阅读说明：本技术 双特异性t细胞活化抗原结合分子 (Bispecific T cell activating antigen binding molecules ) 是由 M·巴卡 P·布鲁恩克尔 C·耶格尔 C·克莱因 E·默斯纳 P·乌马纳 T·韦因策尔 于 2014-02-21 设计创作，主要内容包括：本发明总体上涉及用于T细胞活化和再指向特定靶细胞的新的双特异性抗原结合分子。此外,本发明涉及编码这类双特异性抗原结合分子的多核苷酸以及包含这类多核苷酸的载体和宿主细胞。本发明还涉及用于产生本发明的双特异性抗原结合分子的方法,以及涉及在治疗疾病时使用这些双特异性抗原结合分子的方法。(The present invention relates generally to novel bispecific antigen binding molecules for T cell activation and redirection to specific target cells. Furthermore, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules as well as vectors and host cells comprising such polynucleotides. The invention also relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.)