阅读说明：本技术 一种预防和治疗心脑血管疾病的纯天然中药方剂 (Pure natural traditional Chinese medicine prescription for preventing and treating cardiovascular and cerebrovascular diseases ) 是由 张建国 于 2019-09-30 设计创作，主要内容包括：一种治疗和预防心脑血管疾病的纯天然中药方剂,其特征在于有下述重量配比的中药组成：葛根3-30g丹参3-30g,淫羊藿3-30g,三七3-30g,沙棘3-30g,桑寄生3-30g,水煎浓缩提取物混合粉碎至100-200目粒度后,制成中药制剂。所述的中药制剂为中药学上所述的任何一种剂型。上中药的联合应用,协同发挥临床作用,对于预防和治疗心脑血管疾病具有非常良好的疗效,比使用单一的药物疗效确切。该方剂于2005年投入临床实验。患者普遍满意,适用于心脑血管病患者。(A pure natural traditional Chinese medicine prescription for treating and preventing cardiovascular and cerebrovascular diseases is characterized by comprising the following traditional Chinese medicines in parts by weight: 3-30g of radix puerariae, 3-30g of radix salviae miltiorrhizae, 3-30g of herba epimedii, 3-30g of pseudo-ginseng, 3-30g of sea buckthorn and 3-30g of loranthus parasiticus, and the extract is prepared by mixing, decocting and concentrating the extract, crushing the mixture into powder with the granularity of 100 meshes and 200 meshes, and preparing the powder into a traditional Chinese medicine preparation. The traditional Chinese medicine preparation is any one of the dosage forms in traditional Chinese pharmacology. The combined application of the traditional Chinese medicines synergistically plays a clinical role, has very good curative effect on preventing and treating cardiovascular and cerebrovascular diseases, and is more accurate than the curative effect of a single medicine. The formulation was put into clinical trials in 2005. The patients are generally satisfied and the medicine is suitable for patients with cardiovascular and cerebrovascular diseases.)

1. A pure natural traditional Chinese medicine prescription for treating and preventing cardiovascular and cerebrovascular diseases is characterized by comprising the following traditional Chinese medicines in parts by weight:

3-30g of kudzuvine root, 3-30g of salvia miltiorrhiza, 3-30g of epimedium, 3-30g of pseudo-ginseng, 3-30g of sea-buckthorn and 3-30g of Chinese taxillus twig, and the extracts are decocted in water and concentrated, mixed and crushed to 100-mesh and 200-mesh granularity, and then the Chinese medicinal preparation is prepared.

2. The pure natural traditional Chinese medicine prescription for treating and preventing cardiovascular and cerebrovascular diseases according to claim 1, characterized in that the traditional Chinese medicine preparation is any one of the dosage forms described in traditional Chinese medicine science.

3. The pure natural traditional Chinese medicine prescription for treating and preventing cardiovascular and cerebrovascular diseases according to claim 2, characterized in that the traditional Chinese medicine preparation is a capsule preparation.

4. The pure natural traditional Chinese medicine prescription for treating and preventing cardiovascular and cerebrovascular diseases according to claim 2, characterized in that the traditional Chinese medicine preparation is granule.

5. The pure natural traditional Chinese medicine prescription for treating and preventing cardiovascular and cerebrovascular diseases according to claim 2, characterized in that the traditional Chinese medicine prescription is a tablet.

6. The pure natural traditional Chinese medicine prescription for treating and preventing cardiovascular and cerebrovascular diseases according to claim 2, characterized in that the traditional Chinese medicine preparation is an oral liquid preparation.

7. The pure natural traditional Chinese medicine prescription for treating and preventing cardiovascular and cerebrovascular diseases according to claim 2, characterized in that the traditional Chinese medicine preparation is a soft capsule preparation.

Technical Field

The invention relates to a medicament for preventing and treating cardiovascular and cerebrovascular diseases, in particular to a pure natural traditional Chinese medicine formula for treating and preventing cardiovascular and cerebrovascular diseases.

Background

Cardiovascular and cerebrovascular diseases are one of the most serious diseases threatening human beings in the world today, and the morbidity and mortality of the cardiovascular and cerebrovascular diseases exceed those of tumors and jump the first in the world. Cardiovascular and cerebrovascular diseases such as heart disease and apoplexy are also the first cause of death in China. Therefore, the research and the prevention and treatment of cardiovascular and cerebrovascular diseases have become urgent. In recent years, a series of experimental researches and clinical application researches on the prevention and treatment of cardiovascular and cerebrovascular diseases are carried out on the traditional Chinese medicine, great progress is made, and the advantages of the national traditional Chinese medicine are shown.

The kudzu root is a homologous plant of medicine and food approved by the Ministry of health of China, and the modern medical research shows that: radix Puerariae can dilate coronary blood vessel and cerebral vessels, and increase coronary blood flow and cerebral blood flow; the radix Puerariae total flavone can reduce myocardial oxygen consumption and increase oxygen supply; the kudzu root can directly expand blood vessels to reduce peripheral resistance, has obvious blood pressure reducing effect, is used for preventing and treating cardiovascular and cerebrovascular diseases, and has important effect.

The main chemical component of the salvia miltiorrhiza is tanshinone which has the functions of removing oxygen free radicals, regulating calcium stability, protecting mitochondria and improving energy metabolism and has obvious improvement effect on ischemic reperfusion injury. Meanwhile, the salvia miltiorrhiza plays an internal regulation role on immune response through the action on cytokines, antibodies, immune complexes and immune cells, and the role has bidirectionality.

Icariin has good cardiovascular and cerebrovascular activity, and can directly dilate cerebral vessels, increase cerebral blood flow, reduce cerebrovascular resistance and inhibit blood pressure rise. Both the decoction and icariin can inhibit myocardial contraction, lower peripheral resistance, increase left ventricular output, reduce cardiac load and increase peripheral organ perfusion. Experimental research proves that the epimedium extract can reduce total peripheral vascular resistance and left ventricular end diastolic pressure, increase coronary artery blood flow, cardiac output, stroke output, myocardial contraction parameter, myocardial relaxation parameter, cardiac index and cardiac index, and improve the blood flow dynamics of pseudo-ginseng, which plays an important role in cardiovascular and cerebrovascular blood circulation:

1. notoginseng expands coronary artery, promotes the formation of collateral circulation of myocardial infarction area, increases coronary blood flow, improves myocardial blood oxygen supply, ② inhibits myocardial contractility, slows heart rate, reduces peripheral vascular resistance, reduces myocardial oxygen consumption, ③ resists lipid peroxidation, improves activity of superoxide dismutase (SOD), reduces generation of Malondialdehyde (MDA), ④ improves anoxia resistance, obviously prolongs survival time of myocardium under normal pressure anoxia condition 2. Notoginseng has effects of resisting cerebral ischemia, besides expanding cerebral vessels and increasing local blood flow, it also has effects of delaying decomposition of ischemic tissue ATP, improving energy metabolism, inhibiting lipid peroxidation, improving SOD activity in brain tissue, and eliminating oxygen free radical, 3. Notoginseng has effects of resisting platelet aggregation, resisting thrombin and promoting fibrinolysis process

Seabuckthorn contains 206 active substances beneficial to human bodies, wherein 46 bioactive substances comprise a large amount of vitamin E, vitamin A, flavone and the like, has special pharmacological properties of resisting fatigue, enhancing organism vitality and the like, has the effects of protecting and accelerating the repair of vascular mucosa, reducing plasma cholesterol and reducing the content of cholesterol in vascular walls, can prevent and treat hyperlipidemia and atherosclerosis, and has the effect of promoting wound healing.

The sea-buckthorn fruit contains 7 kinds of flavonolignan substances such as isorhamnetin and its glucoside, quercetin, kaempferol and the like, has the efficacies of dilating coronary vessels and reducing cholesterol, is commonly used for treating ischemic heart disease in modern clinic, and has the effective rate of 94 percent for treating angina pectoris.

The SOD active ingredients in the sea-buckthorn are rich, the SOD content of each gram of fresh sea-buckthorn fruit reaches 2746.0 enzyme units, and the content of the SOD active ingredients is 4 times of that of ginseng. It can block free radical produced by peroxidation of body material, and the free radical is closely related to human body senility and diseases.

In addition, various unsaturated amino acids, phosphorus fat, Rutin and the like with uniform content in the sea buckthorn seed oil have the function of regulating cholesterol.

The results of modern Chinese medicine research prove that the loranthus parasiticus has the functions of expanding coronary artery blood vessels, improving coronary blood flow and reducing blood pressure and excitability of sympathetic nerves and blood vessel motor centers. There is a saying "regulating blood vessels" in sang Ji Sheng from the meridian origin. Clinical research shows that the medicine has reliable curative effect on cardiovascular and cerebrovascular diseases such as high heart disease, angina pectoris, hyperlipemia, cerebral arteriosclerosis, essential hypertension and the like

The above six medicines have effects of preventing and treating cardiovascular and cerebrovascular diseases, but have no combined application, and influence the effect of preventing and treating cardiovascular and cerebrovascular diseases

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides a health-care medicine for preventing and treating cardiovascular and cerebrovascular diseases, which is prepared by combining a kudzu root extract with red sage root, epimedium herb, pseudo-ginseng, sea buckthorn and Chinese taxillus twig in a proper ratio.

The solution of the invention is based on the long-term research of the pathogenesis of the cardiovascular and cerebrovascular diseases in the traditional Chinese medicine, refers to the modern pharmacological research achievement, and screens out six drug combinations which are effective for preventing and treating the cardiovascular and cerebrovascular diseases from the plant Chinese herbal medicines, thereby obtaining good curative effect for preventing and treating the cardiovascular and cerebrovascular diseases.

The kudzu root is a homologous plant of medicine and food approved by the Ministry of health of China, and the modern medical research shows that: radix Puerariae can dilate coronary blood vessel and cerebral vessels, and increase coronary blood flow and cerebral blood flow; the radix Puerariae total flavone can reduce myocardial oxygen consumption and increase oxygen supply; the kudzu root can directly expand blood vessels to reduce peripheral resistance, has obvious blood pressure reducing effect, is used for preventing and treating cardiovascular and cerebrovascular diseases, and has important effect.

The main chemical component of the salvia miltiorrhiza is tanshinone which has the functions of removing oxygen free radicals, regulating calcium stability, protecting mitochondria and improving energy metabolism and has obvious improvement effect on ischemic reperfusion injury. Meanwhile, the salvia miltiorrhiza plays an internal regulation role on immune response through the action on cytokines, antibodies, immune complexes and immune cells, and the role has bidirectionality.

Icariin has good cardiovascular and cerebrovascular activity, and can directly dilate cerebral vessels, increase cerebral blood flow, reduce cerebrovascular resistance and inhibit blood pressure rise. Both the decoction and icariin can inhibit myocardial contraction, lower peripheral resistance, increase left ventricular output, reduce cardiac load and increase peripheral organ perfusion. Experimental research proves that the epimedium extract can reduce total peripheral vascular resistance and left ventricular end diastolic pressure, increase coronary artery blood flow, cardiac output, stroke output, myocardial contraction parameter, myocardial relaxation parameter, cardiac index and cardiac index, and improve the blood flow dynamics of pseudo-ginseng, which plays an important role in cardiovascular and cerebrovascular blood circulation:

1. the panax notoginseng expands coronary artery, promotes the formation of collateral circulation of myocardial infarction area, increases coronary blood flow, improves myocardial blood oxygen supply, ② inhibits myocardial contractility, slows heart rate, reduces peripheral vascular resistance, reduces myocardial oxygen consumption, ③ resists lipid peroxidation, improves the activity of superoxide dismutase (SOD), reduces the generation of Malondialdehyde (MDA), ④ improves anoxia resistance, obviously prolongs the survival time of myocardium under the condition of normal pressure and anoxia 2. the panax notoginseng anti-cerebral ischemia function is related to the functions of expanding cerebral vessels and increasing local blood flow, delaying the decomposition of ATP of ischemic tissues, improving energy metabolism, inhibiting lipid peroxidation, improving the activity of SOD in brain tissues and removing oxygen free radicals and the like 3. the panax notoginseng anti-thrombosis function links comprise platelet aggregation, antithrombin and promoting the fibrinolysis process

Seabuckthorn contains 206 active substances beneficial to human bodies, wherein 46 bioactive substances comprise a large amount of vitamin E, vitamin A, flavone and the like, has special pharmacological properties of resisting fatigue, enhancing organism vitality and the like, has the effects of protecting and accelerating the repair of vascular mucosa, reducing plasma cholesterol and reducing the content of cholesterol in vascular walls, can prevent and treat hyperlipidemia and atherosclerosis, and has the effect of promoting wound healing.

The sea-buckthorn fruit contains 7 kinds of flavonolignan substances such as isorhamnetin and its glucoside, quercetin, kaempferol and the like, has the effects of dilating coronary vessels and reducing cholesterol, is commonly used for treating ischemic heart diseases, and has the effective rate of 94 percent for treating angina.

The SOD active ingredients in the sea-buckthorn are rich, the SOD content of each gram of fresh sea-buckthorn fruit reaches 2746.0 enzyme units, and the content of the SOD active ingredients is 4 times of that of ginseng. It can block free radical produced by peroxidation of body material, and the free radical is closely related to human body senility and diseases. In addition, various unsaturated amino acids, phosphorus fat, Rutin and the like with uniform content in the sea buckthorn seed oil have the function of regulating cholesterol.

The modern Chinese medicine research of the loranthus parasiticus proves that the loranthus parasiticus has the functions of expanding coronary artery blood vessels, improving coronary blood flow and reducing blood pressure and excitability of sympathetic nerves and blood vessel motor centers. There is a saying "regulating blood vessels" in sang Ji Sheng from the meridian origin. Clinical research shows that the medicine has reliable curative effect on cardiovascular and cerebrovascular diseases such as high heart disease, angina pectoris, hyperlipemia, cerebral arteriosclerosis, essential hypertension and the like

The technical scheme of the invention is as follows: the health medicine for preventing and treating cardiac and cerebral vascular diseases is prepared with ginkgo leaf extract in 1-30 weight portions and red sage extract in 1-60 weight portions, and through mixing and crushing kudzu vine root extract and red sage, epimedium, notoginseng, sea buckthorn and Chinese taxillus herb in 80-100 mesh size to prepare the Chinese medicine preparation.

The traditional Chinese medicine preparation is any one of the dosage forms in traditional Chinese pharmacology. Can be made into capsule, tablet, granule, oral liquid, soft capsule, etc.

The combination of the medicines has combined effect, has very good curative effect on preventing and treating cardiovascular and cerebrovascular diseases, and has better and faster curative effect than a single medicine. The drug was put into clinical trials in 2005 and was popular with patients, and the following cases are now explained:

example 1. 150 cases of myocardial infarction are treated, the treatment period is 3 months, the result shows that the medicine has 80 cases, 92 cases are improved, 8 cases are not effective, and the total effective rate is 95 percent.

Example 2, 80 cases of coronary heart disease are treated, 55 cases are cured, 22 cases are improved, 5 cases are ineffective, and 93.7 percent.

Example 3, 120 cases of hyperlipidemia treatment, 100 cases of obvious effect, 6 cases of effect and 14 cases of no effect, and the total effective rate is 88%.

Example 4. Animal experiment for treating cerebral infarction, Wistar rat is selected in the experiment, animal cerebral infarction model is produced by Tamura method, animals are divided into experiment group and control group, each group is 20, the experiment group is drenched with the drug, the control group is drenched with nimodipine, the drug is administrated once every 24 hours, then the ethological inspection and the pathological inspection are carried out, the result experiment group has brain pathological damage and behavior disorder, the effect is clearly improved and treated, the effect is better than that of the control group, and the difference is very obvious (P is less than 0.01).

Example 5 clinical trial for treating cerebral infarction, 60 patients with cerebral infarction had effective 40, 12 and 8 patients with cerebral infarction, and the total effective rate was 96.67% and 0

Detailed Description

The first embodiment is as follows: the health-care medicine for preventing and treating cardiovascular and cerebrovascular diseases comprises the following medicines in parts by weight: the preparation method comprises the following steps of taking the kudzu root extract and the red sage root extract according to a formula, mixing and crushing the kudzu root extract and the red sage root extract into powder with a granularity of 80-100 meshes, granulating, and encapsulating to prepare the capsule preparation. The product is taken 3 times a day, 1 granule each time, and has a weight of 500 mg.

Example two: the health-care medicine for preventing and treating cardiovascular and cerebrovascular diseases comprises the following medicines in parts by weight: the preparation method comprises mixing folium Ginkgo extract and Saviae Miltiorrhizae radix extract according to a formula, pulverizing into 80-100 mesh, dissolving in sterile water, bottling, and making into oral liquid preparation, wherein the extracts of radix Puerariae, herba Epimedii and fructus Hippophae account for 30, the extracts of Saviae Miltiorrhizae radix, Notoginseng radix and herba Taxilli account for 10, and the extract of Saviae Miltiorrhizae radix accounts for 20. The product is administered 1 bottle 1oml daily for 1 time. Mixing radix Puerariae extract and Saviae Miltiorrhizae radix extract according to formula, pulverizing to 80-100 mesh, granulating, tabletting, and making into tablet. The product is taken 3 times a day, 1 tablet each time, and has a weight of 500 mg.

Example three: the health-care medicine for preventing and treating cardiovascular and cerebrovascular diseases comprises the following medicines in parts by weight: the kudzu root epimedium, the sea-buckthorn and the salvia miltiorrhiza, the pseudo-ginseng and the loranthus parasiticus extract account for 15, the honeysuckle kudzu root extract and the salvia miltiorrhiza extract are taken according to the formula, mixed and crushed to 80-100 meshes, and then the traditional Chinese medicine electuary is prepared. The product is 1g in weight, and is taken 1 bag per time 2 times a day.

Example four: the health-care medicine for preventing and treating cardiovascular and cerebrovascular diseases comprises the following medicines in parts by weight: the preparation method comprises mixing radix Puerariae extract and Saviae Miltiorrhizae radix extract, pulverizing into 80-100 mesh powder, dissolving in sterile water, bottling, and making into oral liquid.

Example five: the health-care medicine for preventing and treating cardiovascular and cerebrovascular diseases comprises the following medicines in parts by weight: the preparation method comprises mixing radix Puerariae extract and Saviae Miltiorrhizae radix extract according to a formula, pulverizing into 80-100 mesh powder, dissolving in sterile water, bottling, and making into oral liquid. The product is administered 1 bottle 1oml daily for 1 time.