium Momordicae Charantiae and pulverizing, and the folium Momordicae Charantiae coarse powder is prepared by drying fresh folium Momordicae Charantiae and pulverizing.

5. The method for preparing β -cyclodextrin composition prepared from fructus Momordicae Charantiae leaf/folium Momordicae Charantiae according to any of claims 1-4, comprises mixing folium Momordicae Charantiae coarse powder and/or folium Momordicae Charantiae coarse powder with β -cyclodextrin, pulverizing to obtain fine powder, mixing with pure water, stirring, and oven drying under reduced pressure to obtain β -cyclodextrin composition.

6. The method for preparing β -cyclodextrin composition prepared from fructus Momordicae Charantiae leaf/folium Momordicae Charantiae according to claim 5, wherein the mass ratio of the fine powder to pure water is 1 (1.5-2.5).

7. The method for preparing β -cyclodextrin composition prepared from fructus Momordicae Charantiae leaf/folium Momordicae Charantiae according to claim 5, wherein the fine powder has a particle size of 60-800 meshes, and the β -cyclodextrin composition can be prepared into powder of 60-800 meshes.

8. A preparation containing β -cyclodextrin composition prepared from fructus Momordicae Charantiae leaf/folium Momordicae Charantiae according to any one of claims 1-4.

9. The formulation of claim 8, wherein the formulation comprises a formulation prepared using the β -cyclodextrin composition and a pharmaceutically acceptable excipient.

10. The formulation of claim 8, wherein the formulation comprises a capsule, a tablet, or a granule.

Technical Field

The invention relates to an β -cyclodextrin composition prepared from pellago/balsam pear leaves and a preparation method thereof, belonging to the technical field of β -cyclodextrin compositions.

Background

The fructus Momordicae Charantiae and fructus Momordicae Charantiae are plants of Momordica of Cucurbitaceae, contain active ingredients such as polysaccharide, protein polypeptide, flavone, saponin, etc., have biological activities of reducing blood sugar, reducing blood lipid, and resisting tumor, and both can be edible and medicinal. The balsam pear, balsam pear fruit and balsam pear leaf have been reported in the research of food and medicine, wherein the balsam pear leaf products are developed more in recent years, while the balsam pear leaf products are rarely reported.

The reported bitter gourd leaf application methods comprise various modes such as decoction, extraction, direct eating of powder and the like, for example, the traditional decoction (decoction for removing dregs for taking) is used for treating summer fever of children (medical theory and practice, 1989.2.4: 38), the juice of fresh bitter gourd leaves is mixed with equal amount of lime water to prevent and control the cutworms at the roots of crop seedlings (village and town forum, 1994-08-15: 30), and the organic solvent extract of bitter gourd leaves has obvious inhibition effect on the growth and development of various young/imagoes which harm crops (modern agricultural science and technology, 2012, 22: 107-; the bitter gourd leaf powder is compatible with other foods (CN103329957A and the like) and used for preparing foods such as instant noodles, nutritional rice noodles, pastries and the like, the research on powder is less in products which directly eat the bitter gourd leaf powder, and coarse powder is often used for simplifying a preparation process, so that the use efficiency of bitter gourd leaves is difficult to be well exerted, and the health care effect of the products is influenced. The edible technology of the pellago grape leaves is not reported, and no products which can directly eat the pellago grape leaves are sold on the market at present.

Disclosure of Invention

The invention aims to solve the technical problems and provides an β -cyclodextrin composition prepared from pellago grape leaves/balsam pear leaves and a preparation method thereof.

The technical scheme is as follows: in order to achieve the purpose, the invention adopts the following technical scheme:

an β -cyclodextrin composition prepared from pellago grape leaves/balsam pear leaves is prepared by mixing and crushing pellago grape leaf coarse powder and/or balsam pear leaf coarse powder with β -cyclodextrin, and then performing inclusion, wherein the mass ratio of the pellago grape leaf coarse powder and/or balsam pear leaf coarse powder to β -cyclodextrin is 1 (0.2-3.0).

Preferably, the mass ratio of the coarse powder of the balsam pear leaves and/or the coarse powder of the balsam pear leaves to the β -cyclodextrin is 1 (0.3-2.00), and the optimal mass ratio is 1: 1.5.

Preferably, the composition is prepared by mixing and crushing the coarse powder of the leaves of the balsam pear and the coarse powder of the leaves of the balsam pear with β -cyclodextrin and then performing inclusion, wherein the mass ratio of the leaves of the balsam pear to the leaves of the balsam pear is 1 (0.5-2).

Preferably, the balsam pear leaf coarse powder is obtained by drying and crushing fresh balsam pear leaves.

The preparation method of the β -cyclodextrin composition prepared from fructus Momordicae Charantiae leaf/folium Momordicae Charantiae comprises mixing coarse powder of folium Momordicae Charantiae and/or coarse powder of folium Momordicae Charantiae with β -cyclodextrin, pulverizing to obtain fine powder, mixing with pure water, stirring, and drying under reduced pressure to obtain the β -cyclodextrin composition.

Preferably, the mass ratio of the fine powder to the pure water is 1 (1.5-2.5).

Preferably, the granularity of the fine powder is 60-800 meshes, and the β -cyclodextrin composition can be prepared into powder of 60-800 meshes.

The invention also provides a preparation containing the β -cyclodextrin composition prepared by utilizing the pellago delavayi leaf/balsam pear leaf.

Preferably, the preparation comprises a preparation prepared by using the β -cyclodextrin composition and pharmaceutically acceptable auxiliary materials, and the preparation can be prepared according to the common technical requirements and operation steps so as to be convenient to use.

Preferably, the formulation comprises capsules, tablets, granules or the like. The capsule dosage form comprises: common capsule, hard capsule, soft capsule, sustained release capsule, etc.; the tablet dosage form comprises: tablet dosage forms such as common instant tablet, dispersible tablet, sustained release tablet, chewable tablet, etc.; the granule dosage form comprises: common granule, instant granule, etc.

The coarse powder of the leaves of the balsam pear and/or the coarse powder of the leaves of the balsam pear in the invention can be used independently, or the coarse powder of the leaves of the balsam pear and the coarse powder of the leaves of the balsam pear can be used simultaneously.

The technical effects are as follows: compared with the prior art, the invention has the following advantages:

1. provides a novel relative product of balsam pear leaves and a processing technology;

2. effectively utilizes the existing plant resources, and enlarges the raw material variety of the balsam pear or balsam pear health-care food;

3. the scabby grape leaves are nontoxic when being taken orally, and the safety of the scabby grape leaf product is high;

4. the solubility of the composition product is strong;

5. the balsam pear leaves and the balsam pear leaves have obvious clathration with β -cyclodextrin, which has obvious influence on improving the powder performance;

6. the product has good stability.

Drawings

FIG. 1: the cyclodextrin with different proportions of the obtained sample has solubilization times on sample components.

FIG. 2: solid powder ultraviolet-visible diffuse reflectance Spectroscopy (UV-VisDRS) Pattern of composition (1: 1.5) and sample of mixture

Detailed Description

The present invention will be further illustrated with reference to the following specific examples.