阅读说明：本技术 Nadh和/或nmn在制备脑功能恢复的药物、保健品中的应用 (Application of the NADH and/or NMN in the drug that preparation brain function is restored, health care product ) 是由 *** 于 2019-08-20 设计创作，主要内容包括：本发明涉及一种组合物及其制备脑功能恢复药物和/或保健品中的应用。本发明提供了一种组合物,包括：烟酰胺腺嘌呤二核苷酸和/或烟酰胺腺嘌呤单核苷酸、人参、三七、银杏叶、葛根、灯盏花、红景天。本发明提供的技术方案中,三七、人参、银杏叶、葛根、灯盏花、红景天等可以增强NADH和/或NMN对小鼠神经功能的改善,下调脑组织的氧化应激水平,减少脑组织的细胞凋亡。进一步地,经动物实验测定可得,给药后,受试动物脑功能改善较好,记忆力和空间识别能力都有显著提高。(The present invention relates to a kind of compositions and its preparation brain function to restore the application in drug and/or health care product.The present invention provides a kind of compositions, comprising: nicotinamide adenine dinucleotide and/or nicotinamide adenine mononucleotide, ginseng, Radix Notoginseng, ginkgo leaf, pueraria lobata, fleabane flower, root of kirilow rhodiola.In technical solution provided by the invention, the improvement of NADH and/or NMN to mouse Nerve function is can be enhanced in Radix Notoginseng, ginseng, ginkgo leaf, pueraria lobata, fleabane flower, root of kirilow rhodiola etc., lowers the oxidative stress of brain tissue, reduces the Apoptosis of brain tissue.Further, it can be obtained through zoopery measurement, after administration, animal subject improving brain function is preferable, and memory and space identity ability are all significantly increased.)

1. a kind of composition, which is characterized in that the raw material of the composition includes: nicotinamide adenine dinucleotide and/or cigarette Amide adenine mononucleotide, ginseng, Radix Notoginseng, ginkgo leaf, pueraria lobata, fleabane flower, root of kirilow rhodiola.

2. composition according to claim 1, which is characterized in that the raw material of the composition includes: nicotinamide adenine Dinucleotides and/or nicotinamide adenine mononucleotide, ginseng extract, Notogineng Extract, ginkgo biloba p.e, pueraria lobata extract Object, erigeron breviscapus extracts and gadol extract.

3. composition according to claim 2, which is characterized in that in terms of mass parts, the raw material of the composition includes: cigarette It is 1~10 part of amide adenine-dinucleotide and/or nicotinamide adenine mononucleotide, 1~10 part of ginseng, 1~10 part of Radix Notoginseng, red 1~10 part of red-spotted stonecrop, 1~10 part of ginkgo leaf, 1~10 part of pueraria lobata and 1~10 part of fleabane flower.

4. composition according to claim 3, which is characterized in that in terms of mass parts, the raw material of the composition includes: cigarette Amide adenine-dinucleotide and/or 5-9 parts of nicotinamide adenine mononucleotide, 5~10 parts of ginseng, 3~7 parts of Radix Notoginseng, red scape It 1~2 part, 4~8 parts of ginkgo leaf, 1~5 part of pueraria lobata and 1~4 part of fleabane flower.

5. composition according to claim 4, which is characterized in that in terms of mass parts, the raw material of the composition includes: cigarette Amide adenine-dinucleotide and/or 6~8 parts of nicotinamide adenine mononucleotide, 6~9 parts of ginseng, 4~6 parts of Radix Notoginseng, red scape It 1~2 part, 5~8 parts of ginkgo leaf, 2~4 parts of pueraria lobata and 1~3 part of fleabane flower.

6. composition according to claim 1, which is characterized in that the mass ratio of the NADH:NMN is 10:1~1: 10。

7. a kind of preparation method of composition described in any one of claims 1-6, which comprises the steps of:

It is raw material by the Radix Notoginseng of proportional quantity, ginseng, ginkgo leaf, pueraria lobata, fleabane flower, root of kirilow rhodiola, adds the 8-12 times of mass concentration measured After ethanol water dipping 20-25 hours of 30-50%, refluxing extraction 3 times, combined extract, centrifugation, filter vacuum 60- 70 DEG C of recycling ethyl alcohol, 50-60 DEG C is concentrated to get extracting solution I；

In extracting solution I, the nicotinamide adenine dinucleotide and/or nicotinamide adenine mononucleotide of proportional quantity, In will be added Mixing is sufficiently stirred at room temperature, after being warming up to 50-70 DEG C of vacuum concentration, obtains composition.

8. including the preparation of composition described in any one of claims 1-6, which is characterized in that

The composition is added customary adjuvant and oral preparation and Parenteral administration preparation, the routine is made according to common process Auxiliary material includes conventional pharmaceutical adjuvants or general food auxiliary material.

9. preparation according to claim 8, which is characterized in that do not contain lactose in the preparation.

10. composition described in any one of claims 1-6 answering in the drug and/or health care product that preparation brain function is restored With.

Technical field

The invention belongs to field of Chinese medicinal composition more particularly to a kind of niacinamide-containing adenine-dinucleotides and/or nicotinoyl The application in drug and/or health care product that the composition and its preparation brain function of amine adenine mononucleotide restore.

Background technique

Worldwide aging of population increases the generation of brain function decline, easily causes amnesia, anxiety disorder, desire Reduction, reduction of sleep quality of prestige etc., serious or even can generate memory disorders and senile dementia, this makes impacted The life of people is by huge damaging influence.But the origin cause of formation that brain function lowers is extremely complex, it is most of at present to study only needle To specific cerebral injury disease, the drug studied is larger to human body damage, and side effect is more, and for because of aging or body The drug and diet product of daily maintenence, improvement and the treatment of the decline of brain function caused by other reasons, do not have substantially.

Summary of the invention

In view of this, the present invention provides a kind of niacinamide-containing adenine-dinucleotide (NADH) and/or nicotinoyl amine gland are fast The composition of purine mononucleotide (NMN) and its application in the drug and/or health care product that preparation brain function is restored, for improving Big brain health and cerebral function, including but not limited to cognition, memory, intelligence, motivation, attention, concentration, learning ability and more Good communication and mitigation disease relevant to cognition and memory disorders and similar disease.

Drug and/or health care the present invention provides a kind of composition containing NADH/NMN and its in preparation brain function recovery Application in product, for preventing, controlling and treat and cerebral disorders/obstacle comprising but it is not limited to senile dementia, multiple stalk Fill in dementia, Dyslexia, aphasia, organic brain syndrome, myasthenia gravis, vascular dementia, mild cognitive function Obstacle (MCI), Lewy body dementia, Wei Nike-korsakoff's neurosis, Alzheimer's disease, Parkinson's disease, note Defect of anticipating mostly dynamic obstacle (ADHD), hypoxemia, anoxic, cerebrovascular insufficiency, epilepsy, myoclonia and low cholinergic nerve function barrier Hinder, slows down memory loss, function forfeiture and treatment memory disorders disease, neurodegenerative disease, and control blood in the brain Pressure and blood circulation.

The present invention provides a kind of composition, the raw material of the composition include: NADH and/or NMN, ginseng, root of kirilow rhodiola, Radix Notoginseng, ginkgo leaf, pueraria lobata and fleabane flower.

Preferably, the raw material of the composition includes: NADH and/or NMN, ginseng extract, gadol extract, Radix Notoginseng Extract, ginkgo biloba p.e, kudzu root extract and erigeron breviscapus extracts.

Preferably, in terms of mass parts, the raw material of the composition include: NADH and/or 1~10 part of NMN, ginseng 1~ 10 parts, 1~10 part of Radix Notoginseng, 1~10 part of root of kirilow rhodiola, 1~10 part of ginkgo leaf, 1~10 part of pueraria lobata and 1~10 part of fleabane flower.

Preferably, in terms of mass parts, the raw material of the composition includes: NADH and/or 5~9 parts of NMN, ginseng 5~10 Part, 3~7 parts of Radix Notoginseng, 1~2 part of root of kirilow rhodiola, 4~8 parts of ginkgo leaf, 1~5 part of pueraria lobata and 1~4 part of fleabane flower.

Preferably, in terms of mass parts, the raw material of the composition includes: NADH and/or 6~8 parts of NMN, ginseng 6~9 Part, 4~6 parts of Radix Notoginseng, 1~2 part of root of kirilow rhodiola, 5~8 parts of ginkgo leaf, 2~4 parts of pueraria lobata and 1~3 part of fleabane flower.

Preferably, in terms of mass parts, the raw material of the composition includes: NADH and/or 7 parts of NMN, 7 parts of ginseng, Radix Notoginseng 5 Part, 1 part of root of kirilow rhodiola, 7 parts of ginkgo leaf, 3 parts of pueraria lobata and 2 parts of fleabane flower.

Preferably, the mass ratio of the NADH:NMN is 10:1~1:10.

The present invention also provides the preparation methods of above-mentioned composition, include the following steps:

It is raw material by the Radix Notoginseng of proportional quantity, ginseng, ginkgo leaf, pueraria lobata, fleabane flower, root of kirilow rhodiola, adds the 8-12 times of quality measured After the ethanol water that concentration is 30-50% impregnates 20-25 hours, refluxing extraction 3 times, combined extract, centrifugation, filter vacuum 60-70 DEG C of recycling ethyl alcohol, 50-60 DEG C is concentrated to get extracting solution I；

In extracting solution I, the nicotinamide adenine dinucleotide and/or nicotinamide adenine monokaryon glycosides of proportional quantity will be added Mixing is sufficiently stirred in acid at room temperature, after being warming up to 50-70 DEG C of vacuum concentration, obtains composition.

The present invention also provides a kind of preparations including composition described in any of the above one, comprising:

The composition is added customary adjuvant and oral preparation and Parenteral administration preparation is made according to common process.It is described Customary adjuvant includes conventional pharmaceutical adjuvants or general food auxiliary material.

Preferably, lactose is not contained in the preparation.

Preferably, conventional pharmaceutical adjuvants include but is not limited to:

Acceptable excipient, auxiliary material, carrier and the diluent pharmaceutically or on food include but is not limited to glucose, Fructose, sucrose, maltose, yellow starch gum, white dextrin, silica, microcrystalline cellulose powder, calcium stearate, magnesium stearate, sorb Sugar alcohol, stevioside, corn syrup, citric acid, tartaric acid, malic acid, succinic acid, lactic acid, L-AA, dl- alpha-tocopherol, Glycerol, propylene glycol, fatty acid glyceride, polyglyceryl fatty acid ester, sucrose fatty ester, sorbitan carboxylic esters, propylene glycol Aliphatic ester, Arabic gum, carragheen, casein, gelatin, pectin, agar, niacinamide, calcium pantothenate, calcium salt, pigment, essence, It is preservative, distilled water, salt water, dextrose hydrate solution, ethyl alcohol, propylene glycol and polyethylene glycol, various animal oil and vegetable oil, white Soft paraffin, paraffin and wax.

The present invention also provides a kind of drugs restored including composition described in any of the above one in preparation brain function And/or the application in health care product.

In conclusion the raw material of the composition includes: NADH and/or NMN, people the present invention provides a kind of composition Ginseng, Radix Notoginseng, ginkgo leaf, pueraria lobata, fleabane flower, root of kirilow rhodiola.It is extensive in preparation brain function that the present invention also provides a kind of above-mentioned compositions Application in multiple drug and/or health care product.In technical solution provided by the invention, Radix Notoginseng, ginseng, ginkgo leaf, pueraria lobata, lamp The improvement of NADH and/or NMN to mouse Nerve function can be enhanced in small cup flower, root of kirilow rhodiola etc., lowers the oxidative stress water of brain tissue It is flat, reduce the Apoptosis of brain tissue.Further, it can be obtained through zoopery measurement, after administration, animal subject brain function changes Kind preferable, memory and space identity ability are all significantly increased.

Specific embodiment

The embodiment of the invention provides a kind of composition and its in the drug and/or health care product that preparation brain function is restored Using for solving in the prior art, brain function is restored drug and/or health care product there is therapeutic effect difference and deposited to human body In the technological deficiency of adverse reaction.

The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common Technical staff's every other embodiment obtained without making creative work belongs to the model that the present invention protects It encloses.

In order to which the present invention is described in more detail, to a kind of composition provided by the invention and its prepared below with reference to embodiment The application in drug and/or health care product that brain function is restored, is specifically described.