阅读说明：本技术 一种抗菌抗凝血脑室腹腔分流管硅胶管体及其制备方法和应用 (Antibacterial and anticoagulant ventricles and abdominocentesis shunt tube silica gel tube body and preparation method and application thereof ) 是由 向萌 董爽 向勇 钟奇 钟阳谦 杨琼梅 杨洲 陈建香 于 2019-09-23 设计创作，主要内容包括：本发明涉及一种抗菌抗凝血脑室腹腔分流管硅胶管体及其制备方法和应用,分流管硅胶管体由A组分和B组分按照重量比1:(0.7-1.3)配制而成,其中,A组分包括以下重量份组分：含乙烯基的二甲基硅氧烷100-120份、硫酸钡0.05-10份、抗菌剂0.05-15份、抗凝血剂0.05-15份、分散剂0.5-15份；B组分包括以下重量份组分：含活性氢和铂金催化剂的二甲基硅氧烷70-130份；经过挤出固化成型得到抗菌抗凝血脑室腹腔分流管硅胶管体。本发明材料具有永久抗菌性,且具有较好的抗菌性以及较长的复钙时间、活化部分凝血活酶时间和凝血酶原时间。(The invention relates to an antibacterial anticoagulant ventricles of brain peritoneal shunt tube silica gel tube body and a preparation method and application thereof, wherein the shunt tube silica gel tube body is prepared from a component A and a component B according to the weight ratio of 1 (0.7-1.3), wherein the component A comprises the following components in parts by weight: 100-120 parts of dimethyl siloxane containing vinyl, 0.05-10 parts of barium sulfate, 0.05-15 parts of antibacterial agent, 0.05-15 parts of anticoagulant and 0.5-15 parts of dispersing agent; the component B comprises the following components in parts by weight: 70-130 parts of dimethyl siloxane containing active hydrogen and a platinum catalyst; and obtaining the antibacterial and anticoagulant ventricles and abdominocentesis shunt tube silica gel tube body through extrusion, solidification and molding. The material of the invention has permanent antibacterial property, and has better antibacterial property and longer recalcification time, activated partial thromboplastin time and prothrombin time.)

1. An antibacterial anticoagulant ventricles of brain peritoneal shunt tube silica gel tube body is characterized in that the tube body is prepared by a component A and a component B according to the weight ratio of 1 (0.7-1.3), wherein,

the component A comprises the following components in parts by weight: 100-120 parts of dimethyl siloxane containing vinyl, 0.05-10 parts of barium sulfate, 0.05-15 parts of antibacterial agent, 0.05-15 parts of anticoagulant and 0.5-15 parts of dispersing agent;

the component B comprises the following components in parts by weight: 70-130 parts of dimethyl siloxane containing active hydrogen and a platinum catalyst.

2. The antibacterial anticoagulant ventricular peritoneal shunt silica gel tube body according to claim 1, wherein the vinyl content in the vinyl-containing dimethyl siloxane in the component A is 0.01-5 wt%; in the component B, the active hydrogen content of the dimethyl siloxane containing active hydrogen and platinum catalyst is 0.005-2 wt%, and the platinum catalyst content is 0.01-6 wt%.

3. The antibacterial anticoagulant ventricular peritoneal shunt silica gel tube body according to claim 1, wherein the antibacterial agent is one or more of polypeptides, macrolides, phosphopolysaccharides, polyethers, aminoglycosides, sulfonamides, olaquindox, furazolidone, and nifuroylhydrazone.

4. The antibacterial anticoagulant ventricular peritoneal shunt silica gel tube body according to claim 1, wherein the anticoagulant is one or more of hirudin, chitosan, acetylsalicylic acid, glucosamine, fucoidan, 2,3,5, 6-tetramethylpyrazine, block polyether polyurethane, polyethylene glycol, pyridine sulfur trioxide, 4-hydroxy-3-methoxycinnamic acid.

5. The antibacterial anticoagulant ventricular peritoneal shunt silica gel tube body according to claim 4, wherein the polyether content in the block polyether polyurethane is 1-40 wt%; the molecular weight of the polyethylene glycol is 100 g/mol-20000 g/mol.

6. The antibacterial anticoagulant ventricular peritoneal shunt silica gel tube body according to claim 1, wherein the dispersant is one or more of polyethylene glycol diamine, polyvinyl alcohol, polyacrylamide, polyvinylpyrrolidone, cetyl trimethyl ammonium bromide, sodium dodecyl sulfate, and sodium dodecyl benzene sulfonate.

7. The preparation method of the antibacterial anticoagulant ventricular peritoneal shunt silica gel tube body according to any one of claims 1 to 6, which is characterized by comprising the following steps:

(1) adding barium sulfate, an antibacterial agent, an anticoagulant and a dispersing agent in a formula ratio into dimethyl siloxane containing vinyl, uniformly mixing, and performing ultrasonic treatment to obtain a component A;

(2) and mixing the component A and the component B according to a ratio, pouring the mixture into an extruder, and performing extrusion, solidification and molding to obtain the antibacterial and anticoagulant ventricles and abdominocententeric shunt silica gel tube body.

8. The method for preparing the silica gel tube body of the antibacterial anticoagulant ventricular peritoneal shunt according to claim 7, wherein the power of the ultrasonic treatment is 100W-2000, and the time is 1min-60 min.

9. The antibacterial anticoagulant ventricular peritoneal shunt silica gel tube body according to claim 7, wherein the processing temperature of the extruder is 60-110 ℃.

10. The use of the antibacterial anticoagulant ventricular peritoneal shunt silica gel tube body according to any one of claims 1-6 in hydrocephalus treatment.

Technical Field

The invention relates to the technical field of high polymer materials, in particular to an antibacterial anticoagulation ventricular peritoneal shunt silica gel tube body and a preparation method and application thereof.

Background

Since the 1955 s that Pudenz adopts a shunt system made of silicone resin to treat hydrocephalus, a shunt silica gel tube body made of silicone rubber is still used up to now because of the advantages of softness, elasticity, uneasy breaking and the like. One end of the shunt tube silica gel tube body is arranged in the ventricle, and the other end of the shunt tube silica gel tube body downwards extends to the abdominal cavity or other parts through the subcutaneous tunnel and drains cerebrospinal fluid in the ventricle out to restore the balance between secretion and absorption of the cerebrospinal fluid, thereby achieving the purpose of treating hydrocephalus. However, with its widespread use, the drawbacks of this kind of shunt silicone tube body are gradually exposed, such as not corrosion-resistant, once inflammation is triggered by bacteria, it is very easy to be eroded, rotten, adhered and blocked, if inflammation causes bleeding, blood is easy to be coagulated into a block in the tube, and the shunt silicone tube body is blocked.

The antibacterial agent is coated on the surface of the shunt tube silicone tube, so that bacteria can be killed or the propagation of the bacteria can be inhibited within a certain time, the self-cleaning state is kept, and the cross contamination of bacteria among people, people and objects and between objects caused by using the products is reduced. The antibacterial agent is a chemical component highly sensitive to microorganisms such as bacteria, mould, fungi, yeast and the like, has the effect of sterilization, and plays an important role in the development of the shunt tube silica gel tube body.

After the material implanted into a human body contacts with blood, red blood cells are destroyed, platelets are activated and aggregated, and thrombus is formed, so that complications such as embolism, hemorrhage, infection and the like are generated. Therefore, biomedical materials in direct contact with blood, such as artificial hearts, artificial blood vessels, auxiliary devices for artificial cardiovascular, various catheters entering or remaining in blood vessels and directly contacting with blood, functional stents and other medical devices, require materials with certain anticoagulant property.

Disclosure of Invention

In order to solve the technical problems that an antibacterial and anticoagulant coating is easy to fall off and has a poor effect in the prior art, the antibacterial and anticoagulant ventricular peritoneal shunt silica gel tube body and the preparation method and application thereof are provided. The shunt tube silica gel tube body prepared by the method has high flexibility and good antibacterial and anticoagulant capabilities.

In order to achieve the purpose, the invention is realized by the following technical scheme:

an antibacterial anticoagulant ventricles of brain peritoneal shunt silica gel tube body is prepared by a component A and a component B according to the weight ratio of 1 (0.7-1.3), wherein,

the component A comprises the following components in parts by weight: 100-120 parts of dimethyl siloxane containing vinyl, 0.05-10 parts of barium sulfate, 0.05-15 parts of antibacterial agent, 0.05-15 parts of anticoagulant and 0.5-15 parts of dispersing agent;

the component B comprises the following components in parts by weight: 70-130 parts of dimethyl siloxane containing active hydrogen and a platinum catalyst.

Further, the content of vinyl in the vinyl-containing dimethyl siloxane is 0.01 wt% to 5 wt%. After the A, B components are mixed, under the catalytic action of a platinum catalyst, the vinyl siloxane in the A component and the hydrogen-containing siloxane in the B component are subjected to hydrosilylation reaction, so that the components are crosslinked into silicone rubber; compared with condensed silicone rubber, the addition type silicone rubber has the advantages of no by-product produced in the vulcanization process, extremely low shrinkage rate and deep crosslinking and curing, and is easy to prepare products with high purity, high transparency and special functions.

Further, the antibacterial agent is one or more of polypeptides, macrolides, phosphopolysaccharides, polyethers, aminoglycosides, sulfonamides, olaquindox, furazolidone and nifuroylzone.

Further, the anticoagulant is one or more of hirudin, chitosan, acetylsalicylic acid, glucosamine, fucoidan, 2,3,5, 6-tetramethylpyrazine, block polyether polyurethane, polyethylene glycol, pyridine sulfur trioxide and 4-hydroxy-3-methoxycinnamic acid.

Preferably, the polyether content of the block polyether polyurethane is 1 wt% to 40 wt%; the molecular weight of the polyethylene glycol is 100 g/mol-20000 g/mol.

Further, the dispersing agent is one or more of polyethylene glycol diamine, polyvinyl alcohol, polyacrylamide, polyvinylpyrrolidone, cetyl trimethyl ammonium bromide, sodium dodecyl sulfate and sodium dodecyl benzene sulfonate.

Furthermore, the dimethyl siloxane containing active hydrogen and platinum catalyst contains 0.005-2 wt% of active hydrogen and 0.01-6 wt% of platinum catalyst.

The invention provides a preparation method of an antibacterial anticoagulation ventricular peritoneal shunt tube silica gel tube body, which comprises the following steps:

(1) adding barium sulfate, an antibacterial agent, an anticoagulant and a dispersing agent in a formula ratio into dimethyl siloxane containing vinyl, uniformly mixing, and performing ultrasonic treatment to obtain a component A;

(2) and mixing the component A and the component B according to a ratio, pouring the mixture into an extruder, and performing extrusion, solidification and molding to obtain the antibacterial and anticoagulant ventricles and abdominocententeric shunt silica gel tube body.

Further, the power of the ultrasonic treatment is 100W-2000, and the time is 1min-60 min.

Further, the processing temperature of the extruder is 60-110 ℃.

The last aspect of the invention provides the application of the silica gel tube body of the antibacterial anticoagulant ventricular peritoneal shunt tube in the treatment of hydrocephalus.

The beneficial technical effects are as follows:

(1) under the synergistic action of ultrasonic waves and a dispersing agent, the antibacterial agent and the anticoagulant agent are uniformly dispersed in the silicone rubber matrix in the process of in-situ polymerization of silicone rubber, the prepared shunt tube silicone tube body has permanent antibacterial property and anticoagulation capability, and the shunt tube silicone tube body does not need to be replaced by a secondary operation after being implanted into a patient once, so that the risks of secondary brain injury, cerebral hemorrhage and epilepsy are reduced;

(2) barium sulfate molecules are permanently solidified in a matrix of the silicon rubber, so that X rays are difficult to penetrate, and the position of the barium sulfate molecules in the cranium can be displayed by shooting X rays or CT after the barium sulfate molecules are placed in the ventricle, so that doctors can conveniently analyze pathological focuses.

Detailed Description

The invention is further described below with reference to specific examples, but without limiting the scope of the invention.