阅读说明：本技术 可缩短益生菌料液冷冻干燥时间的规模化干燥装置与方法 (The scale drying device and method of probiotics feed liquid sublimation drying can be shortened ) 是由 李占勇 张帆 马晓宇 徐庆 于 2019-07-24 设计创作，主要内容包括：本发明涉及一种可缩短益生菌料液冷冻干燥时间的规模化干燥装置,其冷冻系统包括循环制冷机、冷凝器、离心风机；喷雾系统包括二流体雾化器、蠕动泵和空压机；除尘系统包括旋风分离器、布袋除尘器；真空系统包括干燥室、旋片式真空泵、冷阱,旋片式真空泵通过冷阱连接至干燥室,制冷液管路的第二支路连接至冷阱,冷阱至干燥室的真空管路上安装的真空规管；加热系统为安装于干燥室底部的电加热器。本发明的规模化干燥装置及方法,利用低温低湿气体将雾化的液滴在下落过程中冻结,冻结过程无需冷冻液体即可实现快速冻结,整个喷雾、冷冻、干燥过程在同一设备内完成,提高了设备集成化程度。(The present invention relates to the scale drying devices that one kind can shorten probiotics feed liquid sublimation drying, and refrigeration system includes circulating refrigerator, condenser, centrifugal blower；Spraying system includes twin fluid atomization device, peristaltic pump and air compressor machine；Dust pelletizing system includes cyclone separator, bag filter；Vacuum system includes hothouse, rotary-vane vaccum pump, cold-trap, and rotary-vane vaccum pump is connected to hothouse by cold-trap, and the second branch for the liquid pipeline that freezes is connected to cold-trap, the vacuum gauge installed on the vacuum line of cold-trap to hothouse；Heating system is the electric heater for being installed on hothouse bottom.Scale drying device of the invention and method; the drop of atomization is freezed in dropping process using low temperature and low humidity gas; quick freezing can be realized without frozen liq in freezing process, and entire spraying, freezing, drying process are completed in the same device, improves integration of equipments degree.)

1. one kind can effectively shorten the large-scale production drying device of probiotics feed liquid drying time, it is characterised in that: the equipment It is mainly made of refrigeration system, spraying system, dust pelletizing system, vacuum system, heating system, electric control system, refrigeration system Including circulating refrigerator, condenser, centrifugal blower, the refrigerating fluid of the circulating refrigerator passes through the first branch of refrigeration liquid pipeline It is connected to condenser, the hothouse is connected to centrifugal blower by cold wind circulation line；Spraying system includes twin fluid atomization Device, peristaltic pump and air compressor machine, the twin fluid atomization device side wall are equipped with air inlet, are connected with air compressor machine interface, twin fluid atomization Device side wall is equipped with inlet, is fed by peristaltic pump；Dust pelletizing system includes cyclone separator, bag filter, the whirlwind point Hothouse is connected to by cold wind circulation line from device entrance, outlet is connect by pipeline with bag filter, and the cloth bag removes Dirt device is connected to centrifugal blower by circulation line；Vacuum system includes hothouse, rotary-vane vaccum pump, cold-trap, the blade Formula vacuum pump is connected to hothouse by cold-trap, and the second branch of the refrigeration liquid pipeline is connected to cold-trap, cold-trap to hothouse Vacuum line on the vacuum gauge installed；Heating system is the electric heater for being installed on hothouse bottom；Electric control system Including programmable controller, frequency converter, power supply, system control panel, the vacuum meter etc. being installed in control cabinet.

2. the large-scale production drying device according to claim 1 for effectively shortening probiotics feed liquid drying time, Be characterized in that: outside the hothouse, cold-trap, condenser external be all made of thermal insulation material package, reduce circulating refrigerator load.

3. the large-scale production drying device according to claim 1 for effectively shortening probiotics feed liquid drying time, It is characterized in that: being equipped with circulation cold air import at the hothouse upper center.

4. the large-scale production drying device according to claim 1 for effectively shortening probiotics feed liquid drying time, Be characterized in that: the twin fluid atomization device is located at the top of hothouse, and atomized drop and circulation cold air are downbeam, can make drop It realizes and freezes in dropping process, and be collected in hothouse bottom and be freeze-dried.

5. the large-scale production drying device according to claim 1 for effectively shortening probiotics feed liquid drying time, Be characterized in that: the cold wind circulation line bottom is provided with water outlet, and outside is wrapped up using thermal insulation material.

6. the large-scale production drying device according to claim 1 for effectively shortening probiotics feed liquid drying time, Be characterized in that: the cold-trap, condenser are provided with water outlet, refrigerating fluid discharge outlet.

7. the large-scale production drying device according to claim 1 for effectively shortening probiotics feed liquid drying time, Be characterized in that: the electric control system further includes the temperature sensor being installed on cold wind circulation line, and is installed on sky The pressure gauge of press gas vent.

8. the large-scale production drying device according to claim 1 for effectively shortening probiotics feed liquid drying time, Be characterized in that: the hothouse is stainless steel material.

9. it is a kind of using any one of claim 1-8 can effectively shorten probiotics feed liquid drying time large-scale production it is dry The drying means of dry device, characterized by the following steps:

1) hothouse is pre-chilled: closing the second bye-pass of refrigeration liquid pipeline and the valve of all discharge outlet, opens refrigeration liquid pipeline The valve of first bye-pass；Vacuum line valve is closed, cold wind circulation line is isolated with vacuum line, sets circularly cooling temperature Degree is -80 DEG C, opens circulating refrigerator, condenser temperature is made to reach -40 DEG C or so；Open hothouse air inlet and air outlet valve Door, hothouse is connected to dust pelletizing system, refrigeration system；Centrifugal blower is opened, cold wind wind speed 2-5m/s is set, makes dry room temperature Degree drops to -40 DEG C to -50 DEG C or so；

2) material is atomized: after pre-cooling, atomizer being placed into atomizer mounting hole and is fixed；Set atomizing pressure 0.2- 0.3 MPa, peristaltic pump charging rate 10-40ml/min open peristaltic pump charging, peristaltic pump are closed after charging, take out mist Change device, fixing port is sealed；

3) it vacuumizes: opening the valve of the second bye-pass of refrigeration liquid pipeline, condenser temperature is made to be down to -80 DEG C or so；Close system The valve of the first bye-pass of cooling liquid tube road；Vacuum line valve is opened after closing blower；Close hothouse air inlet and air outlet Valve is isolated by hothouse with dust pelletizing system, refrigeration system；It opens vacuum pump and vacuumize process is carried out to hothouse inside；

4) dry materials: setting heating temperature is 35-45 DEG C, opens electric heater, and the vacuum degree recorded in the drying process becomes Change, stops drying when drying chamber pressure is lower than 4.4 Pa；

5) drying terminates: drying chamber pressure stops drying after reaching requirement, is first shut off circulating refrigerator, closes electric heater, Vacuum pump is closed, vacuum line discharge outlet is opened；Hothouse is opened when drying chamber pressure, which is, becomes normal pressure, takes out material, is done Constipation beam.

Technical field

The invention belongs to Vacuum Freezing & Drying Technology fields, and in particular to it is dry that one kind can effectively shorten probiotics feed liquid The large-scale production drying device and method of time is particularly suitable for drying and the powder of the heat sensitive materials such as liquid food, drug The preparation of plastochondria.

Background technique

Atomizing freeze drying is spraying and Freeze Drying Technique combination, and the reduction of atomized drop size, which is conducive to improve, to rise Magnificent rate keeps subsequent drying more uniform, in the side such as preservation of product structure, quality, volatile matter and bioactive compound Face is superior to other dry technologies, can produce the fast powder of good fluidity, large specific surface area, solution rate.Spray chilling is dry Dry is usually to be transferred to frozen particle after completing spray chilling in the pallet in freeze drier, bottle or fixed bed and carry out Freeze-drying.But since device integration is poor, cause drying efficiency low and other technologies problem, such as atomizing freeze drying Technique is discontinuous or technique amplification is difficult.In addition, the inconvenience of cryogenic liquid processing is also required to solve.The present invention is a kind of integration Atomizing freeze drying device, technique is continuous and without handling cryogenic liquid, can effectively improve rate of drying, eats to high added value The production of product, medicine, biological products is of great significance.

Patent CN 108709369A proposes a kind of ultrasonic atomization freeze drying plant, and the device is mainly by ultrasonic wave Composition, the inventions such as spraying device, ultrasonic wave controller, freeze drying plant, intelligent conveyer system are directly entered after spraying Cold medium is freezed, but is needed conveyer system that ice particle is transferred in freeze drier and be freeze-dried again.

Patent CN 102226629A proposes a kind of Fluidized-Bed Spray Freeze drying device, coupled fluidisation, it is cold spray, Dry separation process, can make to be atomized, freeze, dry, separating and complete in the same device.But the patent need to be passed through liquid nitrogen, The refrigerants such as dry ice, and fluidize needs and be continuously passed through low temperature and low humidity gas, increase the load of heat-exchange system.

Patent CN 201293522 is proposed using the low dew point gas atomizing freeze drying fuel pulverizing plant of low temperature by cabinet, stream Change bed, atomizer, bag filter composition.The device is not needed using the low dew point gas of low temperature with refrigerants such as liquid nitrogen Ice powder directly is made in liquid to be dried.But the device still needs continuously to be passed through dry gas for a long time, causes unit product Energy consumption it is higher.

101713607 A of patent CN proposes a kind of device of pressure-relief spraying freeze drying pulverizing, and the device is mainly by case Body, collet, atomizer, vacuum pump group at.But the patent only designs hothouse, and equipment integrated degree is low.

Therefore, the integrated degree of atomizing freeze drying equipment how is improved, drying time is shortened, reduces energy consumption, is this Field technical staff's urgent problem to be solved.

Summary of the invention

It is an object of the invention to overcome the deficiencies of the prior art and provide one kind can effectively shorten probiotics drying time Integrated large-scale production drying device, is a kind of atomizing freeze drying device, which will be atomized using low temperature and low humidity gas Drop freeze in dropping process, quick freezing can be realized without frozen liq (e.g., liquid nitrogen) in freezing process, entire to spray Mist, freezing, drying process are completed in the same device, improve the integration degree of equipment, effectively shorten the dry of batch production The dry time, advantageously reduce energy consumption.

The process of prebiotic bacterium solution batch machining drying time can be effectively shortened the present invention also provides one kind.

The present invention solves its technical problem and is achieved through the following technical solutions:

A kind of large-scale production drying device for effectively shortening probiotics feed liquid drying time, it is characterised in that: this sets It is standby to be mainly made of refrigeration system, spraying system, dust pelletizing system, vacuum system, heating system, electric control system, freezing system System includes circulating refrigerator, condenser, centrifugal blower, and the refrigerating fluid of the circulating refrigerator passes through first of refrigeration liquid pipeline Road is connected to condenser, and the hothouse is connected to centrifugal blower by cold wind circulation line；Spraying system includes two fluid mists Change device, peristaltic pump and air compressor machine, the twin fluid atomization device side wall is equipped with air inlet, is connected with air compressor machine interface, two fluid mists Change device side wall and be equipped with inlet, is fed by peristaltic pump；Dust pelletizing system includes cyclone separator, bag filter, the whirlwind Separator inlet is connected to hothouse by cold wind circulation line, and outlet is connect by pipeline with bag filter, the cloth bag Deduster is connected to centrifugal blower by circulation line；Vacuum system includes hothouse, rotary-vane vaccum pump, cold-trap, the rotation Chip vacuum pump is connected to hothouse by cold-trap, and the second branch of the refrigeration liquid pipeline is connected to cold-trap, cold-trap to drying The vacuum gauge installed on the vacuum line of room；Heating system is the electric heater for being installed on hothouse bottom；Electrical control system System includes programmable controller, frequency converter, power supply, system control panel, the vacuum meter etc. being installed in control cabinet.

Moreover, outside the hothouse, cold-trap, condenser external be all made of thermal insulation material package, reduce circulating refrigerator Load.

Moreover, being equipped with circulation cold air import at the hothouse upper center.

Moreover, the twin fluid atomization device is located at the top of hothouse, atomized drop and circulation cold air are downbeam, can be made Drop is realized in dropping process to be freezed, and is collected in hothouse bottom and is freeze-dried.

Moreover, the cold wind circulation line bottom is provided with water outlet, outside is wrapped up using thermal insulation material.

Moreover, the cold-trap, condenser are provided with water outlet, refrigerating fluid discharge outlet.

Moreover, the electric control system further includes the temperature sensor being installed on cold wind circulation line, and installation In the pressure gauge of air compressor machine gas vent.

Moreover, the hothouse is stainless steel material.

A kind of drying means for the large-scale production drying device for effectively shortening probiotics feed liquid drying time comprising Following steps:

1) hothouse is pre-chilled: closing the second bye-pass of refrigeration liquid pipeline and the valve of all discharge outlet, opens refrigerating fluid The valve of the first bye-pass of pipeline；Vacuum line valve is closed, cold wind circulation line is isolated with vacuum line, setting circulation system Cold temperature is -80 DEG C, opens circulating refrigerator, condenser temperature is made to reach -40 DEG C or so；Open hothouse air inlet and outlet air Mouth valve, hothouse is connected to dust pelletizing system, refrigeration system；Centrifugal blower is opened, cold wind wind speed 2-5m/s is set, drying is made Room temperature drops to -40 DEG C to -50 DEG C or so；

2) material is atomized: after pre-cooling, atomizer being placed into atomizer mounting hole and is fixed；Set atomizing pressure 0.2-0.3MPa, peristaltic pump charging rate 10-40ml/min open peristaltic pump charging, peristaltic pump are closed after charging, take out Atomizer seals fixing port；

3) it vacuumizes: opening the valve of the second bye-pass of refrigeration liquid pipeline, condenser temperature is made to be down to -80 DEG C or so；It closes Close the valve of refrigeration the first bye-pass of liquid pipeline；Vacuum line valve is opened after closing blower；It closes hothouse air inlet and goes out Air port valve is isolated by hothouse with dust pelletizing system, refrigeration system；Vacuum pump is opened hothouse inside is carried out to vacuumize place Reason；

4) dry materials: setting heating temperature is 35-45 DEG C, opens electric heater, records vacuum in the drying process Degree variation, stops drying when drying chamber pressure is lower than 4.4Pa；

5) drying terminates: drying chamber pressure stops drying after reaching requirement, is first shut off circulating refrigerator, closes electric heating Device closes vacuum pump, opens vacuum line discharge outlet；Hothouse is opened when drying chamber pressure, which is, becomes normal pressure, takes out material, Drying terminates.

The advantages and benefits of the present invention are:

1, the of the invention large-scale production drying device and drying means for effectively shortening probiotics feed liquid drying time, It is not necessarily to refrigerant in whole process, cryogenic gas is provided by circulating refrigerator, by the prebiotic bacterium solution after atomization in cold environment (cold air Body and cold plate face) under the action of quick freezing at ice powder significantly saved cost and energy consumption without handling cryogenic liquid.

2, the of the invention large-scale production drying device and drying means for effectively shortening probiotics feed liquid drying time, It will directly freeze after hothouse is atomization after siccative liquid as micro mist, and it is micro- by vacuum freeze drying process probiotics to be made Powder, whole process are completed in same equipment, and without shifting freezing micro mist, equipment integrated degree is high.

3, the of the invention large-scale production drying device and drying means for effectively shortening probiotics feed liquid drying time, Atomized drop and circulation cold air are downbeam, and atomized drop can be made to come into full contact in dropping process with dry cold air, real Now freeze rapidly, equipment has high freezing efficiency, and single batch treating capacity is big.

4, the of the invention large-scale production drying device and drying means for effectively shortening probiotics feed liquid drying time, Examining electric control system further includes that temperature detecting resistance is provided in hothouse, and temperature of charge is detected by temperature sensor, material Heating temperature is adjusted by control cabinet, makes the control of feed liquid drying temperature in the reasonable scope, guarantees product quality, very suitable For the drying of the heat sensitive materials such as probiotics, food, while drying time is short.

5, the of the invention large-scale production drying device and drying means for effectively shortening probiotics feed liquid drying time, Using the principle of freeze-drying, the feed liquid surface area after atomization is very big, and compared with original vacuum freeze drying, spray chilling is dry It is dry to shorten drying time, and the product cut size after drying uniformly, regular shape.

6, the of the invention large-scale production drying device and drying means for effectively shortening probiotics feed liquid drying time, The liquid pipeline that freezes is wrapped up using thermal insulation material, and cold wind circulation line uses loop, is increased condenser, cold wind can be made to recycle Air maintains low temperature and drying regime in pipeline, guarantees that dry chamber interior walls without frost is frozen, increase cold between vacuum pump and hothouse Trap improves the service life of vacuum pump.

7, the of the invention large-scale production drying device and drying means for effectively shortening probiotics feed liquid drying time, Using cyclone separator and bag filter two-stage gas filter device, the pollution of cold wind circulation line, cleaning can be effectively prevented It is easy to maintain.

8, the of the invention large-scale production drying device and drying means for effectively shortening probiotics feed liquid drying time, Simple with structure, it is raw can to carry out rapid scale to heat sensitive materials such as food, probiotics for the high feature of integrated degree It produces.

9, the of the invention large-scale production drying device and drying means for effectively shortening probiotics feed liquid drying time, Using atomizing freeze drying technique, directly makes the dry powdering probiotic composition of solution, emulsion, is processed without second-time breakage, The diameter of particle of acquisition is small, and particle size distribution is small, and cost is relatively low in storage, transport for freeze-dried powder, and less input.

10, the of the invention large-scale production drying device for effectively shortening probiotics feed liquid drying time and drying side Method, dry products can directly pack use, and such as addition effectively maintains probiotic active and shorten production in various food Process, preparation method are simple and efficient, also more convenient when client uses.

11, the of the invention large-scale production drying device for effectively shortening probiotics feed liquid drying time and drying side Method, the probiotics micro mist processed have porous structure, and large specific surface area keeps entire drying process shorter, is conducive to probiotics Flora survives.

12, cocoa of the invention effectively shorten probiotics feed liquid drying time large-scale production drying device and drying side Method, to probiotics feed liquid low-temperature atomizing, probiotics material is quickly frozen into particle at low temperature, fast freezing process can produce compared with Small ice crystal structure, is conducive to the survival of probiotics, and freezing dry process is also especially apparent the activity for keeping probiotics.

Detailed description of the invention

Fig. 1 is the structural schematic diagram of atomizing freeze drying device of the invention；

Fig. 2 is atomizing freeze drying time and traditional sublimation drying comparison diagram；

The grain size distribution for the powder product that Fig. 3 is.

Description of symbols

1- electric heater, 2- temperature sensor, 3- hothouse, 4- twin fluid atomization device, 5- feed inlet, 6- pressed gas enter Mouth, 7- cleansing pin gas access, 8- atomizing pressure regulating valve, 9- cleansing pin pressure-regulating valve, 10- air compressor machine, 11- peristaltic pump, 12- system Unite control panel, 13- vacuum meter, 14- control cabinet, 15- bracket, 16- valve, 17- valve, 18- circulating refrigerator, 19- valve, 20- valve, 21- rotary-vane vaccum pump, 22- cold-trap, 23- condenser, 24- temperature sensor, 25- temperature sensor, 26- refrigeration Liquid discharge outlet, 27- refrigerating fluid discharge outlet, 28- condensation-water drain, 29- condensation-water drain, 30- centrifugal blower, 31- condensed water go out Mouth, 32- cyclone separator, 33- valve, 34- bag filter, 35- vacuum gauge, 36- valve, 37- temperature sensor, 38- Valve.

Specific embodiment

Below by specific embodiment, the invention will be further described, and it is not limit that following embodiment, which is descriptive, Qualitatively, this does not limit the scope of protection of the present invention.

A kind of large-scale production drying device for effectively shortening probiotics drying time, including refrigeration system, spraying system System, dust pelletizing system, vacuum system, heating system, electric control system.

Refrigeration system includes circulating refrigerator 18, condenser 23, centrifugal blower 30.Circulating refrigerator 18 passes through refrigeration liquid pipe The road first branch is that condenser 23 provides cryogenic liquid, and temperature sensor 25, control condenser temperature decline are equipped in condenser To preset value, valve 16 and valve 20 are housed in the liquid pipeline first branch of freezing, are provided with below condenser for regularly replacing The refrigerating fluid discharge outlet 27 of refrigerating fluid.When hothouse 3 is pre-chilled, removes atomizer and seal mounting hole, centrifugal blower 30 makes cold Wind recycles in the loop that condenser 23, hothouse 3, dust pelletizing system, centrifugal blower 30 form.Outside cold wind circulation loop It is all made of thermal insulation material package, reduces circulating refrigerator load.Air inlet pipeline is provided with the acquisition air inlet temperature of temperature sensor 37 Degree, hothouse bottom are provided with temperature sensor 2 and acquire dry room temperature and temperature of charge.Cold wind circulation line bottom is provided with Condensation-water drain 31, condenser bottom are provided with condensation-water drain 28, condensed water in pipeline can be discharged in time and avoid pipeline dirty Dye.It is provided with valve 38 at cold wind circulation line upper air inlet, is provided with valve 33 at lower air outlet, when for drying and vacuum Isolation of system.

Spraying system includes twin fluid atomization device 4, peristaltic pump 11 and air compressor machine 10.Twin fluid atomization device 4 is mounted on drying 3 top of room, material are transported to feed inlet 5 by peristaltic pump 11, and the pressed gas that air compressor machine 10 generates passes through Pipeline transport to pressure Power gas access 6, atomizing pressure are adjusted by atomizing pressure regulating valve 8.To prevent material from freezing in atomizer, in atomizer It is provided with cleansing pin, pressed gas acts cleansing pin into atomizer by cleansing pin gas access 7, the size cleansing pin of cleansing pin operation force Pressure-regulating valve 9 controls.It is adjustable according to pressure size, liquid inlet volume and nozzle diameter to generate size droplet diameter.Twin fluid atomization device 4 At cold air inlet, atomized drop falling direction flows to identical with cold wind, and rate of heat transfer is fast, drop can in the sky with hothouse bottom Portion, which realizes, to freeze.

Dust pelletizing system includes cyclone separator 32, bag filter 34.32 entrance of cyclone separator passes through cold wind circulation pipe Road is connected to hothouse 3, and outlet is connect by pipeline with bag filter 34.Aerial drop suspend in cyclone separator Middle carry out primary dedusting, bag filter are final dusting device.Bag filter 34 by cold wind circulation line be connected to from Heart blower.

Vacuum system includes hothouse 3, rotary-vane vaccum pump 21, cold-trap 22.The second branch of refrigeration liquid pipeline is equipped with valve Door 17 and valve 19 are provided with refrigerating fluid discharge outlet 29 below cold-trap 22 for adjusting refrigeration flow quantity.Vacuum pump 21 passes through pipe Road is connected to form loop with cold-trap, hothouse, and hothouse forms negative pressure after vacuum pump is opened, and captures distillation by cold-trap Vapor.

Heating system be include electric heater 1.Electric heater 1 is located at hothouse bottom end, and heating temperature is adjustable.

Electric control system is located in the control cabinet 14 of the top of bracket 15, including programmable controller, frequency converter, power supply, System control panel 12, vacuum meter 13.Vacuum gauge 35 is installed on cold-trap to the vacuum line of hothouse and acquires drying chamber pressure Signal, 13 real-time display hothouse vacuum degree of vacuum meter.Temperature sensor 2, temperature sensor 37, temperature sensor 25, temperature Sensor 24 acquire temperature signal controlled by PLC, system control panel can to spray-freeze dry process parameter into Row setting.

A kind of integrated large-scale production drying means for effectively shortening probiotics drying time is real with prebiotic bacterium solution Material is tested, drying includes the following steps:

1) hothouse is pre-chilled: closing the valve 17 and valve 19 of the second bye-pass of refrigeration liquid pipeline, closes condensed water and go out Mouth 28,29,31 opens the valve 16 and valve 20 of refrigeration the first bye-pass of liquid pipeline；Vacuum line valve 36 is closed, by cold wind Circulation line is isolated with vacuum line, and circulating refrigerator 18 sets circularly cooling temperature as -80 DEG C, is opened circulating refrigerator, is made 23 temperature of condenser reaches -40 DEG C or so；Hothouse air inlet valve 38 and air outlet valve 33 are opened, by hothouse and dedusting System, refrigeration system connection；Centrifugal blower 30 is opened, cold wind wind speed 4m/s is set, dry room temperature is made to drop to -45 DEG C or so；

2) material is atomized: after pre-cooling, twin fluid atomization device 4 being placed into 3 top atomizer mounting hole of hothouse It is fixed, jet diameters 1mm；Atomizing pressure 0.2MPa is set, 11 charging rate of peristaltic pump is set by system control panel 12 20ml/min opens peristaltic pump charging, peristaltic pump is closed after charging, takes out atomizer, fixing port is sealed；

3) vacuumize: open refrigeration liquid pipeline the second bye-pass valve 17 and valve 19, make 22 temperature of cold-trap be down to- 80 DEG C or so；Close the valve 16 and valve 20 of refrigeration the first bye-pass of liquid pipeline；Vacuum tube is opened after closing centrifugal blower 30 Road valve 36；Close hothouse air inlet valve 38 and air outlet valve 33, by hothouse 3 and dust pelletizing system, refrigeration system every From；It opens vacuum pump 21 and vacuumize process is carried out to hothouse inside；

4) dry materials: setting heating temperature is 35 DEG C, opens electric heater 1, records vacuum meter in the drying process The variation of 13 vacuum degrees, stops drying when drying chamber pressure is lower than 4.4Pa；

5) drying terminates: drying chamber pressure stops drying test after reaching requirement, is first shut off circulating refrigerator 18, closes Electric heater 1, closes vacuum pump 21, slowly opens vacuum line condensation-water drain 29 and discharges drying chamber pressure；When dry chamber pressure Power is to become opening hothouse when normal pressure, takes out material, and drying terminates.Open condensation-water drain 28, condensation-water drain 31.

The prebiotic entire drying process of bacterium solution can complete (Fig. 2) in 3-5 hours, and powder product moisture content is lower than after drying 5%, diameter of particle distribution is as shown in Figure 3.

This atomizing freeze drying integrated apparatus completes entire material atomization in hothouse, drop freezes, vacuum refrigeration Drying process, refrigerating process do not need to avoid freezing liquid from contacting with material using cryogenic liquid, and it is direct without transfer to freeze material It dries in the drying chamber, avoids the contaminated risk of material completely.Prebiotic bacterium solution be atomized at low ambient temperatures and quick freezing at The ice crystal of ice pellets, generation is tiny, is conducive to the activity for keeping probiotics.Atomization process generates the specific surface area of probiotics drop more Greatly, ice rate of sublimation faster, keeps drying time shorter, and probiotics survival rate is also just higher.System closed-loop operation further increases The aseptic of atomizing freeze drying technique, and pollution is not generated to environment, reduce production energy consumption and processing cost.It is dry The probiotics micro mist diameter of particle obtained afterwards is small, and particle size distribution is small, processes without second-time breakage.Drying process is under negative pressure It carries out, heating temperature is controllable, is also applied for the atomizing freeze drying of other heat sensitive materials.

Although disclosed the embodiment of the present invention and attached drawing, those skilled in the art can manage for the purpose of illustration Solution, do not departing from the present invention and spirit and scope of the appended claims in, various substitutions, changes and modifications be all it is possible, Therefore the scope of the present invention is not limited to the embodiment and attached drawing disclosure of that.