阅读说明：本技术 氰基取代的稠合双环衍生物及其制备方法和用途 (Cyano-substituted fused bicyclic derivatives, their preparation and use ) 是由 杨新业 黄常伟 马发城 郝学良 王慧 王晓军 张英俊 于 2018-02-28 设计创作，主要内容包括：本发明涉及一类氰基取代的稠合双环衍生物,以及包含该化合物的药物组合物。所述化合物或药物组合物可用于抑制黄嘌呤氧化酶和尿酸盐阴离子转运体1,并降低血中尿酸水平。本发明还涉及制备这类化合物和药物组合物的方法,以及它们在治疗或预防哺乳动物,特别是人类,与血中尿酸值偏高有关的疾病中的用途。(The invention relates to a cyano-substituted fused bicyclic derivative and a pharmaceutical composition containing the compound. The compounds or pharmaceutical compositions are useful for inhibiting xanthine oxidase and urate anion transporter 1, and reducing uric acid levels in blood. The invention also relates to methods for preparing such compounds and pharmaceutical compositions, and their use in the treatment or prevention of diseases associated with elevated blood uric acid levels in mammals, particularly humans.)