阅读说明：本技术 一种抗抑郁的复合制剂及其制备方法 (Anti-depression compound preparation and preparation method thereof ) 是由 宗建成 邹圣灿 李文玉 解植彩 张曾亮 王尚龙 于 2019-09-30 设计创作，主要内容包括：本发明公开了一种抗抑郁的复合制剂及其制备方法,由以下原料组成：贯叶连翘、白芍、栀子、合欢花、牡丹皮。原料按比例称取分别得到提取物,混合制成复合制剂,本发明制备的复合制剂制备简单,安全、毒副作用小,无依赖性等优点,能有效缓解抑郁情绪。(The invention discloses an antidepressant composite preparation and a preparation method thereof, wherein the antidepressant composite preparation comprises the following raw materials: herba Hyperici perforati, radix Paeoniae alba, fructus Gardeniae, flos Albizziae, and cortex moutan. The raw materials are weighed according to a proportion to respectively obtain the extracts, and the extracts are mixed to prepare the composite preparation.)

1. An antidepressant composite preparation is characterized by comprising the following raw materials in parts by weight: 10-50 parts of hypericum perforatum, 100 parts of white paeony root, 150 parts of cape jasmine, 10-100 parts of albizia flower, 50-300 parts of albizia flower and 50-200 parts of moutan bark.

2. the antidepressant composite preparation according to claim 1 is characterized by comprising the following raw materials in parts by weight: 30 parts of hypericum perforatum, 120 parts of white paeony root, 60 parts of gardenia, 100 parts of albizia flower and 100 parts of moutan bark.

3. The preparation method of the antidepressant composite preparation according to any one of claims 1 or 2, characterized by comprising the following specific steps:

S1, weighing herba Hyperici perforati, radix Paeoniae alba, fructus Gardeniae, flos Albizziae, and cortex moutan at a certain proportion, and preparing;

S2, adding hypericum perforatum into 70% ethanol water solution with the material liquid volume ratio of 1:8, extracting for 2 times, each time for 1.5h, combining the extracting solutions, filtering, recovering ethanol, concentrating the filtrate into paste, drying at the set temperature of 60 ℃, crushing under reduced pressure, sieving with a 40-mesh sieve to obtain an extract A, and treating white paeony root similarly to obtain an extract B;

s3, adding the gardenia into an 80% ethanol aqueous solution, wherein the volume ratio of the material liquid to the liquid is 1:8, extracting for 2 times, each time for 1.5h, mixing the extractive solutions, filtering, recovering ethanol, concentrating the filtrate to obtain paste, drying at 60 deg.C, pulverizing under reduced pressure, and sieving with 40 mesh sieve to obtain extract C;

s4, adding the albizia julibrissin into water, wherein the volume ratio of the feed liquid to the water is 1:8, decocting for 2 times, each time for 1 hour, mixing decoctions, filtering, setting the temperature to be 60-65 ℃, concentrating the filtrate into paste with the relative density of 1.10-1.12, naturally cooling to the normal temperature, stirring, adding an ethanol solution with the ethanol content of 50%, standing for 24 hours, taking the supernatant, filtering, recovering ethanol, concentrating the filtrate into paste with the relative density of 1.28-1.30, setting the temperature to be 60 ℃, drying, crushing under reduced pressure, and sieving with a 40-mesh sieve to obtain an extract D;

s5, adding the moutan bark into water, wherein the volume ratio of the material liquid to the water is 1: 14, controlling the flow rate of the distillate, wherein each 200g of the medicinal materials is 6 mL/min < -1 >, distilling for 5 hours, collecting the distillate, placing the distillate in a refrigerator at 4 ℃, refrigerating for 24 hours, crystallizing, filtering, and drying the obtained crystals at 40-45 ℃ to obtain an extract E;

s6, grinding and mixing the obtained extract A-E according to the weight ratio of 15:14:7:5:0.6, and screening by a 80-mesh pharmacopoeia sieve to obtain the antidepressant composite preparation.

4. The method for preparing an antidepressant combination according to claim 3, characterized in that the finished dosage forms include, but are not limited to, tablets, granules, powders, ointments, drops, extracts, syrups.

Technical Field

The invention relates to the technical field of traditional Chinese medicine compound compositions, in particular to an anti-depression compound preparation and a preparation method thereof.

Background

in real life, due to the reasons of fast pace of life, high working economic pressure and the like, depressed mood and depressed mood are easily caused, the mood disorder disease is a common mood disorder disease, the mood disorder disease is mainly caused by mood depression and is an affective disorder disease with corresponding thinking and behavior changes, the clinical manifestations of mood depression, thought retardation, appetite reduction, sleep disorder and the like seriously harm the physical and mental health of people, and the serious depressed mood can even develop into depression and even shows the mood of suicide and the like. According to traditional Chinese medicine, depressed mood is mostly damaged by emotions such as depression, anger, anxiety, sadness, worry and the like. Its etiology is that the disorder of qi activity of five internal organs is caused by emotional disorder and the stagnation of internal organs, thereby causing various mental symptoms.

At present, most of the medicines for treating depression are western medicines which are mainly synthesized by chemical synthesis and have obvious curative effect, but have the defects of large toxic and side effects, addiction, high price, easy relapse and the like. In addition, the western medicines have certain side effects after being taken for a long time, and the virus and bacteria in vivo can generate immunity to the medicines after being taken for a long time. Most western medicines are chemical preparations, are effective in initial treatment, are easy to generate drug resistance after long-term administration, mainly rely on the liver for metabolism of the medicines, have certain pressure on the liver and the kidney after long-term administration, directly influence physical and mental health of people, and directly bring mental and economic burden to patients and families.

The Chinese herbal medicine compound preparation is mainly used for dredging liver qi activity, restoring liver function, soothing nerves, nourishing heart, tonifying heart and spleen and nourishing liver and kidney in clinical treatment by adopting a Chinese herbal medicine treatment method. A single Chinese medicament achieves certain progress in anti-depression treatment, and because depression is caused by a plurality of reasons, unclear causes, complex pathogenesis and the like, the single Chinese medicament has a single treatment effect, has delayed clinical symptom improvement time and large adverse reaction, and limits application. The Chinese herbal compound has a plurality of chemical components, so that the Chinese herbal compound has a synergistic effect with each other, is safe and has no toxic or side effect. Therefore, the research of the Chinese medicinal preparation on the treatment of the depression is more and more emphasized by experts at home and abroad. The invention searches for a traditional Chinese medicine composition with low toxicity, high curative effect, reasonable price and depression resistance from traditional Chinese herbal medicines, the traditional Chinese medicine composition consists of hypericum perforatum, white paeony root, gardenia, moutan bark and albizia flower, and provides scientific compatibility and a preparation method of the traditional Chinese medicine composition and application of the traditional Chinese medicine composition in treating depressed mood.

therefore, in combination with the above problems, it is an urgent need to solve the problems of the art to provide an antidepressant combination preparation and a method for preparing the same.

disclosure of Invention

in view of the above, the invention provides an anti-depression composite preparation and a preparation method thereof, and the composite preparation has the advantages of simple preparation, safety, small toxic and side effects, no dependence and the like, and can effectively relieve depression mood.

In order to achieve the purpose, the invention adopts the following technical scheme:

an anti-depression compound preparation comprises the following raw materials in parts by weight: 10-50 parts of hypericum perforatum, 100 parts of white paeony root, 150 parts of cape jasmine, 10-100 parts of albizia flower, 50-300 parts of albizia flower and 50-200 parts of moutan bark.

preferably, the antidepressant composite preparation is prepared from the following raw materials in parts by weight: 30 parts of hypericum perforatum, 120 parts of white paeony root, 60 parts of gardenia, 100 parts of albizia flower and 100 parts of moutan bark.

A preparation method of an antidepressant composite preparation comprises the following specific steps:

S1, weighing herba Hyperici perforati, radix Paeoniae alba, fructus Gardeniae, flos Albizziae, and cortex moutan at a certain proportion, and preparing;

S2, adding hypericum perforatum into 70% ethanol water solution with the material liquid volume ratio of 1:8, extracting for 2 times, each time for 1.5h, combining the extracting solutions, filtering, recovering ethanol, concentrating the filtrate into paste, drying at the set temperature of 60 ℃, crushing under reduced pressure, sieving with a 40-mesh sieve to obtain an extract A, and treating white paeony root similarly to obtain an extract B;

S3, adding the gardenia into an 80% ethanol aqueous solution, wherein the volume ratio of the material liquid to the liquid is 1:8, extracting for 2 times, each time for 1.5h, mixing the extractive solutions, filtering, recovering ethanol, concentrating the filtrate to obtain paste, drying at 60 deg.C, pulverizing under reduced pressure, and sieving with 40 mesh sieve to obtain extract C;

S4, adding the albizia julibrissin into water, wherein the volume ratio of the feed liquid to the water is 1:8, decocting for 2 times, each time for 1 hour, mixing decoctions, filtering, setting the temperature to be 60-65 ℃, concentrating the filtrate into paste with the relative density of 1.10-1.12, naturally cooling to the normal temperature, stirring, adding an ethanol solution with the ethanol content of 50%, standing for 24 hours, taking the supernatant, filtering, recovering ethanol, concentrating the filtrate into paste with the relative density of 1.28-1.30, setting the temperature to be 60 ℃, drying, crushing under reduced pressure, and sieving with a 40-mesh sieve to obtain an extract D;

S5, adding the moutan bark into water, wherein the volume ratio of the material liquid to the water is 1: 14, controlling the flow rate of the distillate, wherein each 200g of the medicinal materials is 6 mL/min < -1 >, distilling for 5 hours, collecting the distillate, placing the distillate in a refrigerator at 4 ℃, refrigerating for 24 hours, crystallizing, filtering, and drying the obtained crystals at 40-45 ℃ to obtain an extract E;

S6, grinding and mixing the obtained extract A-E according to the weight ratio of 15:14:7:5:0.6, and screening by a 80-mesh pharmacopoeia sieve to obtain the antidepressant composite preparation.

Preferably, the finished product dosage form includes, but is not limited to, tablets, granules, powders, soft extracts, dripping pills, extracts and syrups.

through the technical scheme, compared with the prior art, the invention has the following beneficial effects:

1. The invention establishes a Chinese herbal compound compatibility composition and a preparation method thereof, and accurately matches the weight components of hypericum perforatum, white paeony root, gardenia, albizia flower and moutan bark;

2. The traditional Chinese medicine compound preparation and the preparation method thereof disclosed by the invention have good effects on treating and relieving depression emotion, and the pure traditional Chinese medicine formula has the advantages of safety, small toxic and side effects, no dependence and the like;

3. The hypericum perforatum and the traditional Chinese medicine formula disclosed by the invention can be combined to be applied to obviously enhance the interest of mice in external environment, show obvious anti-depression activity, are equivalent or even superior to that of single hypericum perforatum, reflect the synergistic interaction of the hypericum perforatum and the traditional Chinese medicine formula in the scheme, are beneficial to relieving depression mood, and have the anti-depression tendency.

Detailed Description

The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.