阅读说明：本技术 用于制备环状有机化合物的方法 (Process for preparing cyclic organic compounds ) 是由 本间晶江 侯增烨 伊藤久师 筱仓洁 于 2018-05-11 设计创作，主要内容包括：本发明的目的在于提供使用连续搅拌釜式反应器(CSTR)制备环状有机化合物的方法,所述方法能够实现优异的杂质抑制效果(质量改善)、反应釜尺寸的减小、连续生产等。为了解决上述问题,本发明人对使用CSTR的环化反应进行了研究,该反应器并未常规地用于环状化合物的环化反应。因此,本发明人已经发现与常规环化方法相比,本发明可以实现优异的杂质抑制效果(质量改善)、反应釜尺寸的减小、连续生产等。此外,本发明人已经发现,通过将常规上主要以精细化学品工厂水平使用的模拟方法应用于本发明的环化反应,由此实验性地预测环化反应的反应速率,并且在使用CSTR的环化反应中设定影响这些条件的流量(停留时间)、前体和环状有机化合物的浓度以及用于环化反应的温度等,甚至在环肽和杂环化合物的制备中可以有效地实现上述改善效果。(An object of the present invention is to provide a method for preparing a cyclic organic compound using a Continuous Stirred Tank Reactor (CSTR), which is capable of achieving excellent impurity suppression effect (quality improvement), reduction in reactor size, continuous production, and the like. In order to solve the above problems, the present inventors have studied on a cyclization reaction using a CSTR, which is not conventionally used for a cyclization reaction of a cyclic compound. Therefore, the present inventors have found that the present invention can achieve an excellent impurity suppressing effect (quality improvement), reduction in the size of a reaction vessel, continuous production, and the like, as compared with the conventional cyclization method. Furthermore, the present inventors have found that the above-described improvement effect can be effectively achieved even in the production of cyclic peptides and heterocyclic compounds by applying a simulation method conventionally used mainly at the fine chemical plant level to the cyclization reaction of the present invention, thereby experimentally predicting the reaction rate of the cyclization reaction, and setting the flow rate (residence time), the concentrations of the precursor and cyclic organic compound, and the temperature for the cyclization reaction, etc., which affect these conditions, in the cyclization reaction using CSTR.)