阅读说明：本技术 一种鼻炎喷剂及其制备方法 (Rhinitis spray and preparation method thereof ) 是由 于充 于 2018-06-15 设计创作，主要内容包括：本发明涉及一种鼻炎喷剂及其制备方法。本发明的鼻炎喷剂是选择达子香浓缩液、薄荷油、冰片、聚山梨酯-80进行组合制备的,使得药物在发挥各自的功效,同时相互产生协同作用,能够快速有效减少鼻腔的敏感度并缓解鼻塞鼻痒等症状。(The invention relates to a rhinitis spray and a preparation method thereof. The rhinitis spray is prepared by combining daphne concentrate, peppermint oil, borneol and polysorbate-80, so that the medicaments exert respective effects and generate synergistic action mutually, and the sensitivity of a nasal cavity can be quickly and effectively reduced, and the symptoms of nasal obstruction, rhinocnesmus and the like can be relieved.)

1. The rhinitis spray is prepared by combining daphne seed concentrated solution, peppermint oil, borneol and polysorbate-80.

2. The rhinitis spray according to claim 1, which is prepared from the following materials in parts by weight:

100 g of daphne, 2 g of peppermint oil, 2 g of borneol and 8010 ml of polysorbate-8010 ml are prepared.

3. The process for preparing a rhinitis spray according to claim 1, wherein:

a. preparing a daphne concentrate: extracting volatile oil from Dazixiang medicinal materials by a steam distillation method for later use; extracting the dregs of a decoction with 80% ethanol, filtering, and concentrating until the relative density is 1.00-1.02 to obtain a daphne aroma concentrated solution for later use;

b. preparing borneol solution: dissolving Borneolum in small amount of ethanol, adding polysorbate-80, mixing and stirring to obtain Borneolum solution;

c. adding the volatile oil, oleum Menthae Dementholatum and Borneolum Syntheticum solution into the concentrated solution of DAZIXIANG, and stirring;

d. standing for 24 hours, and filtering;

e. filling: and filling the filtered mixed solution to obtain the product.

Technical Field

The invention relates to a rhinitis spray and a preparation method thereof.

Background

Rhinitis is acute or chronic inflammation of the nasal mucosa or submucosal tissue caused by viral infection, bacterial infection, irritation by irritants, etc., resulting in damage to the nasal mucosa or submucosal tissue. Rhinitis causes excessive mucus, often resulting in runny nose, nasal obstruction, etc. Sometimes complicated by sinusitis, nasal polyps; chronic nasal obstruction is often evident and can develop as a eustachian tube blockage. The result is hearing loss, which is particularly prevalent in children. There are many kinds of rhinitis symptoms, and the rhinitis symptoms are different according to the kinds of rhinitis. The patient often has symptoms of nasal obstruction, watery nasal discharge, nasal itching, throat discomfort, sneeze, cough and the like.

At present, the common medicines for treating rhinitis in western medicine are oral antihistamine medicines, glucocorticoid inhalation medicines and local antihistamine medicines, but the medicines treat symptoms and do not treat root causes, the problem cannot be solved fundamentally, and the medicines have great harm to the body after long-term administration. Traditional Chinese medicine takes conditioning as a main part and takes a method of dispelling wind, dispersing lung qi, tonifying qi and removing turbidity to condition rhinitis, but the formula is complex, the medicine tastes are many, and the cost is high.

Therefore, people have great demands on the rhinitis spray which is convenient to use, low in price and good in effect, and the inventor successfully develops the rhinitis spray through a large number of research experiments, thereby completing the invention.

Disclosure of Invention

The invention aims to provide a rhinitis spray with small side effect on a body, simple formula, low cost and good effect and a preparation method thereof.

The rhinitis spray is prepared by combining daphne concentrate, peppermint oil, borneol and polysorbate-80, so that the medicaments exert respective effects and generate synergistic action mutually, and the sensitivity of a nasal cavity can be quickly and effectively reduced, and the symptoms of nasal obstruction, rhinocnesmus and the like can be relieved.

The daphne odora is distributed in Heilongjiang, Jilin, inner Mongolia and other places, and has wide sources. The main effective component of the daphne odora is total flavonoids, and the content of the effective component can be improved to the maximum extent by adopting steam distillation and ethanol extraction.

The components of the rhinitis spray are summarized by the inventor through repeated groping, and the dosage of each component has better effect in the following weight.

100 g of daphne, 2 g of peppermint oil, 2 g of borneol and 8010 ml of polysorbate.

The specific preparation method comprises the following steps:

first, prepare material

a. Collecting fructus Daziziphi spinosae, removing impurities, cleaning, slightly drying in the air, cutting into segments, and drying

b. Peppermint oil: measuring by volume

c. Borneol: measuring by volume

d. Polysorbate-80: measuring by volume

II, preparation of

a. Preparing a daphne concentrate: extracting volatile oil from Dazixiang medicinal materials by a steam distillation method for later use; extracting the dregs of a decoction with 80% ethanol, filtering, and concentrating until the relative density is 1.00-1.02 to obtain a daphne aroma concentrated solution for later use;

b. preparing borneol solution: dissolving Borneolum in small amount of ethanol, adding polysorbate-80, mixing and stirring to obtain Borneolum solution;

c. adding the volatile oil, oleum Menthae Dementholatum and Borneolum Syntheticum solution into the concentrated solution of DAZIXIANG, and stirring;

d. standing for 24 hours, and filtering;

e. filling: and filling the filtered mixed solution to obtain the product.

Due to the adoption of the technical scheme, the invention has the beneficial effects that.

Dazixiang: has good anti-inflammatory and antibacterial effects, and can be used as anti-inflammatory agent. Contains multiple active components, contains farrerol with antibacterial activity against Staphylococcus aureus, and also has antibacterial and antifungal effects against syringic acid and vanillic acid, and also has antiseptic and antibacterial effects against anisic acid, and syringic acid with tranquilizing and local anesthetic effects.

Peppermint oil: is volatile aromatic oil obtained by steam distillation of fresh stems and leaves of herba Menthae, and is pungent, cool and nontoxic. The oleum Menthae Dementholatum has algefacient, analgesic, and antipruritic effects. The anti-irritation effect of menthol causes new secretion in nasal cavity, so that thick mucus is easy to be discharged, and the menthol has the effect of treating nasal obstruction.

Borneol: dredging orifices, dispelling stagnated fire, removing nebula, improving eyesight, relieving swelling and pain, inhibiting bacteria, and relieving inflammation. It is indicated for wind stroke, vomiting, coma due to febrile disease, epilepsy due to convulsion, phlegm-phlegm, qi block, deafness, sore throat, aphtha, otitis media, carbuncle, swelling, hemorrhoid, nebula, and enterobiasis. It is used to treat chronic tracheitis, infantile burn, chronic rhinitis, and suppurative otitis media.

Polysorbate-80: is oleate and nonionic surfactant, has strong hydrophilicity and has emulsification effect.

The four raw materials supplement each other, so that the anti-inflammatory and itching relieving effects are enhanced, and the defect of single raw material effect is avoided. The formula is simple and easy to implement, and the rhinitis conditioning effect is good.

The formula combination of the invention is novel and unique, the scientific basis is original, and the anti-inflammation and itching-relieving effects of the functional components are effectively improved. The innovation of the formula combination is not reported in China. Through the combination and advanced process of the raw materials. According to a specific proportion, volatile oil is extracted from the daphne odora so as to improve the content of active ingredients and enhance the efficacy of the product. Has no adverse side effect and low cost, and is suitable for children and pregnant women.

Detailed Description

The present invention will be described in further detail with reference to examples, and the starting materials used in the present invention are commercially available unless otherwise specified.