阅读说明：本技术 一种治疗禽肾型传支的中药组合物及其制备方法 (Traditional Chinese medicine composition for treating kidney-type infectious bronchitis of poultry and preparation method thereof ) 是由 解学祥 远德龙 王自然 于 2019-09-20 设计创作，主要内容包括：本发明涉及兽药领域,更具体地,本发明涉及一种治疗禽肾型传支的中药组合物及其制备方法。按重量份计,至少包括以下成分：中药提取物80～120份,营养剂1～10份,添加剂0.1～1.5份。本发明采用车前子、防风、茯苓等制备了中药组合物,车前子、防风、茯苓之间具有较好的协同作用,制备所得中药组合物消化吸收快,治疗效果显著,安全可靠,无毒副作用。(The invention relates to the field of veterinary drugs, and in particular relates to a traditional Chinese medicine composition for treating avian renal type infectious bronchitis and a preparation method thereof. The coating at least comprises the following components in parts by weight: 80-120 parts of traditional Chinese medicine extract, 1-10 parts of nutritional agent and 0.1-1.5 parts of additive. The invention adopts semen plantaginis, radix sileris, tuckahoe and the like to prepare the traditional Chinese medicine composition, the semen plantaginis, the radix sileris and the tuckahoe have better synergistic effect, and the prepared traditional Chinese medicine composition has the advantages of quick digestion and absorption, obvious treatment effect, safety, reliability and no toxic or side effect.)

1. A traditional Chinese medicine composition for treating avian renal type infectious bronchitis is characterized by at least comprising the following components in parts by weight:

80-120 parts of traditional Chinese medicine extract

1-10 parts of nutritional agent

0.1-1.5 parts of an additive;

the traditional Chinese medicine extract is a mixed extract of folium isatidis, common andrographis herb, oriental wormwood, radix sophorae flavescentis, semen plantaginis, fineleaf schizonepeta herb, divaricate saposhnikovia root, poria cocos and akebia stem.

2. The traditional Chinese medicine composition for treating avian kidney-type infectious bronchitis according to claim 1, wherein the mass ratio of the plantain seeds to the sophora flavescens is 1: (1.5 to 3).

3. The traditional Chinese medicine composition for treating avian kidney-type infectious bronchitis according to claim 1, wherein the mass ratio of the plantain seeds, the divaricate saposhnikovia roots and the poria cocos is 1: (0.5-1.2): (0.6-1.5).

4. The traditional Chinese medicine composition for treating avian kidney-type infectious bronchitis according to claim 1, wherein the nutritional agent is one or a combination of more of amino acids, glucose, folic acid, vitamin A, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K and biotin.

5. The Chinese medicinal composition for treating avian renal type infectious bronchitis according to claim 4, wherein the nutritional agents are glucose and vitamin C.

6. The Chinese medicinal composition for treating avian renal type infectious bronchitis according to claim 1, wherein said additive is one or a combination of methyl paraben, ethyl paraben, propyl paraben, butyl paraben, benzoic acid, sodium benzoate, benzyl alcohol, phenethyl alcohol, sorbic acid, potassium sorbate, butyl hydroxy anisole and butyl hydroxy toluene.

7. The Chinese medicinal composition for treating avian kidney-type infectious bronchitis according to claim 6, wherein the additives are methylparaben, ethylparaben and sodium benzoate.

8. The traditional Chinese medicine composition for treating avian kidney-type infectious bronchitis according to claim 7, wherein the mass ratio of the methylparaben to the ethylparaben to the sodium benzoate is 1: (0.5-2): (1.5-5).

9. A traditional Chinese medicine oral liquid for treating avian renal type infectious bronchitis, which is characterized by comprising the traditional Chinese medicine composition for treating avian renal type infectious bronchitis according to any one of claims 1 to 8.

10. A method for preparing the traditional Chinese medicine oral liquid for treating avian renal type infectious bronchitis according to claim 9, characterized by at least comprising the following steps: mixing the Chinese medicinal extract, nutritional agent and additives, stirring, cooling to room temperature, filtering, bottling, sealing, sterilizing, and packaging.

Technical Field

The invention relates to the field of veterinary drugs, and in particular relates to a traditional Chinese medicine composition for treating avian renal type infectious bronchitis and a preparation method thereof.

Background

Nephropathogenic infectious bronchitis, also known as nephropathogenic infectious bronchitis, is a highly contagious viral infectious disease caused by invasion of the kidney during infection of chickens by nephropathogenic infectious virus (nephropathogenic IBV). Kidney-type branches are mainly transmitted through air, and once infection is very rapid, the kidney-type branches spread to the whole henhouse quickly.

At present, interferon drinking water, antibiotic therapy, traditional Chinese medicine treatment and the like are generally adopted for treating avian renal infectious bronchitis. In the early stage of the disease, namely in the acute infection stage, good effect can be achieved by using the interferon, but after the speckled kidney appears, the treatment effect is poor; the method for treating avian renal type infectious bronchitis by adopting an antibiotic therapy has the advantages of high cost, great side effect and easy relapse; the traditional Chinese medicine has a certain curative effect on the kidney-type infectious bronchitis of the poultry, but still has the problems of slow curative effect, insignificant curative effect and the like. Therefore, the invention aims to provide the traditional Chinese medicine composition for treating the avian renal type infectious bronchitis, which is safe, reliable, obvious in effect and free of toxic and side effects.

Disclosure of Invention

In order to solve the above problems, the first aspect of the present invention provides a traditional Chinese medicine composition for treating avian renal type infectious bronchitis, which at least comprises the following components by weight:

80-120 parts of traditional Chinese medicine extract

1-10 parts of nutritional agent

0.1-1.5 parts of an additive;

the traditional Chinese medicine extract is a mixed extract of folium isatidis, common andrographis herb, oriental wormwood, radix sophorae flavescentis, semen plantaginis, fineleaf schizonepeta herb, divaricate saposhnikovia root, poria cocos and akebia stem.

As a preferable technical scheme, the mass ratio of the plantain seeds to the sophora flavescens is 1: (1.5 to 3).

As a preferable technical scheme, the mass ratio of the plantain seeds, the divaricate saposhnikovia roots and the poria cocos is 1: (0.5-1.2): (0.6-1.5).

As a preferable technical scheme, the nutrient is one or a combination of more of amino acid, glucose, folic acid, vitamin A, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K and biotin.

As a preferred technical scheme, the nutrient is glucose and vitamin C.

As a preferable technical scheme, the additive is one or a combination of more of methyl paraben, ethyl paraben, propyl paraben, butyl paraben, benzoic acid, sodium benzoate, benzyl alcohol, phenethyl alcohol, sorbic acid, potassium sorbate, butyl hydroxy anisol and butyl hydroxy toluene.

As a preferable technical scheme, the additive is methyl paraben, ethyl paraben and sodium benzoate.

As a preferable technical scheme, the mass ratio of the methyl paraben to the ethyl paraben to the sodium benzoate is 1: (0.5-2): (1.5-5).

The second aspect of the invention provides a traditional Chinese medicine oral liquid for treating avian renal type infectious bronchitis, which comprises the traditional Chinese medicine composition for treating avian renal type infectious bronchitis.

The third aspect of the invention provides a preparation method of a traditional Chinese medicine oral liquid for treating avian renal type infectious bronchitis, which at least comprises the following steps: mixing the Chinese medicinal extract, nutritional agent and additives, stirring, cooling to room temperature, filtering, bottling, sealing, sterilizing, and packaging.

Has the advantages that: the invention adopts semen plantaginis, radix sileris, tuckahoe and the like to prepare the traditional Chinese medicine composition, the semen plantaginis, the radix sileris and the tuckahoe have better synergistic effect, and the prepared traditional Chinese medicine composition has the advantages of quick digestion and absorption, obvious treatment effect, safety, reliability and no toxic or side effect.

Detailed Description

The technical features of the technical solutions provided by the present invention are further clearly and completely described below with reference to the specific embodiments, but the scope of protection is not limited thereto.

"preferred", "more preferred", and the like, in the present invention, refer to embodiments of the invention that may provide certain benefits, under certain circumstances. However, other embodiments may be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.

The invention provides a traditional Chinese medicine composition for treating avian renal type infectious bronchitis, which at least comprises the following components in parts by weight:

80-120 parts of traditional Chinese medicine extract

1-10 parts of nutritional agent

0.1-1.5 parts of an additive;

the traditional Chinese medicine extract is a mixed extract of folium isatidis, common andrographis herb, oriental wormwood, radix sophorae flavescentis, semen plantaginis, fineleaf schizonepeta herb, divaricate saposhnikovia root, poria cocos and akebia stem.

In one embodiment, the composition at least comprises the following components in parts by weight:

90-110 parts of traditional Chinese medicine extract

3-7 parts of nutritional agent

0.5-1 part of an additive;

the traditional Chinese medicine extract is a mixed extract of folium isatidis, common andrographis herb, oriental wormwood, radix sophorae flavescentis, semen plantaginis, fineleaf schizonepeta herb, divaricate saposhnikovia root, poria cocos and akebia stem.

In a preferred embodiment, at least the following ingredients are included in parts by weight:

100 parts of traditional Chinese medicine extract

5 portions of nutrient

0.8 part of additive;

the traditional Chinese medicine extract is a mixed extract of folium isatidis, common andrographis herb, oriental wormwood, radix sophorae flavescentis, semen plantaginis, fineleaf schizonepeta herb, divaricate saposhnikovia root, poria cocos and akebia stem.

< extracts of Chinese herbs >

The traditional Chinese medicine extract is a traditional Chinese medicine product which is obtained by adopting advanced process technology to extract, separate and process traditional Chinese medicines or traditional Chinese medicine compounds, has relatively definite material basis of medicine effect and strict quality standard, is a new product form in the international natural medicine health-care product market, is a main raw material of a botanical medicine preparation, and can be widely applied to natural health products.

In one embodiment, the Chinese herbal extract is a mixed extract of folium isatidis, herba andrographitis, herba artemisiae scopariae, radix sophorae flavescentis, semen plantaginis, herba schizonepetae, radix sileris, poria cocos and akebia stem.

In one embodiment, the mixed extract of folium isatidis, andrographis paniculata, oriental wormwood, sophora flavescens, plantain seed, schizonepeta, saposhnikovia divaricata, poria cocos and akebiaquinata is extracted by the following method: adding folium Isatidis, herba Andrographitis, herba Artemisiae Scopariae, radix Sophorae Flavescentis, semen plantaginis, herba Schizonepetae, radix Saposhnikoviae, Poria, and caulis Akebiae into a Chinese medicinal extraction tank, and extracting at a ratio of 1: (6-10), adding water for soaking, heating steam to boil, then heating for 5-20 minutes at 70-80 ℃, then filtering through a filter, injecting into a liquid medicine storage tank, starting a double-effect concentrator, pumping the liquid medicine into the concentrator for concentration, and obtaining the traditional Chinese medicine extract.

In a preferred embodiment, the mixed extract of folium isatidis, andrographis paniculata, oriental wormwood, sophora flavescens, plantain seed, schizonepeta, ledebouriella root, poria cocos and akebia stem is extracted by the following method: adding folium Isatidis, herba Andrographitis, herba Artemisiae Scopariae, radix Sophorae Flavescentis, semen plantaginis, herba Schizonepetae, radix Saposhnikoviae, Poria, and caulis Akebiae into a Chinese medicinal extraction tank, and extracting at a ratio of 1: (6-10) adding water for soaking, heating steam to boil, then heating for 5-20 minutes at 70-80 ℃, and then filtering through a filter and injecting into a liquid medicine storage tank; and injecting water into the traditional Chinese medicine extraction tank again, wherein the proportion of the Chinese herbal medicines to the water is 1: (6-10), heating the mixture to boiling by steam, and then heating the mixture for 5-20 minutes at the temperature of 70-80 ℃; filtering the medicinal liquid obtained by the second extraction with a filter, injecting into a medicinal liquid storage tank, mixing with the medicinal liquid obtained by the first extraction, starting a double-effect concentrator, and pumping the medicinal liquid obtained by the second extraction into the concentrator for concentration to obtain the Chinese medicinal extract.

In a more preferred embodiment, the mixed extract of folium isatidis, andrographis paniculata, oriental wormwood, sophora flavescens, plantain seed, schizonepeta, ledebouriella root, poria cocos and akebia stem is extracted by the following method: adding folium Isatidis, herba Andrographitis, herba Artemisiae Scopariae, radix Sophorae Flavescentis, semen plantaginis, herba Schizonepetae, radix Saposhnikoviae, Poria, and caulis Akebiae into a Chinese medicinal extraction tank, and extracting at a ratio of 1: 10, adding purified water for soaking for 1 hour, heating steam to boil, then heating for 10 minutes at 75 ℃, and then filtering through a filter and injecting into a liquid medicine storage tank; and injecting purified water into the traditional Chinese medicine extraction tank again, wherein the ratio of the Chinese herbal medicines to the purified water is 1: 6, heating the mixture to boiling by steam, and then heating the mixture for 10 minutes at 75 ℃; filtering the medicinal liquid obtained by the second extraction through a filter, injecting the filtered medicinal liquid into a medicinal liquid storage tank, mixing the filtered medicinal liquid with the medicinal liquid obtained by the first extraction, starting a double-effect concentrator, pumping the medicinal liquid obtained by the second extraction into the concentrator, and concentrating the concentrated medicinal liquid until the density of the medicinal liquid is 1.05 to obtain the traditional Chinese medicine extract.

In one embodiment, the weight ratio of psyllium to sophora flavescens is 1: (1.5 to 3).

In a preferred embodiment, the mass ratio of the plantain seeds to the sophora flavescens is 1: 2.

in one embodiment, the weight ratio of the plantain seed, the divaricate saposhnikovia root and the poria cocos is 1: (0.5-1.2): (0.6-1.5).

In a preferred embodiment, the mass ratio of the plantain seeds, the divaricate saposhnikovia roots and the poria cocos is 1: 0.8: 1.1.

in one embodiment, the mass ratio of the folium isatidis, the andrographis paniculata, the oriental wormwood, the radix sophorae flavescentis, the schizonepeta and the akebia stem is (10-20): (13-15): (12-18): (14-18): (7-9): (9-11).

In a preferred embodiment, the ratio of the folium isatidis, the andrographis paniculata, the oriental wormwood, the radix sophorae flavescentis, the schizonepeta and the akebia stem is 15: 14: 15: 16: 8: 10.

folium isatidis

Folium Isatidis, the name of Chinese medicine, is the dried leaf of Isatis tinctoria (Isatis tinctoria Fort.) of Cruciferae. The crimps were more wrinkled, and some were broken. After being flattened, the whole blade is in a shape of an oblong to an oblong inverted needle, the length of the whole blade is 5-20 cm, and the width of the whole blade is 2-6 cm; the upper surface is dark gray green, and some visible colors are darker and slightly raised dots; the tip is blunt, the whole edge or microwave shape, the base part is narrow and extends to the petiole to form a wing shape; the leaf stalk is 4-10 cm long and is light brown yellow. The texture is crisp. Light smell, slightly sour, bitter and astringent taste. Dyers woad leaf is bitter and cold in nature and enters heart and stomach meridians. Has effects of clearing away heat and toxic materials, cooling blood, and removing speckle. Can be used for treating warm pathogen entering nutrient, hyperpyrexia, coma, speckle, eruption, jaundice, dysentery with heat, mumps, pharyngitis, erysipelas, and carbuncle.

The main chemical components in folium Isatidis include alkaloids, organic acids, glycosides, flavonoids, and sterols. The alkaloids include 6-indazole-indolo [2,1-b ] quinazolinone-12, 5-light-group-2-indolinone, tryptanthrin, 4(3H) quinazolinone, and 2,4(1H,3H) quinazolinedione. The organic acids include salicylic acid, syringic acid, nicotinic acid, succinic acid, anthranilic acid, benzoic acid, and palmitic acid. The glycoside compounds include glucose brassin, neoglucose brassin, uropyl, adenopyl, etc. The flavonoid compounds include isovitexin, etc. The sterol compounds include hibiscus sterol, beta-sterol, gamma-sitosterol, etc.

Andrographis paniculata (Burm. f.) Nees

Andrographis paniculata (Burm. f.) Nees) is dried aerial part of Andrographis paniculata (Andrographis paniculata) of Acanthaceae. Also called Chunlian autumn willow, once you please, elemena, scabrous elephantfoot herb, lysimachia foenum-graecum hance, golden fungus hook, indian grass, eel grass, etc. The stem is in a square column shape, is multi-branched, is 50-70 cm long, and slightly expands; is brittle and easy to break. The single leaf is opposite, and the petiole is short or nearly without the petiole; the leaves are shriveled and fragile, the whole part is in a needle-like shape or an egg-like needle-like shape after being unfolded, the length is 3-12 cm, the width is 2-5 cm, the tip is tapered, the base part extends downwards in a wedge shape, and the whole edge or the shape of a wave; the upper surface is green, the lower surface is grey green, and the two surfaces are smooth. Light smell, extremely bitter taste. Andrographis paniculata Nees, with bitter and cold properties, enters heart, lung, large intestine and bladder meridians. Has effects in clearing away heat and toxic materials, relieving inflammation, and relieving swelling and pain. It can be used for treating common cold, fever, sore throat, aphtha, cough, diarrhea, dysentery, stranguria, carbuncle, suppurative sore, and snake bite, and has antibacterial, antiviral, and anticancer effects.

The main chemical components in the andrographis paniculata comprise diterpene lactone compounds, flavonoid compounds, alkaloid compounds, polyphenol compounds, sterol compounds and the like. The diterpene lactone compounds include andrographolide, dehydroandrographolide, neoandrographolide, deoxyandrographolide, andrographolide glycoside, 3, 14-dideoxy andrographolide, etc. The diterpene lactone compounds include andrographolide A-E and andrographolide ether. The flavonoids include andrographolide, 5-hydroxy-3, 7,8, 2' -tetramethoxyflavone, 3-O-methyl widmanoflavone, 5,7, 8-trimethoxyflavanone, 7, 8-dimethoxy-5-acetate flavanone, 7, 8-dimethoxy-5-acetate flavone, 5,7, 8-trimethoxyflavone, etc. The alkaloid compounds include guanosine, etc. The polyphenol compounds include eugenol, myristic acid, etc. The sterol compounds include beta-sitosterol, alpha-sitosterol, etc.

Herba Artemisiae Scopariae

Oriental wormwood, name of traditional Chinese medicine. Is dried aerial part of Compositae plant Artemisia scoparia Waldst et Kit or herba Artemisiae Scopariae (Artemisia Capillaris Thunb.). Alias: herba Artemisiae Scopariae, herba Artemisiae Annuae, herba Artemisiae Anomalae, and Hericium erinaceus. The capillary wormwood herb is curled into a dough, is grey white or grey green, is densely covered with white fuzz on the whole, is soft like velvet, has small stem, is 1.5-2.5 cm long and 0.1-0.2 cm in diameter, can be obviously longitudinally striped after the white fuzz on the surface is removed, is crisp in quality and easy to break, has a leaf handle, is split into one to three pinnate parts after being flattened, has a leaf length of 1-3 cm and a width of about 1cm, and has small split pieces which are oval or slightly in the shape of an inverted needle and are in a strip shape, and the tip is sharp, fragrant and slightly bitter; the artemisia capillaris thunb is cylindrical and multi-branched, has the length of 30-100 cm, the diameter of 2-8 mm, the surface is light purple or purple, has longitudinal stripes, is short and soft, is light and crisp, has a white-like section, dense leaves or more drops, has deep cleft of two-to-three-turn pinnate shape of lower leaves, splintered strips or thin strips, has two dense white and soft surfaces, has full cleft of one-to-two-turn pinnate shape of cauline leaves, has a base part embracing the stems, splintered thin filaments, a head-shaped inflorescence egg shape, is mostly integrated into a cone shape, has the length of 1.2-1.5 mm, the diameter of 1-1.2 mm, has short stems, 3-4 layers of total bracts, 3 clefts of bracts, 6-10 female flowers on the outer layer, can be up to 15, 2-10 amphoteric flowers on the inner layer, long round thin fruits, yellow brown, fragrant and slightly bitter. Herba Artemisiae Scopariae is bitter and pungent in flavor, slightly cold in nature, and has effects of invigorating spleen, stomach, liver and gallbladder channels, resisting bacteria and virus, removing dampness and heat, promoting bile flow, and eliminating jaundice, and can be used for treating jaundice, oliguria, damp warmth, summer dampness, and eczema and pruritus.

The chemical components in herba Artemisiae Scopariae include coumarins, chromone, flavonoids, volatile oils, coumaric acids, and organic acids. The coumarins include 6, 7-dimethoxycoumarin, scopoletin, 6-hydroxy-7-methoxycoumarin, and capillin lactone. The chromone includes capillary artemisia chromone, 7-methyl capillary artemisia chromone, 4 '-methyl capillary artemisia chromone, 6-demethyl capillary artemisia chromone and 6-demethoxy-4' -methyl capillary artemisia chromone. The flavonoids include capillin, isocapillin, thimerovin, quercetin, Chinese thistle alcohol, Genkwanin, rhamnitrin, 5,2 ', 4' -trihydroxy-6, 7,5 '-trimethoxy flavone, rhamniferin, 4' -demethyleupatilin, cactus glycoside, isorhamnetin-3-glucoside, and hyperoside. Volatile oils include terpenes, acetylenes, phenols, fatty acids, and others. Terpenes include alpha-pinene, beta-pinene, p-cymene, longipinene, acetyl borneol, alpha-terpinene, gamma-terpinene, beta-caryophyllene, alpha-humulene, beta-guvacene, alpha-bergamotene, beta-elemene, ocimene, camphene, etc. The alkyne includes capillin, o-methoxy capillin, capillin ketene, capillin, dehydrofarenynone, dehydrofarenynol, 1-phenyl-2, 4-hexadiyne-1-ol, 5-phenyl-1, 3-pentadiyne. The phenols include methyl eugenol, phenol, o-cresol, p-cresol, m-cresol, o-ethylphenol, p-ethylphenol, and eugenol. The fatty acid includes palmitic acid, stearic acid, linoleic acid, oleic acid, myristic acid, lauric acid, capric acid, caproic acid, and butyric acid. Others include capillin, dehydrofalcarinol, dehydrofalcarinone. The coumaric acids include capillaris herba coumaric acid A, capillaris herba coumaric acid B, and deoxycapillaris herba coumaric acid. The organic acids include caffeic acid and chlorogenic acid.

Sophora flavescens ait

Kuh-seng, name of traditional Chinese medicine. Is dried root of Sophoraflavoscens Ait. The long cylindrical shape is provided, the lower part is provided with branches, the length is 10-30 cm, and the diameter is 1-2 cm. The surface is gray brown or brownish yellow, has longitudinal wrinkles and transverse long skin holes, the outer skin is thin, is broken and rolled back frequently, is easy to peel off, and the peeled part is yellow and smooth. Hard, not easy to break, and fibrous in cross section; slicing the slices to be 3-6 mm thick; the section is yellowish white, and some of them have radial texture and cracks, and some have concentric ring texture. Light smell, extremely bitter taste. It is bitter and cold in nature and enters heart, liver, stomach, large intestine and bladder meridians. Has the functions of clearing heat, drying dampness, killing parasites and promoting urination. Can be used for treating dysentery with heat, hematochezia, jaundice, anuria, leucorrhea with red and white discharge, pudendal swelling, pruritus vulvae, eczema, skin pruritus, scabies, tinea, and leprosy; it can be used for treating trichomonas vaginitis.

The main chemical components in radix Sophorae Flavescentis include flavonoids, alkaloids, triterpenes and other compounds. The flavonoids include flavonols, flavanones, flavanonols, isoflavones, isoflavanones, homoisoflavones, chalcones, biflavones, pterocarpans, etc. The flavonols include quercetin, rutin, nor-anhydroicaritin, isodehydroicaritin, 8-lavandulyl acetate kaempferide, 8-isopentenyl kaempferide, 5-dehydrokaempferide, 8-lavandulyl acetate-5, 7, 4' -trihydroxy-flavonol, etc. The flavanones include kurarinol A, kurarinol B, kurarinol E, kurarinol F, kurarinol P-W, isokurarinone, 2' -methoxy kurarinone, isoxanthohumol, naringenin, etc. The flavanonols include kurarinol H-N, kurarinol X, etc. The isoflavones include formononetin, daidzein, biochanin A, 7-methoxy-4 ' -hydroxyisoflavone, calycosin, 7,4 ' -dihydroxy-3 ' -methoxyisoflavone, 7,3 ', 4 ' -trihydroxyisoflavone, etc. The isoflavanone compounds include 7,4 '-dihydroxy-isoflavanone-3' -O-beta-D-glucopyranoside. The homoisoflavonoids include 2, 3-dihydroxy-4 '-methoxy homoisoflavonoid-7-O-xylose, 2,3, 4' -trihydroxy homoisoflavonoid-7-O-beta-D-glucopyranoside, etc. Chalcones include 2 ', 4-dihydroxy-4 ', 6 ' -dimethoxy chalcone, kurarinol D, (Z) -4,2 ', 4 ' -trihydroxy chalcone, etc. The biflavones comprise Sophflavanone A, Sophflavanone B and the like. The pterocarpans include Korean sophoricine, pterocarpan, trifoliosid-6' -monoacetate, etc. The alkaloid compounds include matrine type, dimeric matrine type, cytisine type, sparteine type/fetuinine type, lupine type, bispidine type, etc. The matrine type includes sophoridine, 14 beta-hydroxy matrine, cis-form new matrine, trans-form new matrine, 9 alpha-hydroxy sophocarpine N-oxide, 7, 11-dehydromatrine, sophoramine, 7, 8-didehydro sophoramine, 13, 14-dehydrosophoridine, oxyphosphonol, 17 beta-hydroxy sophoridine, 13, 14-dehydrosophocarpine, etc. The dimeric matrine form includes Flavesines A-F. The laburnine type includes N-methyl laburnine, etc. The sparteine type/fetuinine type includes Oxyupanane, 5-hydroxypanane, 7-hydroxypanane, and baptidine. Lupine forms include sophocarpine, and the like. The bispiperidine type includes Isokuraramine and the like. Triterpenes and other types of compounds include lupeol, lupenone, β -resinol, soyasaponin I, etc.

Semen plantaginis

The semen plantaginis is dried mature seed of Plantagoasiatia L or PlantagoaprosaWilld. Is oval, irregular or triangular, and has a length of about 2mm and a width of about 1 mm. The surface is yellow brown to black brown, fine wrinkles are formed, and a gray concave point-shaped hilum is arranged on one surface. Is hard. Light smell, bland taste. Semen plantaginis has sweet and cold nature and flavor, enters kidney, small intestine, liver and lung channels, has effects of clearing heat and promoting diuresis, excreting dampness and treating stranguria, improving eyesight and eliminating phlegm, and can be used for treating edema and fullness, heat stranguria with astringency and pain, summer-heat dampness diarrhea, conjunctival congestion and swelling pain, phlegm heat cough, etc.

The semen plantaginis contains polysaccharides, flavonoids, iridoids, and phenylethanoid glycosides as main chemical components. The flavonoids include hispidulin, apigenin, luteolin-7-O-beta-D-glucoside, luteolin-7-O-beta-D-glucuronide, plantain, 5,7,4 ', 5' -tetrahydroxy-3 '-O-glucosylflavone, quercetin 3-O-rutinoside 3' -O-beta-apioside, rutin, scutellarein-7-glucoside, rhoifolin, apigenin-7-O-glucoside, etc. Iridoids include geniposide, aucubin, 3, 4-dihydroxy aucubin, D-glucosyl aucubin, and geniposide. The phenylethanoid glycosides include acteoside, isoacteoside, plantarenaloside, isoplantarenaloside, forsythiaside B, etc.

The applicant unexpectedly finds that when the mass ratio of the plantain seeds to the sophora flavescens is 1: (1.5-3), and controlling the mass ratio of the plantain seeds, the divaricate saposhnikovia roots and the poria cocos to be 1: (0.5-1.2): (0.6-1.5), the prepared traditional Chinese medicine composition has an obvious curative effect on avian renal type infectious bronchitis. The plantain seed contains polysaccharide molecules, the molecular weight of the plantain seed is more than one million, the plantain seed has a xylan main chain structure, the plantain seed has stable property, has better compatibility with medicines such as radix sophorae flavescentis, divaricate saposhnikovia root and poria cocos in a system, and has an adhesive effect, so that the components can be better dispersed in the system, the activity of the components can be favorably maintained, the pharmacological activity of the components can be exerted to the maximum extent, and the curative effect of the traditional Chinese medicine composition is improved. Meanwhile, the radix sileris and the tuckahoe contain polysaccharide molecules with higher molecular weight, and when the plantain seed, the radix sileris and the tuckahoe exist simultaneously, the steric hindrance of the polysaccharide molecules in the system is increased, which is beneficial to improving the dispersion stability of each component, thereby improving the curative effect of the traditional Chinese medicine composition. When the content of the plantain seeds is too high, the polysaccharide concentration in the system is increased, and under the large system of the traditional Chinese medicine composition, electrostatic repulsion is generated among polysaccharide molecules, so that the stability of each component is reduced, and the dispersibility of each component in the system is poor, thereby affecting the curative effect of the traditional Chinese medicine composition.

Schizonepeta tenuifolia

Herba Schizonepetae is dried aerial part of herba Schizonepetae (Schizonepetatenuifoliabriq.) belonging to Labiatae. Alias: herba Schizonepetae, herba Capsellae, herba Artemisiae Annuae, and herba Stachydis Japonicae. The schizonepeta stem is in a square column shape, the upper part of the schizonepeta stem is provided with branches, the length of the schizonepeta stem is 50-80 cm, and the diameter of the schizonepeta stem is 0.2-0.4 cm; the surface is light yellow green or light purple red, and the quilt is short and soft; light weight, crisp texture and white-like cross section. The leaves are in butt joint and mostly fall off, the leaves are 3-5 feathered and split, and the split pieces are slender. The panicle-shaped cymbidium inflorescence grows at the top, grows for 2-9 cm, and has the diameter of about 0.7 cm. The corolla is mostly fallen off, the persistent calyx is bell-shaped, the tip is 5 teeth fissured, and the corolla is light brown or yellow green and is short and soft; the small nuts are brownish black. Fragrant smell, slightly astringent and pungent-cool taste. Schizonepeta is pungent in flavor, warm in nature, non-toxic and strong in fragrance. Herba Schizonepetae enters lung and liver channels, has effects of relieving exterior syndrome, dispelling pathogenic wind, promoting eruption, eliminating phlegm, and cooling blood, and can be used for treating common cold, headache, measles, rubella, and initial stage of pyocutaneous disease. Stir-baked into charcoal is indicated for hematochezia, metrorrhagia and metrostaxis and postpartum anemic fainting.

The chemical components in herba Schizonepetae include volatile oil, flavone, monoterpene, triterpenes, steroid, organic acid, etc. Volatile oils include pulegone, menthone, isomenthone, nepetalactone, citral, linalool, caryophyllene, 4-methoxy-3-methyl-1, 2-phenylenediamine, 2-octanal, (2R-trans) -5-methyl-2- (1-methylvinyl) cyclohexanone, 2-isopropylidene-5-methylcyclohexanone, 4,11, 11-trimethyl-8-methylenebicyclo [7.2.0] -4-nonene, 1-octen-3-ol, 1-octen-3-one, 3-octanol, cis-p-2, 8-menthadieneol, ethyl alcohol carvacrol E, elemene, guaranolone, dihydrojasmone, oxytetracycline, and the like. The flavonoids include luteolin, apigenin, hesperidin, hesperetin, diosmetin, etc. Monoterpenes include 3-hydroxy-4 (8) -ene-p-menthane-3 (9) -lactone, 1, 2-dihydroxy-8 (9) -ene-p-menthane, and the like. The triterpenes include deoxyoleanolic acid, oleanolic acid, and ursolic acid. Steroids include beta-sitosterol and the like. The organic acids include eicosanoic acid, docosanoic acid, tetracosanoic acid, succinic acid, neononanoic acid, rosmarinic acid, methyl rosmarinate, caffeic acid, nepeta A-F, cinnamic acid, the acrylic acids, and the like.

Wind-proof

Radix Saposhnikoviae is the dried root of Saposhnikoviadivaricata (Turcz.) Schischk.) belonging to the family Umbelliferae. Perennial herbs, thick and strong roots, slender cylinders, light yellow-brown. The windproof part is in a long conical shape or a long cylindrical shape, the lower part of the windproof part is tapered and slightly bent, the windproof part is 15-30 cm long, and the diameter of the windproof part is 0.5-2 cm. The surface is grayish brown and rough, and has longitudinal wrinkles, a plurality of transverse long skin holes and fine root marks protruding in a dot shape. The head of the root has obvious dense ring veins, and dark brown hairy leaf bases remain on the ring veins. Light weight, loose texture, easy breaking, uneven section, light brown skin, fissures and light yellow wood. Special smell, slightly sweet taste. Fang Feng is pungent, sweet and warm in nature, entering bladder, liver and spleen meridians. Has effects of relieving exterior syndrome, dispelling pathogenic wind, eliminating dampness, and relieving spasm, and can be used for treating common cold, headache, rheumatalgia, rubella pruritus, and tetanus.

The chemical components of radix Saposhnikoviae include volatile oils, chromone, coumarins, and polysaccharides. Volatile oils include 2-methyl-3-buten-2-ol, valeraldehyde, alpha-pinene, hexanal, pentanol, hexanol, octanal, nonanal, octanol, phthalene, beta-curcumene, ginseng alcohol, 1-octen-3-ol, acetic acid, alpha-thujene, beta-bisabolene, undecene, thujene, naphthalene, beta-eucalyptol, undecanoic acid, 2-nonadecanone, 2-nonenal, 2-nonanone, palmitic acid, and the like. The chromone includes cimicin, cimicifugal, 3 '-O-acetyl hamaudol, 5-O-methyl vitamin Aminonol, 3' -O-angeloyl hamaudol, and wogonin. The coumarins include psoralen, bergapten, isoimperatorin, imperatorin, nodakenin, xanthotoxin, isoviolaridin, scopoletin, angelica dahurica lactone, corallolide, saporin, fraxidin, isofraxidin, and (3' S) -hydroxy-saporin. The polysaccharides include Saponikovan A, Saponikovan B, Saponikovan C and the like.

Poria cocos (Schw.) wolf

Tuckahoe, name of traditional Chinese medicine. Is dried sclerotium of Poria cocos (Schw.) Wolf) belonging to Polyporaceae. Digging for more than 7-9 months, removing silt after digging, piling up to generate sweat, spreading and drying until the surface is dry, then generating sweat, repeating for a plurality of times until wrinkles appear and most of internal water is lost, and drying in the shade to obtain Poria cocos; or cutting fresh Poria according to different parts, and drying in the shade to obtain Poria block and Poria tablet. Poria cocos is in the shape of sphere, ellipse, oblate or irregular mass with different sizes. The skin was thin and rough, tan to dark brown with a pronounced wrinkled texture. Heavy, firm, granular in cross section, with fissures, light brown on the outer layer, white inside, a few pale red, some with pine roots in the middle. No smell, light taste, sticky teeth when chewed. The poria peel is the cut poria peel, and has different shapes and sizes. The outer surface is dark brown to black brown, and the inner surface is white or light brown. It is soft and slightly elastic. The Poria cocos blocks are sliced poria cocos with different sizes after being peeled. White, light red or light brown. The red poria is to cut the red brown or light red part into blocks or slices. The white part of the Poria is cut off. Poria cocos, is sweet and bland in taste and neutral in nature. It has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart, and can be used for treating edema, oliguria, palpitation due to phlegm and fluid retention, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.

The main chemical components of Poria include triterpenes, polysaccharides, etc. The triterpenes include pachymic acid, methyl pachymic acid, 16 alpha-hydroxy-methyl-porcellate, mycolic acid-methyl ester, 3-hydrogenated pinoceric acid, porcellic acid, dehydroporcellic acid, etc. The polysaccharides include pachyman, pachyman with different concentrations and heights (1,3), (1,6), branched beta-D-dextran H11, etc. In addition, Poria contains chemical components such as caprylic acid, undecanoic acid, lauric acid, dodecanoic ester, palmitic acid, dodecenoic acid ester, caprylic acid, gum, chitin, protein, fat, sterol, lecithin, glucose, adenine, histidine, choline, β -pachyman decomposition enzyme, lipase, protease, etc.

Wood block

Caulis Akebiae (Akebiaquinata (Houtt.) Decne.) is the woody stem of caulis Akebiae, caulis Akebiae of Lardizabalaceae, or caulis Akebiae. Alias: medulla Tetrapanacis, ramulus Cinnamomi, radix Pulsatillae, radix Aconiti lateralis Preparata, caulis et folium fici Tikouae, radix Pulsatillae, radix Rhodiolae, caulis et folium fici Pumilae, Yan's 3415178, radix Aconiti Kusnezoffii , and caulis Sargentodoxae. The dry woody stems of the akebia trifoliata are cylindrical and bent, the length of the stems is 30-60 cm, and the diameter of the stems is 1.2-2 cm. The surface is grayish brown, the outer skin is extremely rough and has a plurality of irregular cracks, the nodes are not obvious, and only lateral branch broken marks can be seen. Hard, hard and hard to break, fibrous in cross section, thick in skin, yellow brown, yellow white in wood, dense arrangement of thin-hole catheters with gray yellow radial patterns. The center has a small marrow. Light smell, bitter and astringent taste. Even strip with yellow inner color is preferred. Produced in Sichuan, Hubei, Hunan, Guangxi, etc. At present, the akebia stem medicinal materials mainly relate to akebia stem, clematis stem, Huaitong and akebia stem, wherein the most widely used akebia stem is the wood stem (detailed 'akebia stem' strip) of akebia fruit aristolochia debilis of aristolochiaceae; secondly, caulis Clematidis Armandii, which is the wooden stem (detailed caulis Clematidis Armandii) of caulis Akebiae and hydrangeae strigosae of Ranunculaceae; rhizoma Dioscoreae is the woody stem of fructus Aristolochiae major Ebenaceae and rhizoma Dioscoreae Aristolochiae (detailed "rhizoma Dioscoreae Tokoro" and "Zhushalian" strips); white wood traffic is produced by itself in only a few areas. While the Mutong recorded in the herbal of all ages is Mutong of Mutong family, which is rarely used at present. Akebia quinata is sweet in taste and slightly cold in nature, and enters heart, small intestine and bladder meridians. Has the effects of purging fire, promoting diuresis, and promoting blood circulation. It can be used for treating dysuria, stranguria with turbid urine, edema, dysphoria with smothery sensation in chest, sore throat, angina, amenorrhea, and galactostasis.

Caulis Akebiae caulis et folium caulis Akebiae stem contains betulin, oleanolic acid, hederagenin, caulis Akebiae saponin, stigmasterol, beta-sitosterol, daucosterol, inositol, sucrose, potassium salt, etc. The flower contains cyanidin-3-xylosyl-glucoside, cyanidin-3-p-coumaroyl-xylosyl-glucoside, etc.

The invention takes dyers woad leaf, common andrographis herb, virgate wormwood herb and lightyellow sophora root as monarch drugs, and dyers woad leaf, the nature and taste are as follows: bitter and cold; meridian tropism: heart and stomach meridians entered; the functional indications are as follows: clearing away heat and toxic material, cooling blood and removing ecchymoses; common andrographis herb, nature and taste: bitter and cold; meridian tropism: the channels of heart, lung, large intestine and bladder; the functional indications are as follows: clearing away heat and toxic materials, relieving inflammation, and relieving swelling and pain; herba artemisiae scopariae, nature and taste: bitter, pungent and cold; meridian tropism: spleen, stomach, liver and gallbladder meridians entered; the functional indications are as follows: antibacterial, antiviral, dampness and heat removing, gallbladder promoting, and jaundice treating effects; kuh-seng, nature and taste: bitter and cold; meridian tropism: the channels of heart, liver, stomach, large intestine and bladder; the functional indications are as follows: clearing heat, eliminating dampness, and promoting urination; semen plantaginis, herba schizonepetae, radix sileris, tuckahoe and akebia stem are taken as ministerial drugs, semen plantaginis has the following properties and flavors: sweet and cold; meridian tropism: it enters kidney, small intestine, liver and lung meridians; the functional indications are as follows: clearing away heat, promoting urination, and eliminating dampness; schizonepeta, nature and taste: pungent and warm; meridian tropism: entering lung and liver meridians; the functional indications are as follows: relieving exterior syndrome, dispelling pathogenic wind, and cooling blood; ledebouriella root, nature and taste: pungent, sweet and warm; meridian tropism: it enters bladder, liver and spleen meridians; the functional indications are as follows: relieving exterior syndrome, dispelling pathogenic wind, eliminating dampness, and relieving spasm; tuckahoe, nature and taste: sweet, bland and mild; meridian tropism: the heart, lung, spleen and kidney meridians are entered; the functional indications are as follows: clearing damp and promoting diuresis; caulis Akebiae, nature and taste: sweet and cold; meridian tropism: heart, small intestine and bladder meridians entered; the functional indications are as follows: purging fire, promoting diuresis, and promoting blood circulation; folium Isatidis, herba Andrographitis, herba Artemisiae Scopariae, and radix Sophorae Flavescentis have effects of clearing away heat and toxic materials, and relieving inflammation and pain; semen plantaginis, herba Schizonepetae, radix Saposhnikoviae, Poria, and caulis Akebiae have effects of cooling blood, promoting diuresis, and eliminating dampness. On the basis of monarch drugs, the effect of the traditional Chinese medicine is exerted to the maximum extent through the auxiliary effect of ministerial drugs and the strict compatibility according to the pharmacological activity of each drug.

< nutritional Agents >

Nutritional agents, also known as nutritional supplements, dietary supplements, and the like, are used as an auxiliary means of diet to supplement amino acids, trace elements, vitamins, minerals, and the like, which are required by the human body. The nutritional agent may be composed of amino acids, polyunsaturated fatty acids, minerals and vitamins, or only one or more vitamins, or one or more dietary components, wherein in addition to the amino acids, vitamins, minerals and other nutrients, there may be herbs or other plant components, or concentrates, extracts or combinations thereof.

In one embodiment, the nutrient is one or more of amino acids, glucose, folic acid, vitamin a, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K, and biotin.

In a preferred embodiment, the nutritional agents are glucose and vitamin C.

In one embodiment, the mass ratio of glucose to vitamin C is 1: (50-80).

In a preferred embodiment, the mass ratio of glucose to vitamin C is 1: 55.

glucose

Glucose (glucose), an organic compound, formula C₆H₁₂O₆. Is a monosaccharide which is the most widely distributed and important monosaccharide in the nature and is a polyhydroxy aldehyde. Pure glucose is colorless crystals, has sweetness less than sucrose, is readily soluble in water, is slightly soluble in ethanol, and is insoluble in diethyl ether. Aqueous natural glucose solution rotates to the right and is thus "dextrose".

Glucose plays an important role in the field of biology, and is an energy source and a metabolic intermediate product of living cells, namely a main energy supply substance of organisms. Plants can produce glucose through photosynthesis. Has wide application in the candy manufacturing industry and the medicine field.

Vitamin C

Vitamin C is structurally similar to glucose, and is a polyhydroxy compound in which two adjacent enol-type hydroxyl groups at the 2 nd and 3 rd positions in the molecule are easily dissociated to release H⁺Therefore, it has the property of acid, also called ascorbic acid. Vitamin C has strong reducibility and is easily oxidized into dehydrovitamin C, but the reaction is reversible, and ascorbic acid and dehydroascorbic acid have the same physiological function, but if the dehydroascorbic acid is continuously oxidized to generate diketogulonic acid, the reaction is irreversible and the physiological effect is completely lost.

Vitamin C is necessary for antibody and collagen formation, tissue repair (including certain redox actions), metabolism of phenylalanine, tyrosine and folic acid, utilization of iron and carbohydrate, synthesis of fat and protein, maintenance of immune function, hydroxylation of 5-hydroxytryptamine, blood vessel integrity maintenance, non-heme iron absorption promotion and the like, and simultaneously the vitamin C also has the effects of oxidation resistance, free radical resistance and tyrosinase inhibition, so that the effects of whitening and spot lightening are achieved. In the human body, vitamin C is a highly effective antioxidant for alleviating the oxidative stress of ascorbate peroxidase. In addition, vitamin C also has effects of removing toxic substance, preventing cancer, and scavenging free radicals in vivo.

< additives >

The additive is an artificial or natural substance added into the product for improving the quality of the product such as color, fragrance, taste and the like and for the requirements of anticorrosion and processing technology.

In one embodiment, the additive is one or more of methyl paraben, ethyl paraben, propyl paraben, butyl paraben, benzoic acid, sodium benzoate, benzyl alcohol, phenethyl alcohol, sorbic acid, potassium sorbate, butyl hydroxy anisole and butyl hydroxy toluene.

In a preferred embodiment, the additive is methyl paraben, ethyl paraben, sodium benzoate.

In one embodiment, the mass ratio of methyl paraben to ethyl paraben to sodium benzoate is 1: (0.5-2): (1.5-5).

In a preferred embodiment, the mass ratio of the methyl paraben to the ethyl paraben to the sodium benzoate is 1: 1: 2.7.

nipagin methyl ester

Methylparaben, also known as methylparaben or methylparaben, white crystalline powder or colorless crystals, readily soluble in alcohol, ether and acetone, very slightly soluble in water, boiling point 270-280 ℃. The product is mainly used as a sterilization preservative for organic synthesis, food, cosmetics and medicines, and also used as a feed preservative. Because it has a phenolic hydroxyl structure, it has stronger antibacterial performance than benzoic acid and sorbic acid. The action mechanism is as follows: destroying the cell membrane of the microorganism, denaturing the protein in the cell, and inhibiting the activities of the respiring enzyme system and the electron transfer enzyme system of the microorganism cell.

Nipagin ethyl ester

Ethylparaben is a white crystalline substance, slightly bitter in taste, and numb in nature. It is mainly used as bactericidal preservative for food, cosmetics and medicine, and also used as feed preservative. The ethylparaben has a strong bacteriostatic effect on fungi, but has a weak bacteriostatic effect on bacteria. Can be used as antibacterial antiseptic, widely used in liquid preparation and semisolid preparation, and can also be used for preserving food and cosmetics.

Sodium benzoate

Sodium benzoate (sodium benzoate) is a white granular or crystalline powder, odorless or slightly benzoin-smelling, slightly sweet in taste, and astringent in taste. Also known as sodium benzoate, relative molecular mass 144.12. Is stable in air, is easily soluble in water, has pH of 8, and is soluble in ethanol. Benzoic acid and its salts are broad spectrum antimicrobial agents, but its antimicrobial effectiveness depends on the pH of the food product. The sterilizing and bacteriostatic effects are enhanced along with the increase of the acidity of the medium, and the sterilizing and bacteriostatic effects are lost in an alkaline medium. The optimum pH value for corrosion prevention is 2.5-4.0.

The second aspect of the invention provides a traditional Chinese medicine oral liquid for treating avian renal type infectious bronchitis, which comprises the traditional Chinese medicine composition for treating avian renal type infectious bronchitis.

The third aspect of the invention provides a preparation method of a traditional Chinese medicine oral liquid for treating avian renal type infectious bronchitis, which at least comprises the following steps: mixing the Chinese medicinal extract, nutritional agent and additives, stirring, cooling to room temperature, filtering, bottling, sealing, sterilizing, and packaging.

In one embodiment, the preparation method of the traditional Chinese medicine oral liquid for treating avian renal type infectious bronchitis at least comprises the following steps: mixing the Chinese medicinal extract, nutritional agent and additives, stirring, cooling to room temperature, filtering, bottling, sealing, sterilizing at 105 deg.C for 10 min, and packaging.

The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.

In addition, the starting materials used are all commercially available, unless otherwise specified.