阅读说明：本技术 一种杀菌止痒治疗神经性皮炎的组合物及制备方法 (Composition for sterilizing, relieving itching and treating neurodermatitis and preparation method thereof ) 是由 陈泽慧 周小仙 陶月英 田应彪 杨智芳 安政远 余孟飞 于 2019-11-07 设计创作，主要内容包括：本申请涉及医疗保健技术领域中的一种杀菌止痒治疗神经性皮炎的组合物,包含的原料按重量份数计为：苯酚10～35份、薄荷脑2～5份、甘油75～150份、乙醇144～270份、苦参提取物50～100份,地肤子提取物60～130份,本发明为中药和化学制剂相结合,兼具中药治本化学制剂起效快的优点,具有不良反应少,作用温和,疗效持久且无副作用,停药后不复发的特点,具有杀菌止痒的功效,尤其是作用于神经性皮炎及皮肤搔痒症有奇效。(The application relates to a composition for sterilizing, relieving itching and treating neurodermatitis in the technical field of medical care, which comprises the following raw materials in parts by weight: 10-35 parts of phenol, 2-5 parts of menthol, 75-150 parts of glycerol, 144-270 parts of ethanol, 50-100 parts of radix sophorae flavescentis extract and 60-130 parts of fructus kochiae extract.)

1. A composition for sterilizing, relieving itching and treating neurodermatitis is characterized in that; the raw materials comprise the following components in parts by weight: 10-35 parts of phenol, 2-5 parts of menthol, 75-150 parts of glycerol, 144-270 parts of ethanol, 50-100 parts of a sophora flavescens extract and 60-130 parts of a fructus kochiae extract.

2. The composition for sterilizing, relieving itching and treating neurodermatitis according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 20-35 parts of phenol, 3-5 parts of menthol, 100-150 parts of glycerol, 200-270 parts of ethanol, 80-100 parts of a sophora flavescens extract and 90-130 parts of a fructus kochiae extract.

3. The composition for sterilizing, relieving itching and treating neurodermatitis according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 10 parts of phenol, 2 parts of menthol, 75 parts of glycerol, 144 parts of ethanol, 50 parts of a sophora flavescens extract and 60 parts of a belvedere fruit extract.

4. The composition for sterilizing, relieving itching and treating neurodermatitis according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 35 parts of phenol, 5 parts of menthol, 150 parts of glycerol, 270 parts of ethanol, 100 parts of a sophora flavescens extract and 130 parts of a belvedere fruit extract.

5. The composition for treating neurodermatitis through sterilization, itching relieving and according to any one of claims 1 to 4, wherein the content of matrine in the sophora flavescens extract is more than 20%; the fructus Kochiae extract has water content of less than 50%.

6. The preparation method of the composition for sterilizing, relieving itching and treating neurodermatitis according to claim 5, wherein the raw materials are taken according to the parts by weight, phenol is dissolved in glycerol, a proper amount of water is added for dilution, menthol is further dissolved in ethanol, the two solutions are combined, then the sophora flavescens extract and the fructus kochiae extract are slowly added into the combined solution, finally purified water is added to 800-1500 parts, and the mixture is stirred to obtain the composition.

7. Use of a composition according to any one of claims 1 to 4 in the preparation of an anti-pruritic agent.

Technical Field

The invention relates to the technical field of medical care, in particular to a composition for sterilizing, relieving itching and treating neurodermatitis and a preparation method thereof.

Background

Neurodermatitis is also called as chronic simple moss; is a chronic skin disease characterized by paroxysmal cutaneous pruritus and cutaneous lichenification. Neurodermatitis is a common skin disease, is commonly seen in adults, and is not commonly seen in children. The skin is only scratchy but has no primary skin damage, and due to scratching and rubbing, the skin gradually appears flat papules from millet grains to mung bean in size, is round or polygonal, hard and glossy, and is pale red or normal in skin color and scattered in distribution. Neurodermatitis is a common skin disease in daily life. At present, although various preparations for treating the disease comprise dermatitis ointment, compound dexamethasone acetate ointment and the like, most of the preparations are western medicines or chemical preparations, the problems of long treatment course, quick response, easy relapse after medicine withdrawal and easy generation of drug resistance exist, and the long-term use can generate side effects on human bodies. If pure traditional Chinese medicines are used, the problem of slow effect can be solved radically, so how to combine traditional Chinese medicine with western medicine, overcoming the defects of the western medicine/chemical preparation and the traditional Chinese medicine, and finding an external traditional Chinese medicine and western medicine preparation with good effect of treating neurodermatitis is very necessary.

Disclosure of Invention

The invention aims to provide a composition for treating neurodermatitis by sterilizing and relieving itching and a preparation method thereof, which combine traditional Chinese medicines and chemical preparations to achieve the purposes of quick response and relapse prevention.

The composition for sterilizing, relieving itching and treating neurodermatitis comprises the following raw materials in parts by weight: 10-35 parts of phenol, 2-5 parts of menthol, 75-150 parts of glycerol, 144-270 parts of ethanol, 50-100 parts of a sophora flavescens extract and 60-130 parts of a fructus kochiae extract.

Preferably, the raw materials comprise the following components in parts by weight: 20-35 parts of phenol, 3-5 parts of menthol, 100-150 parts of glycerol, 200-270 parts of ethanol, 80-100 parts of a sophora flavescens extract and 90-130 parts of a fructus kochiae extract.

Preferably, the raw materials comprise the following components in parts by weight: 10 parts of phenol, 2 parts of menthol, 75 parts of glycerol, 144 parts of ethanol, 50 parts of a sophora flavescens extract and 60 parts of a belvedere fruit extract.

Preferably, the raw materials comprise the following components in parts by weight: 35 parts of phenol, 5 parts of menthol, 150 parts of glycerol, 270 parts of ethanol, 100 parts of a sophora flavescens extract and 130 parts of a belvedere fruit extract.

Further, the content of matrine in the sophora flavescens extract is more than 20 percent; the fructus Kochiae extract has water content of less than 50%.

The invention also aims to provide a preparation method of the composition for treating neurodermatitis, which comprises the following steps: taking the raw materials in parts, dissolving phenol in glycerol, adding a proper amount of water for dilution, dissolving menthol in ethanol, combining the two solutions, slowly adding the sophora flavescens extract and the fructus kochiae extract into the combined solution, finally adding purified water to 800-1500 parts, and stirring to obtain the composition.

Wherein the radix Sophorae Flavescentis extract is ethanol extract or water extract, preferably ethanol extract.

Kochiae fructus can be extracted with water, ethanol, methanol, etc. under reflux, and the extractive solution is concentrated, preferably ethanol.

The invention combines traditional Chinese medicines and chemical preparations, has the advantage of quick effect of the traditional Chinese medicine treatment chemical preparation, has the characteristics of less adverse reaction, mild action, lasting curative effect, no side effect and no relapse after stopping taking the medicine, has the efficacy of sterilizing and relieving itching, and particularly has a remarkable effect on neurodermatitis and skin pruritus.

In the invention, phenol has itching relieving and sterilizing effects, mint is a local irritant and has cooling and itching relieving effects, glycerin has skin moistening effects, and ethanol has disinfection and sterilization effects; the sophora flavescens extract has a strong inhibiting effect on staphylococcus aureus and the like, and the belvedere fruit extract has a phagocytic function of inhibiting a mononuclear phagocyte system; the combination of the medicines has strong permeability, can kill pathogenic bacteria from the outside, the inside to the deep layer, and has strong stripping effect. The composition is applied to a pathological change part, the medicine is cool and comfortable, the pruritus stops, the red swelling gradually disappears, lesion tissues can be thoroughly removed after five days, pathogenic bacteria can be killed, the propagation of the pathogenic bacteria can be stopped, the pathological change part begins to scab and fall off, the peripheral circulation of the skin can be improved, the metabolism is promoted, the normal structure and functions of the damaged tissues on the surface layer and the deep layer can be recovered, a vascular network can be rebuilt, the normal blood circulation is recovered, the focus is further removed, and the recurrence is avoided.

The composition can also be prepared into antipruritic, and is used for treating other pruritus caused by fungal or bacterial infection and mosquito bite.

Detailed Description