阅读说明：本技术 一种基于无线辐射探头和表磁分布测量仪的体内检测系统 (In-vivo detection system based on wireless radiation probe and surface magnetic distribution measuring instrument ) 是由 孙伟民 谢天赐 李松 戴昕宇 张彬 张徐 李昊鹏 马羽 秦壮 于 2019-10-15 设计创作，主要内容包括：本发明属于肿瘤X射线放射治疗技术领域,具体涉及定位测量人体内所受的辐射剂量的一种基于无线辐射探头和表磁分布测量仪的体内检测系统。本系统主要由无线微颗粒辐射剂量检测探头、侧胸表磁分布测量仪、背部表磁分布测量仪和计算机组成。本发明的辐射剂量检测系统所利用的无线微颗粒辐射剂量检测探头尺寸小且无需布线,其接受到的电离辐射信号经过转换后,通过表磁分布测量仪测得磁场强度可测得某一点的辐射强度,并可以转化成吸收剂量,同时分析表磁分布测量仪不同位置磁场探头检测到信号大小来确定探头在人体中的位置。因此理论上可对人体的体内、体表的任一部位剂量进行检测。(The invention belongs to the technical field of tumor X-ray radiotherapy, and particularly relates to an in-vivo detection system based on a wireless radiation probe and a surface magnetic distribution measuring instrument for positioning and measuring radiation dose received by a human body. The system mainly comprises a wireless microparticle radiation dose detection probe, a lateral chest surface magnetic distribution measuring instrument, a back surface magnetic distribution measuring instrument and a computer. The wireless microparticle radiation dose detection probe utilized by the radiation dose detection system is small in size and does not need wiring, the received ionizing radiation signal is converted, the radiation intensity of a certain point can be measured through the magnetic field intensity measured by the surface magnetic distribution measuring instrument and can be converted into the absorbed dose, and meanwhile, the position of the probe in a human body is determined by analyzing the signal size detected by the magnetic field probes at different positions of the surface magnetic distribution measuring instrument. Therefore, the dosage of any part of the human body in vivo and on the body surface can be theoretically detected.)

1. An in vivo detection system based on a wireless radiation probe and a surface magnetic distribution measuring instrument is characterized in that the system mainly comprises a wireless microparticle radiation dose detection probe (3-1), a lateral chest surface magnetic distribution measuring instrument (3-2), a back surface magnetic distribution measuring instrument (3-3) and a computer (3-6); the wireless microparticle radiation dose detection probe (3-1) is placed at a focus part of a phantom (3-5), ionizing radiation (3-4) irradiates the phantom (3-5), the back surface magnetic distribution measuring instrument (3-3) is placed at the back of the phantom (3-5), and the side chest surface magnetic distribution measuring instrument (3-2) is placed at the side of the phantom (3-5) and is respectively connected to the computer (3-6).

2. The in-vivo detection system based on the wireless radiation probe and the surface magnetic distribution measuring instrument as claimed in claim 1, wherein the wireless microparticle radiation dose detection probe (3-1) is composed of a shell (1-1), a filler (1-2), a photocathode (1-3), a photoanode (1-4) and a micro load (1-5).

3. An in-vivo detection system based on a wireless radiation probe and a surface magnetic distribution measuring instrument according to claim 1, characterized in that the lateral chest surface magnetic distribution measuring instrument (3-2) and the back surface magnetic distribution measuring instrument (3-3) each comprise a panel (2-1) and a magnetic field probe (2-2).

Technical Field

The invention belongs to the technical field of tumor X-ray radiotherapy, and particularly relates to an in-vivo detection system based on a wireless radiation probe and a surface magnetic distribution measuring instrument for positioning and measuring radiation dose received by a human body.

Background

Research data show that the prevalence and mortality of tumors in the world population are rising year by year, nearly doubling those before ten years. Therefore, it is very necessary to pay high attention to the treatment of tumors. Radiotherapy is one of the important methods for the clinical comprehensive treatment of tumor, and is called radiotherapy for short, which is the treatment of malignant tumor and some benign diseases by using one or more ionizing radiations. During X-ray radiation therapy, high-energy radiation interacts with intracellular structures, which can cause irreversible damage, either directly or indirectly, to the DNA structure of the cell. In the course of radiotherapy, the focus area and its periphery are monitored by radiation dose, which is concentrated in the lesion area as far as possible to kill tumor cells, while the surrounding normal tissues or organs are less or free from unnecessary radiation. For example, in the course of oral and nasal tumor radiotherapy, a physicist needs to make a precise radiotherapy plan to ensure that the oral mucosa sensitive to radiation is not affected by the radiation, and in order to better distinguish the dose of the focus region from the dose of the normal tissue, a technology capable of accurately measuring the radiation dose at a certain point is needed.

The radiation dose detection sensor in the radiotherapy process is mainly an ionization chamber, and takes a patent of an ionization chamber device (Chinese patent CN106449347A) as an example, the main working principle of the radiation dose detection sensor is that the absorbed dose is obtained by measuring the ionization charge quantity of secondary particles generated in the process of generating interaction between ionizing radiation and substances and calculating. But the ionization chamber is large in size and is in wired measurement, and the ionization chamber is difficult to enter a human body. The focus of radiation dose detection is on how to effectively convert ionizing radiation into measurable quantity, and besides the above-mentioned ionization chamber sensor, there is also a fiber-optic X-ray sensor which can convert ionizing radiation signal into electromagnetic wave in visible light band for detection (chinese patent ZL2015101663730, embedded radiation dose detection fiber-optic probe in tumor X-ray radiotherapy). The optical fiber fluorescence radiation sensing probe in the invention is a probe manufactured by utilizing the principle that certain rare earth fluorescent materials are irradiated by high-energy ionizing radiation to excite fluorescence in a visible light wave band, and special materials of the probe are combined with optical fibers, so that the fluorescence can be conducted in the optical fibers and further received by a light intensity detector. However, the optical fiber X-ray sensor also has the problems of wiring and difficulty in entering a human body. In order to solve the problems, the invention provides an in-vivo radiation dose measuring system based on a wireless microparticle radiation dose detection probe and a surface magnetic distribution measuring instrument. In the above procedure, no wiring is required and the real-time intensity of ionizing radiation can be known during radiotherapy.

Disclosure of Invention

The invention aims to provide an in-vivo detection system based on a wireless radiation probe and a surface magnetic distribution measuring instrument.

The purpose of the invention is realized as follows:

an in vivo detection system based on a wireless radiation probe and a surface magnetic distribution measuring instrument mainly comprises a wireless microparticle radiation dose detection probe (3-1), a lateral chest surface magnetic distribution measuring instrument (3-2), a back surface magnetic distribution measuring instrument (3-3) and a computer (3-6); the wireless microparticle radiation dose detection probe (3-1) is placed at a focus part of a phantom (3-5), ionizing radiation (3-4) irradiates the phantom (3-5), the back surface magnetic distribution measuring instrument (3-3) is placed at the back of the phantom (3-5), and the side chest surface magnetic distribution measuring instrument (3-2) is placed at the side of the phantom (3-5) and is respectively connected to the computer (3-6).

The wireless microparticle radiation dose detection probe (3-1) is composed of a shell (1-1), a filler (1-2), a photocathode (1-3), a photoanode (1-4) and a micro load (1-5).

The lateral chest surface magnetic distribution measuring instrument (3-2) and the back surface magnetic distribution measuring instrument (3-3) both comprise a panel (2-1) and a magnetic field probe (2-2).

The invention has the beneficial effects that: the wireless microparticle radiation dose detection probe utilized by the radiation dose detection system is small in size and does not need wiring, the received ionizing radiation signal is converted, the radiation intensity of a certain point can be measured through the magnetic field intensity measured by the surface magnetic distribution measuring instrument and can be converted into the absorbed dose, and meanwhile, the position of the probe in a human body is determined by analyzing the signal size detected by the magnetic field probes at different positions of the surface magnetic distribution measuring instrument. Therefore, the dosage of any part of the human body in vivo and on the body surface can be theoretically detected.

Drawings

FIG. 1 is a cross-sectional view of a wireless microparticle radiation dose detection probe;

FIG. 2 is a block diagram of a meter for measuring magnetic distribution;

fig. 3 is a diagram of a radiation dose detection system based on a wireless microparticle radiation dose detection probe and a surface magnetic distribution measuring instrument.

Detailed description of the invention

The invention is further described below with reference to the accompanying drawings.

(1) Selecting an electron cathode material capable of being excited by ionizing radiation as a photocathode (1-3), selecting a proper anode material as a photo-anode (1-4), and filling the photo-anode and the photo-anode into an insulating non-ferromagnetic filler (1-2) which is non-toxic to human bodies. The photocathode and the photoanode are connected with the micro load (1-5) to form a magnetic field generating circuit to generate a magnetic field, and a shell (1-1) which is harmless to a human body is wrapped outside the filler to form the wireless micro-particle radiation dose detection probe (3-1).

(2) Selecting a plurality of magnetic field probes (2-2) for detecting the magnitude of the magnetic field, and selecting a material which does not influence the magnitude and distribution of the magnetic field as a panel (2-1). The magnetic field probes are distributed on the panel to form a lateral chest surface magnetic distribution measuring instrument (3-2), and the back surface magnetic distribution measuring instrument (3-3) is formed by the same method.

(3) The wireless microparticle radiation dose detection probe is placed in a human body or a focus part of a phantom (3-5), ionizing radiation (3-4) irradiates the phantom, a back surface magnetic distribution measuring instrument is placed on the back of the phantom, a side chest surface magnetic distribution measuring instrument is placed on the side face of the phantom, and the wireless microparticle radiation dose detection probe and the back surface magnetic distribution measuring instrument are respectively connected to a computer (3-6). The detection system can be applied to the field of various tumor radiotherapy, for example, in the oral cancer, the wireless micro-particles are placed at the focus part of the oral cavity where the disease needs to be detected, the radiation irradiates the wireless micro-particle radiation dose detection probe to enable the wireless micro-particle radiation dose detection probe to generate a magnetic field, the size of the magnetic field can be sensed by the magnetic field probes of the lateral chest and back surface magnetic distribution measuring instruments, the magnetic field probes transmit signals to the computer, the dose size of the focus part can be known, and meanwhile, the position of a human body where the particles are located can be determined by knowing the strength of the signals transmitted by the magnetic field probes. In the radiotherapy of gastric cancer, the probe can be implanted into the part of the corresponding focus needing the dosage detection through a gastroscope, and the steps are repeated.

The system is mainly used for the dose monitoring of tumor X-ray radiotherapy, and the system is used for positioning and measuring the radiation dose in a human body by utilizing a wireless microparticle radiation dose detection probe capable of generating a photoelectric effect and a current magnetic effect and an internal radiation dose measuring system of a surface magnetic distribution measuring instrument.

The invention aims to measure the position of a probe in a human body and the radiation dose at the position by using an internal radiation dose measuring system based on a wireless microparticle radiation dose detection probe and a surface magnetic distribution measuring instrument.

The radiation dose detection system mainly comprises a wireless microparticle radiation dose detection probe and a surface magnetic distribution measuring instrument. The wireless microparticle radiation dose detection probe converts ionizing radiation into a magnetic field signal, and the surface magnetic distribution measuring instrument is divided into a back surface magnetic distribution measuring instrument and a lateral chest surface magnetic distribution measuring instrument to detect the size of a magnetic field. The wireless micro-particles are composed of a shell, a filler, a photocathode, a photoanode and a micro-load. The shell is made of materials harmless to a human body and wraps the internal structure, the filler fixes the structure inside the particles, and the shell and the filler are made of non-ferromagnetic materials and cannot interfere a magnetic field. The photocathode is a sensitive material which can excite photoelectrons when being irradiated by ionizing radiation, the photoelectrons are transmitted between the photocathode and the photocathode to generate electric potential energy and generate current on a micro load, and a magnetic field is generated due to the magnetic effect of the current. The surface magnetic distribution measuring instrument detects the magnitude of the magnetic field and transmits the magnitude to the computer for processing, and then the position of the wireless microparticle radiation dose detection probe and the dose magnitude of the position can be known.

The detectors used for dose monitoring in radiotherapy, such as ionization chambers, semiconductor detectors and the like, which need wiring, bring much inconvenience due to wiring problems in actual operation.