阅读说明：本技术 一种辅助治疗小细胞肺癌的中药组合物 (Traditional Chinese medicine composition for adjuvant therapy of small cell lung cancer ) 是由 姜守刚 于 2019-09-17 设计创作，主要内容包括：本发明提供了一种辅助治疗小细胞肺癌的中药组合物,涉及中药组合物技术领域。本发明所述中药组合物包括以下重量份的原料：向日葵茎髓10～15份,黄芪10～15份,树舌10～15份,黑豆皮40～50份,冬凌草40～50份,积雪草25～30份,白花蛇舌草10～15份和甘草2.5～5份。利用所述中药组合物辅助标准化疗治疗广泛期小细胞肺癌效果显著,既可以配合化疗控制肿瘤的生长,同时还用于为手术期的患者增强体质,提高小细胞肺癌患者抗病修复能力,以延长肿瘤患者的生命,对各个时期的小细胞肺癌具有一定的治疗效果,药效稳定,吸收迅速,见效快,疗效可靠,治疗周期短,没有明显的毒副作用。(The invention provides a traditional Chinese medicine composition for adjuvant therapy of small cell lung cancer, and relates to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-15 parts of sunflower stem pith, 10-15 parts of astragalus membranaceus, 10-15 parts of artist's conk, 40-50 parts of black bean peel, 40-50 parts of rabdosia rubescens, 25-30 parts of centella asiatica, 10-15 parts of oldenlandia diffusa and 2.5-5 parts of liquorice. The traditional Chinese medicine composition has an obvious effect of assisting standard chemotherapy to treat the extensive-stage small cell lung cancer, can be used for controlling the growth of tumors by matching with chemotherapy, simultaneously is used for enhancing the physique of patients in an operation stage and improving the disease-resistant repair capacity of the patients with the small cell lung cancer so as to prolong the life of the patients with the tumors, has a certain treatment effect on the small cell lung cancer in each stage, and has the advantages of stable drug effect, quick absorption, quick response, reliable curative effect, short treatment period and no obvious toxic or side effect.)

1. The traditional Chinese medicine composition for adjuvant therapy of small cell lung cancer is characterized by comprising the following raw materials in parts by weight: 10-15 parts of sunflower stem pith, 10-15 parts of astragalus membranaceus, 10-15 parts of artist's conk, 40-50 parts of black bean peel, 40-50 parts of rabdosia rubescens, 25-30 parts of centella asiatica, 10-15 parts of oldenlandia diffusa and 2.5-5 parts of liquorice.

2. The preparation method of the traditional Chinese medicine composition of claim 1, which is characterized by comprising the following steps: respectively crushing the raw materials and mixing according to the parts by weight; the particle size after the crushing is 80 meshes.

Technical Field

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for adjuvant therapy of small cell lung cancer.

Background

The small cell lung cancer accounts for about 15 percent of the total number of the lung cancer, belongs to neuroendocrine tumors, and is characterized by easy occurrence, early stage transfer to a distant place, strong invasiveness and extremely poor prognosis. According to the American refuge military lung cancer society's second-stage staging method, small-cell lung cancer is divided into a limited stage and a wide stage, the limited-stage small-cell lung cancer is limited to one lateral thorax and can be brought into a radiotherapy field; extensive small cell lung cancer refers to pathological changes in more than one thorax, including hematogenous metastasis, malignant pleural effusion, pericardial effusion, etc. First-line treatments for extensive small cell lung cancer are platinum and etoposide or irinotecan, and patients who cannot tolerate cisplatin toxicity may choose carboplatin. Although small cell lung cancer is sensitive to chemotherapy, it is prone to relapse and drug resistance. Topotecan is the only FDA approved second-line drug for small cell lung cancer. Second-line chemotherapy efficacy is closely related to first-line efficacy and the time interval at which first-line treatment ends. The recurrence interval of the first-line therapy is less than 3 months, which is called refractory or drug-resistant recurrence, and the second-line chemotherapy has poor response (less than or equal to 10 percent) to the drug; if the time to recurrence exceeds 3 months, called sensitive recurrence, the expected response rate is about 25%; the time between relapses was greater than 6 months and first-line regimen chemotherapy was continued. The extensive small cell lung cancer has high malignancy degree and rapid disease development, and should be treated on the principle of comprehensive treatment.

The traditional Chinese medicine for treating the small cell lung cancer is a characteristic of China and is also an advantage of China. For a long time, although some methods and experiences have been obtained for treating small cell lung cancer by traditional Chinese medicines, the traditional Chinese medicines have poor curative effect, limited life cycle extension and limited curative effect on the extensive small cell lung cancer, so that the traditional Chinese medicines cannot be completely popularized.

Disclosure of Invention

In view of the above, the invention aims to provide a traditional Chinese medicine composition for adjuvant therapy of small cell lung cancer, which has the advantages of good treatment effect, short treatment period, small toxic and side effects and low price, and can be used for adjuvant standard chemotherapy for treating extensive-stage small cell lung cancer.

In order to achieve the above object, the present invention provides the following technical solutions:

the invention provides a traditional Chinese medicine composition for adjuvant therapy of small cell lung cancer, which comprises the following raw materials in parts by weight: 10-15 parts of sunflower stem pith, 10-15 parts of astragalus membranaceus, 10-15 parts of artist's conk, 40-50 parts of black bean peel, 40-50 parts of rabdosia rubescens, 25-30 parts of centella asiatica, 10-15 parts of oldenlandia diffusa and 2.5-5 parts of liquorice.

The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: respectively crushing the raw materials and mixing according to the parts by weight; the particle size after the crushing is 80 meshes.

The invention provides a traditional Chinese medicine composition for adjuvant therapy of small cell lung cancer, which comprises the following raw materials in parts by weight: 10-15 parts of sunflower stem pith, 10-15 parts of astragalus membranaceus, 10-15 parts of artist's conk, 40-50 parts of black bean peel, 40-50 parts of rabdosia rubescens, 25-30 parts of centella asiatica, 10-15 parts of oldenlandia diffusa and 2.5-5 parts of liquorice. In the traditional Chinese medicine composition, the sunflower stem pith is used as a monarch drug to exert the effect of strengthening body resistance and eliminating evil, the astragalus membranaceus is used as a ministerial drug to exert the effect of tonifying middle-jiao and Qi, the conk, the black bean peel, the rabdosia rubescens, the centella asiatica and the oldenlandia diffusa are used as adjuvant drugs to exert the effect of clearing heat and removing toxicity, and the liquorice is used as a conductant drug to exert the effect of harmonizing the other drugs.

In the embodiment of the invention, the traditional Chinese medicine composition for treating the extensive-stage small cell lung cancer by using the traditional Chinese medicine composition for assisting standard chemotherapy has a remarkable anti-tumor effect, can control the growth and recurrence of the small cell lung cancer in a short period, can obviously enhance the physique of a human body and improve the disease-resistant repair capacity of the human body so as to prolong the life of a small cell lung cancer patient, has a certain treatment effect on the small cell lung cancer in each stage, and is stable in efficacy, quick to absorb, quick to take effect, reliable in curative effect, short in treatment period, free from remarkable toxic and side effects, and worthy of large-scale industrial production.

Detailed Description

The invention provides a traditional Chinese medicine composition for adjuvant therapy of small cell lung cancer, which comprises the following raw materials in parts by weight:

the traditional Chinese medicine composition comprises sunflower stem pith, and the weight part of the sunflower stem pith is preferably 12.5 parts. The source of the sunflower stem pith is not particularly limited, and the sunflower stem pith can be prepared by utilizing the conventional traditional Chinese medicine raw materials in the field. The sunflower stem pith can exert the effects of strengthening body resistance and eliminating pathogenic factors.

The traditional Chinese medicine composition comprises astragalus membranaceus, and the preferable weight portion of the astragalus membranaceus is 12.5 parts. The source of the astragalus is not particularly limited, and the astragalus can be prepared by using conventional traditional Chinese medicine raw materials in the field. The astragalus membranaceus can play a role in tonifying middle-jiao and Qi.

The traditional Chinese medicine composition comprises the Ganoderma Applanatum, and the weight part of the Ganoderma Applanatum is preferably 12.5 parts. The source of the Ganoderma Applanatum is not particularly limited, and the Ganoderma Applanatum is prepared from conventional Chinese medicinal materials in the field. The Ganoderma applanatum of the invention can exert the effect of clearing heat and removing toxicity.

The traditional Chinese medicine composition comprises black bean curd skin, and the weight part of the black bean curd skin is preferably 45 parts. The source of the black bean curd skin is not particularly limited, and the black bean curd skin is prepared by using conventional traditional Chinese medicine raw materials in the field. The black bean peel disclosed by the invention can play a role in clearing away heat and toxic materials.

The traditional Chinese medicine composition comprises rabdosia rubescens, and the preferred weight part of the rabdosia rubescens is 45 parts. The source of the rabdosia rubescens is not specially limited, and the rabdosia rubescens can be prepared by utilizing the conventional traditional Chinese medicine raw materials in the field. The rabdosia rubescens of the invention can exert the effect of clearing heat and removing toxicity.

The traditional Chinese medicine composition comprises asiatic centella, and the parts by weight of the asiatic centella are preferably 27.5 parts. The invention has no special limitation on the source of the centella asiatica and can be prepared by utilizing the conventional traditional Chinese medicine raw materials in the field. The snowmobile herb can play a role in clearing heat and removing toxicity.

The traditional Chinese medicine composition comprises oldenlandia diffusa, and the preferred weight portion of oldenlandia diffusa is 12.5 portions. The source of the oldenlandia diffusa is not particularly limited, and the oldenlandia diffusa can be prepared by utilizing the conventional traditional Chinese medicine raw materials in the field. The oldenlandia diffusa can play a role in clearing heat and removing toxicity.

The traditional Chinese medicine composition comprises 3.75 parts by weight of liquorice. The source of the liquorice is not particularly limited, and the liquorice is prepared by utilizing the conventional traditional Chinese medicine raw materials in the field. The liquorice can play a role in harmonizing the effects of the other drugs.

When the traditional Chinese medicine composition is used, the traditional Chinese medicine composition is preferably decocted with water for oral administration, 1 dose is taken every day for 1 time, one month is a treatment course, and the weight of each dose is 170-180 g.

The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: respectively crushing the raw materials and mixing according to the parts by weight; the particle size after the crushing is 80 meshes. The present invention preferably further comprises a package after mixing, said package preferably comprising: filling each dose of the traditional Chinese medicine composition into a disposable non-woven fabric filter bag according to the dose, sealing, then filling the filter bag into an aluminum foil bag, carrying out heat sealing, and pasting a medicine label on the aluminum foil bag.

The following examples are provided to describe the Chinese medicinal composition for adjuvant therapy of small cell lung cancer in detail, but they should not be construed as limiting the scope of the present invention.