阅读说明：本技术 一种壬二酸超分子的制备方法 (Preparation method of azelaic acid supermolecule ) 是由 宋晓秋 徐亚杰 叶琳 于 2019-09-27 设计创作，主要内容包括：本发明公开了一种壬二酸超分子的制备方法,其特征在于,将聚乙二醇和丙二醇混合,得到混合溶剂；称取壬二酸溶解于混合溶剂中,形成壬二酸溶液；将去离子水置于反应容器中,加热至95-100℃,在400-700r/min转速下进行搅拌,并将壬二酸溶液以0.5-1mL/min的速度滴加于上述去离子水中,壬二酸溶液的滴加温度控制在48-60℃,滴加完毕后,以400-700r/min的转速继续搅拌1.5-2.5h,即得壬二酸超分子。本发明稳定性高、溶解性好,能够有效解决壬二酸稳定性差、溶解性差的问题,有利于保存,可充分利用壬二酸资源,使其在护肤美容上发挥更大用处。(The invention discloses a preparation method of azelaic acid supermolecule, which is characterized in that polyethylene glycol and propylene glycol are mixed to obtain a mixed solvent; weighing azelaic acid and dissolving in the mixed solvent to form azelaic acid solution; placing deionized water in a reaction vessel, heating to 95-100 ℃, stirring at the rotating speed of 400-700r/min, dropwise adding azelaic acid solution into the deionized water at the speed of 0.5-1mL/min, controlling the dropwise adding temperature of the azelaic acid solution at 48-60 ℃, and continuously stirring at the rotating speed of 400-700r/min for 1.5-2.5h after the dropwise adding is finished, thus obtaining the azelaic acid supermolecule. The invention has high stability and good solubility, can effectively solve the problems of poor stability and poor solubility of azelaic acid, is beneficial to storage, and can fully utilize azelaic acid resources to make the azelaic acid have greater use in skin care and beauty.)

1. A method for preparing azelaic acid supramolecules is characterized by comprising the following steps:

step 1: mixing polyethylene glycol and propylene glycol, and stirring for 5-10min at the speed of 500-600r/min to obtain a mixed solvent;

step 2: weighing azelaic acid, dissolving in the mixed solvent obtained in the step 1, and stirring for 15-20min at 600r/min in a thermostatic water bath at 50-80 ℃ to form azelaic acid solution; the mass ratio of the azelaic acid to the polyethylene glycol and the propylene glycol in the step 1 is 0.4-0.8:12.7-17.78: 5.25-9.45;

and step 3: placing deionized water in a reaction vessel, heating to 95-100 ℃, stirring at the rotating speed of 400-700r/min, dropwise adding azelaic acid solution into the deionized water at the speed of 0.5-1mL/min, controlling the dropwise adding temperature of the azelaic acid solution at 48-60 ℃, and continuously stirring at the rotating speed of 400-700r/min for 1.5-2.5h after the dropwise adding is finished, thus obtaining the azelaic acid supermolecule.

2. The method for preparing supramolecules as claimed in claim 1, wherein the mass ratio of polyethylene glycol to propylene glycol in step 1 is 12.7-17.78: 5.25-9.45.

3. The method for preparing supramolecules as claimed in claim 1, wherein said polyethylene glycol is PEG-400.

4. The method for the preparation of supramolecules as claimed in claim 1, wherein said propylene glycol is 1, 3-propanediol.

5. The method for preparing supramolecules of azelaic acid as claimed in claim 1, wherein the ratio of the amount of azelaic acid in step 2 to the amount of deionized water in step 3 is: 0.4-0.8 g: 100-.

Technical Field

The invention belongs to the field of supermolecule chemistry, and particularly relates to a supermolecule with effects of whitening, removing acnes and freckles.

Background

Azelaic acid, also known as azelaic acid, a naturally occurring natural straight chain saturated carboxylic acid containing 9 carbon atoms, an important chemical raw material, has high value in the aspects of skin care, beauty and prevention and treatment of skin diseases, and firstly can competitively inhibit tyrosinase, whiten skin and remove color spots; the other purpose is bacteriostasis, and the azelaic acid can inhibit the protein synthesis of cells and has inhibition effect on staphylococcus, acne propionic acid bacteria, escherichia coli and the like; in addition, azelaic acid can inhibit the secretion of free fatty acids in sebaceous glands and regulate the normal secretion of sebum, so that azelaic acid can also be used for treating acne. However, the azelaic acid has poor compatibility, poor water solubility, easy color change, difficult dissolution, poor stability when being used in cosmetics and poor spreadability, and when the azelaic acid is dissolved in an unconventional manner, the content of the azelaic acid can be reduced, even the using effect can be reduced, so that the application of the azelaic acid in the cosmetics is greatly limited.

The supramolecular chemistry technology is an emerging technology, and two or more molecules are combined together by means of intermolecular interaction to form a complex and organized aggregate, and certain integrity is maintained, so that the complex and organized aggregate has a definite microstructure and macroscopic characteristics. Substances with larger irritation to human skin and poorer solubility in cosmetics can be dispersed in corresponding cosolvents by a supermolecular chemical technology, so that the sustained-release effect is realized, and the substances can be better absorbed by human bodies; meanwhile, the solubility of the substance is greatly improved, so that the substance is more widely applied to cosmetics; the technology also avoids the influence of light, heat and oxygen on the active components, and plays a certain role in protecting the active components.

The prior literature reports a few applications of azelaic acid in cosmetics and exists mainly as azelaic acid derivative (K-ADG), which is a potassium salt prepared by reacting azelaic acid with amino acids.

Disclosure of Invention

The invention aims to provide a preparation method of azelaic acid supermolecule with high stability and good solubility.

In order to achieve the above object, the present invention provides a method for preparing azelaic acid supramolecules, which is characterized by comprising:

step 1: mixing polyethylene glycol and propylene glycol, and stirring for 5-10min at the speed of 500-600r/min to obtain a mixed solvent;

step 2: weighing azelaic acid, dissolving in the mixed solvent obtained in the step 1, and stirring for 15-20min at 600r/min in a thermostatic water bath at 50-80 ℃ to form azelaic acid solution; the mass ratio of the azelaic acid to the polyethylene glycol and the propylene glycol in the step 1 is 0.4-0.8:12.7-17.78: 5.25-9.45;

and step 3: placing deionized water in a reaction vessel, heating to 95-100 ℃, stirring at the rotating speed of 400-700r/min, dropwise adding azelaic acid solution into the deionized water at the speed of 0.5-1mL/min, controlling the dropwise adding temperature of the azelaic acid solution at 48-60 ℃, and continuously stirring at the rotating speed of 400-700r/min for 1.5-2.5h after the dropwise adding is finished, thus obtaining the azelaic acid supermolecule.

Preferably, the mass ratio of the polyethylene glycol to the propylene glycol in the step 1 is 12.7-17.78: 5.25-9.45.

Preferably, the polyethylene glycol is PEG-400.

Preferably, the propylene glycol is 1, 3-propanediol.

Preferably, the dosage ratio of the azelaic acid in the step 2 to the deionized water in the step 3 is as follows: 0.4-0.8 g: 100-.

The azelaic acid supermolecule obtained by the invention has the advantages that the stability is obviously improved by adopting a supermolecule chemical technology, the release speed of the active component is maintained in a stable state, the compatibility and the solubility of the azelaic acid supermolecule are greatly improved, and the azelaic acid supermolecule exists in a supermolecule form and is more beneficial to skin absorption. It is excellent for application or absorption in cosmetics.

Compared with the prior art, the invention has the beneficial effects that:

1. the invention has high stability and good solubility, can effectively solve the problems of poor stability and poor solubility of azelaic acid, is beneficial to storage, and can fully utilize azelaic acid resources to make the azelaic acid have greater use in skin care and beauty.

2. The azelaic acid factor contained in the acne removing cream can competitively inhibit tyrosinase, remove acne marks, remove freckles and whiten skin in the acne removing process. The azelaic acid factor in the invention can inhibit the secretion of free fatty acid in sebaceous glands, regulate the normal secretion of sebum, inhibit the protein synthesis of cells, and has the functions of bacteriostasis and acne treatment.

3. According to the invention, the supermolecule selects azelaic acid with whitening, freckle removing and acne removing functions, polyethylene glycol which is stable, not easy to deteriorate and easy to absorb by a human body and propylene glycol with a moisturizing effect to perform synergistic action, and the prepared supermolecule azelaic acid can realize effective utilization of azelaic acid and absorption of human skin, so that the stability and compatibility of azelaic acid are greatly improved, and the supermolecule azelaic acid has great development prospects in the fields of acne removing, freckle removing and whitening and the like.

4. The preparation method is simple, the cost is low, and the equipment is simple.

Drawings

FIG. 1 is a diagram showing the structural representation of supramolecular azelaic acid;

FIG. 2 is a representation of azelaic acid.

Detailed Description

The invention will be further illustrated with reference to the following specific examples. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Further, it should be understood that various changes or modifications of the present invention may be made by those skilled in the art after reading the teaching of the present invention, and such equivalents may fall within the scope of the present invention as defined in the appended claims.

Each raw material used in the following examples is a commercially available product.

The specification of various raw materials or reagents used in the invention and the information of manufacturers are as follows:

name of reagent	Specification of	Manufacturer of the product
			Polyethylene glycol-400	Analytical purity	Chemical reagents of national drug group Co Ltd
Azelaic acid	Analytical purity	Chemical reagents of national drug group Co Ltd
			1,3 propanediol	Analytical purity	Chemical reagents of national drug group Co Ltd

Some of the instrument manufacturers and models used in the invention are as follows:

instrumentation and equipment	Model number	Manufacturer of the product
			Electronic balance	PL403	Mettler-Tollido instruments Ltd
Constant temperature magnetic stirring	524G	Shanghai Meiglupu Instrument and Meter manufacturing Co., Ltd
			Heat collection type constant temperature heating magnetic stirrer	DF-101S	Shanghai Yi Ke Instrument Co Ltd