阅读说明：本技术 Lrig-1蛋白的特异性结合分子及其用途 (Specific binding molecules for LRIG-1 proteins and uses thereof ) 是由 金廷镐 金范锡 于 2018-04-18 设计创作，主要内容包括：本发明涉及能够与Lrig-1蛋白特异性结合的结合分子,该蛋白位于调节性T细胞的表面。本发明提供的结合分子可以激活调节性T细胞的功能,以有效预防、改善或治疗由各种免疫细胞和炎性细胞的过度激活或表达引起的疾病,例如免疫相关疾病,如自身免疫疾病、移植物抗宿主病、器官移植排斥、哮喘、特应性疾病、急性或慢性炎性疾病等。此外,本发明的Lrig-1蛋白的特异性结合分子,优选抗体具有以下优点：与先前可商品化购得的抗Lrig-1抗体相比,更有效地靶向Lrig-1蛋白,并且具有非常好的结合能力。(The present invention relates to binding molecules capable of specifically binding to the Lrig-1 protein, which is located on the surface of regulatory T cells. The binding molecules provided by the present invention can activate the function of regulatory T cells to effectively prevent, ameliorate or treat diseases caused by over-activation or expression of various immune cells and inflammatory cells, for example, immune-related diseases such as autoimmune diseases, graft-versus-host disease, organ transplant rejection, asthma, atopic diseases, acute or chronic inflammatory diseases, and the like. Furthermore, specific binding molecules, preferably antibodies, of the Lrig-1 protein of the invention have the following advantages: lrig-1 protein is targeted more efficiently and with very good binding capacity than the anti-Lrig-1 antibodies previously commercially available.)