阅读说明：本技术 一种方便采样的凝血功能测试盒 (Blood coagulation function test box of convenient sampling ) 是由 陈曙 高满达 吴向宇 李秋宏 于 2019-10-22 设计创作，主要内容包括：本发明涉及一种方便采样的凝血功能测试盒,包括测试盒本体、依次连通于测试盒本体上的进样端口、控温部、测试腔、疏水过滤器以及真空端口,测试腔与疏水过滤器之间设有观测口,观测口外相对观测口的位置设有监控组件,控温部包括加热管路以及加热组件,加热管路端部设有温度传感器,受试者的血液样品从进样端口经控温部进入测试腔,通过监控组件对观测口的监测可有效判断测试腔内是否充满待检测的血液样品,温度传感器的设置可对进入测试腔前的血液样品的进行监测,使工作人员根据凝血检测需求调整血液样品的温度,从而更加准确的评估来自受试者血液样品的凝血参数,提高了检测效率,为医疗工作者做出及时准确的医疗决定提供了有效保障。(The invention relates to a blood coagulation function test box convenient for sampling, which comprises a test box body, a sample inlet port, a temperature control part, a test cavity, a hydrophobic filter and a vacuum port which are sequentially communicated with the test box body, wherein an observation port is arranged between the test cavity and the hydrophobic filter, a monitoring component is arranged at the position outside the observation port and opposite to the observation port, the temperature control part comprises a heating pipeline and a heating component, the end part of the heating pipeline is provided with a temperature sensor, a blood sample of a subject enters the test cavity from the sample inlet port through the temperature control part, whether the test cavity is filled with the blood sample to be detected can be effectively judged by monitoring the observation port through the monitoring component, the arrangement of the temperature sensor can monitor the blood sample before entering the test cavity, so that a worker can adjust the temperature of the blood sample according to the blood coagulation detection requirement, thereby more accurately evaluating the coagulation parameters of, the detection efficiency is improved, and effective guarantee is provided for medical workers to make timely and accurate medical decisions.)

1. A blood coagulation function test box convenient for sampling is characterized by comprising a test box body, a sample inlet port, a vacuum port, a test cavity, a hydrophobic filter and a temperature control part, the sample inlet port, the vacuum port, the test cavity and the hydrophobic filter are respectively arranged on the test box body, the test box body is internally provided with a temperature control part, the sample inlet port is communicated with the temperature control part, the temperature control part is communicated with the test cavity, the test cavity is communicated with a hydrophobic filter, the hydrophobic filter is communicated with a vacuum port, an observation port is arranged between the test cavity and the hydrophobic filter, a monitoring component is arranged outside the observation port and opposite to the observation port, the temperature control part comprises a heating pipeline and a heating component, heating pipeline one end is passed through into appearance pipe and sample port intercommunication, and the heating pipeline other end passes through pipette and test chamber intercommunication, the heating pipeline is close to pipette one end and is equipped with temperature sensor.

2. The blood coagulation function test kit convenient for sampling according to claim 1, wherein the temperature control part is communicated with a plurality of test chambers, the test chambers are arranged in parallel, and each test chamber is communicated with the hydrophobic filter.

3. The clot functional test kit that facilitates sampling of claim 2, wherein the monitoring assembly comprises a laser emitter and a light sensing unit.

4. The blood coagulation function testing box convenient for sampling according to claim 3, wherein the temperature control part is isolated in the testing box body by a heat insulation layer.

5. The blood coagulation function testing box convenient for sampling according to claim 4, wherein the heating component is a heating wire, the heating wire is coiled on the outer wall of the heating pipeline, one end of the heating wire is electrically connected with a temperature control port, and the temperature control port is arranged on the testing box body.

6. The blood coagulation function test box of claim 4, wherein the heating component comprises a filler wrapped outside the heating pipeline and a heating pipe arranged in the filler, the heating pipe is electrically connected with a temperature control port, and the temperature control port is arranged on the test box body.

7. The coagulation function test box convenient for sampling according to claim 5 or 6, wherein the test box body is connected with an analysis detection part, the analysis detection part comprises a control unit arranged in the analysis detection part, a sampling port connected with a vacuum port, a sampling pump connected with the sampling port, a fixing ring connected with the test cavity, a sound wave generator arranged opposite to the test cavity and a heater electrically connected with the temperature control part, the control unit is respectively electrically connected with the sampling pump, the sound wave generator, the heater, the photosensitive unit and the temperature sensor, and the heater is electrically connected with the temperature control part through the temperature control port.

Technical Field

The invention relates to the field of clinical medical examination, in particular to a blood coagulation function test box convenient for sampling.

Background

The blood coagulation function is an important function of blood, a patient suffering from heart diseases needs to be subjected to blood coagulation tests regularly to determine parameters such as blood coagulation time of the patient, the parameters are used as important parameters for evaluating the condition of heavy bleeding in an operation during the operation, after the operation, the patient also needs to take anticoagulants such as heparin or warfarin orally to prevent pulmonary embolism thrombosis or other excessive blood coagulation problems, besides, the blood coagulation time of the patient with hyperlipidemia and hyperglycemia needs to be monitored regularly to prevent thrombosis, and therefore, the detection and evaluation of the blood coagulation function are clinically significant in medicine.

The coagulation process is a series of processes in which coagulation factors are sequentially activated by enzymolysis (known as intrinsic and extrinsic coagulation pathways in academia), and prothrombin is activated into thrombin, which promotes fibrinogen to form a solid thrombus clot. Whether the test box that traditional blood coagulation function detection device used can't effective monitoring test intracavity is full of blood sample and whether blood sample state reaches the testing standard to lead to the error of different degrees to appear in the testing result, and then influence medical practitioner and make timely accurate medical decision for the testee.

Disclosure of Invention

The invention aims to solve the technical problem of overcoming the defects in the prior art and provides a blood coagulation function test box convenient for sampling.

The invention is realized by the following technical scheme:

a blood coagulation function test box convenient for sampling is characterized by comprising a test box body, a sample inlet port, a vacuum port, a test cavity, a hydrophobic filter and a temperature control part, the sample inlet port, the vacuum port, the test cavity and the hydrophobic filter are respectively arranged on the test box body, the test box body is internally provided with a temperature control part, the sample inlet port is communicated with the temperature control part, the temperature control part is communicated with the test cavity, the test cavity is communicated with a hydrophobic filter, the hydrophobic filter is communicated with a vacuum port, an observation port is arranged between the test cavity and the hydrophobic filter, a monitoring component is arranged outside the observation port and opposite to the observation port, the temperature control part comprises a heating pipeline and a heating component, heating pipeline one end is passed through into appearance pipe and sample port intercommunication, and the heating pipeline other end passes through pipette and test chamber intercommunication, the heating pipeline is close to pipette one end and is equipped with temperature sensor.

According to the above technical scheme, preferably, the temperature control portion is communicated with a plurality of test chambers, each of the test chambers is arranged in parallel, and each of the test chambers is communicated with the hydrophobic filter.

According to the above technical solution, preferably, the monitoring assembly includes a laser emitter and a photosensitive unit.

According to the above technical solution, preferably, the temperature control portion is isolated in the test box body by a thermal insulation layer.

According to the above technical scheme, preferably, the heating assembly is an electric heating wire, the electric heating wire is coiled on the outer wall of the heating pipeline, one end of the electric heating wire is electrically connected with a temperature control port, and the temperature control port is arranged on the test box body.

According to the above technical scheme, preferably, heating element is including wrapping up the stopping outside heating pipeline and locating the heating pipe in the stopping, heating pipe electricity is connected with accuse temperature port, accuse temperature port is located on the test box body.

According to the above technical scheme, preferably, the test cassette body is connected with analysis detection portion, analysis detection portion is including locating the control unit in the analysis detection portion, the sampling port that links to each other with the vacuum port, the sampling pump that links to each other with the sampling port, the solid fixed ring that links to each other with the test chamber, the acoustic wave generator that sets up relative test chamber position and with the heater that the accuse temperature portion is electric is connected, the control unit is connected with sampling pump, acoustic wave generator, heater, sensitization unit and temperature sensor electricity respectively, the heater passes through the accuse temperature port with accuse temperature portion and is connected electrically.

The invention has the beneficial effects that:

the blood sample of testee gets into the test chamber from the introduction port through accuse temperature portion, can effectively judge through the monitoring subassembly to the monitoring of observation mouth whether be full of the blood sample that waits to detect in the test chamber, in addition, temperature sensor's setting can be to getting into the monitoring of the blood sample before the test chamber, make the staff through adjusting heating element, the temperature according to blood coagulation detection demand adjustment blood sample, thereby the coagulation parameter that more accurate aassessment came from the testee blood sample, the testing result is reliable, it is accurate, the detection efficiency is improved, make timely accurate medical decision provide effective guarantee for medical staff.

Drawings

Fig. 1 is a schematic front view of a heating element of the present invention.

FIG. 2 is a schematic view of the connection setup during the coagulation parameter testing process of the present invention.

Fig. 3 is a schematic front view of the heating element of the present invention as a heating tube.

In the figure: 1. a test box body; 2. a vacuum port; 3. a sample inlet port; 4. a hydrophobic filter; 5. an observation port; 6. a sample inlet pipe; 7. a test chamber; 8. a thermal insulation layer; 9. a pipette; 10. a temperature sensor; 11. an electric heating wire; 12. a temperature control port; 13. heating the pipeline; 14. a temperature control part; 15. a laser transmitter; 16. a light sensing unit; 17. an acoustic wave generator; 18. a control unit; 19. a heater; 20. heating the tube.

Detailed Description

In order to make the technical solutions of the present invention better understood by those skilled in the art, the present invention will be further described in detail with reference to the accompanying drawings and preferred embodiments.

As shown in the figure, the invention comprises a test box body 1, a sample inlet port 3, a vacuum port 2, a test cavity 7, a hydrophobic filter 4 and a temperature control part 14, wherein the sample inlet port 3, the vacuum port 2, the test cavity 7 and the hydrophobic filter 4 are respectively arranged on the test box body 1, the temperature control part 14 is arranged in the test box body 1, the sample inlet port 3 is communicated with the temperature control part 14, the temperature control part 14 is communicated with the test cavity 7, the test cavity 7 is communicated with the hydrophobic filter 4, the hydrophobic filter 4 is communicated with the vacuum port 2, the arrangement of the hydrophobic filter 4 can discharge the gas in the test box body 1 outwards and effectively obstruct the blood sample, prevent the liquid from moving out of the test box body 1 in the sampling process, an observation port 5 is arranged between the test cavity 7 and the hydrophobic filter 4, and a monitoring component is arranged outside the observation port 5 and in the position corresponding to the observation port 5, accuse temperature portion 14 includes heating pipeline 13 and heating element, heating pipeline 13 one end is passed through into appearance pipe 6 and is linked together with introduction port 3, and the heating pipeline 13 other end passes through pipette 9 and test chamber 7 intercommunication, heating pipeline 13 is close to pipette 9 one end and is equipped with temperature sensor 10. The blood sample of testee gets into test chamber 7 from introduction port 3 through accuse temperature portion 14, can effectively judge through the monitoring subassembly to the monitoring of observing port 5 whether be full of the blood sample that waits to detect in the test chamber 7, in addition, temperature sensor 10's setting can be to getting into the blood sample before test chamber 7 monitoring, make the staff through adjusting the heating element, the temperature of blood sample is adjusted according to the blood coagulation detection demand, thereby the blood coagulation parameter that more accurate aassessment came from the testee blood sample, the testing result is reliable, it is accurate, the detection efficiency is improved, make timely accurate medical decision provide effective guarantee for medical staff.

According to the above embodiment, preferably, the temperature control portion 14 is communicated with a plurality of test cavities 7, each test cavity 7 is arranged in parallel, each test cavity 7 is communicated with the hydrophobic filter 4, different types of reagents including abciximab, cytochalasin D, kaolin, diatomite, thrombin, adenosine diphosphate and the like are placed in each test cavity 7 according to test requirements, and interact with a blood sample in each test cavity 7 to test and analyze different coagulation parameters, so that the detection efficiency is improved.

According to the above embodiment, preferably, the monitoring assembly includes the laser emitter 15 and the photosensitive unit 16, and two light beams with different wavelengths are emitted by the laser generator, irradiated to the observation port 5 and reflected to the photosensitive unit 16, when a blood sample passes through the observation port 5 in the test box body 1, a dual-beam method is used in this case, so that two light sources with different wavelengths are reflected from the observation port 5, and the blood has a deep red color, and can be distinguished by comparing the red wavelength reflection with the reflection of another color, so as to determine whether the test chamber 7 is filled with the blood sample.

According to the above embodiment, preferably, the temperature control portion 14 is isolated from the test box body 1 by the thermal insulation layer 8, so as to prevent the heat of the temperature control portion 14 from affecting the normal operation of other components in the test box body 1.

According to the above embodiment, preferably, the heating assembly is the heating wire 11, the heating wire 11 is coiled on the outer wall of the heating pipeline 13, one end of the heating wire 11 is electrically connected with the temperature control port 12, and the temperature control port 12 is arranged on the test box body 1, so that the temperature of the blood sample at the outlet position of the heating pipeline 13 meets the temperature requirement of coagulation detection, thereby ensuring that the blood sample is fully mixed with the reagent in the test cavity 7, and effectively reducing the detection error of coagulation parameters.

According to the above embodiment, preferably, the heating assembly includes the stopping wrapped up outside the heating pipeline 13 and locates the heating pipe 20 in the stopping, the heating pipe 20 electricity is connected with accuse temperature port 12, accuse temperature port 12 is located on the test cassette body 1, physiologically, the coagulation process highly depends on its temperature that takes place, and the filling material is the heat transfer material in this example, can be with the heat transfer of heating pipe 20 to the blood sample in the heating pipeline 13 in, accelerate its and test chamber 7 reagent's interact, make it reach blood coagulation parameter detection requirement.

According to the above embodiment, preferably, the testing cassette body 1 is connected to an analysis and detection portion, the analysis and detection portion includes a control unit 18 disposed in the analysis and detection portion, a sampling port connected to the vacuum port 2, a sampling pump connected to the sampling port, a fixing ring connected to the testing chamber 7, an acoustic wave generator 17 disposed opposite to the testing chamber 7, and a heater 19 electrically connected to the temperature control portion 14, in this example, the testing cassette body 1 is fixedly connected to a positioning substrate at a position opposite to each testing chamber 7, a coupling agent layer is disposed outside the positioning substrate, the positioning substrate is clamped in the fixing ring during the process of mounting the testing cassette body 1 in the analysis and detection portion, the positioning substrate is permeable to ultrasonic waves, the ultrasonic waves output by the acoustic wave generator 17 are transmitted and focused into the testing chamber 7 through the positioning substrate and the coupling agent layer, and are reflected by the acoustic wave generator 17, and the detection terminal determines various blood coagulation parameters according to the sent and received sound wave data. One embodiment of the sound generator 17 in this case is an ultrasonic transducer, which outputs ultrasonic pulses that are transmitted to the blood sample in the test chamber 7 at short intervals Δ T (Δ T is in the order of microseconds) and receives information of the pulses reflected back from the test chamber 7, from which information of their different attenuations in the blood sample, the coagulation parameters of the blood sample from the subject are evaluated by calculation by the detection terminal. The control unit 18 is connected to the ultrasonic transducer for receiving various data of the ultrasonic transducer and transmitting the data to the background detection terminal for calculation and analysis. The control unit 18 is respectively electrically connected with the sampling pump, the sound wave generator 17, the heater 19, the photosensitive unit 16 and the temperature sensor 10, the heater 19 is electrically connected with the temperature control part 14 through the temperature control port 12, the temperature sensor 10 is connected with the control unit 18 through RS485, the control unit 18 controls the output power of the heater 19 according to the temperature of the blood sample, so that the blood coagulation parameter detection requirement is met, the control unit 18 is electrically connected with the photosensitive unit 16 and used for judging whether the test cavity 7 is filled with the sample blood or not, and the sampling pump can be triggered timely according to the condition in the test cavity 7.

The blood sample of testee gets into test chamber 7 from introduction port 3 through accuse temperature portion 14, can effectively judge through the monitoring subassembly to the monitoring of observing port 5 whether be full of the blood sample that waits to detect in the test chamber 7, in addition, temperature sensor 10's setting can be to getting into the blood sample before test chamber 7 monitoring, make the staff through adjusting the heating element, the temperature of blood sample is adjusted according to the blood coagulation detection demand, thereby the blood coagulation parameter that more accurate aassessment came from the testee blood sample, the testing result is reliable, it is accurate, the detection efficiency is improved, make timely accurate medical decision provide effective guarantee for medical staff.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.