阅读说明：本技术 具有尺寸稳定性的样本元件的悬置 (The suspension of sample components with dimensional stability ) 是由 M·J·拉姆洛 D·B·艾伦 于 2018-03-22 设计创作，主要内容包括：公开了用于悬置样本元件的衬底以及包括此类衬底的样本平台,其中能以改善的可靠性对所述样本元件加以分析。在示范性实施例中,此类样本元件用于热致发光剂量计(TLD)或光刺激发光剂量计(OSLD)中来以改善的准确性提供计算出的辐射剂量。与分析样本元件相关联的再现性,并且明确地说是与分析由膜悬置或囊封在膜内的样本元件相关联的再现性可以通过张紧所述膜而得以显著改善。在组装样本平台期间可以使用机械压痕力产生张紧,所述机械压痕力由于样本平台的衬底的配置,例如此衬底的对置区段或板的配置而施加。或者,可以使用抵靠所述衬底的区段或板对膜单独施加的力来实现张紧。(The substrate for suspending sample components and the sample platform including such substrate are disclosed, wherein can be analyzed with improved reliability the sample components.In an exemplary embodiment, such sample components provide calculated dose of radiation for coming in thermoluminescent dosimeter (TLD) or photo stimulated luminescence dosimeter (OSLD) with improved accuracy.Reproducibility associated with analysis sample components, and specifically reproducibility associated with the sample components that analysis is suspended or is encapsulated in film by film can be significantly improved by being tensioned the film.The configuration of the opposed section or plate of the generation tensioning of mechanical indentation power, the configuration of substrate of the mechanical indentation power due to sample platform, such as this substrate can be used during assembling sample platform and apply.Alternatively, the power that individually applies against the section or plate of the substrate to film can be used to realize tensioning.)

1. a kind of for suspending the substrate of sample components, the substrate includes top section and bottom section, the top section Be configured to form substrate opening in alignment with the bottom section, and junction film in extending across the opening Outside area outside heart district；

Wherein the top section and the bottom section are further configured to the institute across the opening mechanically tensioning film State center.

2. substrate according to claim 1, wherein the top section and the bottom section are configured to by making It states film and is mechanically tensioned the film in the square upward displacement of the planar offset from the opening.

3. substrate according to claim 2, wherein the displacement occurs along the edge of the opening.

4. substrate according to claim 3, wherein the marginal portion of opening ground prolonging by the bottom section Element is stretched to be formed.

5. substrate according to claim 4, wherein the extending element of the bottom section is in the institute from the opening The side for stating planar offset is angled up, and wherein the top section and the described of the bottom section are aligned in institute It states in opening and chamfered edge is provided.

6. a kind of sample platform comprising:

Substrate has opening, and the center of film extends across the opening, and

Sample components are suspended in the opening by the center of the film,

Wherein the center of the film is tensioned across the opening, to reduce the movement of the sample components at the time of reading.

7. sample platform according to claim 6, wherein the substrate includes one or more other openings, the film The other center of corresponding one or more extend across one or more of other openings, the sample platform into One step includes:

One or more other sample components, are suspended at the phase by the other center of corresponding one or more In the other opening of the one or more answered,

Wherein each of described other center of film opening other across corresponding one or more Tensioning, to reduce the movement of one or more of other sample components when heated.

8. sample platform according to claim 7, wherein the substrate includes four openings and the sample platform packet Four sample components are included, each sample components include different thermoluminescence material types or quality of materials density for measuring not The ionising radiation of same type.

9. sample platform according to claim 6, wherein the center of the film is by making the film from described The square upward displacement of the planar offset of opening and cross over opening tensioning.

10. sample platform according to claim 9, wherein the displacement occurs along the edge of the opening.

11. sample platform according to claim 10, wherein the displacement be as in the film described in the opening The folding line of edge causes.

12. sample platform according to claim 11, wherein the folding line be the top section for being directed at the substrate with It is formed when the bottom section with extending element of the substrate.

13. sample platform according to claim 1, wherein the opening is circular.

14. sample platform according to claim 13, wherein the diameter of the opening, which is about 5 millimeters (mm), arrives about 30mm.

15. a kind of method for determining dose of radiation, which comprises

The sample is read by the way that the sample components of sample platform according to claim 1 are exposed to heat or light Part, and

Measure the intensity of the electromagnetic radiation emitted by the sample components.

16. according to the method for claim 15, wherein the movement of the sample components is relative to film during the reading The reference method that is not tensioned of center be reduced.

17. according to the method for claim 16, wherein the movement of the sample components being reduced is to moving down Dynamic or torsion movement.

18. according to the method for claim 15, wherein the reading of the sample components is by according to time-temperature The sample components are exposed to heat by quantitative curve.

19. according to the method for claim 18, wherein the time-temperature quantitative curve include at least about 150 DEG C most Big temperature.

20. according to the method for claim 15, wherein the reading of the sample components is by by the sample Part is exposed to light, wherein the first wave length that has of the light is different from the of the electromagnetic radiation emitted by the sample components Two wavelength.

21. a kind of method for manufacturing dosimetry card, which comprises

The outside area of film is attached to the first plate of substrate as follows: so that the center of the support sample components of the film Extend across the first plate opening；

Make the second plate of the second plate be open to be aligned with first plate opening to form substrate opening；

Wherein it is tensioned the film across the substrate opening and folding the film in the edge of the substrate opening.

22. according to the method for claim 21, wherein by being directed at the second plate opening and first plate opening The film is folded against first plate of the substrate before to be tensioned the film.

23. according to the method for claim 21, wherein by the extending element of second plate come in alignment described second The folding is executed when plate, the extending element is radially inwardly into largely relative to first plate opening.

24. according to the method for claim 21, wherein the dosimetry card be thermoluminescence dosimetry (TLD) block or Photo stimulated luminescence dosimetry (OSLD) card.

Technical field

The present invention relates to the substrate for suspending or holding sample components, the sample components are for example including being exposed to heat When transmitting electromagnetic radiation material (thermoluminescence material) or when being exposed to light emit electromagnetic radiation material (photo stimulated luminescence Material or radiophotoluminescence material) element.Exemplary substrate is for thermoluminescent dosimeter (TLD) or photo stimulated luminescence Substrate in dosimeter (OSLD), wherein sample components are read (for example, being exposed to heat or light source) to emit electromagnetic radiation, example Such as visible light or black light, amount is related with the dose of radiation that sample components are subjected to.

Background technique

Certain form of analytical equipment (it may be generally referred to as sample platform) is for suspending or holding sample components, wherein one A possible purpose is that analysis is allowed in the case where having signal contamination as few as possible from surrounding substrate (or " to read Take ") these sample components.The sample components being concerned show it is luminous, thus contained in such as minerals in these elements Material absorbs energy in irradiation, and the energy can be then launched, such as with the photon in the visual field of electromagnetic spectrum Form.Specifically, thermoluminescence is a kind of light emitting species, wherein emitting electromagnetic radiation (usually when heating sample components Visible light or black light).Photo stimulated luminescence be it is another form of shine, wherein by sample components be exposed to light (for example, With the wavelength different from the wavelength of the electromagnetic radiation of transmitting) when emit electromagnetic radiation (generally also visible light or near ultraviolet Light).Passive dosimetry field be based on these properties for using some known materials to interact with ionising radiation, ionising radiation Dosage can be later by using reader that these materials are exposed to form of energy appropriate (for example, proper temperature or wave Heat or light under long) and measure light emitted measure.Typical thermoluminescent dosimeter (TLD) or photo stimulated luminescence Dosimeter (OSLD) is comprising showing the sample of thermoluminescence or photo stimulated luminescence (depending on the circumstances) for suspending or holding The device of the substrate of this element.Dosimeter (such as TLD or OSLD) reader corresponding to its and Response characteristics are collectively known as agent System is determined in measurement.

For many years, TLD and OSLD significantly develops, and has studied the material of many types, these materials show thermotropic hair Light and photo stimulated luminescence, and it is likely to be suited for various dosimetry fields.Such thermoluminescence and photo stimulated luminescence material It can be in its structure memory energy storage capacity, because electronics and electric hole are trapped within and " are caught due to the defects of material when being illuminated Collect in " center ".When material is exposed to hot (in the case where thermoluminescence material) or light (the case where in photo stimulated luminescence material Under) when, electrons and holes recombinate at " centre of luminescence ", so as to cause the transmitting of electromagnetic radiation, usually visible light.Reader Using photomultiplier tube (PMT), such as charge coupled device (CCD) solid-state detector or device in similar light converter come This electromagnetic radiation is measured, such as the photon of the composition signal emitted in visual field.If according to preferred luminescent material, from every A trapping center emits a photon, then the signal measured is the index of the number in electronic/electrical hole pair, and absorbs with previous Dose of radiation it is proportional.

TLD and OSLD is commonly used in personal radiation monitoring, such as is likely to be exposed at 3/10 more than dose equivalent limit The people of radiation.It is monitored in some settings, such as the research of reparation or research radiochemistry application in nuclear power plant's accident In laboratory, it is ensured that it is most important to meet permitted maximum Dose standard.For this purpose, multiple types can be used in TLD and OSLD Sample components more fully determine received at the certain depth of the body interior and body region dosage of individual.Citing comes It says, can measure at (1) to whole body 10mm (Hp (10)), (2) are arrived at eye lens 3mm (Hp (3)) and/or (3) arrive four limbs Dosage at 0.07mm (Hp (0.07)).The application extension of TLD and OSLD is to environmental neutron and clinical monitoring, commercial weight Taking purposes is radiotherapy, diagnosing radiation measurement, material survey year and aerolite analysis use for cancer treatment.

Constantly seek TLD and OSLD, and can be analyzed by reliable fashion more generally for suspension or fixing or Read the improvement of any kind of substrate and associated sample platform of the sample components of (by being exposed to appropriate energy source).

Summary of the invention

Aspect of the invention and discovery are for suspending or holding the substrate of sample components and the sample including such substrate Platform is associated, wherein the reliability that can improve analyzes the sample components.In an exemplary embodiment, such sample This element provides calculated spoke for coming in dosimeter (for example, TLD or OSLD) with improved accuracy and/or repeatability Penetrate dosage.According to specific embodiment, sample components can be suspended for example, by the film of plastic layer or laminated plastics layered product, and In some cases, the sample components can be encapsulated in two between film or layered product.Certain aspects of the present disclosure is related to sending out Existing such film is analysis in the reader of dosimetry system or may be susceptible to generation during reading given sample components can not The movement of prediction, such as energy source is exposed to (for example, being exposed to heat with reasonable time-temperature quantitative curve or suitable at it When being exposed to light under wavelength) when, as described above.These movements may negatively affect light again, and to collect optical element (such as PMT, solid State detector or other light converters as described above) measurement, so as to cause dosimetry system or for analyzing or reading The unacceptable reproducibility of other systems of the sample components of suspension.

It was unexpectedly determined that it has now been discovered that if tensioning film is (such as by relative to non-during assembling sample platform Tensioning or relaxed state or alternatively relative to pre-strained state increase assembling during layer tension), then with analysis sample components, And it is specifically suspended by film or is held (such as being encapsulated in film (for example, in any case in the opening of substrate)) Sample components, associated reproducibility and/or repeatability available significantly improve.Term " tensioning ", which can refer to, applies power It is added on (something), the power is tended to make its stretching.For example, can by the tensioning state of film in non-tensioned or loose The film of relaxation state (that is, the state for not applying drawing force) is compared.Can be used due to sample platform substrate (for example, this The opposed section or plate of substrate) configuration or in other ways due to against substrate section or plate power is separately applied to film and The mechanical indentation power of film is applied to realize tensioning.This individually applies can be in the opposed section of aligning substrate or the advance of plate Film is fastened or is sandwiched between the section or plate by row.

As described above, whether through substrate configuration still by independent applied force (or both) Lai Shixian film (for example, Extend across the center of the film of substrate opening) tensioning, obtain those skilled in the art of knowledge from this specification and all will Solution, in the preparation (group of sample platform (including substrate and the sample components suspended by the center of the film in the opening of substrate) Dress) during can advantageously increase the tension of film.That is, such preparation may include: that the outside area of film is attached to by (1) The first section or the first plate of substrate, so that the central mode area of support sample components extends across the first section opening or the first plate Opening, and (2) will (the second section or the second plate) second section opening or the second plate opening and the first section openings or the The opening alignment of one plate is to form substrate opening.The initial tension of the center of film attaches at least one in film that is, in step (1) A tension to extend across the first section or plate opening the second section of alignment opening or the second plate can be opened in step (2) Mouth is increased with being formed after sample platform.Therefore, the center of the film of representative sample platform can have the center greater than film The final tension of initial tension of the area when being initially attached to the first section opening or the first plate is open.As described above, tension This increase can be relative to non-tensioned or relaxed state the initial tension for indicating film.Alternatively, this increase of tension can be Initial tension relative to the pre-strained state for indicating film has applied some drawing forces, but initial tension under pre-strained state Still less than the final tension of the center of the film in sample platform as assembled.

Due to film tensioning (for example, to realize final tension as described above) caused by analyze measurement performance improvement can It is attributed to the significant of sample components (for example, in the case where conventional untensioned film) movement originally admissible during analysis Reduction partially (for example, more than 50%).In subjective aspect, widely studies have shown that there is no film tensioning, this Sample components described in text tend to move up with its analysis during being exposed to heat, light or other energy sources, It reverses or moves down.In turn, in these researchs, small sample is mobile experimentally with analyze or read sample The significant decrease of reliability (for example, in terms of reproducibility and/or repeatability) when element (for example, to determine dose of radiation) It is related.Generally speaking, improve associated with tensioning has important commercial significance, is especially considering that dosimetry system Demand increase and its commercial performance requirement.

The embodiment of the present invention be related to it is a kind of for suspending or holding the substrate of sample components, wherein the top of the substrate Section and bottom section are configured to the center of mechanically tensioning film, are hanged for crossing over by the substrate opening that these sections are formed Set sample components.In an exemplary embodiment, sample components can be encapsulated in two films, such as support membrane and cover film, and two Person is tensioned as described herein.According to specific embodiment, the top section and the bottom section of the substrate are configured At the final tension for the center for providing the film, the final tension is more than that the film is attached to the top section Or the initial tension of the bottom section (relative to its increase).

Other embodiments are related to sample platform, such as dosimetry card, in addition to the center suspension by film or hold, or According to embodiment particularly, be encapsulated in substrate opening between support membrane and the center of cover film, sample components it It outside further include substrate as described above.According to specific embodiment, the center of the film has in the sample platform More than the final tension of initial tension as described above.

Other embodiments are related to a kind of method for determining dose of radiation comprising read suspension or be retained on institute as above Sample components in the opening for the sample platform stated.It (can include thermoluminescence by the way that the sample components are exposed to heat In the case where the sample components of compound) or light (in the case where including the sample components of photo stimulated luminescence compound) Lai Zhihang It reads.In the first case, the method especially may include according to time-temperature quantitative curve heat sample components, and Measurement during heating, such as during the specific acquisition period of heating, the electromagnetic radiation that is emitted by the sample components (such as Visible light or black light) intensity.In a second situation, the method may include the sample components are exposed to light, Wherein for stimulating the light of the sample components that may have first wave length, the first wave length is different from during obtaining the period By the second wave length for the electromagnetic radiation that the sample components emit.For example, for stimulating the light and the electricity of sample components Both magnetic radiations can be all visible light, but (for example, green light can be used for stimulating, and blue light can be sent out with different wave length It penetrates and its intensity is measured as basis for determining dose of radiation).Emit from the sample components for including luminophor Electromagnetic radiation in the case where, the representative wavelength of such electromagnetic radiation is typically about 200 nanometers (nm) to about 700nm, and More typically about 300nm to about 550nm indicates visible light or near ultraviolet ray.

According to as described herein for any of the method for determining dose of radiation, such method be may further include Keep the measured intensity emitted during obtaining the period by sample components related to dose of radiation.These are more fully hereinafter described The advantages of method, again especially with regard to the determining associated increase of the movement and multiple dose of radiation for reducing sample components Existing property and/or repeatability.

Other embodiments be related to it is a kind of manufacture dosimeter card (for example, TLD card or OSLD card) method comprising: (i) with As the outside area of film is attached to the first plate of substrate by under type: so that the center of the film of support or fixing sample components The first plate opening is extended across, and the second plate opening of the second plate is aligned with first plate opening to form substrate by (ii) Opening.The film can be made to open across the substrate by the folding line formed in the film in the edge of the substrate opening Mouth tensioning.Specifically, tensioning can for example, by the lower comer edge of the first plate the first plate opening will be described Film is folded on first plate of the substrate and executes.It is such before being directed at the second plate opening with the first plate opening Folding can be independent step.Configuration due to the first plate with the second plate when it is aligned to form substrate opening, such as the For the extending element of two plates relative to the protruding radially inward configuration to a greater extent of the first plate opening, folding can be with " automatic Ground " executes.Such extending element can be angled relative to the plane of substrate opening.The angled extending element the case where Under, the first plate can provide chamfered edge or inclined-plane when being aligned with the second plate for substrate opening.As described above, according to particular implementation The final tension of example, the center for the film realized when the second plate of alignment in step (ii) can be advantageously more than in step (i) In attach film initial tension.

These and other embodiment will be from described in detail below and become apparent.

Detailed description of the invention

Fig. 1 illustrates the side view cutaway drawing of a part of the conventional sample platform of such as dosimetry card.

Fig. 2 illustrates the side view cutaway drawing of a part of sample platform, wherein by being folded against film at open edge The top plate of the substrate of sample platform and make film across substrate opening be tensioned.

Fig. 3 illustrates second embodiment, and according to the second embodiment, film is tensioned across substrate opening, but due to bottom plate Modified configuration, film are folded against top plate.

Fig. 4 illustrates 3rd embodiment, and according to the 3rd embodiment, film is tensioned across substrate opening, but with shown in Fig. 3 The case where compare, the modified configuration of bottom plate includes the extending element with different angle.

Fig. 5 illustrates fourth embodiment, and according to the fourth embodiment, the modified configuration using top plate and bottom plate makes film It is tensioned across substrate opening.

Fig. 6 A and 6B illustrate the top section of substrate and the top view of bottom section respectively, and wherein film is attached to top substrate Section, and support the center suspension of the film of sample components or be retained in top section opening.

Fig. 7 illustrates as flat in described sample after the top section and bottom section of aligning substrate in Fig. 6 A and 6B Platform, wherein the sample platform includes the sample components of film and suspension.

Fig. 8 illustrates that the possibility for suspending or being encapsulated sample components between two films by film is mobile.

Fig. 9 illustrates time-temperature quantitative curve, according to the time-temperature quantitative curve, can heat thermoluminescence agent Meter (TLD) sample components are to determine dose of radiation that sample components are exposed to.

All figures are interpreted as that the explanation of the embodiment of the present invention and/or involved principle is presented.Such as understanding the disclosure It should be apparent to those skilled in the art that other devices, method and specifically equipment used in dosimetry, Such as dosimetry card, will there is the configuration partly determined by its special-purpose and component.Through several views of attached drawing, phase Same appended drawing reference refers to corresponding part.

Specific embodiment

Specified such as "upper", "lower", " upward ", " downward ", " top ", " bottom " and " lower part " particular space orient or The term in direction is to use to should be readily appreciated that, and specifically, be used to indicate position of the particular element relative to other elements It sets.These terms can be with preferred orientation of the finger element when being positioned in dosimetry card reader.However, these terms are not Substrate described herein and sample platform are limited to particular space orientation.For example, those skilled in the art It will be understood that the interchangeability of " top substrate section " and " base substrate section ", particularly in view of element described herein It may substitute, such as " top substrate section " and " base substrate section " uses the substitution of " the first plate " and " the second plate " respectively.

(i.e. such sample components institute is sudden and violent for the light of sample components especially for reading including photo stimulated luminescence compound Be exposed to the light to cause the transmitting of electromagnetic radiation) context in, term " light " refers generally to electromagnetic radiation and be not limited to " can It is light-exposed ", it is seen that light more specifically refers to the electromagnetic radiation in the visible part of electromagnetic spectrum.So that it takes up a position, for example, term " light " can refer to the radioactive wave for stimulating radiophotoluminescence material.Therefore, it is mainly used to distinguish using term " light " and is used for The electromagnetic radiation of stimulating light emission material and the electromagnetic radiation emitted for example during reading from such material as described herein.

Term " reading " refers to any kind of energy for being exposed to sample components and allowing to obtain information from sample components, Comprising heat, light, sound, vibration etc., the dose of radiation that the information such as sample components are subjected to is (for example, being in close proximity to During the ionising radiation exposure cycles of the study subject of sample components).More specifically, " reading " can refer to include thermoluminescence The sample components of compound are exposed to heat source (for example, resistive element) or the sample components including photo stimulated luminescence compound are sudden and violent It is exposed to light source (for example, from lamp).As described herein, the size of aspect of the invention and the improvement sample components during reading Stability is associated so as to cause corresponding improve when measuring the information needed from sample components.

As noted above, the embodiment of the present invention is related to the substrate for suspending or holding sample components.These substrates Combination with sample components together with the film (for example, being encapsulated) sample components are suspended or held across substrate opening is properly termed as Sample platform.According to specific embodiment, such sample platform may be used as thermoluminescent dosimeter (TLD) and referred to as TLD card, can For use as photo stimulated luminescence dosimeter (OSLD), and referred to as OSLD card, or may be used as radiophotoluminescent dosimeter (RPLD), and referred to as RPLD card.By means of being applied to for suspending or holding sample components (for example, sample components are encapsulated The tension of one or more films between two films), substrate and sample platform described herein advantageously improve sample The positional stability (that is, reduction is upward, downward and/or torsion movement) of part, especially during analysis or reading sample components When being heated or exposed to the energy of light or other forms.It can apply according to the mode of substrate or part thereof is mechanically configured Such tension.Alternatively, tension can be caused by (for example, manually) applied force independent during assembling sample platform.In any feelings It under condition, has shown that the associated improvement of stability greatlys improve analysis reproducibility, and therefore improves total constitution of sample platform Amount.It includes to be exposed to or the risky dosage for being exposed to ionising radiation that this, which provides significant benefit to the user of such sample platform again, Measure the user of card.As described above, applying tension or " tensioning " can refer to be directed at or be adjoined to adjoining for the section of substrate or plate The second section or plate before it is one or more relative to initially the initial tension that film applies or be attached to the section or plate is increased The tension of the center of a film.

Fig. 1 illustrates the side view of a part of the conventional sample platform 100 of such as dosimetry card.The platform includes lining Bottom 20, having can be in the top substrate section 1 and base substrate section 3 of top substrate plate and base substrate plate form.These Section 1,3 is configured to form the opening across substrate, example when being directed at top section opening 11 with bottom section opening 13 Such as substrate opening 15, there can be the openings of sizes being substantially the same with top section opening 11 and bottom section opening 13 (for example, diameter in the case where circular substrate opening).The shape of substrate opening 15 is alterable, and for reality of the invention It tramples not important.Representative substrate opening can be round, ellipse or polygon (for example, rectangle, such as square).Such as figure It is further illustrated in 1, the center 17a of film 17 extends across substrate opening 15, and top substrate section 1 and base substrate section 3 are configured to the outside area 17b outside the 17a of center of the junction film 17 in alignment.This engagement at outside area 17b is logical It crosses and the contact of top substrate section 1 and base substrate section 3 (and the corresponding top surface 17 ' in film 17 and bottom surface in particular 17 " locate) Lai Shixian.That is, top substrate section 1 and base substrate section 3 be properly termed as at outside area 17b on cover, clamp or Sandwich film 17.

Therefore the center 17a of film 17 extends across substrate opening 15, and further illustrate as shown in figure 1, by sample Part 25 is suspended or is retained in opening 15.Sample components 25 can be identical as the shape of substrate opening 15 as described above in having Or the form of the flat disc of different cross-sectional shapes.Such as substrate opening 15, sample components 25 can have round, oval Shape or polygon (for example, rectangle, such as square) cross-sectional shape, wherein the key of definite geometry and non-present invention is special Sign.More relevant is that substrate opening 15 can have enough size to surround sample components 25 and in sample components 25 and substrate Sufficient space is provided between section 1,3, so that analyzing or reading sample components (for example, using TLD card reader or OSLD card reading Device) when, the signal contamination from substrate section 1,3 is minimum or negligible.Those skilled in the art will understand that substrate openings 15 and sample components 25 appropriate geometry and size.According to specific embodiment, substrate opening 15 is round, and sample The cross-sectional shape of part 25 be also it is round and substantially concentric with substrate opening 15 but have relative to the substrate opening compared with Small diameter.

For in TLD, sample components 25 may include thermoluminescence compound, such as lithium fluoride (LiF), boron Sour lithium (Li₂B₄O₇), beryllium oxide (BeO), antifungin (MgB₄O₇), calcium sulfate (CaSO₄), calcirm-fluoride (CaF₂), aluminium oxide (Al₂O₃), or positive magnesium silicate (Mg₂SiO₄).According to the specific application being related to the radiation dose monitoring of human or animal tissues, sample This element 25 may include doped with selected from group consisting of doped chemical lithium fluoride: magnesium, titanium, copper, phosphorus, silver, dysprosium, thulium and A combination thereof, wherein the particular instance of doped thermoluminescence compound is LiF:Mg, Ti and LiF:Mg, Cu, P.Such application Other examples include doped with dysprosium or manganese (CaF₂: Dy or CaF₂: Mn) calcirm-fluoride.Sample components 25 alternatively include polished bard Excite optical compounds, such as carbon doped aluminium (Al₂O₃: C), europium ion-doped rubidium magnesium fluoride (RbMgF₃: Eu⁺²) or radiating light Electroluminescent material, such as silver activation phosphate glass.

Film 17 or film 17,18 (using the second film 18) generally transparent or at least translucent plastics material Material, (for about 0.013mm to about 0.25mm), usually from about 1 to about 5 mil is (about for representative thickness usually from about 0.5 to about 10 mil 0.025mm is to about 0.13mm) and usually from about 1.5 mils to about 2.5 mils (about 0.038mm to about 0.64mm).It can make Such thickness is obtained with single layer or plate layer or in addition using multiple layers or plate layer (for example, 2 or more plate layers).It is using Film is come in the case where suspending or being encapsulated the sample components including thermoluminescence compound, such as according to predetermined protocol, film is preferably It is heat-resisting material, fusion temperature is greater than the fusion temperature of sample components 25 to be heated.Representative protocol is to determine correlation Join dose of radiation when for parse sample glow curve time-temperature quantitative curve (TTP).Such heating is applied, Film can have the fusing point beyond 300 DEG C.It can be with for the representative film in any of embodiment described herein For example including fluoropolymer, such as polytetrafluoroethylene (PTFE) (for example,) or polyimides (for example,).Root The specific embodiment of sample components 25 is encapsulated according to film 17,18 is used, such film can be surrounded by applying pressure and/or heat The periphery bonding of sample components.Representative film with suitable property includes that unsintered non-directional extrudes film.Alternatively, film 17, it 18 can be bonded by using sticker.Such as machine direction orientation (MDO) film or transverse direction can also be used to orient (TDO) the direction film of film.The temperature stability of film can be improved by being crosslinked.Preferably, film is to visible transparent.Equally, Sample components 25 can also include heat-resisting material (for example, fluoropolymer of such as polytetrafluoroethylene (PTFE)), and serve as luminousization It closes the carrier of object (for example, thermoluminescence compound or photo stimulated luminescence compound) and according to specific embodiment, has with institute With needing even concentration luminophor dispersed therein.

Fig. 2 illustrates the film 17 being tensioned by forming folding line 30, such as by the top section 1 against substrate 20 to film 17 Apply upward mechanical force or manual force, the mechanical force or manual force can more specifically be applied at top section opening 11 It is added at the lower comer edge 32 of top substrate section 1.It can be considered as support membrane below sample element 25 in addition to using Film 17 except, Fig. 2 further illustrates the second film 18 that can be considered as cover film of the top of sample element 25.By this method, root According to the embodiment of Fig. 2, sample element 25 can be suspended or be held by the center 17a of film 17, as illustrated in Figure 1, Huo Zheke Be encapsulated between center 17a, 18a of the film 17 and the second film 18 that are respectively served as support membrane and cover film otherwise. Outside area 17b, 18b of film 17 and the second film 18 can refer to and with top substrate section 1 and the contact of base substrate section 3 Area those of outside respective center area 17a, 18a of engagement, as shown in Figure 2.According to embodiment illustrated in fig. 3, the second film 18 only include its center 18a, it is sufficient to cover sample element and is encapsulated between film 17 and the second film 18.Although in order to Do not illustrate in figures 4 and 5 convenient for explanation, but can the same way use as illustrated in Fig. 2 and 3 serve as sample element Second film 18 of 25 cover film, it is same in discribed embodiment in figures 4 and 5.

As shown in Fig. 2, due to forming folding line 30 on tension film 17 (and second film 18), this film in the case to Top upward displacement so that film 17 in wherein heart district 17a from the plane 40 of substrate opening 15 (that is, being parallel to top substrate area Section 1 and base substrate section 3 and the plane disposed between two parties relative to it) offset.Due to tensioning (its cause film 17 (and film 18, If used) and therefore this displacement or bending of sample components 25), sample components are stable in position, so that it may be moved It is dynamic (such as during heating, or to be in other ways exposed to light or other energy sources as needed to read sample components simultaneously And during determining dose of radiation) be substantially reduced.It suspends or is retained in tensioning film 17 in sample components 25, or capsule in other ways In the case where being enclosed between tensioning film 17 and the second film 18 (the second film can be tensioned or not be tensioned), it has been found that this improved position It is associated with important advantage as described above to set stability.

As illustrated in Figure 3, top substrate section 1 and base substrate section 3 are advantageously configured to for example in itself at it When 11,13 alignment (as described above with reference to Figure 1) of corresponding opening, across the center 17a of the mechanically tensioning film 17 of substrate opening 15. Such as in embodiment illustrated in fig. 2, film 17 shifts again, so that it is in the 17a of center from the plane of substrate opening 15 40 (for example, center 17a is above) offset.It is subjected to displacement or is bent along the edge 38 of substrate opening 15 or periphery, and In the case, edge 38 is at least partly formed by the extending element 45 of base substrate section 3.As shown, extending element 45 extend beyond the periphery of top substrate section 1 or are radially inwardly into top section opening 11.In other words, bottom serves as a contrast The extending element 45 of bottom point 3 extends in substrate opening 15 to a greater degree relative to top substrate section 1.Therefore, in Fig. 3 Embodiment and Fig. 4 embodiment in, bottom section opening 13 11 narrows relative to top section opening, so that these are open Alignment can more specifically refer in the case these openings respective center alignment (such as vertical or coaxial alignment) (example Such as, so that the circular open in top substrate section 1 and base substrate section 3 is concentric).In addition, in the case, substrate opening 15 can be designated as corresponding in size with larger diameter or in other ways with larger size (in non-circular openings In the case where) substrate portions (1 or 3) in opening.Therefore, in the embodiment of Fig. 3 and the embodiment of Fig. 4, substrate is opened Mouth 15 can be designated as corresponding to top section opening 11 in size.

As further shown in Figure 3, the extending element 45 of base substrate section 3 is angled, and especially such as by angle It spends on the direction of direction offset of the plane 40 of slave substrate opening 15 specified by the nonzero value of α, as described above.Representative angle α is 45 °, but angle usually within the scope of 10-80 ° and other angles are suitable.Due to the angulation in the embodiment of Fig. 3 The extending element 45 of degree, the alignment of top substrate section 1 and base substrate section 3 can provide chamfered edge to form substrate opening 15 Or inclined-plane 57.According to Fig. 4, the angle of extending element 45 increases to 90 °.Shown in such embodiment, and it is commonly available to herein Any of described angled extending element, for causing the edge 38 of center 17a upward displacement of film can be It is circular.Other edges of angled extending element 45, such as second edge 38 ', can be similarly it is circular, to delay Solve the local stress on film 17.Fig. 5 illustrates another embodiment, wherein by using in top substrate section 1 with base substrate area Cooperation protruding portion or flange 50 that corresponding recess or groove 55 in section 3 are aligned realizes the tensioning of film 17, so that when section 1,3 When alignment is to form substrate opening 15, film 17 is pulled in groove 55 with desired mechanical tensioning result.

Fig. 6 A and 6B provide the substitution view of top substrate section (or first plate) 1 and base substrate section (or second plate) 3 Figure is aligned to form substrate 20 as shown in Figs. 1-5.Specifically, these figures illustrate the element of sample platform, such as dosage Meter card 200 can be thermoluminescent dosimeter (TLD) card or light stimulus dosimeter (OSLD) card, to assemble shape such as in Fig. 7 Shown in formula.In the exemplary process for assembling or manufacturing sample platform, the outside area 17b of film 17 can be attached as follows It is connected to the top substrate section or the first plate 1 of substrate: so that support, fixing or the center for being at least partly encapsulated sample components 25 Area 17a extends across top section opening or the first plate opening 11.Show that Fig. 6 A explanation of the first plate 1 extends across two first The center 17a of the film 17 of plate opening 11, and other two first plate opening 11 is shown as non-envelope 17 and covers.Second plate 3 At least one base substrate section opening or the second plate opening 13 can be aligned at least one first plate opening 11 to form lining Bottom opening 15, as described in such as Fig. 2.The film can cross over substrate and the edge folded membrane in substrate opening 15 15 tensioning of opening.It, can be by being open film 17 before 11 being directed at the second plate opening 13 and the first plate according to specific embodiment Against the first plate 1 folding be tensioned, such as the first plate opening 11 at the lower comer edge 32 of the first plate 1 (such as Described about the top substrate section 1 in Fig. 2).It, can be in the extending element 45 for passing through this plate according to another specific embodiment Folding is executed when (being described as described above and relative to the base substrate section 3 in Fig. 3 and 4) second plate 3 of alignment, it is described to prolong Element is stretched to extend to or be radially inwardly into the first plate opening 11.In other words, this extending element 45 of the second plate 3 is opposite It is extended in substrate opening 15 to a greater degree in the first plate 1.

Therefore, Fig. 6 A and 6B illustrates as depicted in figure 7 and including having the sample platform of the substrate 20 of opening 15a or agent The center 17a of the component of meter card 200, film extends across the opening.As further shown in Figure 7, sample platform is into one Step includes the sample components 25a that thus center 17a is suspended or held in opening 15a.As described in Fig. 2 and 3, sample Part 25a can also be closed or be encapsulated between film 17 (such as bottom film) and the second film 18 (such as top or cover film), same Sample can extend across opening 15 (Fig. 2) or can be applied locally on sample components 25a (Fig. 3) in other ways, without Extend across opening 15.The center 17a of film (can include the spy illustrated by such as Fig. 2-5 according to any mode as described herein Determine to be described in embodiment) across opening 15a tensioning, to reduce the movement of sample components at the time of reading, as described herein.

As further illustrated in Fig. 7, the substrate 20 of sample platform 200 may include one or more other openings 15b, 15c, 15d, the center 17a that the one or more of film is other extend across the opening or the first and second samples Other center 17a, 18a that part is encapsulated both films 17,18 may extend across the opening, as in Fig. 2 and 3 in more detail It is bright.Therefore, sample platform may further include by corresponding one or more other center 17a suspensions or be retained on phase One or more other sample components 25b, 25c, 25d in the one or more answered other opening 15b, 15c, 15d.It can To be further appreciated that, the center 17a of the single film of sample platform can be single in different opening 15a-d, or in other ways Only diaphragm can in these different openings, but such diaphragm still by the first underboarding 1 and the second underboarding 3 covering, It clamps or sandwiches, as shown in Figure 6 A and 6B.According to any mode as described herein, include the particular implementation as described in Fig. 2-5 Described in example, at least subset in each of other center 17a of film or such area crosses over corresponding one or more A other opening 15b, 15c, 15d tensioning, to reduce the movement of sample components at the time of reading.

In the specific embodiment of Fig. 7, substrate 20 includes four opening 15a-d, and each opening is suspended or held wherein Corresponding sample components 25a-d.Each of this four sample components 25a-d may include different luminescent material types (for example, being selected from doped compound as described above) and/or quality of materials density, for measuring or monitoring different types of ionization Radiation.For example, first sample element can be used for monitoring in the horizontal received radiation (Hp (3)) of eyes/eyeglass, the second sample This element can be used for monitoring in the received radiation (Hp (10)) of internal organ level, and third sample components can be used for monitoring The horizontal received radiation (Hp (0.07)) of skin/limbs, and the 4th sample components can be used for monitoring to penetrate with medium The horizontal received radiation of neutron form.In sample platform 200 illustrated in fig. 7, the center 17a of film or with other sides The film of formula separation can be by any mode as described herein across the tensioning of any of its corresponding opening, comprising by making film exist From the square upward displacement of the planar offset of corresponding opening, as described above.For example, the respective edges that can be open along these It is displaced, and specifically can cause to shift and the edge in corresponding opening folds film.Institute as above It states, before being directed at the second plate opening and the first plate opening, (example on the first plate of substrate can be folded in particular by by film Such as in the first plate opening in the lower comer edge of the first plate) it is tensioned film.It can be otherwise in aligning substrate The first plate when being aligned with the second plate with extending element (such as angled extending element as described above) of substrate Form the folding line in film.This angled extending element can be radially inwardly into respective substrate opening, to be open herein Middle offer chamfered edge or inclined-plane.In an exemplary embodiment, opening 15a-d is respectively circular, and diameter range is typically about 5 millis Rice (mm) arrives about 75mm, and typically about 10mm to about 30mm.In other exemplary embodiments, sample components 25a-d is Circular, diameter range is typically about 3mm to about 50mm, and typically about 5mm to about 35mm.

Such as the sample platform of dosimetry card as described herein can make in conjunction with the reader in dosimetry system With the dosimetry system allows to determine the received dose of radiation of sample components by these platforms or card.Therefore, of the invention Representative embodiment be related to a kind of method for determining dose of radiation comprising for example read in dosimetry card reader The sample components of suspension or fixing (for example, being encapsulated) in the opening of sample platform as described above.Reading sample components can be with Including being exposed to heat, such as according to scheduled time-temperature quantitative curve (TTP).TTP can be included at least at high temperature Thermoluminescence dosimetry (TLD) obtain the period, such as usually between about 150 DEG C and about 400 DEG C, and usually about Between 300 DEG C and about 400 DEG C.Alternatively, photo stimulated luminescence dosimetry (OSLD) can be alternatively included in by reading sample components The light of stimulation wavelength appropriate is exposed to during obtaining the period.In any case, the method may include measurements extremely The intensity of few electromagnetic radiation (such as visible light or black light) emitted during obtaining the period by sample components.The method It can also be associated with dose of radiation comprising making to obtain the intensity measured during the period herein.

According to exemplary process, tensioning that is identical relative to all parameters but not including film as described herein with reference to method Reference method, it is possible to reduce the movement of sample components.These identical parameters include (i) sample platform and its component, include The configuration of substrate, sample components and film and these components as described above, and (ii) sample during reading sample components The energy (for example, energy of time-temperature quantitative curve, light or other forms) that platform is subjected to.According to other embodiments, phase It is identical for all parameters (received by sample components comprising above-mentioned parameter (i) and (ii), and before executing the method The type and amount of ionising radiation) the reference method for determining dose of radiation reproducibility, the method can provide increase Reproducibility (that is, for received identical dose of radiation sample components multiple dose of radiations determine, variation reduce).

Fig. 8 explanation is being read to determine dose of radiation (such as by being heated according to time-temperature quantitative curve or by sudden and violent Be exposed to the light of stimulation wavelength) during sample components 25 it is various possible mobile.These include mobile (direction z) upward or downward with And torsion it is mobile (direction θ andDirection).By means of the center for suspending the film of (such as being encapsulated) sample components as described above Upward displacement, what the movement of the sample components reduced during reading can be sample components moves down or reverses movement.

Fig. 9 illustrates representative time-temperature quantitative curve, sample platform (for example, thermoluminescence dosimetry card) and The sample components for specifically suspending or holding are subjected to the time-temperature quantitative curve in card reader to determine to sample The dose of radiation of element.As shown, time-temperature quantitative curve may include at least about 150 DEG C of maximum temperature, for example, about 150 DEG C to about 300 DEG C of maximum temperature.According to specific embodiment, this quantitative curve may include preheating cycle A, transmitting radiation Obtain period B and annealing cycle C.Electromagnetic radiation (such as visible light or black light) can be measured during obtaining period B Intensity, and according to the area under glow curve D, measured intensity can be related to by the received dose of radiation of sample components Connection.Annealing cycle C at high temperature (temperature being subjected to during obtaining period B higher than sample components) can be used to ensure that The signal of the sample components of sample platform (for example, TLD card) is erased entirely, and makes it possible to reuse.

Example

Following instance is illustrated as representativeness of the invention.The range that these examples should not be construed as limiting the invention, because It will be evident for these and other equivalent embodiment in view of the present invention and the appended claims.

The mechanically or manually folding of film, such as be effective, but big against the lower comer edge of substrate top section It is not always reproducible in scale manufacturing environment.Therefore seek more robust way to realize same or similar folding effect Fruit.It was previously folded mechanically with what hand was completed for this purpose, changing sample platform substrate with effectively assigning.Specifically, will be at The extending element of angle is added to the bottom plate of this substrate, this leads to higher success rate, close to 100%, reduces sample components Torsion and the chance that moves down.In fact, when " distortion " and " downward " mobile generation for preventing sample components, reproducibility It is shown as being increased to from about 14% lower than 7%, that is, improve twice.

Following table provide the observation result of the conventional sample platform (i.e. " conventional A plate " (Fig. 1)) manufactured in the standard fashion with Wherein it is flat to be modified to the sample comprising wrinkle as described above " antelabium " or angled extending element for bottom or the second substrate The comparison of platform (i.e. " invention A plate " (Fig. 3)).In tables of data below, it is assumed that sample moves up when heated, because " upward " is Main Patterns.Therefore, any recording mark is all problematic that is, for " T " of torsion or for downward " D " 's.Following table indicates 720 observation results., it is apparent that invention A plate completely eliminates sample components from these tables Any torsion moves down.

Conventional A plate

Invention A plate

Generally, it is flat to be related to substrate, sample for suspending or holding (for example, being encapsulated) sample components to aspect of the invention Platform (for example, TLD card), the method for manufacturing such platform and the method for determining dose of radiation, it is all these to be ok It is associated with the overall reproducibility of the positional stability and radiation dose measurement that improve sample components.It is such improvement may be by In being tensioned the film for suspending or holding such sample components according to embodiment as described herein.With being obtained from the disclosure Knowledge those skilled in the art will realize that when realizing these and other advantage, this hair can not departed from Various changes are carried out to disclosed device and method in the case where bright range.It will be understood, therefore, that spy described herein Sign is easy to be changed or substitute.It is described herein and description specific embodiment for illustration purposes only, without limit Such as the present invention illustrated in the following claims.